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MECR (mitochondrial trans-2-enoyl-CoA reductase)

Identity

Alias_symbol (synonym)CGI-63
NRBF1
FASN2B
Other aliasDYTOABG
ETR1
HGNC (Hugo) MECR
LocusID (NCBI) 51102
Atlas_Id 68868
Location 1p35.3  [Link to chromosome band 1p35]
Location_base_pair Starts at 29192657 and ends at 29230958 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MECR (1p35.3) / NAALADL2 (3q26.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MECR   19691
Cards
Entrez_Gene (NCBI)MECR  51102  mitochondrial trans-2-enoyl-CoA reductase
AliasesCGI-63; DYTOABG; ETR1; FASN2B; 
NRBF1
GeneCards (Weizmann)MECR
Ensembl hg19 (Hinxton)ENSG00000116353 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116353 [Gene_View]  chr1:29192657-29230958 [Contig_View]  MECR [Vega]
ICGC DataPortalENSG00000116353
TCGA cBioPortalMECR
AceView (NCBI)MECR
Genatlas (Paris)MECR
WikiGenes51102
SOURCE (Princeton)MECR
Genetics Home Reference (NIH)MECR
Genomic and cartography
GoldenPath hg38 (UCSC)MECR  -     chr1:29192657-29230958 -  1p35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MECR  -     1p35.3   [Description]    (hg19-Feb_2009)
EnsemblMECR - 1p35.3 [CytoView hg19]  MECR - 1p35.3 [CytoView hg38]
Mapping of homologs : NCBIMECR [Mapview hg19]  MECR [Mapview hg38]
OMIM608205   617282   
Gene and transcription
Genbank (Entrez)AF151821 AK025830 AK095099 AK225687 AK226084
RefSeq transcript (Entrez)NM_001024732 NM_001349711 NM_001349712 NM_001349713 NM_001349714 NM_001349715 NM_001349716 NM_001349717 NM_016011
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MECR
Cluster EST : UnigeneHs.183646 [ NCBI ]
CGAP (NCI)Hs.183646
Alternative Splicing GalleryENSG00000116353
Gene ExpressionMECR [ NCBI-GEO ]   MECR [ EBI - ARRAY_EXPRESS ]   MECR [ SEEK ]   MECR [ MEM ]
Gene Expression Viewer (FireBrowse)MECR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51102
GTEX Portal (Tissue expression)MECR
Human Protein AtlasENSG00000116353-MECR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BV79   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BV79  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BV79
Splice isoforms : SwissVarQ9BV79
Catalytic activity : Enzyme1.3.1.38 [ Enzyme-Expasy ]   1.3.1.381.3.1.38 [ IntEnz-EBI ]   1.3.1.38 [ BRENDA ]   1.3.1.38 [ KEGG ]   
PhosPhoSitePlusQ9BV79
Domains : Interpro (EBI)ADH_C    ADH_N    GroES-like    NAD(P)-bd_dom    PKS_ER   
Domain families : Pfam (Sanger)ADH_N (PF08240)    ADH_zinc_N (PF00107)   
Domain families : Pfam (NCBI)pfam08240    pfam00107   
Domain families : Smart (EMBL)PKS_ER (SM00829)  
Conserved Domain (NCBI)MECR
DMDM Disease mutations51102
Blocks (Seattle)MECR
PDB (SRS)1ZSY    2VCY   
PDB (PDBSum)1ZSY    2VCY   
PDB (IMB)1ZSY    2VCY   
PDB (RSDB)1ZSY    2VCY   
Structural Biology KnowledgeBase1ZSY    2VCY   
SCOP (Structural Classification of Proteins)1ZSY    2VCY   
CATH (Classification of proteins structures)1ZSY    2VCY   
SuperfamilyQ9BV79
Human Protein Atlas [tissue]ENSG00000116353-MECR [tissue]
Peptide AtlasQ9BV79
HPRD12192
IPIIPI00306159   IPI00607794   IPI00514714   IPI00983016   
Protein Interaction databases
DIP (DOE-UCLA)Q9BV79
IntAct (EBI)Q9BV79
FunCoupENSG00000116353
BioGRIDMECR
STRING (EMBL)MECR
ZODIACMECR
Ontologies - Pathways
QuickGOQ9BV79
Ontology : AmiGOnucleus  mitochondrion  fatty acid metabolic process  fatty acid metabolic process  fatty acid biosynthetic process  trans-2-enoyl-CoA reductase (NADPH) activity  oxidation-reduction process  
Ontology : EGO-EBInucleus  mitochondrion  fatty acid metabolic process  fatty acid metabolic process  fatty acid biosynthetic process  trans-2-enoyl-CoA reductase (NADPH) activity  oxidation-reduction process  
Pathways : KEGGFatty acid elongation   
NDEx NetworkMECR
Atlas of Cancer Signalling NetworkMECR
Wikipedia pathwaysMECR
Orthology - Evolution
OrthoDB51102
GeneTree (enSembl)ENSG00000116353
Phylogenetic Trees/Animal Genes : TreeFamMECR
HOVERGENQ9BV79
HOGENOMQ9BV79
Homologs : HomoloGeneMECR
Homology/Alignments : Family Browser (UCSC)MECR
Gene fusions - Rearrangements
Tumor Fusion PortalMECR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMECR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MECR
dbVarMECR
ClinVarMECR
1000_GenomesMECR 
Exome Variant ServerMECR
ExAC (Exome Aggregation Consortium)ENSG00000116353
GNOMAD BrowserENSG00000116353
Genetic variants : HAPMAP51102
Genomic Variants (DGV)MECR [DGVbeta]
DECIPHERMECR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMECR 
Mutations
ICGC Data PortalMECR 
TCGA Data PortalMECR 
Broad Tumor PortalMECR
OASIS PortalMECR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMECR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMECR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MECR
DgiDB (Drug Gene Interaction Database)MECR
DoCM (Curated mutations)MECR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MECR (select a term)
intoGenMECR
Cancer3DMECR(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608205    617282   
Orphanet
DisGeNETMECR
MedgenMECR
Genetic Testing Registry MECR
NextProtQ9BV79 [Medical]
TSGene51102
GENETestsMECR
Target ValidationMECR
Huge Navigator MECR [HugePedia]
snp3D : Map Gene to Disease51102
BioCentury BCIQMECR
ClinGenMECR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51102
Chemical/Pharm GKB GenePA142671471
Clinical trialMECR
Miscellaneous
canSAR (ICR)MECR (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMECR
EVEXMECR
GoPubMedMECR
iHOPMECR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:01:23 CET 2017

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