MDK (midkine)

2003-02-01  

Identity

HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
ARAP,MK,NEGF2
FUSION GENES

Other Information

Locus ID:

NCBI: 4192
MIM: 162096
HGNC: 6972
Ensembl: ENSG00000110492

Variants:

dbSNP: 4192
ClinVar: 4192
TCGA: ENSG00000110492
COSMIC: MDK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110492ENST00000359803P21741
ENSG00000110492ENST00000395565P21741
ENSG00000110492ENST00000395566P21741
ENSG00000110492ENST00000395569P21741
ENSG00000110492ENST00000405308P21741
ENSG00000110492ENST00000407067P21741
ENSG00000110492ENST00000441869C9JHA4
ENSG00000110492ENST00000489525E9PLM6
ENSG00000110492ENST00000533952E9PPJ5
ENSG00000110492ENST00000617138A0A087WXB6

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH2REACTOMER-HSA-1980145
NOTCH2 Activation and Transmission of Signal to the NucleusREACTOMER-HSA-2979096

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121220092002Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types.94
222492492012Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling.86
121476812002The anti-HIV cytokine midkine binds the cell surface-expressed nucleolin as a low affinity receptor.42
237192642013Evaluation of midkine as a diagnostic serum biomarker in hepatocellular carcinoma.42
219899142011Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition.36
212338442011Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action.29
151464112004Midkine, a heparin-binding growth factor, is fundamentally involved in the pathogenesis of rheumatoid arthritis.28
186571272008Impact of alcohol abuse on protein expression of midkine and excitatory amino acid transporter 1 in the human prefrontal cortex.26
184695192008Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes.25
128418732003Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma.24

Citation

Dessen P

MDK (midkine)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41328/mdk