Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MED18 (mediator complex subunit 18)

Identity

Alias_namesmediator of RNA polymerase II transcription
Alias_symbol (synonym)FLJ20045
p28b
Other aliasSRB5
HGNC (Hugo) MED18
LocusID (NCBI) 54797
Atlas_Id 47356
Location 1p35.3  [Link to chromosome band 1p35]
Location_base_pair Starts at 28329002 and ends at 28335967 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MED18 (1p35.3) / EVI5 (1p22.1)UBE4B (1p36.22) / MED18 (1p35.3)UBE4B 1p36.22 / MED18 1p35.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(p35;p36) UBE4B/MED18


External links

Nomenclature
HGNC (Hugo)MED18   25944
Cards
Entrez_Gene (NCBI)MED18  54797  mediator complex subunit 18
AliasesSRB5; p28b
GeneCards (Weizmann)MED18
Ensembl hg19 (Hinxton)ENSG00000130772 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130772 [Gene_View]  ENSG00000130772 [Sequence]  chr1:28329002-28335967 [Contig_View]  MED18 [Vega]
ICGC DataPortalENSG00000130772
TCGA cBioPortalMED18
AceView (NCBI)MED18
Genatlas (Paris)MED18
WikiGenes54797
SOURCE (Princeton)MED18
Genetics Home Reference (NIH)MED18
Genomic and cartography
GoldenPath hg38 (UCSC)MED18  -     chr1:28329002-28335967 +  1p35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED18  -     1p35.3   [Description]    (hg19-Feb_2009)
GoldenPathMED18 - 1p35.3 [CytoView hg19]  MED18 - 1p35.3 [CytoView hg38]
ImmunoBaseENSG00000130772
Mapping of homologs : NCBIMED18 [Mapview hg19]  MED18 [Mapview hg38]
OMIM612384   
Gene and transcription
Genbank (Entrez)AB107222 AK000052 AK296130 BC002694 BG752399
RefSeq transcript (Entrez)NM_001127350 NM_017638
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED18
Cluster EST : UnigeneHs.479911 [ NCBI ]
CGAP (NCI)Hs.479911
Alternative Splicing GalleryENSG00000130772
Gene ExpressionMED18 [ NCBI-GEO ]   MED18 [ EBI - ARRAY_EXPRESS ]   MED18 [ SEEK ]   MED18 [ MEM ]
Gene Expression Viewer (FireBrowse)MED18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54797
GTEX Portal (Tissue expression)MED18
Human Protein AtlasENSG00000130772-MED18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BUE0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BUE0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BUE0
Splice isoforms : SwissVarQ9BUE0
PhosPhoSitePlusQ9BUE0
Domains : Interpro (EBI)Mediator_Med18   
Domain families : Pfam (Sanger)Med18 (PF09637)   
Domain families : Pfam (NCBI)pfam09637   
Conserved Domain (NCBI)MED18
DMDM Disease mutations54797
Blocks (Seattle)MED18
SuperfamilyQ9BUE0
Human Protein Atlas [tissue]ENSG00000130772-MED18 [tissue]
Peptide AtlasQ9BUE0
HPRD17476
IPIIPI00305986   
Protein Interaction databases
DIP (DOE-UCLA)Q9BUE0
IntAct (EBI)Q9BUE0
FunCoupENSG00000130772
BioGRIDMED18
STRING (EMBL)MED18
ZODIACMED18
Ontologies - Pathways
QuickGOQ9BUE0
Ontology : AmiGOtranscription coregulator activity  transcription coregulator activity  protein binding  regulation of transcription by RNA polymerase II  termination of RNA polymerase II transcription  mediator complex  mediator complex  core mediator complex  
Ontology : EGO-EBItranscription coregulator activity  transcription coregulator activity  protein binding  regulation of transcription by RNA polymerase II  termination of RNA polymerase II transcription  mediator complex  mediator complex  core mediator complex  
NDEx NetworkMED18
Atlas of Cancer Signalling NetworkMED18
Wikipedia pathwaysMED18
Orthology - Evolution
OrthoDB54797
GeneTree (enSembl)ENSG00000130772
Phylogenetic Trees/Animal Genes : TreeFamMED18
HOGENOMQ9BUE0
Homologs : HomoloGeneMED18
Homology/Alignments : Family Browser (UCSC)MED18
Gene fusions - Rearrangements
Fusion : MitelmanUBE4B/MED18 [1p36.22/1p35.3]  [t(1;1)(p35;p36)]  
Fusion PortalUBE4B 1p36.22 MED18 1p35.3 GBM
Fusion : QuiverMED18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED18
dbVarMED18
ClinVarMED18
1000_GenomesMED18 
Exome Variant ServerMED18
ExAC (Exome Aggregation Consortium)ENSG00000130772
GNOMAD BrowserENSG00000130772
Varsome BrowserMED18
Genetic variants : HAPMAP54797
Genomic Variants (DGV)MED18 [DGVbeta]
DECIPHERMED18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED18 
Mutations
ICGC Data PortalMED18 
TCGA Data PortalMED18 
Broad Tumor PortalMED18
OASIS PortalMED18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED18
DgiDB (Drug Gene Interaction Database)MED18
DoCM (Curated mutations)MED18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED18 (select a term)
intoGenMED18
Cancer3DMED18(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612384   
Orphanet
DisGeNETMED18
MedgenMED18
Genetic Testing Registry MED18
NextProtQ9BUE0 [Medical]
TSGene54797
GENETestsMED18
Target ValidationMED18
Huge Navigator MED18 [HugePedia]
snp3D : Map Gene to Disease54797
BioCentury BCIQMED18
ClinGenMED18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54797
Chemical/Pharm GKB GenePA134884523
Clinical trialMED18
Miscellaneous
canSAR (ICR)MED18 (select the gene name)
DataMed IndexMED18
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED18
EVEXMED18
GoPubMedMED18
iHOPMED18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jul 8 11:28:40 CEST 2019

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.