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MED15 (mediator complex subunit 15)

Identity

Alias_namesTNRC7
PCQAP
trinucleotide repeat containing 7
PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein
Alias_symbol (synonym)TIG-1
CAG7A
Arc105
Other aliasARC105
CTG7A
TIG1
HGNC (Hugo) MED15
LocusID (NCBI) 51586
Atlas_Id 43823
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 20507542 and ends at 20587632 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EWSR1 (22q12.2) / MED15 (22q11.21)FAM46A (6q14.1) / MED15 (22q11.21)MED15 (22q11.21) / COMT (22q11.21)
MED15 (22q11.21) / GNB1L (22q11.21)MED15 (22q11.21) / MED15 (22q11.21)MED15 (22q11.21) / PI4KA (22q11.21)
MED15 (22q11.21) / TRIM40 (6p22.1)MED15 (22q11.21) / TXNRD2 (22q11.21)RPLP2 (11p15.5) / MED15 (22q11.21)
RPN2 (20q11.23) / MED15 (22q11.21)ZNRF3 (22q12.1) / MED15 (22q11.21)MED15 22q11.21 / COMT 22q11.21
MED15 22q11.21 / GNB1L 22q11.21MED15 22q11.21 / PI4KA 22q11.21ZNRF3 22q12.1 / MED15 22q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  MED15/COMT (22q11)
MED15/GNB1L (22q11)
MED15/PI4KA (22q11)
t(22;22)(q11;q12) ZNRF3/MED15


External links

Nomenclature
HGNC (Hugo)MED15   14248
Cards
Entrez_Gene (NCBI)MED15  51586  mediator complex subunit 15
AliasesARC105; CAG7A; CTG7A; PCQAP; 
TIG-1; TIG1; TNRC7
GeneCards (Weizmann)MED15
Ensembl hg19 (Hinxton)ENSG00000099917 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000099917 [Gene_View]  ENSG00000099917 [Sequence]  chr22:20507542-20587632 [Contig_View]  MED15 [Vega]
ICGC DataPortalENSG00000099917
TCGA cBioPortalMED15
AceView (NCBI)MED15
Genatlas (Paris)MED15
WikiGenes51586
SOURCE (Princeton)MED15
Genetics Home Reference (NIH)MED15
Genomic and cartography
GoldenPath hg38 (UCSC)MED15  -     chr22:20507542-20587632 +  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED15  -     22q11.21   [Description]    (hg19-Feb_2009)
EnsemblMED15 - 22q11.21 [CytoView hg19]  MED15 - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBIMED15 [Mapview hg19]  MED15 [Mapview hg38]
OMIM607372   
Gene and transcription
Genbank (Entrez)AF056191 AF328769 AK000003 AK074230 AK074268
RefSeq transcript (Entrez)NM_001003891 NM_001293234 NM_001293235 NM_001293236 NM_001293237 NM_015889
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED15
Cluster EST : UnigeneHs.517421 [ NCBI ]
CGAP (NCI)Hs.517421
Alternative Splicing GalleryENSG00000099917
Gene ExpressionMED15 [ NCBI-GEO ]   MED15 [ EBI - ARRAY_EXPRESS ]   MED15 [ SEEK ]   MED15 [ MEM ]
Gene Expression Viewer (FireBrowse)MED15 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51586
GTEX Portal (Tissue expression)MED15
Human Protein AtlasENSG00000099917-MED15 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RN5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RN5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RN5
Splice isoforms : SwissVarQ96RN5
PhosPhoSitePlusQ96RN5
Domains : Interpro (EBI)Med15   
Domain families : Pfam (Sanger)Med15 (PF09606)   
Domain families : Pfam (NCBI)pfam09606   
Conserved Domain (NCBI)MED15
DMDM Disease mutations51586
Blocks (Seattle)MED15
PDB (SRS)2GUT   
PDB (PDBSum)2GUT   
PDB (IMB)2GUT   
PDB (RSDB)2GUT   
Structural Biology KnowledgeBase2GUT   
SCOP (Structural Classification of Proteins)2GUT   
CATH (Classification of proteins structures)2GUT   
SuperfamilyQ96RN5
Human Protein Atlas [tissue]ENSG00000099917-MED15 [tissue]
Peptide AtlasQ96RN5
HPRD12117
IPIIPI00107693   IPI00220307   IPI00554734   IPI00878460   IPI01012122   IPI00386124   IPI00878147   IPI00877942   IPI00878775   IPI00878264   IPI00879109   IPI00878582   IPI00879387   IPI00879723   IPI00879890   IPI00879996   IPI00892898   IPI00892865   IPI00894280   IPI00894172   
Protein Interaction databases
DIP (DOE-UCLA)Q96RN5
IntAct (EBI)Q96RN5
FunCoupENSG00000099917
BioGRIDMED15
STRING (EMBL)MED15
ZODIACMED15
Ontologies - Pathways
QuickGOQ96RN5
Ontology : AmiGOtranscription coregulator activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  regulation of transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  membrane  mediator complex  stem cell population maintenance  
Ontology : EGO-EBItranscription coregulator activity  protein binding  nucleus  nucleus  nucleoplasm  cytoplasm  regulation of transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  membrane  mediator complex  stem cell population maintenance  
NDEx NetworkMED15
Atlas of Cancer Signalling NetworkMED15
Wikipedia pathwaysMED15
Orthology - Evolution
OrthoDB51586
GeneTree (enSembl)ENSG00000099917
Phylogenetic Trees/Animal Genes : TreeFamMED15
HOVERGENQ96RN5
HOGENOMQ96RN5
Homologs : HomoloGeneMED15
Homology/Alignments : Family Browser (UCSC)MED15
Gene fusions - Rearrangements
Fusion : MitelmanMED15/COMT [22q11.21/22q11.21]  
Fusion : MitelmanMED15/GNB1L [22q11.21/22q11.21]  [t(22;22)(q11;q11)]  
Fusion : MitelmanMED15/PI4KA [22q11.21/22q11.21]  [t(22;22)(q11;q11)]  
Fusion : MitelmanZNRF3/MED15 [22q12.1/22q11.21]  [t(22;22)(q11;q12)]  
Fusion PortalMED15 22q11.21 COMT 22q11.21 GBM
Fusion PortalMED15 22q11.21 GNB1L 22q11.21 BLCA
Fusion PortalMED15 22q11.21 PI4KA 22q11.21 LUSC
Fusion PortalZNRF3 22q12.1 MED15 22q11.21 LUSC
Fusion : QuiverMED15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED15
dbVarMED15
ClinVarMED15
1000_GenomesMED15 
Exome Variant ServerMED15
ExAC (Exome Aggregation Consortium)ENSG00000099917
GNOMAD BrowserENSG00000099917
Varsome BrowserMED15
Genetic variants : HAPMAP51586
Genomic Variants (DGV)MED15 [DGVbeta]
DECIPHERMED15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED15 
Mutations
ICGC Data PortalMED15 
TCGA Data PortalMED15 
Broad Tumor PortalMED15
OASIS PortalMED15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED15  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED15
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED15
DgiDB (Drug Gene Interaction Database)MED15
DoCM (Curated mutations)MED15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED15 (select a term)
intoGenMED15
Cancer3DMED15(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607372   
Orphanet
DisGeNETMED15
MedgenMED15
Genetic Testing Registry MED15
NextProtQ96RN5 [Medical]
TSGene51586
GENETestsMED15
Target ValidationMED15
Huge Navigator MED15 [HugePedia]
snp3D : Map Gene to Disease51586
BioCentury BCIQMED15
ClinGenMED15
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51586
Chemical/Pharm GKB GenePA33088
Clinical trialMED15
Miscellaneous
canSAR (ICR)MED15 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED15
EVEXMED15
GoPubMedMED15
iHOPMED15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:19:30 CET 2018

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