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MED17 (mediator complex subunit 17)

Identity

Alias_namesCRSP6
cofactor required for Sp1 transcriptional activation, subunit 6 (77kD)
cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa
Alias_symbol (synonym)CRSP77
TRAP80
DRIP80
Other alias
HGNC (Hugo) MED17
LocusID (NCBI) 9440
Atlas_Id 55422
Location 11q21  [Link to chromosome band 11q21]
Location_base_pair Starts at 93784239 and ends at 93813330 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RMI2 (16p13.13) / MED17 (11q21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MED17   2375
Cards
Entrez_Gene (NCBI)MED17  9440  mediator complex subunit 17
AliasesCRSP6; CRSP77; DRIP80; TRAP80
GeneCards (Weizmann)MED17
Ensembl hg19 (Hinxton)ENSG00000042429 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000042429 [Gene_View]  chr11:93784239-93813330 [Contig_View]  MED17 [Vega]
ICGC DataPortalENSG00000042429
TCGA cBioPortalMED17
AceView (NCBI)MED17
Genatlas (Paris)MED17
WikiGenes9440
SOURCE (Princeton)MED17
Genetics Home Reference (NIH)MED17
Genomic and cartography
GoldenPath hg38 (UCSC)MED17  -     chr11:93784239-93813330 +  11q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED17  -     11q21   [Description]    (hg19-Feb_2009)
EnsemblMED17 - 11q21 [CytoView hg19]  MED17 - 11q21 [CytoView hg38]
Mapping of homologs : NCBIMED17 [Mapview hg19]  MED17 [Mapview hg38]
OMIM603810   613668   
Gene and transcription
Genbank (Entrez)AF104254 AF105421 AF117657 AK001674 AK022156
RefSeq transcript (Entrez)NM_004268
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED17
Cluster EST : UnigeneHs.444931 [ NCBI ]
CGAP (NCI)Hs.444931
Alternative Splicing GalleryENSG00000042429
Gene ExpressionMED17 [ NCBI-GEO ]   MED17 [ EBI - ARRAY_EXPRESS ]   MED17 [ SEEK ]   MED17 [ MEM ]
Gene Expression Viewer (FireBrowse)MED17 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9440
GTEX Portal (Tissue expression)MED17
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NVC6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NVC6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NVC6
Splice isoforms : SwissVarQ9NVC6
PhosPhoSitePlusQ9NVC6
Domains : Interpro (EBI)Mediator_Med17   
Domain families : Pfam (Sanger)Med17 (PF10156)   
Domain families : Pfam (NCBI)pfam10156   
Conserved Domain (NCBI)MED17
DMDM Disease mutations9440
Blocks (Seattle)MED17
SuperfamilyQ9NVC6
Human Protein AtlasENSG00000042429
Peptide AtlasQ9NVC6
HPRD04816
IPIIPI00301139   IPI00855753   IPI00909893   IPI00981707   IPI00981046   
Protein Interaction databases
DIP (DOE-UCLA)Q9NVC6
IntAct (EBI)Q9NVC6
FunCoupENSG00000042429
BioGRIDMED17
STRING (EMBL)MED17
ZODIACMED17
Ontologies - Pathways
QuickGOQ9NVC6
Ontology : AmiGORNA polymerase II transcription cofactor activity  transcription cofactor activity  transcription coactivator activity  receptor activity  protein binding  nucleus  nucleoplasm  transcription factor complex  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  membrane  mediator complex  ligand-dependent nuclear receptor transcription coactivator activity  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  vitamin D receptor binding  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  thyroid hormone receptor binding  
Ontology : EGO-EBIRNA polymerase II transcription cofactor activity  transcription cofactor activity  transcription coactivator activity  receptor activity  protein binding  nucleus  nucleoplasm  transcription factor complex  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  membrane  mediator complex  ligand-dependent nuclear receptor transcription coactivator activity  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  vitamin D receptor binding  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  thyroid hormone receptor binding  
Pathways : KEGGThyroid hormone signaling pathway   
NDEx NetworkMED17
Atlas of Cancer Signalling NetworkMED17
Wikipedia pathwaysMED17
Orthology - Evolution
OrthoDB9440
GeneTree (enSembl)ENSG00000042429
Phylogenetic Trees/Animal Genes : TreeFamMED17
HOVERGENQ9NVC6
HOGENOMQ9NVC6
Homologs : HomoloGeneMED17
Homology/Alignments : Family Browser (UCSC)MED17
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED17 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED17
dbVarMED17
ClinVarMED17
1000_GenomesMED17 
Exome Variant ServerMED17
ExAC (Exome Aggregation Consortium)MED17 (select the gene name)
Genetic variants : HAPMAP9440
Genomic Variants (DGV)MED17 [DGVbeta]
DECIPHERMED17 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED17 
Mutations
ICGC Data PortalMED17 
TCGA Data PortalMED17 
Broad Tumor PortalMED17
OASIS PortalMED17 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED17  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED17
intOGen PortalMED17
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED17
DgiDB (Drug Gene Interaction Database)MED17
DoCM (Curated mutations)MED17 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED17 (select a term)
intoGenMED17
Cancer3DMED17(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603810    613668   
Orphanet22879   
MedgenMED17
Genetic Testing Registry MED17
NextProtQ9NVC6 [Medical]
TSGene9440
GENETestsMED17
Target ValidationMED17
Huge Navigator MED17 [HugePedia]
snp3D : Map Gene to Disease9440
BioCentury BCIQMED17
ClinGenMED17
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9440
Chemical/Pharm GKB GenePA162395443
Clinical trialMED17
Miscellaneous
canSAR (ICR)MED17 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED17
EVEXMED17
GoPubMedMED17
iHOPMED17
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:17:39 CEST 2017

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