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MECR (mitochondrial trans-2-enoyl-CoA reductase)

Identity

Alias (NCBI)CGI-63
DYTOABG
ETR1
FASN2B
NRBF1
HGNC (Hugo) MECR
HGNC Alias symbCGI-63
NRBF1
FASN2B
HGNC Alias namenuclear receptor binding factor 1
 mitochondrial 2-enoyl thioester reductase
LocusID (NCBI) 51102
Atlas_Id 68868
Location 1p35.3  [Link to chromosome band 1p35]
Location_base_pair Starts at 29192657 and ends at 29230934 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MECR (1p35.3) / NAALADL2 (3q26.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MECR   19691
Cards
Entrez_Gene (NCBI)MECR    mitochondrial trans-2-enoyl-CoA reductase
AliasesCGI-63; DYTOABG; ETR1; FASN2B; 
NRBF1
GeneCards (Weizmann)MECR
Ensembl hg19 (Hinxton)ENSG00000116353 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116353 [Gene_View]  ENSG00000116353 [Sequence]  chr1:29192657-29230934 [Contig_View]  MECR [Vega]
ICGC DataPortalENSG00000116353
TCGA cBioPortalMECR
AceView (NCBI)MECR
Genatlas (Paris)MECR
SOURCE (Princeton)MECR
Genetics Home Reference (NIH)MECR
Genomic and cartography
GoldenPath hg38 (UCSC)MECR  -     chr1:29192657-29230934 -  1p35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MECR  -     1p35.3   [Description]    (hg19-Feb_2009)
GoldenPathMECR - 1p35.3 [CytoView hg19]  MECR - 1p35.3 [CytoView hg38]
ImmunoBaseENSG00000116353
Genome Data Viewer NCBIMECR [Mapview hg19]  
OMIM608205   617282   
Gene and transcription
Genbank (Entrez)AF151821 AK025830 AK095099 AK225687 AK226084
RefSeq transcript (Entrez)NM_001024732 NM_001349711 NM_001349712 NM_001349713 NM_001349714 NM_001349715 NM_001349716 NM_001349717 NM_016011
Consensus coding sequences : CCDS (NCBI)MECR
Gene ExpressionMECR [ NCBI-GEO ]   MECR [ EBI - ARRAY_EXPRESS ]   MECR [ SEEK ]   MECR [ MEM ]
Gene Expression Viewer (FireBrowse)MECR [ Firebrowse - Broad ]
GenevisibleExpression of MECR in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51102
GTEX Portal (Tissue expression)MECR
Human Protein AtlasENSG00000116353-MECR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BV79   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BV79  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BV79
PhosPhoSitePlusQ9BV79
Domains : Interpro (EBI)ADH_C    ADH_N    GroES-like_sf    NAD(P)-bd_dom_sf    PKS_ER   
Domain families : Pfam (Sanger)ADH_N (PF08240)    ADH_zinc_N (PF00107)   
Domain families : Pfam (NCBI)pfam08240    pfam00107   
Domain families : Smart (EMBL)PKS_ER (SM00829)  
Conserved Domain (NCBI)MECR
PDB (RSDB)1ZSY    2VCY   
PDB Europe1ZSY    2VCY   
PDB (PDBSum)1ZSY    2VCY   
PDB (IMB)1ZSY    2VCY   
Structural Biology KnowledgeBase1ZSY    2VCY   
SCOP (Structural Classification of Proteins)1ZSY    2VCY   
CATH (Classification of proteins structures)1ZSY    2VCY   
SuperfamilyQ9BV79
AlphaFold pdb e-kbQ9BV79   
Human Protein Atlas [tissue]ENSG00000116353-MECR [tissue]
HPRD12192
Protein Interaction databases
DIP (DOE-UCLA)Q9BV79
IntAct (EBI)Q9BV79
BioGRIDMECR
STRING (EMBL)MECR
ZODIACMECR
Ontologies - Pathways
QuickGOQ9BV79
Ontology : AmiGOnucleus  mitochondrion  mitochondrion  mitochondrial matrix  fatty acid metabolic process  fatty acid metabolic process  fatty acid metabolic process  fatty acid biosynthetic process  fatty acid beta-oxidation  trans-2-enoyl-CoA reductase (NADPH) activity  trans-2-enoyl-CoA reductase (NADPH) activity  
Ontology : EGO-EBInucleus  mitochondrion  mitochondrion  mitochondrial matrix  fatty acid metabolic process  fatty acid metabolic process  fatty acid metabolic process  fatty acid biosynthetic process  fatty acid beta-oxidation  trans-2-enoyl-CoA reductase (NADPH) activity  trans-2-enoyl-CoA reductase (NADPH) activity  
Pathways : KEGGFatty acid elongation in mitochondria   
NDEx NetworkMECR
Atlas of Cancer Signalling NetworkMECR
Wikipedia pathwaysMECR
Orthology - Evolution
OrthoDB51102
GeneTree (enSembl)ENSG00000116353
Phylogenetic Trees/Animal Genes : TreeFamMECR
Homologs : HomoloGeneMECR
Homology/Alignments : Family Browser (UCSC)MECR
Gene fusions - Rearrangements
Fusion : QuiverMECR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMECR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MECR
dbVarMECR
ClinVarMECR
MonarchMECR
1000_GenomesMECR 
Exome Variant ServerMECR
GNOMAD BrowserENSG00000116353
Varsome BrowserMECR
ACMGMECR variants
VarityQ9BV79
Genomic Variants (DGV)MECR [DGVbeta]
DECIPHERMECR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMECR 
Mutations
ICGC Data PortalMECR 
TCGA Data PortalMECR 
Broad Tumor PortalMECR
OASIS PortalMECR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMECR  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMECR
Mutations and Diseases : HGMDMECR
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMECR
DgiDB (Drug Gene Interaction Database)MECR
DoCM (Curated mutations)MECR
CIViC (Clinical Interpretations of Variants in Cancer)MECR
Cancer3DMECR
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608205    617282   
Orphanet
DisGeNETMECR
MedgenMECR
Genetic Testing Registry MECR
NextProtQ9BV79 [Medical]
GENETestsMECR
Target ValidationMECR
Huge Navigator MECR [HugePedia]
ClinGenMECR
Clinical trials, drugs, therapy
MyCancerGenomeMECR
Protein Interactions : CTDMECR
Pharm GKB GenePA142671471
PharosQ9BV79
Clinical trialMECR
Miscellaneous
canSAR (ICR)MECR
HarmonizomeMECR
DataMed IndexMECR
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMECR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:07:02 CEST 2021

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