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MED24 (mediator complex subunit 24)

Identity

Alias (NCBI)ARC100
CRSP100
CRSP4
DRIP100
MED5
THRAP4
TRAP100
HGNC (Hugo) MED24
HGNC Alias symbTRAP100
KIAA0130
DRIP100
CRSP100
MED5
HGNC Previous nameTHRAP4
 CRSP4
HGNC Previous namethyroid hormone receptor associated protein 4
 cofactor required for Sp1 transcriptional activation, subunit 4, 100kDa
LocusID (NCBI) 9862
Atlas_Id 68877
Location 17q21.1  [Link to chromosome band 17q21]
Location_base_pair Starts at 40019104 and ends at 40054408 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CWC25 (17q12) / MED24 (17q21.1)EIF3CL (16p11.2) / MED24 (17q21.1)MED24 (17q21.1) / CEP112 (17q24.1)
MED24 (17q21.1) / CEP95 (17q23.3)MED24 (17q21.1) / KRT40 (17q21.2)MED24 (17q21.1) / MED24 (17q21.1)
MED24 (17q21.1) / SSH2 (17q11.2)PIP4K2B (17q12) / MED24 (17q21.1)SETD5 (3p25.3) / MED24 (17q21.1)
TADA2A (17q12) / MED24 (17q21.1)UFD1L (22q11.21) / MED24 (17q21.1)MED24 CEP112
MED24 CEP95MED24 SSH2MED24 KRT40
PIP4K2B MED24TADA2A MED24CWC25 MED24

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MED24   22963
Cards
Entrez_Gene (NCBI)MED24    mediator complex subunit 24
AliasesARC100; CRSP100; CRSP4; DRIP100; 
MED5; THRAP4; TRAP100
GeneCards (Weizmann)MED24
Ensembl hg19 (Hinxton)ENSG00000008838 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008838 [Gene_View]  ENSG00000008838 [Sequence]  chr17:40019104-40054408 [Contig_View]  MED24 [Vega]
ICGC DataPortalENSG00000008838
TCGA cBioPortalMED24
AceView (NCBI)MED24
Genatlas (Paris)MED24
SOURCE (Princeton)MED24
Genetics Home Reference (NIH)MED24
Genomic and cartography
GoldenPath hg38 (UCSC)MED24  -     chr17:40019104-40054408 -  17q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED24  -     17q21.1   [Description]    (hg19-Feb_2009)
GoldenPathMED24 - 17q21.1 [CytoView hg19]  MED24 - 17q21.1 [CytoView hg38]
ImmunoBaseENSG00000008838
Genome Data Viewer NCBIMED24 [Mapview hg19]  
OMIM607000   
Gene and transcription
Genbank (Entrez)AF055995 AF277379 AK022508 AK291040 AK293309
RefSeq transcript (Entrez)NM_001079518 NM_001267797 NM_001330211 NM_014815
Consensus coding sequences : CCDS (NCBI)MED24
Gene ExpressionMED24 [ NCBI-GEO ]   MED24 [ EBI - ARRAY_EXPRESS ]   MED24 [ SEEK ]   MED24 [ MEM ]
Gene Expression Viewer (FireBrowse)MED24 [ Firebrowse - Broad ]
GenevisibleExpression of MED24 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9862
GTEX Portal (Tissue expression)MED24
Human Protein AtlasENSG00000008838-MED24 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75448   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75448  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75448
PhosPhoSitePlusO75448
Domains : Interpro (EBI)Mediator_Med24   
Domain families : Pfam (Sanger)Med24_N (PF11277)   
Domain families : Pfam (NCBI)pfam11277   
Conserved Domain (NCBI)MED24
SuperfamilyO75448
AlphaFold pdb e-kbO75448   
Human Protein Atlas [tissue]ENSG00000008838-MED24 [tissue]
HPRD06107
Protein Interaction databases
DIP (DOE-UCLA)O75448
IntAct (EBI)O75448
BioGRIDMED24
STRING (EMBL)MED24
ZODIACMED24
Ontologies - Pathways
QuickGOO75448
Ontology : AmiGOubiquitin ligase complex  transcription coregulator activity  transcription coregulator activity  transcription coactivator activity  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  protein ubiquitination  histone acetylation  mediator complex  mediator complex  nuclear receptor coactivator activity  vitamin D receptor binding  protein-containing complex binding  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  regulation of transcription initiation from RNA polymerase II promoter  positive regulation of transcription initiation from RNA polymerase II promoter  ubiquitin protein ligase activity  
Ontology : EGO-EBIubiquitin ligase complex  transcription coregulator activity  transcription coregulator activity  transcription coactivator activity  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  protein ubiquitination  histone acetylation  mediator complex  mediator complex  nuclear receptor coactivator activity  vitamin D receptor binding  protein-containing complex binding  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  regulation of transcription initiation from RNA polymerase II promoter  positive regulation of transcription initiation from RNA polymerase II promoter  ubiquitin protein ligase activity  
NDEx NetworkMED24
Atlas of Cancer Signalling NetworkMED24
Wikipedia pathwaysMED24
Orthology - Evolution
OrthoDB9862
GeneTree (enSembl)ENSG00000008838
Phylogenetic Trees/Animal Genes : TreeFamMED24
Homologs : HomoloGeneMED24
Homology/Alignments : Family Browser (UCSC)MED24
Gene fusions - Rearrangements
Fusion : QuiverMED24
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED24 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED24
dbVarMED24
ClinVarMED24
MonarchMED24
1000_GenomesMED24 
Exome Variant ServerMED24
GNOMAD BrowserENSG00000008838
Varsome BrowserMED24
ACMGMED24 variants
VarityO75448
Genomic Variants (DGV)MED24 [DGVbeta]
DECIPHERMED24 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED24 
Mutations
ICGC Data PortalMED24 
TCGA Data PortalMED24 
Broad Tumor PortalMED24
OASIS PortalMED24 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED24  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMED24
Mutations and Diseases : HGMDMED24
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMED24
DgiDB (Drug Gene Interaction Database)MED24
DoCM (Curated mutations)MED24
CIViC (Clinical Interpretations of Variants in Cancer)MED24
Cancer3DMED24
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607000   
Orphanet
DisGeNETMED24
MedgenMED24
Genetic Testing Registry MED24
NextProtO75448 [Medical]
GENETestsMED24
Target ValidationMED24
Huge Navigator MED24 [HugePedia]
ClinGenMED24
Clinical trials, drugs, therapy
MyCancerGenomeMED24
Protein Interactions : CTDMED24
Pharm GKB GenePA162395566
PharosO75448
Clinical trialMED24
Miscellaneous
canSAR (ICR)MED24
HarmonizomeMED24
DataMed IndexMED24
Probes
Litterature
PubMed74 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMED24
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:07:04 CEST 2021

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