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MDK (midkine (neurite growth-promoting factor 2))

Identity

Other namesARAP
MK
NEGF2
HGNC (Hugo) MDK
LocusID (NCBI) 4192
Location 11p11.2
Location_base_pair Starts at 46403261 and ends at 46405387 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MDK   6972
Entrez_Gene (NCBI)MDK  4192  midkine (neurite growth-promoting factor 2)
Cards
GeneCards (Weizmann)MDK
Ensembl (Hinxton)ENSG00000110492 [Gene_View]  chr11:46403261-46405387 [Contig_View]  MDK [Vega]
AceView (NCBI)MDK
Genatlas (Paris)MDK
SOURCE (Stanford)NM_001012333 NM_001012334 NM_001270550 NM_001270551 NM_001270552 NM_002391
Genomic and cartography
GoldenPath (UCSC)MDK  -  11p11.2   chr11:46403261-46405387 +  11p11.2   [Description]    (hg19-Feb_2009)
EnsemblMDK - 11p11.2 [CytoView]
Mapping of homologs : NCBIMDK [Mapview]
OMIM162096   
Gene and transcription
Genbank (Entrez)AI494596 AK130889 AK308210 AK309963 BC011704
RefSeq transcript (SRS)NM_001012333 NM_001012334 NM_001270550 NM_001270551 NM_001270552 NM_002391
RefSeq transcript (Entrez)NM_001012333 NM_001012334 NM_001270550 NM_001270551 NM_001270552 NM_002391
RefSeq genomic (SRS)AC_000143 NC_000011 NC_018922 NT_009237 NW_001838022 NW_004078070
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NT_009237 NW_001838022 NW_004078070
Consensus coding sequences : CCDS (NCBI)MDK
Cluster EST : UnigeneHs.82045 [ SRS ] Hs.82045 [ NCBI ]
CGAP (NCI)Hs.82045
Alternative Splicing : Fast-db (Paris)GSHG0004794
Alternative Splicing GalleryENSG00000110492
Gene ExpressionMDK [ NCBI-GEO ]   MDK [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21741 (SRS) P21741 (Uniprot)
NextProtP21741
With graphics : InterProP21741
Splice isoforms : SwissVarP21741(Swissvar)
Domaine pattern : Prosite (SRS)PTN_MK_1 (PS00619)    PTN_MK_2 (PS00620)   
Domaine pattern : Prosite (Expaxy)PTN_MK_1 (PS00619)    PTN_MK_2 (PS00620)   
Domains : Interpro (SRS)Midkine_heparin-bd_GF    Midkine_heparin-bd_GF_C    Midkine_heparin-bd_GF_CS    Midkine_heparin-bd_GF_diS    Midkine_heparin-bd_GF_N   
Domains : Interpro (EBI)Midkine_heparin-bd_GF    Midkine_heparin-bd_GF_C    Midkine_heparin-bd_GF_CS    Midkine_heparin-bd_GF_diS    Midkine_heparin-bd_GF_N   
Related proteins : CluSTrP21741
Domain families : Pfam (SRS)PTN_MK_C (PF01091)    PTN_MK_N (PF05196)   
Domain families : Pfam (Sanger)PTN_MK_C (PF01091)    PTN_MK_N (PF05196)   
Domain families : Pfam (NCBI)pfam01091    pfam05196   
Domain families : Smart (EMBL)PTN (SM00193)  
Domain structure : Prodom (Prabi Lyon)PTN_MK_hepar_bd (PD005592)   
DMDM4192
Blocks (Seattle)P21741
PDB (SRS)1MKC    1MKN   
PDB (PDBSum)1MKC    1MKN   
PDB (IMB)1MKC    1MKN   
PDB (RSDB)1MKC    1MKN   
Human Protein AtlasENSG00000110492
HPRD01200
IPIIPI00010333   IPI00942093   IPI00719019   IPI00719099   IPI01018295   IPI00979574   IPI00719163   
Protein Interaction databases
DIP (DOE-UCLA)P21741
IntAct (EBI)P21741
FunCoupENSG00000110492
REACTOMEMDK
Protein Interaction Database4192
BioGRIDMDK
InParanoidP21741
Interologous Interaction database P21741
IntegromeDBMDK
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MDK
SNP (GeneSNP Utah)MDK
SNP : HGBaseMDK
Genetic variants : HAPMAPMDK
Somatic Mutations in Cancer : COSMICMDK 
CONAN: Copy Number AnalysisMDK 
Mutations and Diseases : HGMDMDK
OMIM162096   
GENETests162096   
Disease Genetic AssociationMDK
Huge Navigator MDK [HugePedia]  MDK [HugeCancerGEM]
Genomic VariantsMDK  MDK [DGVbeta]
snp3D : Map Gene to Disease4192
General knowledge
Homologs : HomoloGeneMDK
Homology/Alignments : Family Browser (UCSC)MDK
Phylogenetic Trees/Animal Genes : TreeFamMDK
Chemical/Protein Interactions : CTD4192
Chemical/Pharm GKB GenePA30717
Clinical trialMDK
Cancer Resource (Charite)ENSG00000110492
Ontology : AmiGObehavioral fear response  extracellular region  signal transduction  nervous system development  short-term memory  growth factor activity  heparin binding  response to wounding  dentate gyrus development  cerebellar granular layer development  cerebral cortex development  cell differentiation  adrenal gland development  defecation  positive regulation of transcription, DNA-dependent  regulation of behavior  positive regulation of cell division  
Ontology : EGO-EBIbehavioral fear response  extracellular region  signal transduction  nervous system development  short-term memory  growth factor activity  heparin binding  response to wounding  dentate gyrus development  cerebellar granular layer development  cerebral cortex development  cell differentiation  adrenal gland development  defecation  positive regulation of transcription, DNA-dependent  regulation of behavior  positive regulation of cell division  
Other databases
Probes
Litterature
PubMed105 Pubmed reference(s) in Entrez
PubGeneMDK
iHOPMDK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:47:08 CEST 2013
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