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MED14 (mediator complex subunit 14)

Identity

Alias_namesCXorf4
CRSP2
cofactor required for Sp1 transcriptional activation
Alias_symbol (synonym)EXLM1
CRSP150
TRAP170
RGR1
CSRP
Other aliasDRIP150
HGNC (Hugo) MED14
LocusID (NCBI) 9282
Atlas_Id 47338
Location Xp11.4  [Link to chromosome band Xp11]
Location_base_pair Starts at 40649543 and ends at 40735552 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ESYT1 (12q13.2) / MED14 (Xp11.4)MED14 (Xp11.4) / CDR2L (17q25.1)ESYT1 12q13.2 / MED14 Xp11.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MED14   2370
Cards
Entrez_Gene (NCBI)MED14  9282  mediator complex subunit 14
AliasesCRSP150; CRSP2; CSRP; CXorf4; 
DRIP150; EXLM1; RGR1; TRAP170
GeneCards (Weizmann)MED14
Ensembl hg19 (Hinxton)ENSG00000180182 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180182 [Gene_View]  chrX:40649543-40735552 [Contig_View]  MED14 [Vega]
ICGC DataPortalENSG00000180182
TCGA cBioPortalMED14
AceView (NCBI)MED14
Genatlas (Paris)MED14
WikiGenes9282
SOURCE (Princeton)MED14
Genetics Home Reference (NIH)MED14
Genomic and cartography
GoldenPath hg38 (UCSC)MED14  -     chrX:40649543-40735552 -  Xp11.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED14  -     Xp11.4   [Description]    (hg19-Feb_2009)
EnsemblMED14 - Xp11.4 [CytoView hg19]  MED14 - Xp11.4 [CytoView hg38]
Mapping of homologs : NCBIMED14 [Mapview hg19]  MED14 [Mapview hg38]
OMIM300182   
Gene and transcription
Genbank (Entrez)AB006651 AF070563 AF104256 AF135802 AF304448
RefSeq transcript (Entrez)NM_004229
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED14
Cluster EST : UnigeneHs.407604 [ NCBI ]
CGAP (NCI)Hs.407604
Alternative Splicing GalleryENSG00000180182
Gene ExpressionMED14 [ NCBI-GEO ]   MED14 [ EBI - ARRAY_EXPRESS ]   MED14 [ SEEK ]   MED14 [ MEM ]
Gene Expression Viewer (FireBrowse)MED14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9282
GTEX Portal (Tissue expression)MED14
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60244   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60244  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60244
Splice isoforms : SwissVarO60244
PhosPhoSitePlusO60244
Domains : Interpro (EBI)Mediator_Med14   
Domain families : Pfam (Sanger)Med14 (PF08638)   
Domain families : Pfam (NCBI)pfam08638   
Conserved Domain (NCBI)MED14
DMDM Disease mutations9282
Blocks (Seattle)MED14
SuperfamilyO60244
Human Protein AtlasENSG00000180182
Peptide AtlasO60244
HPRD02172
IPIIPI00297191   IPI00646675   IPI00644871   
Protein Interaction databases
DIP (DOE-UCLA)O60244
IntAct (EBI)O60244
FunCoupENSG00000180182
BioGRIDMED14
STRING (EMBL)MED14
ZODIACMED14
Ontologies - Pathways
QuickGOO60244
Ontology : AmiGORNA polymerase II transcription cofactor activity  transcription cofactor activity  transcription coactivator activity  receptor activity  protein binding  nucleus  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  membrane  mediator complex  stem cell population maintenance  ligand-dependent nuclear receptor transcription coactivator activity  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  vitamin D receptor binding  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  core mediator complex  
Ontology : EGO-EBIRNA polymerase II transcription cofactor activity  transcription cofactor activity  transcription coactivator activity  receptor activity  protein binding  nucleus  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  membrane  mediator complex  stem cell population maintenance  ligand-dependent nuclear receptor transcription coactivator activity  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  vitamin D receptor binding  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  core mediator complex  
Pathways : KEGGThyroid hormone signaling pathway   
NDEx NetworkMED14
Atlas of Cancer Signalling NetworkMED14
Wikipedia pathwaysMED14
Orthology - Evolution
OrthoDB9282
GeneTree (enSembl)ENSG00000180182
Phylogenetic Trees/Animal Genes : TreeFamMED14
HOVERGENO60244
HOGENOMO60244
Homologs : HomoloGeneMED14
Homology/Alignments : Family Browser (UCSC)MED14
Gene fusions - Rearrangements
Fusion : MitelmanESYT1/MED14 [12q13.2/Xp11.4]  [t(X;12)(p11;q13)]  
Fusion: TCGAESYT1 12q13.2 MED14 Xp11.4 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED14
dbVarMED14
ClinVarMED14
1000_GenomesMED14 
Exome Variant ServerMED14
ExAC (Exome Aggregation Consortium)MED14 (select the gene name)
Genetic variants : HAPMAP9282
Genomic Variants (DGV)MED14 [DGVbeta]
DECIPHERMED14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED14 
Mutations
ICGC Data PortalMED14 
TCGA Data PortalMED14 
Broad Tumor PortalMED14
OASIS PortalMED14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch MED14
DgiDB (Drug Gene Interaction Database)MED14
DoCM (Curated mutations)MED14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED14 (select a term)
intoGenMED14
Cancer3DMED14(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300182   
Orphanet
MedgenMED14
Genetic Testing Registry MED14
NextProtO60244 [Medical]
TSGene9282
GENETestsMED14
Target ValidationMED14
Huge Navigator MED14 [HugePedia]
snp3D : Map Gene to Disease9282
BioCentury BCIQMED14
ClinGenMED14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9282
Chemical/Pharm GKB GenePA26890
Clinical trialMED14
Miscellaneous
canSAR (ICR)MED14 (select the gene name)
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED14
EVEXMED14
GoPubMedMED14
iHOPMED14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:42:41 CEST 2017

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