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MEAK7 (MTOR associated protein, eak-7 homolog)

Identity

Alias (NCBI)EAK7
KIAA1609
TLDC1
mEAK-7
HGNC (Hugo) MEAK7
HGNC Alias symbmEAK-7
HGNC Alias nameTLD domain containing 1
 mammalian EAK-7
HGNC Previous nameKIAA1609
 TLDC1
HGNC Previous nameKIAA1609
 TBC/LysM-associated domain containing 1
LocusID (NCBI) 57707
Atlas_Id 57864
Location 16q24.1  [Link to chromosome band 16q24]
Location_base_pair Starts at 84476355 and ends at 84504659 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)MEAK7   29325
Cards
Entrez_Gene (NCBI)MEAK7    MTOR associated protein, eak-7 homolog
AliasesEAK7; KIAA1609; TLDC1; mEAK-7
GeneCards (Weizmann)MEAK7
Ensembl hg19 (Hinxton)ENSG00000140950 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140950 [Gene_View]  ENSG00000140950 [Sequence]  chr16:84476355-84504659 [Contig_View]  MEAK7 [Vega]
ICGC DataPortalENSG00000140950
TCGA cBioPortalMEAK7
AceView (NCBI)MEAK7
Genatlas (Paris)MEAK7
SOURCE (Princeton)MEAK7
Genetics Home Reference (NIH)MEAK7
Genomic and cartography
GoldenPath hg38 (UCSC)MEAK7  -     chr16:84476355-84504659 -  16q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MEAK7  -     16q24.1   [Description]    (hg19-Feb_2009)
GoldenPathMEAK7 - 16q24.1 [CytoView hg19]  MEAK7 - 16q24.1 [CytoView hg38]
ImmunoBaseENSG00000140950
Genome Data Viewer NCBIMEAK7 [Mapview hg19]  
OMIM619331   
Gene and transcription
Genbank (Entrez)AA115393 AB046829 AK021995 AK291237 AK297241
RefSeq transcript (Entrez)NM_020947
Consensus coding sequences : CCDS (NCBI)MEAK7
Gene ExpressionMEAK7 [ NCBI-GEO ]   MEAK7 [ EBI - ARRAY_EXPRESS ]   MEAK7 [ SEEK ]   MEAK7 [ MEM ]
Gene Expression Viewer (FireBrowse)MEAK7 [ Firebrowse - Broad ]
GenevisibleExpression of MEAK7 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57707
GTEX Portal (Tissue expression)MEAK7
Human Protein AtlasENSG00000140950-MEAK7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P9B6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P9B6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P9B6
PhosPhoSitePlusQ6P9B6
Domaine pattern : Prosite (Expaxy)TLDC (PS51886)   
Domains : Interpro (EBI)TLDc_dom   
Domain families : Pfam (Sanger)TLD (PF07534)   
Domain families : Pfam (NCBI)pfam07534   
Domain families : Smart (EMBL)TLDc (SM00584)  
Conserved Domain (NCBI)MEAK7
SuperfamilyQ6P9B6
AlphaFold pdb e-kbQ6P9B6   
Human Protein Atlas [tissue]ENSG00000140950-MEAK7 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q6P9B6
IntAct (EBI)Q6P9B6
BioGRIDMEAK7
STRING (EMBL)MEAK7
ZODIACMEAK7
Ontologies - Pathways
QuickGOQ6P9B6
Ontology : AmiGOprotein binding  nucleoplasm  nucleolus  cytoplasm  lysosomal membrane  lysosomal membrane  cytosol  membrane  regulation of cell migration  response to nutrient levels  TOR signaling  TOR signaling  response to insulin  regulation of cell population proliferation  response to amino acid  positive regulation of protein localization to lysosome  negative regulation of oxidative stress-induced neuron death  
Ontology : EGO-EBIprotein binding  nucleoplasm  nucleolus  cytoplasm  lysosomal membrane  lysosomal membrane  cytosol  membrane  regulation of cell migration  response to nutrient levels  TOR signaling  TOR signaling  response to insulin  regulation of cell population proliferation  response to amino acid  positive regulation of protein localization to lysosome  negative regulation of oxidative stress-induced neuron death  
NDEx NetworkMEAK7
Atlas of Cancer Signalling NetworkMEAK7
Wikipedia pathwaysMEAK7
Orthology - Evolution
OrthoDB57707
GeneTree (enSembl)ENSG00000140950
Phylogenetic Trees/Animal Genes : TreeFamMEAK7
Homologs : HomoloGeneMEAK7
Homology/Alignments : Family Browser (UCSC)MEAK7
Gene fusions - Rearrangements
Fusion : QuiverMEAK7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMEAK7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MEAK7
dbVarMEAK7
ClinVarMEAK7
MonarchMEAK7
1000_GenomesMEAK7 
Exome Variant ServerMEAK7
GNOMAD BrowserENSG00000140950
Varsome BrowserMEAK7
ACMGMEAK7 variants
VarityQ6P9B6
Genomic Variants (DGV)MEAK7 [DGVbeta]
DECIPHERMEAK7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMEAK7 
Mutations
ICGC Data PortalMEAK7 
TCGA Data PortalMEAK7 
Broad Tumor PortalMEAK7
OASIS PortalMEAK7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMEAK7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMEAK7
Mutations and Diseases : HGMDMEAK7
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMEAK7
DgiDB (Drug Gene Interaction Database)MEAK7
DoCM (Curated mutations)MEAK7
CIViC (Clinical Interpretations of Variants in Cancer)MEAK7
Cancer3DMEAK7
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM619331   
Orphanet
DisGeNETMEAK7
MedgenMEAK7
Genetic Testing Registry MEAK7
NextProtQ6P9B6 [Medical]
GENETestsMEAK7
Target ValidationMEAK7
Huge Navigator MEAK7 [HugePedia]
ClinGenMEAK7
Clinical trials, drugs, therapy
MyCancerGenomeMEAK7
Protein Interactions : CTDMEAK7
Pharm GKB GenePA144596416
PharosQ6P9B6
Clinical trialMEAK7
Miscellaneous
canSAR (ICR)MEAK7
HarmonizomeMEAK7
DataMed IndexMEAK7
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMEAK7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:18:11 CEST 2021

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