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MED1 (mediator complex subunit 1)

Identity

Alias_namesTRIP2
PPARGBP
PPARBP
PPAR binding protein
Alias_symbol (synonym)PBP
TRAP220
RB18A
DRIP230
CRSP200
CRSP1
Other aliasDRIP205
HGNC (Hugo) MED1
LocusID (NCBI) 5469
Atlas_Id 185
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 39404285 and ends at 39451274 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C19orf25 (19p13.3) / MED1 (17q12)CASC3 (17q21.1) / MED1 (17q12)DNAJC5 (20q13.33) / MED1 (17q12)
MED1 (17q12) / ABCC3 (17q21.33)MED1 (17q12) / ACSF2 (17q21.33)MED1 (17q12) / ARHGAP23 (17q12)
MED1 (17q12) / CAP2 (6p22.3)MED1 (17q12) / CDK12 (17q12)MED1 (17q12) / EYS (6q12)
MED1 (17q12) / GDPD1 (17q22)MED1 (17q12) / HPCAL4 (1p34.2)MED1 (17q12) / KRT222 (17q21.2)
MED1 (17q12) / LMNTD1 (12p12.1)MED1 (17q12) / ODF3L2 (19p13.3)MED1 (17q12) / PHOSPHO1 (17q21.32)
MED1 (17q12) / RHBDL3 (17q11.2)MED1 (17q12) / STXBP4 (17q22)MED1 (17q12) / TMPRSS9 (19p13.3)
USP32 (17q23.1) / MED1 (17q12)WSB1 (17q11.1) / MED1 (17q12)C19orf25 19p13.3 / MED1 17q12
CASC3 17q21.1 / MED1 17q12MED1 17q12 / ABCC3 17q21.33MED1 17q12 / ARHGAP23 17q12
MED1 17q12 / CAP2 6p22.3MED1 17q12 / CDK12 17q12MED1 17q12 / EYS 6q12
MED1 17q12 / GDPD1 17q22MED1 17q12 IFLTD1MED1 17q12 / KRT222 17q21.2
MED1 17q12 / ODF3L2 19p13.3MED1 17q12 / PHOSPHO1 17q21.32MED1 17q12 / RHBDL3 17q11.2
MED1 17q12 / TMPRSS9 19p13.3WSB1 17q11.1 / MED1 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MED1   9234
Cards
Entrez_Gene (NCBI)MED1  5469  mediator complex subunit 1
AliasesCRSP1; CRSP200; DRIP205; DRIP230; 
PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2
GeneCards (Weizmann)MED1
Ensembl hg19 (Hinxton)ENSG00000125686 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125686 [Gene_View]  chr17:39404285-39451274 [Contig_View]  MED1 [Vega]
ICGC DataPortalENSG00000125686
TCGA cBioPortalMED1
AceView (NCBI)MED1
Genatlas (Paris)MED1
WikiGenes5469
SOURCE (Princeton)MED1
Genetics Home Reference (NIH)MED1
Genomic and cartography
GoldenPath hg38 (UCSC)MED1  -     chr17:39404285-39451274 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED1  -     17q12   [Description]    (hg19-Feb_2009)
EnsemblMED1 - 17q12 [CytoView hg19]  MED1 - 17q12 [CytoView hg38]
Mapping of homologs : NCBIMED1 [Mapview hg19]  MED1 [Mapview hg38]
OMIM604311   
Gene and transcription
Genbank (Entrez)AF055994 AF283812 AK299789 AK314185 BC006517
RefSeq transcript (Entrez)NM_004774
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED1
Cluster EST : UnigeneHs.643754 [ NCBI ]
CGAP (NCI)Hs.643754
Alternative Splicing GalleryENSG00000125686
Gene ExpressionMED1 [ NCBI-GEO ]   MED1 [ EBI - ARRAY_EXPRESS ]   MED1 [ SEEK ]   MED1 [ MEM ]
Gene Expression Viewer (FireBrowse)MED1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5469
GTEX Portal (Tissue expression)MED1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15648   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15648  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15648
Splice isoforms : SwissVarQ15648
PhosPhoSitePlusQ15648
Domains : Interpro (EBI)Mediator_Med1   
Domain families : Pfam (Sanger)Med1 (PF10744)   
Domain families : Pfam (NCBI)pfam10744   
Conserved Domain (NCBI)MED1
DMDM Disease mutations5469
Blocks (Seattle)MED1
PDB (SRS)1RJK    1RK3    1RKG    1RKH    2O4J    2O4R    2ZFX    3A2H    3AUN    3VJS    3VJT    3VRT    3VRU    3VRV    3VRW    3W0G    3W0H    3W0I    3W0J    3W5P    3W5Q    3W5R    3W5T    3WT5    3WT6    3WT7    3WTQ    4YNK    5AWJ    5AWK    5B41    5B5B    5GIC    5GID    5GIE   
PDB (PDBSum)1RJK    1RK3    1RKG    1RKH    2O4J    2O4R    2ZFX    3A2H    3AUN    3VJS    3VJT    3VRT    3VRU    3VRV    3VRW    3W0G    3W0H    3W0I    3W0J    3W5P    3W5Q    3W5R    3W5T    3WT5    3WT6    3WT7    3WTQ    4YNK    5AWJ    5AWK    5B41    5B5B    5GIC    5GID    5GIE   
PDB (IMB)1RJK    1RK3    1RKG    1RKH    2O4J    2O4R    2ZFX    3A2H    3AUN    3VJS    3VJT    3VRT    3VRU    3VRV    3VRW    3W0G    3W0H    3W0I    3W0J    3W5P    3W5Q    3W5R    3W5T    3WT5    3WT6    3WT7    3WTQ    4YNK    5AWJ    5AWK    5B41    5B5B    5GIC    5GID    5GIE   
PDB (RSDB)1RJK    1RK3    1RKG    1RKH    2O4J    2O4R    2ZFX    3A2H    3AUN    3VJS    3VJT    3VRT    3VRU    3VRV    3VRW    3W0G    3W0H    3W0I    3W0J    3W5P    3W5Q    3W5R    3W5T    3WT5    3WT6    3WT7    3WTQ    4YNK    5AWJ    5AWK    5B41    5B5B    5GIC    5GID    5GIE   
Structural Biology KnowledgeBase1RJK    1RK3    1RKG    1RKH    2O4J    2O4R    2ZFX    3A2H    3AUN    3VJS    3VJT    3VRT    3VRU    3VRV    3VRW    3W0G    3W0H    3W0I    3W0J    3W5P    3W5Q    3W5R    3W5T    3WT5    3WT6    3WT7    3WTQ    4YNK    5AWJ    5AWK    5B41    5B5B    5GIC    5GID    5GIE   
SCOP (Structural Classification of Proteins)1RJK    1RK3    1RKG    1RKH    2O4J    2O4R    2ZFX    3A2H    3AUN    3VJS    3VJT    3VRT    3VRU    3VRV    3VRW    3W0G    3W0H    3W0I    3W0J    3W5P    3W5Q    3W5R    3W5T    3WT5    3WT6    3WT7    3WTQ    4YNK    5AWJ    5AWK    5B41    5B5B    5GIC    5GID    5GIE   
CATH (Classification of proteins structures)1RJK    1RK3    1RKG    1RKH    2O4J    2O4R    2ZFX    3A2H    3AUN    3VJS    3VJT    3VRT    3VRU    3VRV    3VRW    3W0G    3W0H    3W0I    3W0J    3W5P    3W5Q    3W5R    3W5T    3WT5    3WT6    3WT7    3WTQ    4YNK    5AWJ    5AWK    5B41    5B5B    5GIC    5GID    5GIE   
SuperfamilyQ15648
Human Protein AtlasENSG00000125686
Peptide AtlasQ15648
HPRD05055
IPIIPI00829826   IPI00790747   
Protein Interaction databases
DIP (DOE-UCLA)Q15648
IntAct (EBI)Q15648
FunCoupENSG00000125686
BioGRIDMED1
STRING (EMBL)MED1
ZODIACMED1
Ontologies - Pathways
QuickGOQ15648
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  ubiquitin ligase complex  chromatin  cell morphogenesis  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  core promoter binding  RNA polymerase II transcription cofactor activity  angiogenesis  liver development  embryonic placenta development  lens development in camera-type eye  thyroid hormone mediated signaling pathway  ventricular trabecula myocardium morphogenesis  retinal pigment epithelium development  chromatin binding  transcription cofactor activity  transcription coactivator activity  transcription coactivator activity  receptor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  regulation of transcription from RNA polymerase I promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  thyroid hormone generation  androgen biosynthetic process  brain development  lactation  transcription factor binding  positive regulation of gene expression  positive regulation of gene expression  negative regulation of keratinocyte proliferation  membrane  protein ubiquitination  mediator complex  mediator complex  ligand-dependent nuclear receptor binding  ligand-dependent nuclear receptor binding  keratinocyte differentiation  monocyte differentiation  estrogen receptor binding  ligand-dependent nuclear receptor transcription coactivator activity  ligand-dependent nuclear receptor transcription coactivator activity  thyroid hormone receptor coactivator activity  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  animal organ regeneration  chromatin DNA binding  protein-DNA complex  positive regulation of intracellular estrogen receptor signaling pathway  positive regulation of protein import into nucleus, translocation  positive regulation of mammary gland epithelial cell proliferation  embryonic heart tube development  embryonic hindlimb morphogenesis  embryonic hemopoiesis  nuclear hormone receptor binding  peroxisome proliferator activated receptor signaling pathway  cellular response to hepatocyte growth factor stimulus  megakaryocyte development  mediator complex binding  mRNA transcription from RNA polymerase II promoter  vitamin D receptor binding  vitamin D receptor binding  vitamin D receptor binding  retinoic acid receptor binding  peroxisome proliferator activated receptor binding  negative regulation of apoptotic process  cellular lipid metabolic process  fat cell differentiation  positive regulation of keratinocyte differentiation  positive regulation of erythrocyte differentiation  negative regulation of neuron differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  thyroid hormone receptor binding  thyroid hormone receptor binding  erythrocyte development  enucleate erythrocyte development  LBD domain binding  regulation of cell cycle  positive regulation of interferon-gamma-mediated signaling pathway  mammary gland branching involved in thelarche  mammary gland branching involved in pregnancy  epithelial cell proliferation involved in mammary gland duct elongation  ubiquitin protein ligase activity  positive regulation of G0 to G1 transition  ERK1 and ERK2 cascade  regulation of vitamin D receptor signaling pathway  cellular response to epidermal growth factor stimulus  cellular response to steroid hormone stimulus  cellular response to thyroid hormone stimulus  positive regulation of receptor activity  positive regulation of hepatocyte proliferation  regulation of RNA biosynthetic process  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  ubiquitin ligase complex  chromatin  cell morphogenesis  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  core promoter binding  RNA polymerase II transcription cofactor activity  angiogenesis  liver development  embryonic placenta development  lens development in camera-type eye  thyroid hormone mediated signaling pathway  ventricular trabecula myocardium morphogenesis  retinal pigment epithelium development  chromatin binding  transcription cofactor activity  transcription coactivator activity  transcription coactivator activity  receptor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  regulation of transcription from RNA polymerase I promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  thyroid hormone generation  androgen biosynthetic process  brain development  lactation  transcription factor binding  positive regulation of gene expression  positive regulation of gene expression  negative regulation of keratinocyte proliferation  membrane  protein ubiquitination  mediator complex  mediator complex  ligand-dependent nuclear receptor binding  ligand-dependent nuclear receptor binding  keratinocyte differentiation  monocyte differentiation  estrogen receptor binding  ligand-dependent nuclear receptor transcription coactivator activity  ligand-dependent nuclear receptor transcription coactivator activity  thyroid hormone receptor coactivator activity  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  animal organ regeneration  chromatin DNA binding  protein-DNA complex  positive regulation of intracellular estrogen receptor signaling pathway  positive regulation of protein import into nucleus, translocation  positive regulation of mammary gland epithelial cell proliferation  embryonic heart tube development  embryonic hindlimb morphogenesis  embryonic hemopoiesis  nuclear hormone receptor binding  peroxisome proliferator activated receptor signaling pathway  cellular response to hepatocyte growth factor stimulus  megakaryocyte development  mediator complex binding  mRNA transcription from RNA polymerase II promoter  vitamin D receptor binding  vitamin D receptor binding  vitamin D receptor binding  retinoic acid receptor binding  peroxisome proliferator activated receptor binding  negative regulation of apoptotic process  cellular lipid metabolic process  fat cell differentiation  positive regulation of keratinocyte differentiation  positive regulation of erythrocyte differentiation  negative regulation of neuron differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  thyroid hormone receptor binding  thyroid hormone receptor binding  erythrocyte development  enucleate erythrocyte development  LBD domain binding  regulation of cell cycle  positive regulation of interferon-gamma-mediated signaling pathway  mammary gland branching involved in thelarche  mammary gland branching involved in pregnancy  epithelial cell proliferation involved in mammary gland duct elongation  ubiquitin protein ligase activity  positive regulation of G0 to G1 transition  ERK1 and ERK2 cascade  regulation of vitamin D receptor signaling pathway  cellular response to epidermal growth factor stimulus  cellular response to steroid hormone stimulus  cellular response to thyroid hormone stimulus  positive regulation of receptor activity  positive regulation of hepatocyte proliferation  regulation of RNA biosynthetic process  
Pathways : BIOCARTA [Genes]   
Pathways : KEGGThyroid hormone signaling pathway   
NDEx NetworkMED1
Atlas of Cancer Signalling NetworkMED1
Wikipedia pathwaysMED1
Orthology - Evolution
OrthoDB5469
GeneTree (enSembl)ENSG00000125686
Phylogenetic Trees/Animal Genes : TreeFamMED1
HOVERGENQ15648
HOGENOMQ15648
Homologs : HomoloGeneMED1
Homology/Alignments : Family Browser (UCSC)MED1
Gene fusions - Rearrangements
Fusion : MitelmanC19orf25/MED1 [19p13.3/17q12]  [t(17;19)(q12;p13)]  
Fusion : MitelmanCASC3/MED1 [17q21.1/17q12]  [t(17;17)(q12;q21)]  
Fusion : MitelmanMED1/ABCC3 [17q12/17q21.33]  [t(17;17)(q12;q21)]  
Fusion : MitelmanMED1/ACSF2 [17q12/17q21.33]  [t(17;17)(q12;q21)]  
Fusion : MitelmanMED1/CAP2 [17q12/6p22.3]  [t(6;17)(p22;q12)]  
Fusion : MitelmanMED1/KRT222 [17q12/17q21.2]  [t(17;17)(q12;q21)]  
Fusion : MitelmanMED1/LMNTD1 [17q12/12p12.1]  [t(12;17)(p12;q12)]  
Fusion : MitelmanMED1/ODF3L2 [17q12/19p13.3]  [t(17;19)(q12;p13)]  
Fusion : MitelmanMED1/PHOSPHO1 [17q12/17q21.32]  [t(17;17)(q12;q21)]  
Fusion : MitelmanMED1/RHBDL3 [17q12/17q11.2]  [t(17;17)(q11;q12)]  
Fusion : MitelmanMED1/TMPRSS9 [17q12/19p13.3]  [t(17;19)(q12;p13)]  
Fusion : MitelmanUSP32/MED1 [17q23.1/17q12]  [t(17;17)(q12;q23)]  
Fusion : MitelmanWSB1/MED1 [17q11.1/17q12]  [t(17;17)(q11;q12)]  
Fusion: TCGAC19orf25 19p13.3 MED1 17q12 BRCA
Fusion: TCGACASC3 17q21.1 MED1 17q12 BRCA
Fusion: TCGAMED1 17q12 ABCC3 17q21.33 BRCA
Fusion: TCGAMED1 17q12 ARHGAP23 17q12 BRCA
Fusion: TCGAMED1 17q12 CAP2 6p22.3 BRCA
Fusion: TCGAMED1 17q12 CDK12 17q12 LUAD
Fusion: TCGAMED1 17q12 EYS 6q12 BRCA
Fusion: TCGAMED1 17q12 GDPD1 17q22 BRCA
Fusion: TCGAMED1 17q12 IFLTD1 BRCA
Fusion: TCGAMED1 17q12 KRT222 17q21.2 SKCM
Fusion: TCGAMED1 17q12 ODF3L2 19p13.3 BRCA
Fusion: TCGAMED1 17q12 PHOSPHO1 17q21.32 BRCA
Fusion: TCGAMED1 17q12 RHBDL3 17q11.2 BRCA
Fusion: TCGAMED1 17q12 TMPRSS9 19p13.3 BRCA
Fusion: TCGAWSB1 17q11.1 MED1 17q12 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED1
dbVarMED1
ClinVarMED1
1000_GenomesMED1 
Exome Variant ServerMED1
ExAC (Exome Aggregation Consortium)MED1 (select the gene name)
Genetic variants : HAPMAP5469
Genomic Variants (DGV)MED1 [DGVbeta]
DECIPHERMED1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED1 
Mutations
ICGC Data PortalMED1 
TCGA Data PortalMED1 
Broad Tumor PortalMED1
OASIS PortalMED1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED1
DgiDB (Drug Gene Interaction Database)MED1
DoCM (Curated mutations)MED1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED1 (select a term)
intoGenMED1
Cancer3DMED1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604311   
Orphanet
MedgenMED1
Genetic Testing Registry MED1
NextProtQ15648 [Medical]
TSGene5469
GENETestsMED1
Huge Navigator MED1 [HugePedia]
snp3D : Map Gene to Disease5469
BioCentury BCIQMED1
ClinGenMED1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5469
Chemical/Pharm GKB GenePA33556
Clinical trialMED1
Miscellaneous
canSAR (ICR)MED1 (select the gene name)
Probes
Litterature
PubMed159 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED1
EVEXMED1
GoPubMedMED1
iHOPMED1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:24:34 CEST 2017

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