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ME3 (malic enzyme 3)

Identity

Alias_namesmalic enzyme 3, NADP(+)-dependent, mitochondrial
Other aliasNADP-ME
HGNC (Hugo) ME3
LocusID (NCBI) 10873
Atlas_Id 68866
Location 11q14.2  [Link to chromosome band 11q14]
Location_base_pair Starts at 86441108 and ends at 86672198 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ME3 (11q14.2) / TPT1 (13q14.13)ME3 (11q14.2) / TYR (11q14.3)NARS2 (11q14.1) / ME3 (11q14.2)
RPA3 (7p21.3) / ME3 (11q14.2)TRIM52 (5q35.3) / ME3 (11q14.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ME3   6985
Cards
Entrez_Gene (NCBI)ME3  10873  malic enzyme 3
AliasesNADP-ME
GeneCards (Weizmann)ME3
Ensembl hg19 (Hinxton)ENSG00000151376 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151376 [Gene_View]  chr11:86441108-86672198 [Contig_View]  ME3 [Vega]
ICGC DataPortalENSG00000151376
TCGA cBioPortalME3
AceView (NCBI)ME3
Genatlas (Paris)ME3
WikiGenes10873
SOURCE (Princeton)ME3
Genetics Home Reference (NIH)ME3
Genomic and cartography
GoldenPath hg38 (UCSC)ME3  -     chr11:86441108-86672198 -  11q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ME3  -     11q14.2   [Description]    (hg19-Feb_2009)
EnsemblME3 - 11q14.2 [CytoView hg19]  ME3 - 11q14.2 [CytoView hg38]
Mapping of homologs : NCBIME3 [Mapview hg19]  ME3 [Mapview hg38]
OMIM604626   
Gene and transcription
Genbank (Entrez)AA403046 AA449933 AI198184 AI560417 AI948779
RefSeq transcript (Entrez)NM_001014811 NM_001161586 NM_006680
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ME3
Cluster EST : UnigeneHs.199743 [ NCBI ]
CGAP (NCI)Hs.199743
Alternative Splicing GalleryENSG00000151376
Gene ExpressionME3 [ NCBI-GEO ]   ME3 [ EBI - ARRAY_EXPRESS ]   ME3 [ SEEK ]   ME3 [ MEM ]
Gene Expression Viewer (FireBrowse)ME3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10873
GTEX Portal (Tissue expression)ME3
Human Protein AtlasENSG00000151376-ME3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16798   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16798  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16798
Splice isoforms : SwissVarQ16798
Catalytic activity : Enzyme1.1.1.40 [ Enzyme-Expasy ]   1.1.1.401.1.1.40 [ IntEnz-EBI ]   1.1.1.40 [ BRENDA ]   1.1.1.40 [ KEGG ]   
PhosPhoSitePlusQ16798
Domaine pattern : Prosite (Expaxy)MALIC_ENZYMES (PS00331)   
Domains : Interpro (EBI)Malic_enzyme_CS    Malic_N_dom    Malic_NAD-bd    Malic_OxRdtase    NAD(P)-bd_dom   
Domain families : Pfam (Sanger)malic (PF00390)    Malic_M (PF03949)   
Domain families : Pfam (NCBI)pfam00390    pfam03949   
Domain families : Smart (EMBL)malic (SM01274)  Malic_M (SM00919)  
Conserved Domain (NCBI)ME3
DMDM Disease mutations10873
Blocks (Seattle)ME3
SuperfamilyQ16798
Human Protein Atlas [tissue]ENSG00000151376-ME3 [tissue]
Peptide AtlasQ16798
HPRD06862
IPIIPI00003970   IPI00747874   IPI01013591   IPI00984697   IPI00922516   IPI00977786   IPI00978149   IPI00978858   IPI00977117   
Protein Interaction databases
DIP (DOE-UCLA)Q16798
IntAct (EBI)Q16798
FunCoupENSG00000151376
BioGRIDME3
STRING (EMBL)ME3
ZODIACME3
Ontologies - Pathways
QuickGOQ16798
Ontology : AmiGOmalic enzyme activity  malate dehydrogenase (decarboxylating) (NAD+) activity  malate dehydrogenase (decarboxylating) (NADP+) activity  mitochondrion  mitochondrial matrix  pyruvate metabolic process  malate metabolic process  oxaloacetate decarboxylase activity  aerobic respiration  metal ion binding  cofactor binding  NAD binding  oxidation-reduction process  oxygen metabolic process  
Ontology : EGO-EBImalic enzyme activity  malate dehydrogenase (decarboxylating) (NAD+) activity  malate dehydrogenase (decarboxylating) (NADP+) activity  mitochondrion  mitochondrial matrix  pyruvate metabolic process  malate metabolic process  oxaloacetate decarboxylase activity  aerobic respiration  metal ion binding  cofactor binding  NAD binding  oxidation-reduction process  oxygen metabolic process  
Pathways : KEGGPyruvate metabolism   
NDEx NetworkME3
Atlas of Cancer Signalling NetworkME3
Wikipedia pathwaysME3
Orthology - Evolution
OrthoDB10873
GeneTree (enSembl)ENSG00000151376
Phylogenetic Trees/Animal Genes : TreeFamME3
HOVERGENQ16798
HOGENOMQ16798
Homologs : HomoloGeneME3
Homology/Alignments : Family Browser (UCSC)ME3
Gene fusions - Rearrangements
Fusion: Tumor Portal ME3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerME3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ME3
dbVarME3
ClinVarME3
1000_GenomesME3 
Exome Variant ServerME3
ExAC (Exome Aggregation Consortium)ENSG00000151376
GNOMAD BrowserENSG00000151376
Genetic variants : HAPMAP10873
Genomic Variants (DGV)ME3 [DGVbeta]
DECIPHERME3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisME3 
Mutations
ICGC Data PortalME3 
TCGA Data PortalME3 
Broad Tumor PortalME3
OASIS PortalME3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICME3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDME3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ME3
DgiDB (Drug Gene Interaction Database)ME3
DoCM (Curated mutations)ME3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ME3 (select a term)
intoGenME3
Cancer3DME3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604626   
Orphanet
MedgenME3
Genetic Testing Registry ME3
NextProtQ16798 [Medical]
TSGene10873
GENETestsME3
Target ValidationME3
Huge Navigator ME3 [HugePedia]
snp3D : Map Gene to Disease10873
BioCentury BCIQME3
ClinGenME3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10873
Chemical/Pharm GKB GenePA30725
Clinical trialME3
Miscellaneous
canSAR (ICR)ME3 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineME3
EVEXME3
GoPubMedME3
iHOPME3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:12:25 CET 2017

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