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MED14 (mediator complex subunit 14)

Identity

Alias (NCBI)CRSP150
CRSP2
CSRP
CXorf4
DRIP150
EXLM1
RGR1
TRAP170
HGNC (Hugo) MED14
HGNC Alias symbEXLM1
CRSP150
TRAP170
RGR1
CSRP
HGNC Previous nameCXorf4
 CRSP2
HGNC Previous namecofactor required for Sp1 transcriptional activation, subunit 2, 150kDa
LocusID (NCBI) 9282
Atlas_Id 47338
Location Xp11.4  [Link to chromosome band Xp11]
Location_base_pair Starts at 40648305 and ends at 40735542 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ESYT1 (12q13.2) / MED14 (Xp11.4)MED14 (Xp11.4) / CDR2L (17q25.1)ESYT1 12q13.2 / MED14 Xp11.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MED14   2370
Cards
Entrez_Gene (NCBI)MED14    mediator complex subunit 14
AliasesCRSP150; CRSP2; CSRP; CXorf4; 
DRIP150; EXLM1; RGR1; TRAP170
GeneCards (Weizmann)MED14
Ensembl hg19 (Hinxton)ENSG00000180182 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180182 [Gene_View]  ENSG00000180182 [Sequence]  chrX:40648305-40735542 [Contig_View]  MED14 [Vega]
ICGC DataPortalENSG00000180182
TCGA cBioPortalMED14
AceView (NCBI)MED14
Genatlas (Paris)MED14
SOURCE (Princeton)MED14
Genetics Home Reference (NIH)MED14
Genomic and cartography
GoldenPath hg38 (UCSC)MED14  -     chrX:40648305-40735542 -  Xp11.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED14  -     Xp11.4   [Description]    (hg19-Feb_2009)
GoldenPathMED14 - Xp11.4 [CytoView hg19]  MED14 - Xp11.4 [CytoView hg38]
ImmunoBaseENSG00000180182
Genome Data Viewer NCBIMED14 [Mapview hg19]  
OMIM300182   
Gene and transcription
Genbank (Entrez)AB006651 AF070563 AF104256 AF135802 AF304448
RefSeq transcript (Entrez)NM_004229
Consensus coding sequences : CCDS (NCBI)MED14
Gene ExpressionMED14 [ NCBI-GEO ]   MED14 [ EBI - ARRAY_EXPRESS ]   MED14 [ SEEK ]   MED14 [ MEM ]
Gene Expression Viewer (FireBrowse)MED14 [ Firebrowse - Broad ]
GenevisibleExpression of MED14 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9282
GTEX Portal (Tissue expression)MED14
Human Protein AtlasENSG00000180182-MED14 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60244   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60244  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60244
PhosPhoSitePlusO60244
Domains : Interpro (EBI)Mediator_Med14   
Domain families : Pfam (Sanger)Med14 (PF08638)   
Domain families : Pfam (NCBI)pfam08638   
Conserved Domain (NCBI)MED14
SuperfamilyO60244
AlphaFold pdb e-kbO60244   
Human Protein Atlas [tissue]ENSG00000180182-MED14 [tissue]
HPRD02172
Protein Interaction databases
DIP (DOE-UCLA)O60244
IntAct (EBI)O60244
BioGRIDMED14
STRING (EMBL)MED14
ZODIACMED14
Ontologies - Pathways
QuickGOO60244
Ontology : AmiGOtranscription coregulator activity  transcription coregulator activity  transcription coactivator activity  protein binding  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  membrane  mediator complex  mediator complex  stem cell population maintenance  nuclear receptor coactivator activity  vitamin D receptor binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  regulation of transcription initiation from RNA polymerase II promoter  positive regulation of transcription initiation from RNA polymerase II promoter  core mediator complex  
Ontology : EGO-EBItranscription coregulator activity  transcription coregulator activity  transcription coactivator activity  protein binding  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  membrane  mediator complex  mediator complex  stem cell population maintenance  nuclear receptor coactivator activity  vitamin D receptor binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  regulation of transcription initiation from RNA polymerase II promoter  positive regulation of transcription initiation from RNA polymerase II promoter  core mediator complex  
Pathways : KEGGThyroid hormone signaling pathway   
NDEx NetworkMED14
Atlas of Cancer Signalling NetworkMED14
Wikipedia pathwaysMED14
Orthology - Evolution
OrthoDB9282
GeneTree (enSembl)ENSG00000180182
Phylogenetic Trees/Animal Genes : TreeFamMED14
Homologs : HomoloGeneMED14
Homology/Alignments : Family Browser (UCSC)MED14
Gene fusions - Rearrangements
Fusion : MitelmanESYT1/MED14 [12q13.2/Xp11.4]  
Fusion : QuiverMED14
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED14
dbVarMED14
ClinVarMED14
MonarchMED14
1000_GenomesMED14 
Exome Variant ServerMED14
GNOMAD BrowserENSG00000180182
Varsome BrowserMED14
ACMGMED14 variants
VarityO60244
Genomic Variants (DGV)MED14 [DGVbeta]
DECIPHERMED14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED14 
Mutations
ICGC Data PortalMED14 
TCGA Data PortalMED14 
Broad Tumor PortalMED14
OASIS PortalMED14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED14  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMED14
Mutations and Diseases : HGMDMED14
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMED14
DgiDB (Drug Gene Interaction Database)MED14
DoCM (Curated mutations)MED14
CIViC (Clinical Interpretations of Variants in Cancer)MED14
Cancer3DMED14
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300182   
Orphanet
DisGeNETMED14
MedgenMED14
Genetic Testing Registry MED14
NextProtO60244 [Medical]
GENETestsMED14
Target ValidationMED14
Huge Navigator MED14 [HugePedia]
ClinGenMED14
Clinical trials, drugs, therapy
MyCancerGenomeMED14
Protein Interactions : CTDMED14
Pharm GKB GenePA26890
PharosO60244
Clinical trialMED14
Miscellaneous
canSAR (ICR)MED14
HarmonizomeMED14
DataMed IndexMED14
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMED14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:18:12 CEST 2021

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