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MEAF6 (MYST/Esa1 associated factor 6)

Identity

Alias_namesC1orf149
chromosome 1 open reading frame 149
MYST/Esa1-associated factor 6
Alias_symbol (synonym)NY-SAR-91
FLJ11730
Eaf6
CENP-28
Other aliasEAF6
HGNC (Hugo) MEAF6
LocusID (NCBI) 64769
Atlas_Id 45510
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 37489961 and ends at 37514819 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AKIRIN1 (1p34.3) / MEAF6 (1p34.3)MEAF6 (1p34.3) / PHF1 (6p21.32)MEAF6 (1p34.3) / SCMH1 (1p34.2)
MEAF6 1p34.3 / PHF1 6p21.32AKIRIN1 1p34.3 / MEAF6 1p34.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(2;8)(p23;p11) KAT6A/ASXL2
t(9;22)(p13;q13) PAX5/BRD1


External links

Nomenclature
HGNC (Hugo)MEAF6   25674
Cards
Entrez_Gene (NCBI)MEAF6  64769  MYST/Esa1 associated factor 6
AliasesC1orf149; CENP-28; EAF6; NY-SAR-91
GeneCards (Weizmann)MEAF6
Ensembl hg19 (Hinxton)ENSG00000163875 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163875 [Gene_View]  chr1:37489961-37514819 [Contig_View]  MEAF6 [Vega]
ICGC DataPortalENSG00000163875
TCGA cBioPortalMEAF6
AceView (NCBI)MEAF6
Genatlas (Paris)MEAF6
WikiGenes64769
SOURCE (Princeton)MEAF6
Genetics Home Reference (NIH)MEAF6
Genomic and cartography
GoldenPath hg38 (UCSC)MEAF6  -     chr1:37489961-37514819 -  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MEAF6  -     1p34.3   [Description]    (hg19-Feb_2009)
EnsemblMEAF6 - 1p34.3 [CytoView hg19]  MEAF6 - 1p34.3 [CytoView hg38]
Mapping of homologs : NCBIMEAF6 [Mapview hg19]  MEAF6 [Mapview hg38]
OMIM611001   
Gene and transcription
Genbank (Entrez)AK021792 AK225434 AK225598 AK308118 AK309663
RefSeq transcript (Entrez)NM_001270875 NM_001270876 NM_022756
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MEAF6
Cluster EST : UnigeneHs.17118 [ NCBI ]
CGAP (NCI)Hs.17118
Alternative Splicing GalleryENSG00000163875
Gene ExpressionMEAF6 [ NCBI-GEO ]   MEAF6 [ EBI - ARRAY_EXPRESS ]   MEAF6 [ SEEK ]   MEAF6 [ MEM ]
Gene Expression Viewer (FireBrowse)MEAF6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64769
GTEX Portal (Tissue expression)MEAF6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HAF1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HAF1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HAF1
Splice isoforms : SwissVarQ9HAF1
PhosPhoSitePlusQ9HAF1
Domains : Interpro (EBI)Eaf6   
Domain families : Pfam (Sanger)NuA4 (PF09340)   
Domain families : Pfam (NCBI)pfam09340   
Conserved Domain (NCBI)MEAF6
DMDM Disease mutations64769
Blocks (Seattle)MEAF6
SuperfamilyQ9HAF1
Human Protein AtlasENSG00000163875
Peptide AtlasQ9HAF1
HPRD13347
IPIIPI00642467   IPI00828199   IPI00009373   IPI00645730   IPI00515006   
Protein Interaction databases
DIP (DOE-UCLA)Q9HAF1
IntAct (EBI)Q9HAF1
FunCoupENSG00000163875
BioGRIDMEAF6
STRING (EMBL)MEAF6
ZODIACMEAF6
Ontologies - Pathways
QuickGOQ9HAF1
Ontology : AmiGOkinetochore  condensed chromosome kinetochore  protein binding  nucleoplasm  nucleoplasm  nucleolus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  nuclear body  NuA4 histone acetyltransferase complex  histone H2A acetylation  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K12 acetylation  histone H4-K16 acetylation  histone H3-K14 acetylation  MOZ/MORF histone acetyltransferase complex  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIkinetochore  condensed chromosome kinetochore  protein binding  nucleoplasm  nucleoplasm  nucleolus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  nuclear body  NuA4 histone acetyltransferase complex  histone H2A acetylation  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K12 acetylation  histone H4-K16 acetylation  histone H3-K14 acetylation  MOZ/MORF histone acetyltransferase complex  regulation of signal transduction by p53 class mediator  
NDEx NetworkMEAF6
Atlas of Cancer Signalling NetworkMEAF6
Wikipedia pathwaysMEAF6
Orthology - Evolution
OrthoDB64769
GeneTree (enSembl)ENSG00000163875
Phylogenetic Trees/Animal Genes : TreeFamMEAF6
HOVERGENQ9HAF1
HOGENOMQ9HAF1
Homologs : HomoloGeneMEAF6
Homology/Alignments : Family Browser (UCSC)MEAF6
Gene fusions - Rearrangements
Fusion : MitelmanAKIRIN1/MEAF6 [1p34.3/1p34.3]  [t(1;1)(p34;p34)]  
Fusion : MitelmanMEAF6/PHF1 [1p34.3/6p21.32]  [t(1;6)(p34;p21)]  
Fusion: TCGAAKIRIN1 1p34.3 MEAF6 1p34.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMEAF6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MEAF6
dbVarMEAF6
ClinVarMEAF6
1000_GenomesMEAF6 
Exome Variant ServerMEAF6
ExAC (Exome Aggregation Consortium)MEAF6 (select the gene name)
Genetic variants : HAPMAP64769
Genomic Variants (DGV)MEAF6 [DGVbeta]
DECIPHERMEAF6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMEAF6 
Mutations
ICGC Data PortalMEAF6 
TCGA Data PortalMEAF6 
Broad Tumor PortalMEAF6
OASIS PortalMEAF6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMEAF6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMEAF6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MEAF6
DgiDB (Drug Gene Interaction Database)MEAF6
DoCM (Curated mutations)MEAF6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MEAF6 (select a term)
intoGenMEAF6
Cancer3DMEAF6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611001   
Orphanet
MedgenMEAF6
Genetic Testing Registry MEAF6
NextProtQ9HAF1 [Medical]
TSGene64769
GENETestsMEAF6
Huge Navigator MEAF6 [HugePedia]
snp3D : Map Gene to Disease64769
BioCentury BCIQMEAF6
ClinGenMEAF6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64769
Chemical/Pharm GKB GenePA165751536
Clinical trialMEAF6
Miscellaneous
canSAR (ICR)MEAF6 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMEAF6
EVEXMEAF6
GoPubMedMEAF6
iHOPMEAF6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:24:33 CEST 2017

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