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MED16 (mediator complex subunit 16)

Identity

Alias_namesTHRAP5
thyroid hormone receptor associated protein 5
Alias_symbol (synonym)DRIP92
TRAP95
Other alias
HGNC (Hugo) MED16
LocusID (NCBI) 10025
Atlas_Id 68874
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 867962 and ends at 893218 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CFD (19p13.3) / MED16 (19p13.3)CNN2 (19p13.3) / MED16 (19p13.3)MED16 (19p13.3) / MED16 (19p13.3)
RBFOX2 (22q12.3) / MED16 (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MED16   17556
Cards
Entrez_Gene (NCBI)MED16  10025  mediator complex subunit 16
AliasesDRIP92; THRAP5; TRAP95
GeneCards (Weizmann)MED16
Ensembl hg19 (Hinxton)ENSG00000175221 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175221 [Gene_View]  chr19:867962-893218 [Contig_View]  MED16 [Vega]
ICGC DataPortalENSG00000175221
TCGA cBioPortalMED16
AceView (NCBI)MED16
Genatlas (Paris)MED16
WikiGenes10025
SOURCE (Princeton)MED16
Genetics Home Reference (NIH)MED16
Genomic and cartography
GoldenPath hg38 (UCSC)MED16  -     chr19:867962-893218 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED16  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblMED16 - 19p13.3 [CytoView hg19]  MED16 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIMED16 [Mapview hg19]  MED16 [Mapview hg38]
OMIM604062   
Gene and transcription
Genbank (Entrez)AF106934 AF121228 AL137732 AU098434 BC004554
RefSeq transcript (Entrez)NM_005481
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_187622
Consensus coding sequences : CCDS (NCBI)MED16
Cluster EST : UnigeneHs.365207 [ NCBI ]
CGAP (NCI)Hs.365207
Alternative Splicing GalleryENSG00000175221
Gene ExpressionMED16 [ NCBI-GEO ]   MED16 [ EBI - ARRAY_EXPRESS ]   MED16 [ SEEK ]   MED16 [ MEM ]
Gene Expression Viewer (FireBrowse)MED16 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10025
GTEX Portal (Tissue expression)MED16
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2X0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2X0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2X0
Splice isoforms : SwissVarQ9Y2X0
PhosPhoSitePlusQ9Y2X0
Domaine pattern : Prosite (Expaxy)WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Mediator_Med16    Quinoprot_gluc/sorb_DH    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)Med16 (PF11635)   
Domain families : Pfam (NCBI)pfam11635   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)MED16
DMDM Disease mutations10025
Blocks (Seattle)MED16
SuperfamilyQ9Y2X0
Human Protein AtlasENSG00000175221
Peptide AtlasQ9Y2X0
HPRD06816
IPIIPI00037401   IPI00556603   IPI00157783   IPI00063274   IPI00869327   IPI01008916   IPI00923622   IPI00923418   IPI00923433   IPI00923499   IPI00927353   IPI01009133   IPI00983892   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2X0
IntAct (EBI)Q9Y2X0
FunCoupENSG00000175221
BioGRIDMED16
STRING (EMBL)MED16
ZODIACMED16
Ontologies - Pathways
QuickGOQ9Y2X0
Ontology : AmiGOtranscription cofactor activity  transcription coactivator activity  catalytic activity  receptor activity  protein binding  nucleus  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  membrane  mediator complex  thyroid hormone receptor coactivator activity  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  vitamin D receptor binding  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  positive regulation of receptor activity  
Ontology : EGO-EBItranscription cofactor activity  transcription coactivator activity  catalytic activity  receptor activity  protein binding  nucleus  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  membrane  mediator complex  thyroid hormone receptor coactivator activity  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  vitamin D receptor binding  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  positive regulation of receptor activity  
Pathways : KEGGThyroid hormone signaling pathway   
NDEx NetworkMED16
Atlas of Cancer Signalling NetworkMED16
Wikipedia pathwaysMED16
Orthology - Evolution
OrthoDB10025
GeneTree (enSembl)ENSG00000175221
Phylogenetic Trees/Animal Genes : TreeFamMED16
HOVERGENQ9Y2X0
HOGENOMQ9Y2X0
Homologs : HomoloGeneMED16
Homology/Alignments : Family Browser (UCSC)MED16
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED16 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED16
dbVarMED16
ClinVarMED16
1000_GenomesMED16 
Exome Variant ServerMED16
ExAC (Exome Aggregation Consortium)MED16 (select the gene name)
Genetic variants : HAPMAP10025
Genomic Variants (DGV)MED16 [DGVbeta]
DECIPHERMED16 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED16 
Mutations
ICGC Data PortalMED16 
TCGA Data PortalMED16 
Broad Tumor PortalMED16
OASIS PortalMED16 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED16  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED16
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED16
DgiDB (Drug Gene Interaction Database)MED16
DoCM (Curated mutations)MED16 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED16 (select a term)
intoGenMED16
Cancer3DMED16(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604062   
Orphanet
MedgenMED16
Genetic Testing Registry MED16
NextProtQ9Y2X0 [Medical]
TSGene10025
GENETestsMED16
Target ValidationMED16
Huge Navigator MED16 [HugePedia]
snp3D : Map Gene to Disease10025
BioCentury BCIQMED16
ClinGenMED16
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10025
Chemical/Pharm GKB GenePA162395406
Clinical trialMED16
Miscellaneous
canSAR (ICR)MED16 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED16
EVEXMED16
GoPubMedMED16
iHOPMED16
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:27:07 CEST 2017

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