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MED13 (mediator complex subunit 13)

Identity

Alias (NCBI)ARC250
DRIP250
HSPC221
MRD61
THRAP1
TRAP240
HGNC (Hugo) MED13
HGNC Alias symbKIAA0593
TRAP240
HGNC Previous nameTHRAP1
HGNC Previous namethyroid hormone receptor associated protein 1
LocusID (NCBI) 9969
Atlas_Id 54448
Location 17q23.2  [Link to chromosome band 17q23]
Location_base_pair Starts at 61942605 and ends at 62065278 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCAS3 (17q23.2) / MED13 (17q23.2)LOC100506054 () / MED13 (17q23.2)MED13 (17q23.2) / ABCA9 (17q24.2)
MED13 (17q23.2) / BCAS3 (17q23.2)MED13 (17q23.2) / BRWD1 (21q22.2)MED13 (17q23.2) / DDX42 (17q23.3)
MED13 (17q23.2) / ITGA3 (17q21.33)MED13 (17q23.2) / KCNJ2 (17q24.3)MED13 (17q23.2) / MED13 (17q23.2)
MED13 (17q23.2) / TANC2 (17q23.2)MED13 (17q23.2) / TEX2 (17q23.3)MED13 (17q23.2) / TLDC2 (20q11.23)
MED13 (17q23.2) / VMP1 (17q23.1)MED13 17q23.2 / ABCA9 17q24.2MED13 17q23.2 C20orf118
MED13 17q23.2 / DDX42 17q23.3MED13 17q23.2 / ITGA3 17q21.33MED13 17q23.2 / KCNJ2 17q24.3
MED13 17q23.2 / TANC2 17q23.2MED13 17q23.2 / TEX2 17q23.3MED13 17q23.2 / VMP1 17q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MED13   22474
Cards
Entrez_Gene (NCBI)MED13    mediator complex subunit 13
AliasesARC250; DRIP250; HSPC221; MRD61; 
THRAP1; TRAP240
GeneCards (Weizmann)MED13
Ensembl hg19 (Hinxton)ENSG00000108510 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108510 [Gene_View]  ENSG00000108510 [Sequence]  chr17:61942605-62065278 [Contig_View]  MED13 [Vega]
ICGC DataPortalENSG00000108510
TCGA cBioPortalMED13
AceView (NCBI)MED13
Genatlas (Paris)MED13
SOURCE (Princeton)MED13
Genetics Home Reference (NIH)MED13
Genomic and cartography
GoldenPath hg38 (UCSC)MED13  -     chr17:61942605-62065278 -  17q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED13  -     17q23.2   [Description]    (hg19-Feb_2009)
GoldenPathMED13 - 17q23.2 [CytoView hg19]  MED13 - 17q23.2 [CytoView hg38]
ImmunoBaseENSG00000108510
Genome Data Viewer NCBIMED13 [Mapview hg19]  
OMIM603808   618009   
Gene and transcription
Genbank (Entrez)AB011165 AF117754 AF151055 AK054894 BC044258
RefSeq transcript (Entrez)NM_005121
Consensus coding sequences : CCDS (NCBI)MED13
Gene ExpressionMED13 [ NCBI-GEO ]   MED13 [ EBI - ARRAY_EXPRESS ]   MED13 [ SEEK ]   MED13 [ MEM ]
Gene Expression Viewer (FireBrowse)MED13 [ Firebrowse - Broad ]
GenevisibleExpression of MED13 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9969
GTEX Portal (Tissue expression)MED13
Human Protein AtlasENSG00000108510-MED13 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHV7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHV7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHV7
PhosPhoSitePlusQ9UHV7
Domains : Interpro (EBI)Med13_C    MID_MedPIWI   
Domain families : Pfam (Sanger)Med13_C (PF06333)    MID_MedPIWI (PF18296)   
Domain families : Pfam (NCBI)pfam06333    pfam18296   
Conserved Domain (NCBI)MED13
SuperfamilyQ9UHV7
AlphaFold pdb e-kbQ9UHV7   
Human Protein Atlas [tissue]ENSG00000108510-MED13 [tissue]
HPRD07229
Protein Interaction databases
DIP (DOE-UCLA)Q9UHV7
IntAct (EBI)Q9UHV7
BioGRIDMED13
STRING (EMBL)MED13
ZODIACMED13
Ontologies - Pathways
QuickGOQ9UHV7
Ontology : AmiGOtranscription coregulator activity  transcription coregulator activity  transcription coactivator activity  nucleus  nucleoplasm  nucleoplasm  regulation of transcription by RNA polymerase II  membrane  mediator complex  mediator complex  nuclear receptor coactivator activity  vitamin D receptor binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  thyroid hormone receptor binding  regulation of transcription initiation from RNA polymerase II promoter  positive regulation of transcription initiation from RNA polymerase II promoter  
Ontology : EGO-EBItranscription coregulator activity  transcription coregulator activity  transcription coactivator activity  nucleus  nucleoplasm  nucleoplasm  regulation of transcription by RNA polymerase II  membrane  mediator complex  mediator complex  nuclear receptor coactivator activity  vitamin D receptor binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  thyroid hormone receptor binding  regulation of transcription initiation from RNA polymerase II promoter  positive regulation of transcription initiation from RNA polymerase II promoter  
Pathways : KEGGThyroid hormone signaling pathway   
NDEx NetworkMED13
Atlas of Cancer Signalling NetworkMED13
Wikipedia pathwaysMED13
Orthology - Evolution
OrthoDB9969
GeneTree (enSembl)ENSG00000108510
Phylogenetic Trees/Animal Genes : TreeFamMED13
Homologs : HomoloGeneMED13
Homology/Alignments : Family Browser (UCSC)MED13
Gene fusions - Rearrangements
Fusion : MitelmanBCAS3/MED13 [17q23.2/17q23.2]  
Fusion : MitelmanMED13/ABCA9 [17q23.2/17q24.2]  
Fusion : MitelmanMED13/BCAS3 [17q23.2/17q23.2]  
Fusion : MitelmanMED13/DDX42 [17q23.2/17q23.3]  
Fusion : MitelmanMED13/ITGA3 [17q23.2/17q21.33]  
Fusion : MitelmanMED13/KCNJ2 [17q23.2/17q24.3]  
Fusion : MitelmanMED13/TANC2 [17q23.2/17q23.2]  
Fusion : MitelmanMED13/TEX2 [17q23.2/17q23.3]  
Fusion : MitelmanMED13/TLDC2 [17q23.2/20q11.23]  
Fusion : MitelmanMED13/VMP1 [17q23.2/17q23.1]  
Fusion : QuiverMED13
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED13 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED13
dbVarMED13
ClinVarMED13
MonarchMED13
1000_GenomesMED13 
Exome Variant ServerMED13
GNOMAD BrowserENSG00000108510
Varsome BrowserMED13
ACMGMED13 variants
VarityQ9UHV7
Genomic Variants (DGV)MED13 [DGVbeta]
DECIPHERMED13 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED13 
Mutations
ICGC Data PortalMED13 
TCGA Data PortalMED13 
Broad Tumor PortalMED13
OASIS PortalMED13 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED13  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMED13
Mutations and Diseases : HGMDMED13
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMED13
DgiDB (Drug Gene Interaction Database)MED13
DoCM (Curated mutations)MED13
CIViC (Clinical Interpretations of Variants in Cancer)MED13
Cancer3DMED13
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603808    618009   
Orphanet
DisGeNETMED13
MedgenMED13
Genetic Testing Registry MED13
NextProtQ9UHV7 [Medical]
GENETestsMED13
Target ValidationMED13
Huge Navigator MED13 [HugePedia]
ClinGenMED13
Clinical trials, drugs, therapy
MyCancerGenomeMED13
Protein Interactions : CTDMED13
Pharm GKB GenePA162395168
PharosQ9UHV7
Clinical trialMED13
Miscellaneous
canSAR (ICR)MED13
HarmonizomeMED13
DataMed IndexMED13
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMED13
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:18:12 CEST 2021

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