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MDK (midkine (neurite growth-promoting factor 2))

Identity

Other namesARAP
MK
NEGF2
HGNC (Hugo) MDK
LocusID (NCBI) 4192
Atlas_Id 41328
Location 11p11.2
Location_base_pair Starts at 46403261 and ends at 46405387 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MDK   6972
Cards
Entrez_Gene (NCBI)MDK  4192  midkine (neurite growth-promoting factor 2)
GeneCards (Weizmann)MDK
Ensembl hg19 (Hinxton)ENSG00000110492 [Gene_View]  chr11:46403261-46405387 [Contig_View]  MDK [Vega]
Ensembl hg38 (Hinxton)ENSG00000110492 [Gene_View]  chr11:46403261-46405387 [Contig_View]  MDK [Vega]
ICGC DataPortalENSG00000110492
TCGA cBioPortalMDK
AceView (NCBI)MDK
Genatlas (Paris)MDK
WikiGenes4192
SOURCE (Princeton)MDK
Genomic and cartography
GoldenPath hg19 (UCSC)MDK  -     chr11:46403261-46405387 +  11p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MDK  -     11p11.2   [Description]    (hg38-Dec_2013)
EnsemblMDK - 11p11.2 [CytoView hg19]  MDK - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBIMDK [Mapview hg19]  MDK [Mapview hg38]
OMIM162096   
Gene and transcription
Genbank (Entrez)AI494596 AK130889 AK308210 AK309963 BC011704
RefSeq transcript (Entrez)NM_001012333 NM_001012334 NM_001270550 NM_001270551 NM_001270552 NM_002391
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)MDK
Cluster EST : UnigeneHs.82045 [ NCBI ]
CGAP (NCI)Hs.82045
Alternative Splicing : Fast-db (Paris)GSHG0004794
Alternative Splicing GalleryENSG00000110492
Gene ExpressionMDK [ NCBI-GEO ]     MDK [ SEEK ]   MDK [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21741 (Uniprot)
NextProtP21741  [Medical]  [Publications]
With graphics : InterProP21741
Splice isoforms : SwissVarP21741 (Swissvar)
Domaine pattern : Prosite (Expaxy)PTN_MK_1 (PS00619)    PTN_MK_2 (PS00620)   
Domains : Interpro (EBI)Midkine_heparin-bd_GF    PTN/MK_C_dom    PTN/MK_diS    PTN/MK_N_dom    PTN_MK_heparin-bd_GF_CS   
Related proteins : CluSTrP21741
Domain families : Pfam (Sanger)PTN_MK_C (PF01091)    PTN_MK_N (PF05196)   
Domain families : Pfam (NCBI)pfam01091    pfam05196   
Domain families : Smart (EMBL)PTN (SM00193)  
Domain structure : Prodom (Prabi Lyon)PTN_MK_hepar_bd (PD005592)   
DMDM Disease mutations4192
Blocks (Seattle)P21741
PDB (SRS)1MKC    1MKN   
PDB (PDBSum)1MKC    1MKN   
PDB (IMB)1MKC    1MKN   
PDB (RSDB)1MKC    1MKN   
Human Protein AtlasENSG00000110492
Peptide AtlasP21741
HPRD01200
IPIIPI00010333   IPI00942093   IPI00719019   IPI00719099   IPI01018295   IPI00979574   IPI00719163   
Protein Interaction databases
DIP (DOE-UCLA)P21741
IntAct (EBI)P21741
FunCoupENSG00000110492
BioGRIDMDK
IntegromeDBMDK
STRING (EMBL)MDK
Ontologies - Pathways
QuickGOP21741
Ontology : AmiGObehavioral fear response  extracellular region  cytoplasm  signal transduction  Notch signaling pathway  nervous system development  short-term memory  growth factor activity  heparin binding  response to wounding  cell migration  dentate gyrus development  cerebellar granular layer development  cerebral cortex development  cell differentiation  adrenal gland development  defecation  response to drug  cell projection  negative regulation of neuron apoptotic process  positive regulation of transcription, DNA-templated  regulation of behavior  response to glucocorticoid  positive regulation of cell division  
Ontology : EGO-EBIbehavioral fear response  extracellular region  cytoplasm  signal transduction  Notch signaling pathway  nervous system development  short-term memory  growth factor activity  heparin binding  response to wounding  cell migration  dentate gyrus development  cerebellar granular layer development  cerebral cortex development  cell differentiation  adrenal gland development  defecation  response to drug  cell projection  negative regulation of neuron apoptotic process  positive regulation of transcription, DNA-templated  regulation of behavior  response to glucocorticoid  positive regulation of cell division  
Protein Interaction DatabaseMDK
DoCM (Curated mutations)MDK
Wikipedia pathwaysMDK
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerMDK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MDK
dbVarMDK
ClinVarMDK
1000_GenomesMDK 
Exome Variant ServerMDK
SNP (GeneSNP Utah)MDK
SNP : HGBaseMDK
Genetic variants : HAPMAPMDK
Genomic Variants (DGV)MDK [DGVbeta]
Mutations
ICGC Data PortalMDK 
TCGA Data PortalMDK 
Tumor PortalMDK
Somatic Mutations in Cancer : COSMICMDK 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:46403261-46405387
CONAN: Copy Number AnalysisMDK 
Mutations and Diseases : HGMDMDK
OMIM162096   
MedgenMDK
NextProtP21741 [Medical]
GENETestsMDK
Disease Genetic AssociationMDK
Huge Navigator MDK [HugePedia]  MDK [HugeCancerGEM]
snp3D : Map Gene to Disease4192
DGIdb (Drug Gene Interaction db)MDK
BioCentury BCIQMDK
General knowledge
Homologs : HomoloGeneMDK
Homology/Alignments : Family Browser (UCSC)MDK
Phylogenetic Trees/Animal Genes : TreeFamMDK
Chemical/Protein Interactions : CTD4192
Chemical/Pharm GKB GenePA30717
Clinical trialMDK
Cancer Resource (Charite)ENSG00000110492
Other databases
Probes
Litterature
PubMed127 Pubmed reference(s) in Entrez
CoreMineMDK
GoPubMedMDK
iHOPMDK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 11:51:45 CEST 2015

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