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ME2 (malic enzyme 2)

Identity

Alias_namesmalic enzyme 2
Other aliasODS1
HGNC (Hugo) ME2
LocusID (NCBI) 4200
Atlas_Id 50969
Location 18q21.2  [Link to chromosome band 18q21]
Location_base_pair Starts at 50879062 and ends at 50949792 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KMT2A (11q23.3) / ME2 (18q21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ME2   6984
Cards
Entrez_Gene (NCBI)ME2  4200  malic enzyme 2
AliasesODS1
GeneCards (Weizmann)ME2
Ensembl hg19 (Hinxton)ENSG00000082212 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000082212 [Gene_View]  chr18:50879062-50949792 [Contig_View]  ME2 [Vega]
ICGC DataPortalENSG00000082212
TCGA cBioPortalME2
AceView (NCBI)ME2
Genatlas (Paris)ME2
WikiGenes4200
SOURCE (Princeton)ME2
Genetics Home Reference (NIH)ME2
Genomic and cartography
GoldenPath hg38 (UCSC)ME2  -     chr18:50879062-50949792 +  18q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ME2  -     18q21.2   [Description]    (hg19-Feb_2009)
EnsemblME2 - 18q21.2 [CytoView hg19]  ME2 - 18q21.2 [CytoView hg38]
Mapping of homologs : NCBIME2 [Mapview hg19]  ME2 [Mapview hg38]
OMIM154270   
Gene and transcription
Genbank (Entrez)AJ294818 AK313391 AU119085 BC000147 BI465083
RefSeq transcript (Entrez)NM_001168335 NM_002396
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ME2
Cluster EST : UnigeneHs.233119 [ NCBI ]
CGAP (NCI)Hs.233119
Alternative Splicing GalleryENSG00000082212
Gene ExpressionME2 [ NCBI-GEO ]   ME2 [ EBI - ARRAY_EXPRESS ]   ME2 [ SEEK ]   ME2 [ MEM ]
Gene Expression Viewer (FireBrowse)ME2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4200
GTEX Portal (Tissue expression)ME2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23368   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23368  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23368
Splice isoforms : SwissVarP23368
Catalytic activity : Enzyme1.1.1.38 [ Enzyme-Expasy ]   1.1.1.381.1.1.38 [ IntEnz-EBI ]   1.1.1.38 [ BRENDA ]   1.1.1.38 [ KEGG ]   
PhosPhoSitePlusP23368
Domaine pattern : Prosite (Expaxy)MALIC_ENZYMES (PS00331)   
Domains : Interpro (EBI)Malic_enzyme_CS    Malic_N_dom    Malic_NAD-bd    Malic_OxRdtase    NAD(P)-bd_dom   
Domain families : Pfam (Sanger)malic (PF00390)    Malic_M (PF03949)   
Domain families : Pfam (NCBI)pfam00390    pfam03949   
Domain families : Smart (EMBL)malic (SM01274)  Malic_M (SM00919)  
Conserved Domain (NCBI)ME2
DMDM Disease mutations4200
Blocks (Seattle)ME2
PDB (SRS)1DO8    1EFK    1EFL    1GZ3    1GZ4    1PJ2    1PJ3    1PJ4    1PJL    1QR6   
PDB (PDBSum)1DO8    1EFK    1EFL    1GZ3    1GZ4    1PJ2    1PJ3    1PJ4    1PJL    1QR6   
PDB (IMB)1DO8    1EFK    1EFL    1GZ3    1GZ4    1PJ2    1PJ3    1PJ4    1PJL    1QR6   
PDB (RSDB)1DO8    1EFK    1EFL    1GZ3    1GZ4    1PJ2    1PJ3    1PJ4    1PJL    1QR6   
Structural Biology KnowledgeBase1DO8    1EFK    1EFL    1GZ3    1GZ4    1PJ2    1PJ3    1PJ4    1PJL    1QR6   
SCOP (Structural Classification of Proteins)1DO8    1EFK    1EFL    1GZ3    1GZ4    1PJ2    1PJ3    1PJ4    1PJL    1QR6   
CATH (Classification of proteins structures)1DO8    1EFK    1EFL    1GZ3    1GZ4    1PJ2    1PJ3    1PJ4    1PJL    1QR6   
SuperfamilyP23368
Human Protein AtlasENSG00000082212
Peptide AtlasP23368
HPRD01103
IPIIPI00011201   IPI00643577   
Protein Interaction databases
DIP (DOE-UCLA)P23368
IntAct (EBI)P23368
FunCoupENSG00000082212
BioGRIDME2
STRING (EMBL)ME2
ZODIACME2
Ontologies - Pathways
QuickGOP23368
Ontology : AmiGOmalic enzyme activity  malate dehydrogenase (decarboxylating) (NAD+) activity  malate dehydrogenase (decarboxylating) (NADP+) activity  mitochondrion  mitochondrion  mitochondrial matrix  pyruvate metabolic process  malate metabolic process  oxaloacetate decarboxylase activity  electron carrier activity  metal ion binding  NAD binding  oxidation-reduction process  regulation of NADP metabolic process  
Ontology : EGO-EBImalic enzyme activity  malate dehydrogenase (decarboxylating) (NAD+) activity  malate dehydrogenase (decarboxylating) (NADP+) activity  mitochondrion  mitochondrion  mitochondrial matrix  pyruvate metabolic process  malate metabolic process  oxaloacetate decarboxylase activity  electron carrier activity  metal ion binding  NAD binding  oxidation-reduction process  regulation of NADP metabolic process  
Pathways : KEGGPyruvate metabolism   
NDEx NetworkME2
Atlas of Cancer Signalling NetworkME2
Wikipedia pathwaysME2
Orthology - Evolution
OrthoDB4200
GeneTree (enSembl)ENSG00000082212
Phylogenetic Trees/Animal Genes : TreeFamME2
HOVERGENP23368
HOGENOMP23368
Homologs : HomoloGeneME2
Homology/Alignments : Family Browser (UCSC)ME2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerME2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ME2
dbVarME2
ClinVarME2
1000_GenomesME2 
Exome Variant ServerME2
ExAC (Exome Aggregation Consortium)ME2 (select the gene name)
Genetic variants : HAPMAP4200
Genomic Variants (DGV)ME2 [DGVbeta]
DECIPHERME2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisME2 
Mutations
ICGC Data PortalME2 
TCGA Data PortalME2 
Broad Tumor PortalME2
OASIS PortalME2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICME2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDME2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ME2
DgiDB (Drug Gene Interaction Database)ME2
DoCM (Curated mutations)ME2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ME2 (select a term)
intoGenME2
Cancer3DME2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM154270   
Orphanet
MedgenME2
Genetic Testing Registry ME2
NextProtP23368 [Medical]
TSGene4200
GENETestsME2
Target ValidationME2
Huge Navigator ME2 [HugePedia]
snp3D : Map Gene to Disease4200
BioCentury BCIQME2
ClinGenME2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4200
Chemical/Pharm GKB GenePA30724
Clinical trialME2
Miscellaneous
canSAR (ICR)ME2 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineME2
EVEXME2
GoPubMedME2
iHOPME2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:42:39 CEST 2017

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