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MED16 (mediator complex subunit 16)

Identity

Alias (NCBI)DRIP92
THRAP5
TRAP95
HGNC (Hugo) MED16
HGNC Alias symbDRIP92
TRAP95
HGNC Previous nameTHRAP5
HGNC Previous namethyroid hormone receptor associated protein 5
LocusID (NCBI) 10025
Atlas_Id 68874
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 867963 and ends at 893187 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CFD (19p13.3) / MED16 (19p13.3)CNN2 (19p13.3) / MED16 (19p13.3)MED16 (19p13.3) / MED16 (19p13.3)
RBFOX2 (22q12.3) / MED16 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MED16   17556
Cards
Entrez_Gene (NCBI)MED16    mediator complex subunit 16
AliasesDRIP92; THRAP5; TRAP95
GeneCards (Weizmann)MED16
Ensembl hg19 (Hinxton)ENSG00000175221 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175221 [Gene_View]  ENSG00000175221 [Sequence]  chr19:867963-893187 [Contig_View]  MED16 [Vega]
ICGC DataPortalENSG00000175221
TCGA cBioPortalMED16
AceView (NCBI)MED16
Genatlas (Paris)MED16
SOURCE (Princeton)MED16
Genetics Home Reference (NIH)MED16
Genomic and cartography
GoldenPath hg38 (UCSC)MED16  -     chr19:867963-893187 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED16  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathMED16 - 19p13.3 [CytoView hg19]  MED16 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000175221
Genome Data Viewer NCBIMED16 [Mapview hg19]  
OMIM604062   
Gene and transcription
Genbank (Entrez)AF106934 AF121228 AL137732 AU098434 BC004554
RefSeq transcript (Entrez)NM_005481
Consensus coding sequences : CCDS (NCBI)MED16
Gene ExpressionMED16 [ NCBI-GEO ]   MED16 [ EBI - ARRAY_EXPRESS ]   MED16 [ SEEK ]   MED16 [ MEM ]
Gene Expression Viewer (FireBrowse)MED16 [ Firebrowse - Broad ]
GenevisibleExpression of MED16 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10025
GTEX Portal (Tissue expression)MED16
Human Protein AtlasENSG00000175221-MED16 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2X0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2X0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2X0
PhosPhoSitePlusQ9Y2X0
Domaine pattern : Prosite (Expaxy)WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Mediator_Med16    Quinoprot_gluc/sorb_DH    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)Med16 (PF11635)   
Domain families : Pfam (NCBI)pfam11635   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)MED16
SuperfamilyQ9Y2X0
AlphaFold pdb e-kbQ9Y2X0   
Human Protein Atlas [tissue]ENSG00000175221-MED16 [tissue]
HPRD06816
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2X0
IntAct (EBI)Q9Y2X0
BioGRIDMED16
STRING (EMBL)MED16
ZODIACMED16
Ontologies - Pathways
QuickGOQ9Y2X0
Ontology : AmiGOtranscription coactivator activity  catalytic activity  protein binding  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  membrane  mediator complex  mediator complex  vitamin D receptor binding  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  regulation of transcription initiation from RNA polymerase II promoter  positive regulation of transcription initiation from RNA polymerase II promoter  
Ontology : EGO-EBItranscription coactivator activity  catalytic activity  protein binding  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  membrane  mediator complex  mediator complex  vitamin D receptor binding  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  regulation of transcription initiation from RNA polymerase II promoter  positive regulation of transcription initiation from RNA polymerase II promoter  
NDEx NetworkMED16
Atlas of Cancer Signalling NetworkMED16
Wikipedia pathwaysMED16
Orthology - Evolution
OrthoDB10025
GeneTree (enSembl)ENSG00000175221
Phylogenetic Trees/Animal Genes : TreeFamMED16
Homologs : HomoloGeneMED16
Homology/Alignments : Family Browser (UCSC)MED16
Gene fusions - Rearrangements
Fusion : QuiverMED16
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED16 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED16
dbVarMED16
ClinVarMED16
MonarchMED16
1000_GenomesMED16 
Exome Variant ServerMED16
GNOMAD BrowserENSG00000175221
Varsome BrowserMED16
ACMGMED16 variants
VarityQ9Y2X0
Genomic Variants (DGV)MED16 [DGVbeta]
DECIPHERMED16 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED16 
Mutations
ICGC Data PortalMED16 
TCGA Data PortalMED16 
Broad Tumor PortalMED16
OASIS PortalMED16 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED16  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMED16
Mutations and Diseases : HGMDMED16
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMED16
DgiDB (Drug Gene Interaction Database)MED16
DoCM (Curated mutations)MED16
CIViC (Clinical Interpretations of Variants in Cancer)MED16
Cancer3DMED16
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604062   
Orphanet
DisGeNETMED16
MedgenMED16
Genetic Testing Registry MED16
NextProtQ9Y2X0 [Medical]
GENETestsMED16
Target ValidationMED16
Huge Navigator MED16 [HugePedia]
ClinGenMED16
Clinical trials, drugs, therapy
MyCancerGenomeMED16
Protein Interactions : CTDMED16
Pharm GKB GenePA162395406
PharosQ9Y2X0
Clinical trialMED16
Miscellaneous
canSAR (ICR)MED16
HarmonizomeMED16
DataMed IndexMED16
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMED16
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:07:03 CEST 2021

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