Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MED10 (mediator complex subunit 10)

Identity

Alias_namesmediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae)
Alias_symbol (synonym)TRG20
L6
MGC5309
NUT2
Other alias
HGNC (Hugo) MED10
LocusID (NCBI) 84246
Atlas_Id 68869
Location 5p15.31  [Link to chromosome band 5p15]
Location_base_pair Starts at 6371926 and ends at 6378526 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ATP11B (3q26.33) / MED10 (5p15.31)CC2D1A (19p13.12) / MED10 (5p15.31)MCCC1 (3q27.1) / MED10 (5p15.31)
MED10 (5p15.31) / MCCC1 (3q27.1)MED10 (5p15.31) / SPARCL1 (4q22.1)SUN2 (22q13.1) / MED10 (5p15.31)
MCCC1 MED10ATP11B MED10

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MED10   28760
Cards
Entrez_Gene (NCBI)MED10  84246  mediator complex subunit 10
AliasesL6; NUT2; TRG20
GeneCards (Weizmann)MED10
Ensembl hg19 (Hinxton)ENSG00000133398 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133398 [Gene_View]  chr5:6371926-6378526 [Contig_View]  MED10 [Vega]
ICGC DataPortalENSG00000133398
TCGA cBioPortalMED10
AceView (NCBI)MED10
Genatlas (Paris)MED10
WikiGenes84246
SOURCE (Princeton)MED10
Genetics Home Reference (NIH)MED10
Genomic and cartography
GoldenPath hg38 (UCSC)MED10  -     chr5:6371926-6378526 -  5p15.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED10  -     5p15.31   [Description]    (hg19-Feb_2009)
EnsemblMED10 - 5p15.31 [CytoView hg19]  MED10 - 5p15.31 [CytoView hg38]
Mapping of homologs : NCBIMED10 [Mapview hg19]  MED10 [Mapview hg38]
OMIM612382   
Gene and transcription
Genbank (Entrez)AA648258 AK075493 AY277599 AY453397 AY598325
RefSeq transcript (Entrez)NM_032286
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED10
Cluster EST : UnigeneHs.13885 [ NCBI ]
CGAP (NCI)Hs.13885
Alternative Splicing GalleryENSG00000133398
Gene ExpressionMED10 [ NCBI-GEO ]   MED10 [ EBI - ARRAY_EXPRESS ]   MED10 [ SEEK ]   MED10 [ MEM ]
Gene Expression Viewer (FireBrowse)MED10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84246
GTEX Portal (Tissue expression)MED10
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BTT4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BTT4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BTT4
Splice isoforms : SwissVarQ9BTT4
PhosPhoSitePlusQ9BTT4
Domains : Interpro (EBI)Mediator_Med10   
Domain families : Pfam (Sanger)Med10 (PF09748)   
Domain families : Pfam (NCBI)pfam09748   
Conserved Domain (NCBI)MED10
DMDM Disease mutations84246
Blocks (Seattle)MED10
SuperfamilyQ9BTT4
Human Protein AtlasENSG00000133398
Peptide AtlasQ9BTT4
HPRD14680
IPIIPI00030481   
Protein Interaction databases
DIP (DOE-UCLA)Q9BTT4
IntAct (EBI)Q9BTT4
FunCoupENSG00000133398
BioGRIDMED10
STRING (EMBL)MED10
ZODIACMED10
Ontologies - Pathways
QuickGOQ9BTT4
Ontology : AmiGOubiquitin ligase complex  RNA polymerase II transcription cofactor activity  protein binding  nucleoplasm  nucleoplasm  transcription initiation from RNA polymerase II promoter  protein ubiquitination  mediator complex  stem cell population maintenance  positive regulation of transcription from RNA polymerase II promoter  ubiquitin protein ligase activity  core mediator complex  
Ontology : EGO-EBIubiquitin ligase complex  RNA polymerase II transcription cofactor activity  protein binding  nucleoplasm  nucleoplasm  transcription initiation from RNA polymerase II promoter  protein ubiquitination  mediator complex  stem cell population maintenance  positive regulation of transcription from RNA polymerase II promoter  ubiquitin protein ligase activity  core mediator complex  
NDEx NetworkMED10
Atlas of Cancer Signalling NetworkMED10
Wikipedia pathwaysMED10
Orthology - Evolution
OrthoDB84246
GeneTree (enSembl)ENSG00000133398
Phylogenetic Trees/Animal Genes : TreeFamMED10
HOVERGENQ9BTT4
HOGENOMQ9BTT4
Homologs : HomoloGeneMED10
Homology/Alignments : Family Browser (UCSC)MED10
Gene fusions - Rearrangements
Fusion: TCGAMCCC1 MED10
Fusion: TCGAATP11B MED10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED10
dbVarMED10
ClinVarMED10
1000_GenomesMED10 
Exome Variant ServerMED10
ExAC (Exome Aggregation Consortium)MED10 (select the gene name)
Genetic variants : HAPMAP84246
Genomic Variants (DGV)MED10 [DGVbeta]
DECIPHERMED10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED10 
Mutations
ICGC Data PortalMED10 
TCGA Data PortalMED10 
Broad Tumor PortalMED10
OASIS PortalMED10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED10
DgiDB (Drug Gene Interaction Database)MED10
DoCM (Curated mutations)MED10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED10 (select a term)
intoGenMED10
Cancer3DMED10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612382   
Orphanet
MedgenMED10
Genetic Testing Registry MED10
NextProtQ9BTT4 [Medical]
TSGene84246
GENETestsMED10
Target ValidationMED10
Huge Navigator MED10 [HugePedia]
snp3D : Map Gene to Disease84246
BioCentury BCIQMED10
ClinGenMED10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84246
Chemical/Pharm GKB GenePA144596412
Clinical trialMED10
Miscellaneous
canSAR (ICR)MED10 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED10
EVEXMED10
GoPubMedMED10
iHOPMED10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 31 15:25:45 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.