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MED18 (mediator complex subunit 18)

Identity

Alias (NCBI)SRB5
p28b
HGNC (Hugo) MED18
HGNC Alias symbFLJ20045
p28b
SRB5
HGNC Previous namemediator of RNA polymerase II transcription, subunit 18 homolog (S. cerevisiae)
LocusID (NCBI) 54797
Atlas_Id 47356
Location 1p35.3  [Link to chromosome band 1p35]
Location_base_pair Starts at 28329040 and ends at 28335965 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MED18 (1p35.3) / EVI5 (1p22.1)UBE4B (1p36.22) / MED18 (1p35.3)UBE4B 1p36.22 / MED18 1p35.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MED18   25944
Cards
Entrez_Gene (NCBI)MED18    mediator complex subunit 18
AliasesSRB5; p28b
GeneCards (Weizmann)MED18
Ensembl hg19 (Hinxton)ENSG00000130772 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130772 [Gene_View]  ENSG00000130772 [Sequence]  chr1:28329040-28335965 [Contig_View]  MED18 [Vega]
ICGC DataPortalENSG00000130772
TCGA cBioPortalMED18
AceView (NCBI)MED18
Genatlas (Paris)MED18
SOURCE (Princeton)MED18
Genetics Home Reference (NIH)MED18
Genomic and cartography
GoldenPath hg38 (UCSC)MED18  -     chr1:28329040-28335965 +  1p35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED18  -     1p35.3   [Description]    (hg19-Feb_2009)
GoldenPathMED18 - 1p35.3 [CytoView hg19]  MED18 - 1p35.3 [CytoView hg38]
ImmunoBaseENSG00000130772
Genome Data Viewer NCBIMED18 [Mapview hg19]  
OMIM612384   
Gene and transcription
Genbank (Entrez)AB107222 AK000052 AK296130 BC002694 BG752399
RefSeq transcript (Entrez)NM_001127350 NM_017638
Consensus coding sequences : CCDS (NCBI)MED18
Gene ExpressionMED18 [ NCBI-GEO ]   MED18 [ EBI - ARRAY_EXPRESS ]   MED18 [ SEEK ]   MED18 [ MEM ]
Gene Expression Viewer (FireBrowse)MED18 [ Firebrowse - Broad ]
GenevisibleExpression of MED18 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54797
GTEX Portal (Tissue expression)MED18
Human Protein AtlasENSG00000130772-MED18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BUE0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BUE0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BUE0
PhosPhoSitePlusQ9BUE0
Domains : Interpro (EBI)Mediator_Med18   
Domain families : Pfam (Sanger)Med18 (PF09637)   
Domain families : Pfam (NCBI)pfam09637   
Conserved Domain (NCBI)MED18
SuperfamilyQ9BUE0
AlphaFold pdb e-kbQ9BUE0   
Human Protein Atlas [tissue]ENSG00000130772-MED18 [tissue]
HPRD17476
Protein Interaction databases
DIP (DOE-UCLA)Q9BUE0
IntAct (EBI)Q9BUE0
BioGRIDMED18
STRING (EMBL)MED18
ZODIACMED18
Ontologies - Pathways
QuickGOQ9BUE0
Ontology : AmiGOubiquitin ligase complex  transcription coregulator activity  protein binding  regulation of transcription by RNA polymerase II  termination of RNA polymerase II transcription  protein ubiquitination  mediator complex  mediator complex  ubiquitin protein ligase activity  core mediator complex  
Ontology : EGO-EBIubiquitin ligase complex  transcription coregulator activity  protein binding  regulation of transcription by RNA polymerase II  termination of RNA polymerase II transcription  protein ubiquitination  mediator complex  mediator complex  ubiquitin protein ligase activity  core mediator complex  
NDEx NetworkMED18
Atlas of Cancer Signalling NetworkMED18
Wikipedia pathwaysMED18
Orthology - Evolution
OrthoDB54797
GeneTree (enSembl)ENSG00000130772
Phylogenetic Trees/Animal Genes : TreeFamMED18
Homologs : HomoloGeneMED18
Homology/Alignments : Family Browser (UCSC)MED18
Gene fusions - Rearrangements
Fusion : MitelmanUBE4B/MED18 [1p36.22/1p35.3]  
Fusion : QuiverMED18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED18
dbVarMED18
ClinVarMED18
MonarchMED18
1000_GenomesMED18 
Exome Variant ServerMED18
GNOMAD BrowserENSG00000130772
Varsome BrowserMED18
ACMGMED18 variants
VarityQ9BUE0
Genomic Variants (DGV)MED18 [DGVbeta]
DECIPHERMED18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED18 
Mutations
ICGC Data PortalMED18 
TCGA Data PortalMED18 
Broad Tumor PortalMED18
OASIS PortalMED18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED18  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMED18
Mutations and Diseases : HGMDMED18
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMED18
DgiDB (Drug Gene Interaction Database)MED18
DoCM (Curated mutations)MED18
CIViC (Clinical Interpretations of Variants in Cancer)MED18
Cancer3DMED18
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612384   
Orphanet
DisGeNETMED18
MedgenMED18
Genetic Testing Registry MED18
NextProtQ9BUE0 [Medical]
GENETestsMED18
Target ValidationMED18
Huge Navigator MED18 [HugePedia]
ClinGenMED18
Clinical trials, drugs, therapy
MyCancerGenomeMED18
Protein Interactions : CTDMED18
Pharm GKB GenePA134884523
PharosQ9BUE0
Clinical trialMED18
Miscellaneous
canSAR (ICR)MED18
HarmonizomeMED18
DataMed IndexMED18
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMED18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:18:13 CEST 2021

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