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MED12L (mediator complex subunit 12L)

Identity

Alias (NCBI)NIZIDS
NOPAR
TNRC11L
TRALP
TRALPUSH
HGNC (Hugo) MED12L
HGNC Alias symbKIAA1635
TNRC11L
TRALPUSH
TRALP
HGNC Previous namemediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae)-like
 mediator complex subunit 12-like
LocusID (NCBI) 116931
Atlas_Id 68871
Location 3q25.1  [Link to chromosome band 3q25]
Location_base_pair Starts at 151086798 and ends at 151436677 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EIF2A (3q25.1) / MED12L (3q25.1)LRCH3 (3q29) / MED12L (3q25.1)MED12L (3q25.1) / MED12L (3q25.1)
MED12L (3q25.1) / MTCH1 (6p21.2)ROBO1 (3p12.3) / MED12L (3q25.1)SRRM1 (1p36.11) / MED12L (3q25.1)
LRCH3 MED12LROBO1 MED12L

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MED12L   16050
Cards
Entrez_Gene (NCBI)MED12L    mediator complex subunit 12L
AliasesNIZIDS; NOPAR; TNRC11L; TRALP; 
TRALPUSH
GeneCards (Weizmann)MED12L
Ensembl hg19 (Hinxton)ENSG00000144893 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144893 [Gene_View]  ENSG00000144893 [Sequence]  chr3:151086798-151436677 [Contig_View]  MED12L [Vega]
ICGC DataPortalENSG00000144893
TCGA cBioPortalMED12L
AceView (NCBI)MED12L
Genatlas (Paris)MED12L
SOURCE (Princeton)MED12L
Genetics Home Reference (NIH)MED12L
Genomic and cartography
GoldenPath hg38 (UCSC)MED12L  -     chr3:151086798-151436677 +  3q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED12L  -     3q25.1   [Description]    (hg19-Feb_2009)
GoldenPathMED12L - 3q25.1 [CytoView hg19]  MED12L - 3q25.1 [CytoView hg38]
ImmunoBaseENSG00000144893
Genome Data Viewer NCBIMED12L [Mapview hg19]  
OMIM611318   618872   
Gene and transcription
Genbank (Entrez)AB046855 AF087980 AF090917 AF388364 AF388365
RefSeq transcript (Entrez)NM_001393769 NM_053002
Consensus coding sequences : CCDS (NCBI)MED12L
Gene ExpressionMED12L [ NCBI-GEO ]   MED12L [ EBI - ARRAY_EXPRESS ]   MED12L [ SEEK ]   MED12L [ MEM ]
Gene Expression Viewer (FireBrowse)MED12L [ Firebrowse - Broad ]
GenevisibleExpression of MED12L in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)116931
GTEX Portal (Tissue expression)MED12L
Human Protein AtlasENSG00000144893-MED12L [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86YW9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86YW9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86YW9
PhosPhoSitePlusQ86YW9
Domains : Interpro (EBI)Mediator_Med12    Mediator_Med12_catenin-bd    Mediator_Med12_LCEWAV   
Domain families : Pfam (Sanger)Med12 (PF09497)    Med12-LCEWAV (PF12145)    Med12-PQL (PF12144)   
Domain families : Pfam (NCBI)pfam09497    pfam12145    pfam12144   
Domain families : Smart (EMBL)Med12 (SM01281)  
Conserved Domain (NCBI)MED12L
SuperfamilyQ86YW9
AlphaFold pdb e-kbQ86YW9   
Human Protein Atlas [tissue]ENSG00000144893-MED12L [tissue]
HPRD10278
Protein Interaction databases
DIP (DOE-UCLA)Q86YW9
IntAct (EBI)Q86YW9
BioGRIDMED12L
STRING (EMBL)MED12L
ZODIACMED12L
Ontologies - Pathways
QuickGOQ86YW9
Ontology : AmiGOtranscription coactivator activity  protein binding  regulation of transcription by RNA polymerase II  beta-catenin binding  mediator complex  positive regulation of transcription, DNA-templated  
Ontology : EGO-EBItranscription coactivator activity  protein binding  regulation of transcription by RNA polymerase II  beta-catenin binding  mediator complex  positive regulation of transcription, DNA-templated  
NDEx NetworkMED12L
Atlas of Cancer Signalling NetworkMED12L
Wikipedia pathwaysMED12L
Orthology - Evolution
OrthoDB116931
GeneTree (enSembl)ENSG00000144893
Phylogenetic Trees/Animal Genes : TreeFamMED12L
Homologs : HomoloGeneMED12L
Homology/Alignments : Family Browser (UCSC)MED12L
Gene fusions - Rearrangements
Fusion : QuiverMED12L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED12L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED12L
dbVarMED12L
ClinVarMED12L
MonarchMED12L
1000_GenomesMED12L 
Exome Variant ServerMED12L
GNOMAD BrowserENSG00000144893
Varsome BrowserMED12L
ACMGMED12L variants
VarityQ86YW9
Genomic Variants (DGV)MED12L [DGVbeta]
DECIPHERMED12L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED12L 
Mutations
ICGC Data PortalMED12L 
TCGA Data PortalMED12L 
Broad Tumor PortalMED12L
OASIS PortalMED12L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED12L  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMED12L
Mutations and Diseases : HGMDMED12L
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMED12L
DgiDB (Drug Gene Interaction Database)MED12L
DoCM (Curated mutations)MED12L
CIViC (Clinical Interpretations of Variants in Cancer)MED12L
Cancer3DMED12L
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611318    618872   
Orphanet
DisGeNETMED12L
MedgenMED12L
Genetic Testing Registry MED12L
NextProtQ86YW9 [Medical]
GENETestsMED12L
Target ValidationMED12L
Huge Navigator MED12L [HugePedia]
ClinGenMED12L
Clinical trials, drugs, therapy
MyCancerGenomeMED12L
Protein Interactions : CTDMED12L
Pharm GKB GenePA134884590
PharosQ86YW9
Clinical trialMED12L
Miscellaneous
canSAR (ICR)MED12L
HarmonizomeMED12L
DataMed IndexMED12L
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMED12L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:07:03 CEST 2021

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