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MED21 (mediator complex subunit 21)

Identity

Alias_namesSURB7
SRB7 (suppressor of RNA polymerase B, yeast) homolog
SRB7 suppressor of RNA polymerase B homolog (yeast)
Alias_symbol (synonym)SRB7
Other aliashSrb7
HGNC (Hugo) MED21
LocusID (NCBI) 9412
Atlas_Id 43520
Location 12p11.23  [Link to chromosome band 12p11]
Location_base_pair Starts at 27022522 and ends at 27030673 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MED21 (12p11.23) / FBXO11 (2p16.3)MED21 (12p11.23) / MED21 (12p11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MED21   11473
Cards
Entrez_Gene (NCBI)MED21  9412  mediator complex subunit 21
AliasesSRB7; SURB7; hSrb7
GeneCards (Weizmann)MED21
Ensembl hg19 (Hinxton)ENSG00000152944 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152944 [Gene_View]  chr12:27022522-27030673 [Contig_View]  MED21 [Vega]
ICGC DataPortalENSG00000152944
TCGA cBioPortalMED21
AceView (NCBI)MED21
Genatlas (Paris)MED21
WikiGenes9412
SOURCE (Princeton)MED21
Genetics Home Reference (NIH)MED21
Genomic and cartography
GoldenPath hg38 (UCSC)MED21  -     chr12:27022522-27030673 +  12p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED21  -     12p11.23   [Description]    (hg19-Feb_2009)
EnsemblMED21 - 12p11.23 [CytoView hg19]  MED21 - 12p11.23 [CytoView hg38]
Mapping of homologs : NCBIMED21 [Mapview hg19]  MED21 [Mapview hg38]
OMIM603800   
Gene and transcription
Genbank (Entrez)AK309064 AK311838 BC008380 CR456999 DA420057
RefSeq transcript (Entrez)NM_001271811 NM_004264
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED21
Cluster EST : UnigeneHs.286145 [ NCBI ]
CGAP (NCI)Hs.286145
Alternative Splicing GalleryENSG00000152944
Gene ExpressionMED21 [ NCBI-GEO ]   MED21 [ EBI - ARRAY_EXPRESS ]   MED21 [ SEEK ]   MED21 [ MEM ]
Gene Expression Viewer (FireBrowse)MED21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9412
GTEX Portal (Tissue expression)MED21
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13503   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13503  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13503
Splice isoforms : SwissVarQ13503
PhosPhoSitePlusQ13503
Domains : Interpro (EBI)Mediator_Med21   
Domain families : Pfam (Sanger)Med21 (PF11221)   
Domain families : Pfam (NCBI)pfam11221   
Conserved Domain (NCBI)MED21
DMDM Disease mutations9412
Blocks (Seattle)MED21
SuperfamilyQ13503
Human Protein AtlasENSG00000152944
Peptide AtlasQ13503
HPRD09156
IPIIPI00013677   IPI01015167   IPI01013550   
Protein Interaction databases
DIP (DOE-UCLA)Q13503
IntAct (EBI)Q13503
FunCoupENSG00000152944
BioGRIDMED21
STRING (EMBL)MED21
ZODIACMED21
Ontologies - Pathways
QuickGOQ13503
Ontology : AmiGOubiquitin ligase complex  RNA polymerase II transcription cofactor activity  blastocyst development  transcription coactivator activity  DNA-directed 5'-3' RNA polymerase activity  protein binding  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  protein ubiquitination  mediator complex  stem cell population maintenance  positive regulation of transcription from RNA polymerase II promoter  ubiquitin protein ligase activity  
Ontology : EGO-EBIubiquitin ligase complex  RNA polymerase II transcription cofactor activity  blastocyst development  transcription coactivator activity  DNA-directed 5'-3' RNA polymerase activity  protein binding  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  protein ubiquitination  mediator complex  stem cell population maintenance  positive regulation of transcription from RNA polymerase II promoter  ubiquitin protein ligase activity  
NDEx NetworkMED21
Atlas of Cancer Signalling NetworkMED21
Wikipedia pathwaysMED21
Orthology - Evolution
OrthoDB9412
GeneTree (enSembl)ENSG00000152944
Phylogenetic Trees/Animal Genes : TreeFamMED21
HOVERGENQ13503
HOGENOMQ13503
Homologs : HomoloGeneMED21
Homology/Alignments : Family Browser (UCSC)MED21
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED21
dbVarMED21
ClinVarMED21
1000_GenomesMED21 
Exome Variant ServerMED21
ExAC (Exome Aggregation Consortium)MED21 (select the gene name)
Genetic variants : HAPMAP9412
Genomic Variants (DGV)MED21 [DGVbeta]
DECIPHERMED21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED21 
Mutations
ICGC Data PortalMED21 
TCGA Data PortalMED21 
Broad Tumor PortalMED21
OASIS PortalMED21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED21
DgiDB (Drug Gene Interaction Database)MED21
DoCM (Curated mutations)MED21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED21 (select a term)
intoGenMED21
Cancer3DMED21(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603800   
Orphanet
MedgenMED21
Genetic Testing Registry MED21
NextProtQ13503 [Medical]
TSGene9412
GENETestsMED21
Huge Navigator MED21 [HugePedia]
snp3D : Map Gene to Disease9412
BioCentury BCIQMED21
ClinGenMED21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9412
Chemical/Pharm GKB GenePA162395485
Clinical trialMED21
Miscellaneous
canSAR (ICR)MED21 (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED21
EVEXMED21
GoPubMedMED21
iHOPMED21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:24:36 CEST 2017

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