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MED23 (mediator complex subunit 23)

Identity

Alias_namesCRSP3
cofactor required for Sp1 transcriptional activation
Alias_symbol (synonym)CRSP130
DRIP130
Sur2
Other aliasARC130
CRSP133
MRT18
SUR-2
SUR2
HGNC (Hugo) MED23
LocusID (NCBI) 9439
Atlas_Id 40153
Location 6q23.2  [Link to chromosome band 6q23]
Location_base_pair Starts at 131573966 and ends at 131628239 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MED23 (6q23.2) / BEND3 (6q21)MED23 (6q23.2) / KLHL32 (6q16.1)MED23 (6q23.2) / MED23 (6q23.2)
MMP14 (14q11.2) / MED23 (6q23.2)PEX7 (6q23.3) / MED23 (6q23.2)MED23 6q23.2 / BEND3 6q21
MED23 6q23.2 / KLHL32 6q16.1PEX7 6q23.3 / MED23 6q23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(6;6)(q16;q23) MED23/KLHL32
t(6;6)(q21;q23) MED23/BEND3
PEX7/MED23 (6q23)


External links

Nomenclature
HGNC (Hugo)MED23   2372
Cards
Entrez_Gene (NCBI)MED23  9439  mediator complex subunit 23
AliasesARC130; CRSP130; CRSP133; CRSP3; 
DRIP130; MRT18; SUR-2; SUR2
GeneCards (Weizmann)MED23
Ensembl hg19 (Hinxton)ENSG00000112282 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112282 [Gene_View]  ENSG00000112282 [Sequence]  chr6:131573966-131628239 [Contig_View]  MED23 [Vega]
ICGC DataPortalENSG00000112282
TCGA cBioPortalMED23
AceView (NCBI)MED23
Genatlas (Paris)MED23
WikiGenes9439
SOURCE (Princeton)MED23
Genetics Home Reference (NIH)MED23
Genomic and cartography
GoldenPath hg38 (UCSC)MED23  -     chr6:131573966-131628239 -  6q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED23  -     6q23.2   [Description]    (hg19-Feb_2009)
EnsemblMED23 - 6q23.2 [CytoView hg19]  MED23 - 6q23.2 [CytoView hg38]
Mapping of homologs : NCBIMED23 [Mapview hg19]  MED23 [Mapview hg38]
OMIM605042   614249   
Gene and transcription
Genbank (Entrez)AB033042 AF104255 AF105332 AF135022 AI249380
RefSeq transcript (Entrez)NM_001270521 NM_001270522 NM_004830 NM_015979
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED23
Cluster EST : UnigeneHs.29679 [ NCBI ]
CGAP (NCI)Hs.29679
Alternative Splicing GalleryENSG00000112282
Gene ExpressionMED23 [ NCBI-GEO ]   MED23 [ EBI - ARRAY_EXPRESS ]   MED23 [ SEEK ]   MED23 [ MEM ]
Gene Expression Viewer (FireBrowse)MED23 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9439
GTEX Portal (Tissue expression)MED23
Human Protein AtlasENSG00000112282-MED23 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULK4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULK4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULK4
Splice isoforms : SwissVarQ9ULK4
PhosPhoSitePlusQ9ULK4
Domains : Interpro (EBI)Mediator_Med23   
Domain families : Pfam (Sanger)Med23 (PF11573)   
Domain families : Pfam (NCBI)pfam11573   
Conserved Domain (NCBI)MED23
DMDM Disease mutations9439
Blocks (Seattle)MED23
SuperfamilyQ9ULK4
Human Protein Atlas [tissue]ENSG00000112282-MED23 [tissue]
Peptide AtlasQ9ULK4
HPRD05436
IPIIPI00844220   IPI00472333   IPI00413272   IPI00867654   IPI00646226   IPI00923399   IPI00923419   IPI01018121   IPI01015673   IPI00479534   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULK4
IntAct (EBI)Q9ULK4
FunCoupENSG00000112282
BioGRIDMED23
STRING (EMBL)MED23
ZODIACMED23
Ontologies - Pathways
QuickGOQ9ULK4
Ontology : AmiGOtranscription coactivator activity  protein binding  nucleoplasm  transcription factor complex  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  positive regulation of nucleic acid-templated transcription  
Ontology : EGO-EBItranscription coactivator activity  protein binding  nucleoplasm  transcription factor complex  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  positive regulation of nucleic acid-templated transcription  
NDEx NetworkMED23
Atlas of Cancer Signalling NetworkMED23
Wikipedia pathwaysMED23
Orthology - Evolution
OrthoDB9439
GeneTree (enSembl)ENSG00000112282
Phylogenetic Trees/Animal Genes : TreeFamMED23
HOVERGENQ9ULK4
HOGENOMQ9ULK4
Homologs : HomoloGeneMED23
Homology/Alignments : Family Browser (UCSC)MED23
Gene fusions - Rearrangements
Fusion : MitelmanMED23/BEND3 [6q23.2/6q21]  
Fusion : MitelmanMED23/KLHL32 [6q23.2/6q16.1]  [t(6;6)(q16;q23)]  
Fusion : MitelmanPEX7/MED23 [6q23.3/6q23.2]  [t(6;6)(q23;q23)]  
Fusion PortalMED23 6q23.2 BEND3 6q21 BRCA
Fusion PortalMED23 6q23.2 KLHL32 6q16.1 BRCA
Fusion PortalPEX7 6q23.3 MED23 6q23.2 BRCA
Fusion : QuiverMED23
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED23 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED23
dbVarMED23
ClinVarMED23
1000_GenomesMED23 
Exome Variant ServerMED23
ExAC (Exome Aggregation Consortium)ENSG00000112282
GNOMAD BrowserENSG00000112282
Varsome BrowserMED23
Genetic variants : HAPMAP9439
Genomic Variants (DGV)MED23 [DGVbeta]
DECIPHERMED23 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED23 
Mutations
ICGC Data PortalMED23 
TCGA Data PortalMED23 
Broad Tumor PortalMED23
OASIS PortalMED23 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED23  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED23
intOGen PortalMED23
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED23
DgiDB (Drug Gene Interaction Database)MED23
DoCM (Curated mutations)MED23 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED23 (select a term)
intoGenMED23
Cancer3DMED23(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605042    614249   
Orphanet11804   
DisGeNETMED23
MedgenMED23
Genetic Testing Registry MED23
NextProtQ9ULK4 [Medical]
TSGene9439
GENETestsMED23
Target ValidationMED23
Huge Navigator MED23 [HugePedia]
snp3D : Map Gene to Disease9439
BioCentury BCIQMED23
ClinGenMED23
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9439
Chemical/Pharm GKB GenePA162395499
Clinical trialMED23
Miscellaneous
canSAR (ICR)MED23 (select the gene name)
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED23
EVEXMED23
GoPubMedMED23
iHOPMED23
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:19:32 CET 2018

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