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MDM4 (MDM4, p53 regulator)

Identity

Alias_namesmouse double minute 4, human homolog of; p53-binding protein
Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)
Mdm4 p53 binding protein homolog (mouse)
Alias_symbol (synonym)MDMX
HDMX
Other aliasMRP1
HGNC (Hugo) MDM4
LocusID (NCBI) 4194
Atlas_Id 41329
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 204516379 and ends at 204558120 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ATP6V1C2 (2p25.1) / MDM4 (1q32.1)DNMT3B (20q11.21) / MDM4 (1q32.1)MDM4 (1q32.1) / DNMT3B (20q11.21)
MDM4 (1q32.1) / MDM4 (1q32.1)MDM4 (1q32.1) / NT5C3A (7p14.3)MDM4 (1q32.1) / SRGAP3 (3p25.3)
MDM4 (1q32.1) / UTP6 (17q11.2)NAT8L (4p16.3) / MDM4 (1q32.1)PPP1R9A (7q21.3) / MDM4 (1q32.1)
STK40 (1p34.3) / MDM4 (1q32.1)DNMT3B 20q11.21 / MDM4 1q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Head and neck: Retinoblastoma


External links

Nomenclature
HGNC (Hugo)MDM4   6974
Cards
Entrez_Gene (NCBI)MDM4  4194  MDM4, p53 regulator
AliasesHDMX; MDMX; MRP1
GeneCards (Weizmann)MDM4
Ensembl hg19 (Hinxton)ENSG00000198625 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198625 [Gene_View]  chr1:204516379-204558120 [Contig_View]  MDM4 [Vega]
ICGC DataPortalENSG00000198625
TCGA cBioPortalMDM4
AceView (NCBI)MDM4
Genatlas (Paris)MDM4
WikiGenes4194
SOURCE (Princeton)MDM4
Genetics Home Reference (NIH)MDM4
Genomic and cartography
GoldenPath hg38 (UCSC)MDM4  -     chr1:204516379-204558120 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MDM4  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblMDM4 - 1q32.1 [CytoView hg19]  MDM4 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBIMDM4 [Mapview hg19]  MDM4 [Mapview hg38]
OMIM602704   
Gene and transcription
Genbank (Entrez)AB209383 AF007111 AK097188 AK130328 AK223228
RefSeq transcript (Entrez)NM_001204171 NM_001204172 NM_001278516 NM_001278517 NM_001278518 NM_001278519 NM_002393
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MDM4
Cluster EST : UnigeneHs.715871 [ NCBI ]
CGAP (NCI)Hs.715871
Alternative Splicing GalleryENSG00000198625
Gene ExpressionMDM4 [ NCBI-GEO ]   MDM4 [ EBI - ARRAY_EXPRESS ]   MDM4 [ SEEK ]   MDM4 [ MEM ]
Gene Expression Viewer (FireBrowse)MDM4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4194
GTEX Portal (Tissue expression)MDM4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15151   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15151  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15151
Splice isoforms : SwissVarO15151
PhosPhoSitePlusO15151
Domaine pattern : Prosite (Expaxy)ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)MDM4    p53_neg-reg_MDM_2/4    SWIB_MDM2_domain    Znf_RanBP2    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)SWIB (PF02201)    zf-RanBP (PF00641)   
Domain families : Pfam (NCBI)pfam02201    pfam00641   
Conserved Domain (NCBI)MDM4
DMDM Disease mutations4194
Blocks (Seattle)MDM4
PDB (SRS)2CR8    2MWY    2N06    2N0U    2N0W    2N14    2VJE    2VJF    2VYR    3DAB    3EQY    3FDO    3FE7    3FEA    3JZO    3JZP    3JZQ    3LBJ    3MQR    3U15    4RXZ   
PDB (PDBSum)2CR8    2MWY    2N06    2N0U    2N0W    2N14    2VJE    2VJF    2VYR    3DAB    3EQY    3FDO    3FE7    3FEA    3JZO    3JZP    3JZQ    3LBJ    3MQR    3U15    4RXZ   
PDB (IMB)2CR8    2MWY    2N06    2N0U    2N0W    2N14    2VJE    2VJF    2VYR    3DAB    3EQY    3FDO    3FE7    3FEA    3JZO    3JZP    3JZQ    3LBJ    3MQR    3U15    4RXZ   
PDB (RSDB)2CR8    2MWY    2N06    2N0U    2N0W    2N14    2VJE    2VJF    2VYR    3DAB    3EQY    3FDO    3FE7    3FEA    3JZO    3JZP    3JZQ    3LBJ    3MQR    3U15    4RXZ   
Structural Biology KnowledgeBase2CR8    2MWY    2N06    2N0U    2N0W    2N14    2VJE    2VJF    2VYR    3DAB    3EQY    3FDO    3FE7    3FEA    3JZO    3JZP    3JZQ    3LBJ    3MQR    3U15    4RXZ   
SCOP (Structural Classification of Proteins)2CR8    2MWY    2N06    2N0U    2N0W    2N14    2VJE    2VJF    2VYR    3DAB    3EQY    3FDO    3FE7    3FEA    3JZO    3JZP    3JZQ    3LBJ    3MQR    3U15    4RXZ   
CATH (Classification of proteins structures)2CR8    2MWY    2N06    2N0U    2N0W    2N14    2VJE    2VJF    2VYR    3DAB    3EQY    3FDO    3FE7    3FEA    3JZO    3JZP    3JZQ    3LBJ    3MQR    3U15    4RXZ   
SuperfamilyO15151
Human Protein AtlasENSG00000198625
Peptide AtlasO15151
HPRD04082
IPIIPI00005170   IPI00914644   IPI00914667   IPI01015068   IPI00556404   IPI00426020   IPI00513968   IPI00655963   IPI00514556   IPI00514095   
Protein Interaction databases
DIP (DOE-UCLA)O15151
IntAct (EBI)O15151
FunCoupENSG00000198625
BioGRIDMDM4
STRING (EMBL)MDM4
ZODIACMDM4
Ontologies - Pathways
QuickGOO15151
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  protein binding  nucleus  nucleus  nucleoplasm  protein complex assembly  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  zinc ion binding  cell proliferation  negative regulation of cell proliferation  protein ubiquitination  protein deubiquitination  enzyme binding  DNA damage response, signal transduction by p53 class mediator  negative regulation of protein catabolic process  negative regulation of apoptotic process  G0 to G1 transition  protein stabilization  ubiquitin protein ligase activity  negative regulation of cell cycle arrest  cellular response to hypoxia  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  protein binding  nucleus  nucleus  nucleoplasm  protein complex assembly  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  zinc ion binding  cell proliferation  negative regulation of cell proliferation  protein ubiquitination  protein deubiquitination  enzyme binding  DNA damage response, signal transduction by p53 class mediator  negative regulation of protein catabolic process  negative regulation of apoptotic process  G0 to G1 transition  protein stabilization  ubiquitin protein ligase activity  negative regulation of cell cycle arrest  cellular response to hypoxia  regulation of signal transduction by p53 class mediator  
Pathways : KEGGp53 signaling pathway    MicroRNAs in cancer   
NDEx NetworkMDM4
Atlas of Cancer Signalling NetworkMDM4
Wikipedia pathwaysMDM4
Orthology - Evolution
OrthoDB4194
GeneTree (enSembl)ENSG00000198625
Phylogenetic Trees/Animal Genes : TreeFamMDM4
HOVERGENO15151
HOGENOMO15151
Homologs : HomoloGeneMDM4
Homology/Alignments : Family Browser (UCSC)MDM4
Gene fusions - Rearrangements
Fusion : MitelmanDNMT3B/MDM4 [20q11.21/1q32.1]  [t(1;20)(q32;q11)]  
Fusion : MitelmanMDM4/DNMT3B [1q32.1/20q11.21]  [t(1;20)(q32;q11)]  
Fusion : MitelmanSTK40/MDM4 [1p34.3/1q32.1]  [t(1;1)(p34;q32)]  
Fusion: TCGADNMT3B 20q11.21 MDM4 1q32.1 LAML
Fusion Cancer (Beijing)MDM4 [1q32.1]  -  UTP6 [17q11.2]  [FUSC000366]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMDM4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MDM4
dbVarMDM4
ClinVarMDM4
1000_GenomesMDM4 
Exome Variant ServerMDM4
ExAC (Exome Aggregation Consortium)MDM4 (select the gene name)
Genetic variants : HAPMAP4194
Genomic Variants (DGV)MDM4 [DGVbeta]
DECIPHERMDM4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMDM4 
Mutations
ICGC Data PortalMDM4 
TCGA Data PortalMDM4 
Broad Tumor PortalMDM4
OASIS PortalMDM4 [ Somatic mutations - Copy number]
Cancer Gene: CensusMDM4 
Somatic Mutations in Cancer : COSMICMDM4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMDM4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MDM4
DgiDB (Drug Gene Interaction Database)MDM4
DoCM (Curated mutations)MDM4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MDM4 (select a term)
intoGenMDM4
Cancer3DMDM4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602704   
Orphanet
MedgenMDM4
Genetic Testing Registry MDM4
NextProtO15151 [Medical]
TSGene4194
GENETestsMDM4
Huge Navigator MDM4 [HugePedia]
snp3D : Map Gene to Disease4194
BioCentury BCIQMDM4
ClinGenMDM4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4194
Chemical/Pharm GKB GenePA30719
Clinical trialMDM4
Miscellaneous
canSAR (ICR)MDM4 (select the gene name)
Probes
Litterature
PubMed223 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMDM4
EVEXMDM4
GoPubMedMDM4
iHOPMDM4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:24:32 CEST 2017

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