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MED10 (mediator complex subunit 10)

Identity

Alias (NCBI)L6
NUT2
TRG20
HGNC (Hugo) MED10
HGNC Alias symbTRG20
L6
MGC5309
NUT2
HGNC Alias nameNUT2 homolog (S. cerevisiae)
HGNC Previous namemediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae)
LocusID (NCBI) 84246
Atlas_Id 68869
Location 5p15.31  [Link to chromosome band 5p15]
Location_base_pair Starts at 6371874 and ends at 6378547 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP11B (3q26.33) / MED10 (5p15.31)CC2D1A (19p13.12) / MED10 (5p15.31)MCCC1 (3q27.1) / MED10 (5p15.31)
MED10 (5p15.31) / MCCC1 (3q27.1)MED10 (5p15.31) / SPARCL1 (4q22.1)SUN2 (22q13.1) / MED10 (5p15.31)
MCCC1 MED10ATP11B MED10

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MED10   28760
Cards
Entrez_Gene (NCBI)MED10    mediator complex subunit 10
AliasesL6; NUT2; TRG20
GeneCards (Weizmann)MED10
Ensembl hg19 (Hinxton)ENSG00000133398 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133398 [Gene_View]  ENSG00000133398 [Sequence]  chr5:6371874-6378547 [Contig_View]  MED10 [Vega]
ICGC DataPortalENSG00000133398
TCGA cBioPortalMED10
AceView (NCBI)MED10
Genatlas (Paris)MED10
SOURCE (Princeton)MED10
Genetics Home Reference (NIH)MED10
Genomic and cartography
GoldenPath hg38 (UCSC)MED10  -     chr5:6371874-6378547 -  5p15.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED10  -     5p15.31   [Description]    (hg19-Feb_2009)
GoldenPathMED10 - 5p15.31 [CytoView hg19]  MED10 - 5p15.31 [CytoView hg38]
ImmunoBaseENSG00000133398
Genome Data Viewer NCBIMED10 [Mapview hg19]  
OMIM612382   
Gene and transcription
Genbank (Entrez)AA648258 AK075493 AY277599 AY453397 AY598325
RefSeq transcript (Entrez)NM_032286
Consensus coding sequences : CCDS (NCBI)MED10
Gene ExpressionMED10 [ NCBI-GEO ]   MED10 [ EBI - ARRAY_EXPRESS ]   MED10 [ SEEK ]   MED10 [ MEM ]
Gene Expression Viewer (FireBrowse)MED10 [ Firebrowse - Broad ]
GenevisibleExpression of MED10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84246
GTEX Portal (Tissue expression)MED10
Human Protein AtlasENSG00000133398-MED10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BTT4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BTT4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BTT4
PhosPhoSitePlusQ9BTT4
Domains : Interpro (EBI)Mediator_Med10   
Domain families : Pfam (Sanger)Med10 (PF09748)   
Domain families : Pfam (NCBI)pfam09748   
Conserved Domain (NCBI)MED10
SuperfamilyQ9BTT4
AlphaFold pdb e-kbQ9BTT4   
Human Protein Atlas [tissue]ENSG00000133398-MED10 [tissue]
HPRD14680
Protein Interaction databases
DIP (DOE-UCLA)Q9BTT4
IntAct (EBI)Q9BTT4
BioGRIDMED10
STRING (EMBL)MED10
ZODIACMED10
Ontologies - Pathways
QuickGOQ9BTT4
Ontology : AmiGOubiquitin ligase complex  chromatin  transcription coregulator activity  protein binding  nucleoplasm  nucleoplasm  protein ubiquitination  mediator complex  positive regulation of transcription by RNA polymerase II  regulation of transcription initiation from RNA polymerase II promoter  ubiquitin protein ligase activity  
Ontology : EGO-EBIubiquitin ligase complex  chromatin  transcription coregulator activity  protein binding  nucleoplasm  nucleoplasm  protein ubiquitination  mediator complex  positive regulation of transcription by RNA polymerase II  regulation of transcription initiation from RNA polymerase II promoter  ubiquitin protein ligase activity  
NDEx NetworkMED10
Atlas of Cancer Signalling NetworkMED10
Wikipedia pathwaysMED10
Orthology - Evolution
OrthoDB84246
GeneTree (enSembl)ENSG00000133398
Phylogenetic Trees/Animal Genes : TreeFamMED10
Homologs : HomoloGeneMED10
Homology/Alignments : Family Browser (UCSC)MED10
Gene fusions - Rearrangements
Fusion : QuiverMED10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED10
dbVarMED10
ClinVarMED10
MonarchMED10
1000_GenomesMED10 
Exome Variant ServerMED10
GNOMAD BrowserENSG00000133398
Varsome BrowserMED10
ACMGMED10 variants
VarityQ9BTT4
Genomic Variants (DGV)MED10 [DGVbeta]
DECIPHERMED10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED10 
Mutations
ICGC Data PortalMED10 
TCGA Data PortalMED10 
Broad Tumor PortalMED10
OASIS PortalMED10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMED10
Mutations and Diseases : HGMDMED10
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMED10
DgiDB (Drug Gene Interaction Database)MED10
DoCM (Curated mutations)MED10
CIViC (Clinical Interpretations of Variants in Cancer)MED10
Cancer3DMED10
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612382   
Orphanet
DisGeNETMED10
MedgenMED10
Genetic Testing Registry MED10
NextProtQ9BTT4 [Medical]
GENETestsMED10
Target ValidationMED10
Huge Navigator MED10 [HugePedia]
ClinGenMED10
Clinical trials, drugs, therapy
MyCancerGenomeMED10
Protein Interactions : CTDMED10
Pharm GKB GenePA144596412
PharosQ9BTT4
Clinical trialMED10
Miscellaneous
canSAR (ICR)MED10
HarmonizomeMED10
DataMed IndexMED10
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMED10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:07:02 CEST 2021

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