Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MCRS1 (microspherule protein 1)

Identity

Alias_symbol (synonym)ICP22BP
MSP58
P78
MCRS2
INO80Q
Other alias
HGNC (Hugo) MCRS1
LocusID (NCBI) 10445
Atlas_Id 51076
Location 12q13.12  [Link to chromosome band 12q13]
Location_base_pair Starts at 49558303 and ends at 49566439 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MCRS1 (12q13.12) / CFL1 (11q13.1)MCRS1 (12q13.12) / MCRS1 (12q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MCRS1   6960
Cards
Entrez_Gene (NCBI)MCRS1  10445  microspherule protein 1
AliasesICP22BP; INO80Q; MCRS2; MSP58; 
P78
GeneCards (Weizmann)MCRS1
Ensembl hg19 (Hinxton)ENSG00000187778 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187778 [Gene_View]  chr12:49558303-49566439 [Contig_View]  MCRS1 [Vega]
ICGC DataPortalENSG00000187778
TCGA cBioPortalMCRS1
AceView (NCBI)MCRS1
Genatlas (Paris)MCRS1
WikiGenes10445
SOURCE (Princeton)MCRS1
Genetics Home Reference (NIH)MCRS1
Genomic and cartography
GoldenPath hg38 (UCSC)MCRS1  -     chr12:49558303-49566439 -  12q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MCRS1  -     12q13.12   [Description]    (hg19-Feb_2009)
EnsemblMCRS1 - 12q13.12 [CytoView hg19]  MCRS1 - 12q13.12 [CytoView hg38]
Mapping of homologs : NCBIMCRS1 [Mapview hg19]  MCRS1 [Mapview hg38]
OMIM609504   
Gene and transcription
Genbank (Entrez)AF015308 AF068007 AK308581 AY336730 BC011794
RefSeq transcript (Entrez)NM_001012300 NM_001278341 NM_006337
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MCRS1
Cluster EST : UnigeneHs.25313 [ NCBI ]
CGAP (NCI)Hs.25313
Alternative Splicing GalleryENSG00000187778
Gene ExpressionMCRS1 [ NCBI-GEO ]   MCRS1 [ EBI - ARRAY_EXPRESS ]   MCRS1 [ SEEK ]   MCRS1 [ MEM ]
Gene Expression Viewer (FireBrowse)MCRS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10445
GTEX Portal (Tissue expression)MCRS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96EZ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96EZ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96EZ8
Splice isoforms : SwissVarQ96EZ8
PhosPhoSitePlusQ96EZ8
Domaine pattern : Prosite (Expaxy)FHA_DOMAIN (PS50006)   
Domains : Interpro (EBI)FHA_dom    MCRS_N    SMAD_FHA_domain   
Domain families : Pfam (Sanger)FHA (PF00498)    MCRS_N (PF13325)   
Domain families : Pfam (NCBI)pfam00498    pfam13325   
Domain families : Smart (EMBL)FHA (SM00240)  
Conserved Domain (NCBI)MCRS1
DMDM Disease mutations10445
Blocks (Seattle)MCRS1
SuperfamilyQ96EZ8
Human Protein AtlasENSG00000187778
Peptide AtlasQ96EZ8
HPRD11298
IPIIPI00479000   IPI00220477   IPI00655820   IPI01013881   IPI01026237   IPI01022664   IPI01022837   IPI01021054   IPI01021171   IPI01021349   IPI01021496   
Protein Interaction databases
DIP (DOE-UCLA)Q96EZ8
IntAct (EBI)Q96EZ8
FunCoupENSG00000187778
BioGRIDMCRS1
STRING (EMBL)MCRS1
ZODIACMCRS1
Ontologies - Pathways
QuickGOQ96EZ8
Ontology : AmiGOhistone acetyltransferase complex  G-quadruplex RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  endoplasmic reticulum  polysome  DNA repair  DNA recombination  transcription, DNA-templated  regulation of transcription, DNA-templated  cellular protein modification process  poly(U) RNA binding  protein deubiquitination  dendrite  Ino80 complex  poly(G) binding  perikaryon  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K16 acetylation  histone acetyltransferase activity (H4-K5 specific)  histone acetyltransferase activity (H4-K8 specific)  histone acetyltransferase activity (H4-K16 specific)  MLL1 complex  positive regulation of protein localization to nucleolus  
Ontology : EGO-EBIhistone acetyltransferase complex  G-quadruplex RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  endoplasmic reticulum  polysome  DNA repair  DNA recombination  transcription, DNA-templated  regulation of transcription, DNA-templated  cellular protein modification process  poly(U) RNA binding  protein deubiquitination  dendrite  Ino80 complex  poly(G) binding  perikaryon  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K16 acetylation  histone acetyltransferase activity (H4-K5 specific)  histone acetyltransferase activity (H4-K8 specific)  histone acetyltransferase activity (H4-K16 specific)  MLL1 complex  positive regulation of protein localization to nucleolus  
Pathways : KEGGHerpes simplex infection   
NDEx NetworkMCRS1
Atlas of Cancer Signalling NetworkMCRS1
Wikipedia pathwaysMCRS1
Orthology - Evolution
OrthoDB10445
GeneTree (enSembl)ENSG00000187778
Phylogenetic Trees/Animal Genes : TreeFamMCRS1
HOVERGENQ96EZ8
HOGENOMQ96EZ8
Homologs : HomoloGeneMCRS1
Homology/Alignments : Family Browser (UCSC)MCRS1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMCRS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MCRS1
dbVarMCRS1
ClinVarMCRS1
1000_GenomesMCRS1 
Exome Variant ServerMCRS1
ExAC (Exome Aggregation Consortium)MCRS1 (select the gene name)
Genetic variants : HAPMAP10445
Genomic Variants (DGV)MCRS1 [DGVbeta]
DECIPHERMCRS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMCRS1 
Mutations
ICGC Data PortalMCRS1 
TCGA Data PortalMCRS1 
Broad Tumor PortalMCRS1
OASIS PortalMCRS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMCRS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMCRS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MCRS1
DgiDB (Drug Gene Interaction Database)MCRS1
DoCM (Curated mutations)MCRS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MCRS1 (select a term)
intoGenMCRS1
Cancer3DMCRS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609504   
Orphanet
MedgenMCRS1
Genetic Testing Registry MCRS1
NextProtQ96EZ8 [Medical]
TSGene10445
GENETestsMCRS1
Target ValidationMCRS1
Huge Navigator MCRS1 [HugePedia]
snp3D : Map Gene to Disease10445
BioCentury BCIQMCRS1
ClinGenMCRS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10445
Chemical/Pharm GKB GenePA30708
Clinical trialMCRS1
Miscellaneous
canSAR (ICR)MCRS1 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMCRS1
EVEXMCRS1
GoPubMedMCRS1
iHOPMCRS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:58:55 CEST 2017

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