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MED12L (mediator complex subunit 12 like)

Identity

Alias_namesmediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae)-like
mediator complex subunit 12-like
Alias_symbol (synonym)KIAA1635
TNRC11L
TRALPUSH
TRALP
Other aliasNOPAR
HGNC (Hugo) MED12L
LocusID (NCBI) 116931
Atlas_Id 68871
Location 3q25.1  [Link to chromosome band 3q25]
Location_base_pair Starts at 151086798 and ends at 151436677 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EIF2A (3q25.1) / MED12L (3q25.1)LRCH3 (3q29) / MED12L (3q25.1)MED12L (3q25.1) / MED12L (3q25.1)
MED12L (3q25.1) / MTCH1 (6p21.2)ROBO1 (3p12.3) / MED12L (3q25.1)SRRM1 (1p36.11) / MED12L (3q25.1)
LRCH3 MED12LROBO1 MED12L

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MED12L   16050
Cards
Entrez_Gene (NCBI)MED12L  116931  mediator complex subunit 12 like
AliasesNOPAR; TNRC11L; TRALP; TRALPUSH
GeneCards (Weizmann)MED12L
Ensembl hg19 (Hinxton)ENSG00000144893 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144893 [Gene_View]  chr3:151086798-151436677 [Contig_View]  MED12L [Vega]
ICGC DataPortalENSG00000144893
TCGA cBioPortalMED12L
AceView (NCBI)MED12L
Genatlas (Paris)MED12L
WikiGenes116931
SOURCE (Princeton)MED12L
Genetics Home Reference (NIH)MED12L
Genomic and cartography
GoldenPath hg38 (UCSC)MED12L  -     chr3:151086798-151436677 +  3q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED12L  -     3q25.1   [Description]    (hg19-Feb_2009)
EnsemblMED12L - 3q25.1 [CytoView hg19]  MED12L - 3q25.1 [CytoView hg38]
Mapping of homologs : NCBIMED12L [Mapview hg19]  MED12L [Mapview hg38]
OMIM611318   
Gene and transcription
Genbank (Entrez)AB046855 AF087980 AF090917 AF388364 AF388365
RefSeq transcript (Entrez)NM_053002
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED12L
Cluster EST : UnigeneHs.744234 [ NCBI ]
CGAP (NCI)Hs.744234
Alternative Splicing GalleryENSG00000144893
Gene ExpressionMED12L [ NCBI-GEO ]   MED12L [ EBI - ARRAY_EXPRESS ]   MED12L [ SEEK ]   MED12L [ MEM ]
Gene Expression Viewer (FireBrowse)MED12L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)116931
GTEX Portal (Tissue expression)MED12L
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86YW9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86YW9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86YW9
Splice isoforms : SwissVarQ86YW9
PhosPhoSitePlusQ86YW9
Domains : Interpro (EBI)Mediator_Med12    Mediator_Med12_catenin-bd    Mediator_Med12_LCEWAV   
Domain families : Pfam (Sanger)Med12 (PF09497)    Med12-LCEWAV (PF12145)    Med12-PQL (PF12144)   
Domain families : Pfam (NCBI)pfam09497    pfam12145    pfam12144   
Domain families : Smart (EMBL)Med12 (SM01281)  
Conserved Domain (NCBI)MED12L
DMDM Disease mutations116931
Blocks (Seattle)MED12L
SuperfamilyQ86YW9
Human Protein AtlasENSG00000144893
Peptide AtlasQ86YW9
HPRD10278
IPIIPI00783833   IPI00796214   IPI00797218   IPI00044353   IPI00976506   IPI00794919   
Protein Interaction databases
DIP (DOE-UCLA)Q86YW9
IntAct (EBI)Q86YW9
FunCoupENSG00000144893
BioGRIDMED12L
STRING (EMBL)MED12L
ZODIACMED12L
Ontologies - Pathways
QuickGOQ86YW9
Ontology : AmiGORNA polymerase II transcription coactivator activity  transcription, DNA-templated  beta-catenin binding  mediator complex  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBIRNA polymerase II transcription coactivator activity  transcription, DNA-templated  beta-catenin binding  mediator complex  positive regulation of transcription from RNA polymerase II promoter  
Pathways : KEGGThyroid hormone signaling pathway   
NDEx NetworkMED12L
Atlas of Cancer Signalling NetworkMED12L
Wikipedia pathwaysMED12L
Orthology - Evolution
OrthoDB116931
GeneTree (enSembl)ENSG00000144893
Phylogenetic Trees/Animal Genes : TreeFamMED12L
HOVERGENQ86YW9
HOGENOMQ86YW9
Homologs : HomoloGeneMED12L
Homology/Alignments : Family Browser (UCSC)MED12L
Gene fusions - Rearrangements
Fusion: TCGALRCH3 MED12L
Fusion: TCGAROBO1 MED12L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED12L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED12L
dbVarMED12L
ClinVarMED12L
1000_GenomesMED12L 
Exome Variant ServerMED12L
ExAC (Exome Aggregation Consortium)MED12L (select the gene name)
Genetic variants : HAPMAP116931
Genomic Variants (DGV)MED12L [DGVbeta]
DECIPHERMED12L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED12L 
Mutations
ICGC Data PortalMED12L 
TCGA Data PortalMED12L 
Broad Tumor PortalMED12L
OASIS PortalMED12L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED12L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED12L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED12L
DgiDB (Drug Gene Interaction Database)MED12L
DoCM (Curated mutations)MED12L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED12L (select a term)
intoGenMED12L
Cancer3DMED12L(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611318   
Orphanet
MedgenMED12L
Genetic Testing Registry MED12L
NextProtQ86YW9 [Medical]
TSGene116931
GENETestsMED12L
Target ValidationMED12L
Huge Navigator MED12L [HugePedia]
snp3D : Map Gene to Disease116931
BioCentury BCIQMED12L
ClinGenMED12L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD116931
Chemical/Pharm GKB GenePA134884590
Clinical trialMED12L
Miscellaneous
canSAR (ICR)MED12L (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED12L
EVEXMED12L
GoPubMedMED12L
iHOPMED12L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:25:45 CEST 2017

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