MED23 (mediator complex subunit 23)

2003-06-01  

Identity

HGNC
LOCATION
6q23.2
LOCUSID
ALIAS
ARC130,CRSP130,CRSP133,CRSP3,DRIP130,MRT18,SUR-2,SUR2
FUSION GENES

Other Information

Locus ID:

NCBI: 9439
MIM: 605042
HGNC: 2372
Ensembl: ENSG00000112282

Variants:

dbSNP: 9439
ClinVar: 9439
TCGA: ENSG00000112282
COSMIC: MED23

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112282ENST00000354577Q9ULK4
ENSG00000112282ENST00000368053Q9ULK4
ENSG00000112282ENST00000368058Q5JWT2
ENSG00000112282ENST00000368060Q9ULK4
ENSG00000112282ENST00000368068Q9ULK4
ENSG00000112282ENST00000539158Q9ULK4

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

References

Pubmed IDYearTitleCitations
119349872002Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit.107
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
218686772011MED23 mutation links intellectual disability to dysregulation of immediate early gene expression.35
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
233402092013Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb.22
169642862007Transcriptional regulation of KiSS-1 gene expression in metastatic melanoma by specificity protein-1 and its coactivator DRIP-130.20
122423382002External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator.19
229880932012Selective requirement for Mediator MED23 in Ras-active lung cancer.18
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
256843932015Mediator subunit 23 overexpression as a novel target for suppressing proliferation and tumorigenesis in hepatocellular carcinoma.5

Citation

Dessen P

MED23 (mediator complex subunit 23)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40153/med23