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MED15 (mediator complex subunit 15)

Identity

Alias (NCBI)ARC105
CAG7A
CTG7A
PCQAP
TIG-1
TIG1
TNRC7
HGNC (Hugo) MED15
HGNC Alias symbTIG-1
CAG7A
Arc105
HGNC Previous nameTNRC7
 PCQAP
HGNC Previous nametrinucleotide repeat containing 7
 PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein
LocusID (NCBI) 51586
Atlas_Id 43823
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 20507610 and ends at 20587619 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EWSR1 (22q12.2) / MED15 (22q11.21)FAM46A (6q14.1) / MED15 (22q11.21)MED15 (22q11.21) / COMT (22q11.21)
MED15 (22q11.21) / GNB1L (22q11.21)MED15 (22q11.21) / MED15 (22q11.21)MED15 (22q11.21) / PI4KA (22q11.21)
MED15 (22q11.21) / TRIM40 (6p22.1)MED15 (22q11.21) / TXNRD2 (22q11.21)RPLP2 (11p15.5) / MED15 (22q11.21)
RPN2 (20q11.23) / MED15 (22q11.21)ZNRF3 (22q12.1) / MED15 (22q11.21)MED15 22q11.21 / COMT 22q11.21
MED15 22q11.21 / GNB1L 22q11.21MED15 22q11.21 / PI4KA 22q11.21ZNRF3 22q12.1 / MED15 22q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MED15   14248
Cards
Entrez_Gene (NCBI)MED15    mediator complex subunit 15
AliasesARC105; CAG7A; CTG7A; PCQAP; 
TIG-1; TIG1; TNRC7
GeneCards (Weizmann)MED15
Ensembl hg19 (Hinxton)ENSG00000099917 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000099917 [Gene_View]  ENSG00000099917 [Sequence]  chr22:20507610-20587619 [Contig_View]  MED15 [Vega]
ICGC DataPortalENSG00000099917
TCGA cBioPortalMED15
AceView (NCBI)MED15
Genatlas (Paris)MED15
SOURCE (Princeton)MED15
Genetics Home Reference (NIH)MED15
Genomic and cartography
GoldenPath hg38 (UCSC)MED15  -     chr22:20507610-20587619 +  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED15  -     22q11.21   [Description]    (hg19-Feb_2009)
GoldenPathMED15 - 22q11.21 [CytoView hg19]  MED15 - 22q11.21 [CytoView hg38]
ImmunoBaseENSG00000099917
Genome Data Viewer NCBIMED15 [Mapview hg19]  
OMIM607372   
Gene and transcription
Genbank (Entrez)AF056191 AF328769 AK000003 AK074230 AK074268
RefSeq transcript (Entrez)NM_001003891 NM_001293234 NM_001293235 NM_001293236 NM_001293237 NM_015889
Consensus coding sequences : CCDS (NCBI)MED15
Gene ExpressionMED15 [ NCBI-GEO ]   MED15 [ EBI - ARRAY_EXPRESS ]   MED15 [ SEEK ]   MED15 [ MEM ]
Gene Expression Viewer (FireBrowse)MED15 [ Firebrowse - Broad ]
GenevisibleExpression of MED15 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51586
GTEX Portal (Tissue expression)MED15
Human Protein AtlasENSG00000099917-MED15 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RN5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RN5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RN5
PhosPhoSitePlusQ96RN5
Domains : Interpro (EBI)KIX_dom_sf    Med15   
Domain families : Pfam (Sanger)Med15 (PF09606)   
Domain families : Pfam (NCBI)pfam09606   
Conserved Domain (NCBI)MED15
PDB (RSDB)2GUT   
PDB Europe2GUT   
PDB (PDBSum)2GUT   
PDB (IMB)2GUT   
Structural Biology KnowledgeBase2GUT   
SCOP (Structural Classification of Proteins)2GUT   
CATH (Classification of proteins structures)2GUT   
SuperfamilyQ96RN5
AlphaFold pdb e-kbQ96RN5   
Human Protein Atlas [tissue]ENSG00000099917-MED15 [tissue]
HPRD12117
Protein Interaction databases
DIP (DOE-UCLA)Q96RN5
IntAct (EBI)Q96RN5
BioGRIDMED15
STRING (EMBL)MED15
ZODIACMED15
Ontologies - Pathways
QuickGOQ96RN5
Ontology : AmiGOtranscription coregulator activity  protein binding  nucleoplasm  nucleoplasm  cytoplasm  membrane  mediator complex  regulation of transcription initiation from RNA polymerase II promoter  
Ontology : EGO-EBItranscription coregulator activity  protein binding  nucleoplasm  nucleoplasm  cytoplasm  membrane  mediator complex  regulation of transcription initiation from RNA polymerase II promoter  
NDEx NetworkMED15
Atlas of Cancer Signalling NetworkMED15
Wikipedia pathwaysMED15
Orthology - Evolution
OrthoDB51586
GeneTree (enSembl)ENSG00000099917
Phylogenetic Trees/Animal Genes : TreeFamMED15
Homologs : HomoloGeneMED15
Homology/Alignments : Family Browser (UCSC)MED15
Gene fusions - Rearrangements
Fusion : MitelmanMED15/COMT [22q11.21/22q11.21]  
Fusion : MitelmanMED15/GNB1L [22q11.21/22q11.21]  
Fusion : MitelmanMED15/PI4KA [22q11.21/22q11.21]  
Fusion : MitelmanZNRF3/MED15 [22q12.1/22q11.21]  
Fusion : QuiverMED15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED15
dbVarMED15
ClinVarMED15
MonarchMED15
1000_GenomesMED15 
Exome Variant ServerMED15
GNOMAD BrowserENSG00000099917
Varsome BrowserMED15
ACMGMED15 variants
VarityQ96RN5
Genomic Variants (DGV)MED15 [DGVbeta]
DECIPHERMED15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED15 
Mutations
ICGC Data PortalMED15 
TCGA Data PortalMED15 
Broad Tumor PortalMED15
OASIS PortalMED15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED15  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMED15
Mutations and Diseases : HGMDMED15
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMED15
DgiDB (Drug Gene Interaction Database)MED15
DoCM (Curated mutations)MED15
CIViC (Clinical Interpretations of Variants in Cancer)MED15
Cancer3DMED15
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607372   
Orphanet
DisGeNETMED15
MedgenMED15
Genetic Testing Registry MED15
NextProtQ96RN5 [Medical]
GENETestsMED15
Target ValidationMED15
Huge Navigator MED15 [HugePedia]
ClinGenMED15
Clinical trials, drugs, therapy
MyCancerGenomeMED15
Protein Interactions : CTDMED15
Pharm GKB GenePA33088
PharosQ96RN5
Clinical trialMED15
Miscellaneous
canSAR (ICR)MED15
HarmonizomeMED15
DataMed IndexMED15
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMED15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:18:12 CEST 2021

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