MED14 (mediator complex subunit 14)

2007-04-01  

Identity

HGNC
LOCATION
Xp11.4
LOCUSID
ALIAS
CRSP150,CRSP2,CSRP,CXorf4,DRIP150,EXLM1,RGR1,TRAP170
FUSION GENES

Other Information

Locus ID:

NCBI: 9282
MIM: 300182
HGNC: 2370
Ensembl: ENSG00000180182

Variants:

dbSNP: 9282
ClinVar: 9282
TCGA: ENSG00000180182
COSMIC: MED14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180182ENST00000324817O60244
ENSG00000180182ENST00000416199H7C017
ENSG00000180182ENST00000433003H7C3E5

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Thyroid hormone signaling pathwayKEGGhsa04919
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

References

Pubmed IDYearTitleCitations
162392572006MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor.71
253836692014Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit.39
125094592003Role of metazoan mediator proteins in interferon-responsive transcription.30
235725302013Vitamin D enhances glucocorticoid action in human monocytes: involvement of granulocyte-macrophage colony-stimulating factor and mediator complex subunit 14.23
156250662005DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs.12
288136672017Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.10
173067562007Coactivation of estrogen receptor alpha (ER alpha)/Sp1 by vitamin D receptor interacting protein 150 (DRIP150).5
128253532003Refinement of the physical location and the genomic characterization of the CRSP2 (EXLM1) gene on Xp11.4.0

Citation

Dessen P

MED14 (mediator complex subunit 14)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47338/med14