Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MED24 (mediator complex subunit 24)

Identity

Alias_namesTHRAP4
CRSP4
thyroid hormone receptor associated protein 4
cofactor required for Sp1 transcriptional activation, subunit 4, 100kDa
Alias_symbol (synonym)TRAP100
KIAA0130
DRIP100
CRSP100
MED5
Other aliasARC100
HGNC (Hugo) MED24
LocusID (NCBI) 9862
Atlas_Id 68877
Location 17q21.1  [Link to chromosome band 17q21]
Location_base_pair Starts at 40019097 and ends at 40054636 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CWC25 (17q12) / MED24 (17q21.1)EIF3CL (16p11.2) / MED24 (17q21.1)MED24 (17q21.1) / CEP112 (17q24.1)
MED24 (17q21.1) / CEP95 (17q23.3)MED24 (17q21.1) / KRT40 (17q21.2)MED24 (17q21.1) / MED24 (17q21.1)
MED24 (17q21.1) / SSH2 (17q11.2)PIP4K2B (17q12) / MED24 (17q21.1)SETD5 (3p25.3) / MED24 (17q21.1)
TADA2A (17q12) / MED24 (17q21.1)UFD1L (22q11.21) / MED24 (17q21.1)MED24 CEP112
MED24 CEP95MED24 SSH2MED24 KRT40
PIP4K2B MED24TADA2A MED24CWC25 MED24

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MED24   22963
Cards
Entrez_Gene (NCBI)MED24  9862  mediator complex subunit 24
AliasesARC100; CRSP100; CRSP4; DRIP100; 
MED5; THRAP4; TRAP100
GeneCards (Weizmann)MED24
Ensembl hg19 (Hinxton)ENSG00000008838 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008838 [Gene_View]  chr17:40019097-40054636 [Contig_View]  MED24 [Vega]
ICGC DataPortalENSG00000008838
TCGA cBioPortalMED24
AceView (NCBI)MED24
Genatlas (Paris)MED24
WikiGenes9862
SOURCE (Princeton)MED24
Genetics Home Reference (NIH)MED24
Genomic and cartography
GoldenPath hg38 (UCSC)MED24  -     chr17:40019097-40054636 -  17q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED24  -     17q21.1   [Description]    (hg19-Feb_2009)
EnsemblMED24 - 17q21.1 [CytoView hg19]  MED24 - 17q21.1 [CytoView hg38]
Mapping of homologs : NCBIMED24 [Mapview hg19]  MED24 [Mapview hg38]
OMIM607000   
Gene and transcription
Genbank (Entrez)AF055995 AF277379 AK022508 AK291040 AK293309
RefSeq transcript (Entrez)NM_001079518 NM_001267797 NM_001330211 NM_014815
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED24
Cluster EST : UnigeneHs.462983 [ NCBI ]
CGAP (NCI)Hs.462983
Alternative Splicing GalleryENSG00000008838
Gene ExpressionMED24 [ NCBI-GEO ]   MED24 [ EBI - ARRAY_EXPRESS ]   MED24 [ SEEK ]   MED24 [ MEM ]
Gene Expression Viewer (FireBrowse)MED24 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9862
GTEX Portal (Tissue expression)MED24
Human Protein AtlasENSG00000008838-MED24 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75448   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75448  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75448
Splice isoforms : SwissVarO75448
PhosPhoSitePlusO75448
Domains : Interpro (EBI)Mediator_Med24_N   
Domain families : Pfam (Sanger)Med24_N (PF11277)   
Domain families : Pfam (NCBI)pfam11277   
Conserved Domain (NCBI)MED24
DMDM Disease mutations9862
Blocks (Seattle)MED24
SuperfamilyO75448
Human Protein Atlas [tissue]ENSG00000008838-MED24 [tissue]
Peptide AtlasO75448
HPRD06107
IPIIPI00794854   IPI00792903   IPI00923479   IPI00923512   IPI01008728   IPI00923498   IPI00923393   IPI00923414   IPI01015154   IPI01018073   IPI00792423   IPI00793594   IPI00980250   
Protein Interaction databases
DIP (DOE-UCLA)O75448
IntAct (EBI)O75448
FunCoupENSG00000008838
BioGRIDMED24
STRING (EMBL)MED24
ZODIACMED24
Ontologies - Pathways
QuickGOO75448
Ontology : AmiGORNA polymerase II transcription cofactor activity  transcription cofactor activity  receptor activity  protein binding  nucleus  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  mediator complex  mediator complex  ligand-dependent nuclear receptor transcription coactivator activity  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  vitamin D receptor binding  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  
Ontology : EGO-EBIRNA polymerase II transcription cofactor activity  transcription cofactor activity  receptor activity  protein binding  nucleus  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  mediator complex  mediator complex  ligand-dependent nuclear receptor transcription coactivator activity  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  vitamin D receptor binding  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  
Pathways : KEGGThyroid hormone signaling pathway   
NDEx NetworkMED24
Atlas of Cancer Signalling NetworkMED24
Wikipedia pathwaysMED24
Orthology - Evolution
OrthoDB9862
GeneTree (enSembl)ENSG00000008838
Phylogenetic Trees/Animal Genes : TreeFamMED24
HOVERGENO75448
HOGENOMO75448
Homologs : HomoloGeneMED24
Homology/Alignments : Family Browser (UCSC)MED24
Gene fusions - Rearrangements
Fusion: TCGAMED24 CEP112
Fusion: TCGAMED24 CEP95
Fusion: TCGAMED24 SSH2
Fusion: TCGAMED24 KRT40
Fusion: TCGAPIP4K2B MED24
Fusion: TCGATADA2A MED24
Fusion: TCGACWC25 MED24
Fusion: Tumor Portal MED24
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED24 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED24
dbVarMED24
ClinVarMED24
1000_GenomesMED24 
Exome Variant ServerMED24
ExAC (Exome Aggregation Consortium)ENSG00000008838
GNOMAD BrowserENSG00000008838
Genetic variants : HAPMAP9862
Genomic Variants (DGV)MED24 [DGVbeta]
DECIPHERMED24 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED24 
Mutations
ICGC Data PortalMED24 
TCGA Data PortalMED24 
Broad Tumor PortalMED24
OASIS PortalMED24 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED24  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED24
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED24
DgiDB (Drug Gene Interaction Database)MED24
DoCM (Curated mutations)MED24 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED24 (select a term)
intoGenMED24
Cancer3DMED24(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607000   
Orphanet
MedgenMED24
Genetic Testing Registry MED24
NextProtO75448 [Medical]
TSGene9862
GENETestsMED24
Target ValidationMED24
Huge Navigator MED24 [HugePedia]
snp3D : Map Gene to Disease9862
BioCentury BCIQMED24
ClinGenMED24
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9862
Chemical/Pharm GKB GenePA162395566
Clinical trialMED24
Miscellaneous
canSAR (ICR)MED24 (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED24
EVEXMED24
GoPubMedMED24
iHOPMED24
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:12:27 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.