| Nomenclature | | HGNC (Hugo) | MECP2 6990 |
| Cards | | Entrez_Gene (NCBI) | MECP2 4204 methyl CpG binding protein 2 (Rett syndrome) |
| GeneCards (Weizmann) | MECP2 |
| Ensembl (Hinxton) | ENSG00000169057 [Gene_View] chrX:153295686-153363188 [Contig_View] MECP2 [Vega] |
| ICGC DataPortal | ENSG00000169057 |
| cBioPortal | MECP2 |
| AceView (NCBI) | MECP2 |
| Genatlas (Paris) | MECP2 |
| WikiGenes | 4204 |
| SOURCE (Princeton) | NM_001110792 NM_004992 |
| Genomic and cartography | | GoldenPath (UCSC) | MECP2 - Xq28 chrX:153295686-153363188 - Xq28 [Description] (hg19-Feb_2009) |
| Ensembl | MECP2 - Xq28 [CytoView] |
| Mapping of homologs : NCBI | MECP2 [Mapview] |
| OMIM | 105830 300005 300055 300260 300496 300673 312750 |
| Gene and transcription |
| Genbank (Entrez) | AB209464 AF158180 AJ132917 AK289444 AM392557 |
| RefSeq transcript (Entrez) | NM_001110792 NM_004992 |
| RefSeq genomic (Entrez) | AC_000155 NC_000023 NC_018934 NG_007107 NT_167198 NW_001842419 NW_003871103 NW_004929448 |
| Consensus coding sequences : CCDS (NCBI) | MECP2 |
| Cluster EST : Unigene | Hs.702514 [ NCBI ] |
| CGAP (NCI) | Hs.702514 |
| Alternative Splicing : Fast-db (Paris) | GSHG0032426 |
| Alternative Splicing Gallery | ENSG00000169057 |
| Gene Expression | MECP2 [ NCBI-GEO ] MECP2 [ SEEK ] MECP2 [ MEM ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P51608 (Uniprot) |
| NextProt | P51608 [Medical] |
| With graphics : InterPro | P51608 |
| Splice isoforms : SwissVar | P51608 (Swissvar) |
| Domaine pattern : Prosite (Expaxy) | MBD (PS50982) |
| Domains : Interpro (EBI) | AT_hook_DNA-bd_motif [organisation] DNA-bd_dom [organisation] Me_CpG-bd_MeCP2 [organisation] Methyl_CpG_DNA-bd [organisation] |
| Related proteins : CluSTr | P51608 |
| Domain families : Pfam (Sanger) | MBD (PF01429) |
| Domain families : Pfam (NCBI) | pfam01429 |
| Domain families : Smart (EMBL) | AT_hook (SM00384) MBD (SM00391) |
| DMDM Disease mutations | 4204 |
| Blocks (Seattle) | P51608 |
| PDB (SRS) | 1QK9 3C2I |
| PDB (PDBSum) | 1QK9 3C2I |
| PDB (IMB) | 1QK9 3C2I |
| PDB (RSDB) | 1QK9 3C2I |
| Human Protein Atlas | ENSG00000169057 [gene] [tissue] [antibody] [cell] [cancer] |
| Peptide Atlas | P51608 |
| HPRD | 02050 |
| IPI | IPI00418234 IPI00964558 IPI00645192 IPI01010228 IPI00852714 IPI01021519 IPI00816549 IPI00878746 IPI00893388 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P51608 |
| IntAct (EBI) | P51608 |
| FunCoup | ENSG00000169057 |
| BioGRID | MECP2 |
| InParanoid | P51608 |
| Interologous Interaction database | P51608 |
| IntegromeDB | MECP2 |
| STRING (EMBL) | MECP2 |
| Ontologies - Pathways | | Ontology : AmiGO | negative regulation of transcription from RNA polymerase II promoter heterochromatin behavioral fear response response to hypoxia startle response neurological system process involved in regulation of systemic arterial blood pressure regulation of respiratory gaseous exchange by neurological system process DNA binding chromatin binding sequence-specific DNA binding transcription factor activity transcription corepressor activity mRNA binding protein binding nucleus cytosol inositol metabolic process mitochondrial electron transport, ubiquinol to cytochrome c chromatin silencing regulation of gene expression by genetic imprinting transcription, DNA-templated glutamine metabolic process synapse assembly respiratory gaseous exchange long-term memory protein localization transcription factor binding glucocorticoid metabolic process positive regulation of cell proliferation methyl-CpG binding adult locomotory behavior visual learning pathogenesis embryo development post-embryonic development double-stranded methylated DNA binding dendrite development histone methylation histone acetylation proprioception sensory perception of pain protein domain specific binding cerebellum development ventricular system development negative regulation of histone methylation cardiolipin metabolic process negative regulation of histone acetylation social behavior siRNA binding neuron maturation negative regulation of neuron apoptotic process negative regulation of transcription, DNA-dependent positive regulation of transcription, DNA-dependent phosphatidylcholine metabolic process protein N-terminus binding catecholamine secretion positive regulation of synapse assembly regulation of excitatory postsynaptic membrane potential long-term synaptic potentiation |
| Ontology : EGO-EBI | negative regulation of transcription from RNA polymerase II promoter heterochromatin behavioral fear response response to hypoxia startle response neurological system process involved in regulation of systemic arterial blood pressure regulation of respiratory gaseous exchange by neurological system process DNA binding chromatin binding sequence-specific DNA binding transcription factor activity transcription corepressor activity mRNA binding protein binding nucleus cytosol inositol metabolic process mitochondrial electron transport, ubiquinol to cytochrome c chromatin silencing regulation of gene expression by genetic imprinting transcription, DNA-templated glutamine metabolic process synapse assembly respiratory gaseous exchange long-term memory protein localization transcription factor binding glucocorticoid metabolic process positive regulation of cell proliferation methyl-CpG binding adult locomotory behavior visual learning pathogenesis embryo development post-embryonic development double-stranded methylated DNA binding dendrite development histone methylation histone acetylation proprioception sensory perception of pain protein domain specific binding cerebellum development ventricular system development negative regulation of histone methylation cardiolipin metabolic process negative regulation of histone acetylation social behavior siRNA binding neuron maturation negative regulation of neuron apoptotic process negative regulation of transcription, DNA-dependent positive regulation of transcription, DNA-dependent phosphatidylcholine metabolic process protein N-terminus binding catecholamine secretion positive regulation of synapse assembly regulation of excitatory postsynaptic membrane potential long-term synaptic potentiation |
| Protein Interaction Database | MECP2 |
| Wikipedia pathways | MECP2 |
| Gene fusion - rearrangments | | Polymorphisms : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | MECP2 |
| snp3D : Map Gene to Disease | 4204 |
| SNP (GeneSNP Utah) | MECP2 |
| SNP : HGBase | MECP2 |
| Genetic variants : HAPMAP | MECP2 |
| Exome Variant | MECP2 |
| 1000_Genomes | MECP2 |
| ICGC program | ENSG00000169057 |
| Somatic Mutations in Cancer : COSMIC | MECP2 |
| CONAN: Copy Number Analysis | MECP2 |
| Mutations and Diseases : HGMD | MECP2 |
| Genomic Variants | MECP2 MECP2 [DGVbeta] |
| dbVar | MECP2 |
| ClinVar | MECP2 |
| Pred. of missenses | PolyPhen-2 SIFT(SG) SIFT(JCVI) Align-GVGD MutAssessor Mutanalyser |
| Pred. splices | GeneSplicer Human Splicing Finder MaxEntScan |
| Diseases | | OMIM | 105830 300005 300055 300260 300496 300673 312750 |
| Medgen | MECP2 |
| GENETests | MECP2 |
| Disease Genetic Association | MECP2 |
| Huge Navigator |
MECP2 [HugePedia] MECP2 [HugeCancerGEM] |
| General knowledge |
|---|
| Homologs : HomoloGene | MECP2 |
| Homology/Alignments : Family Browser (UCSC) | MECP2 |
| Phylogenetic Trees/Animal Genes : TreeFam | MECP2 |
| Chemical/Protein Interactions : CTD | 4204 |
| Chemical/Pharm GKB Gene | PA30729 |
| Clinical trial | MECP2 |
| Cancer Resource (Charite) | ENSG00000169057 |
| Other databases | | Probes |
|---|
| Litterature | | PubMed | 398 Pubmed reference(s) in Entrez |
| CoreMine | MECP2 |
| iHOP | MECP2 |
