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MED25 (mediator complex subunit 25)

Identity

Alias_namesmediator of RNA polymerase II transcription, subunit 25 homolog (S. cerevisiae)
Alias_symbol (synonym)ARC92
ACID1
TCBAP0758
DKFZp434K0512
Other aliasBVSYS
CMT2B2
P78
PTOV2
HGNC (Hugo) MED25
LocusID (NCBI) 81857
Atlas_Id 52109
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 49818279 and ends at 49836980 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MED25 (19q13.33) / AP2A1 (19q13.33)MED25 (19q13.33) / MAPK15 (8q24.3)MED25 (19q13.33) / SIGLEC12 (19q13.41)
SIRT3 (11p15.5) / MED25 (19q13.33)TBC1D17 (19q13.33) / MED25 (19q13.33)MED25 19q13.33 / AP2A1 19q13.33
MED25 19q13.33 / MAPK15 8q24.3MED25 19q13.33 / SIGLEC12 19q13.41

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(8;19)(q24;q13) MED25/MAPK15
MED25/AP2A1 (19q13)
MED25/SIGLEC12 (19q13)

External links

Nomenclature
HGNC (Hugo)MED25   28845
LRG (Locus Reference Genomic)LRG_368
Cards
Entrez_Gene (NCBI)MED25  81857  mediator complex subunit 25
AliasesACID1; ARC92; BVSYS; CMT2B2; 
P78; PTOV2; TCBAP0758
GeneCards (Weizmann)MED25
Ensembl hg19 (Hinxton)ENSG00000104973 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104973 [Gene_View]  ENSG00000104973 [Sequence]  chr19:49818279-49836980 [Contig_View]  MED25 [Vega]
ICGC DataPortalENSG00000104973
TCGA cBioPortalMED25
AceView (NCBI)MED25
Genatlas (Paris)MED25
WikiGenes81857
SOURCE (Princeton)MED25
Genetics Home Reference (NIH)MED25
Genomic and cartography
GoldenPath hg38 (UCSC)MED25  -     chr19:49818279-49836980 +  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED25  -     19q13.33   [Description]    (hg19-Feb_2009)
GoldenPathMED25 - 19q13.33 [CytoView hg19]  MED25 - 19q13.33 [CytoView hg38]
ImmunoBaseENSG00000104973
Mapping of homologs : NCBIMED25 [Mapview hg19]  MED25 [Mapview hg38]
OMIM605589   610197   616449   
Gene and transcription
Genbank (Entrez)AF261072 AF283769 AF447873 AJ617479 AK055844
RefSeq transcript (Entrez)NM_001378355 NM_030973
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED25
Alternative Splicing GalleryENSG00000104973
Gene ExpressionMED25 [ NCBI-GEO ]   MED25 [ EBI - ARRAY_EXPRESS ]   MED25 [ SEEK ]   MED25 [ MEM ]
Gene Expression Viewer (FireBrowse)MED25 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81857
GTEX Portal (Tissue expression)MED25
Human Protein AtlasENSG00000104973-MED25 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ71SY5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ71SY5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ71SY5
Splice isoforms : SwissVarQ71SY5
PhosPhoSitePlusQ71SY5
Domains : Interpro (EBI)Med25_PTOV    Mediator_Med25_NR-box    Mediator_Med25_SD1    Mediator_Med25_VWA    PTOV_dom_sf    vWFA_dom_sf   
Domain families : Pfam (Sanger)Med25 (PF11232)    Med25_NR-box (PF11244)    Med25_SD1 (PF11235)    Med25_VWA (PF11265)   
Domain families : Pfam (NCBI)pfam11232    pfam11244    pfam11235    pfam11265   
Conserved Domain (NCBI)MED25
DMDM Disease mutations81857
Blocks (Seattle)MED25
PDB (RSDB)2KY6    2L23    2L6U    2XNF   
PDB Europe2KY6    2L23    2L6U    2XNF   
PDB (PDBSum)2KY6    2L23    2L6U    2XNF   
PDB (IMB)2KY6    2L23    2L6U    2XNF   
Structural Biology KnowledgeBase2KY6    2L23    2L6U    2XNF   
SCOP (Structural Classification of Proteins)2KY6    2L23    2L6U    2XNF   
CATH (Classification of proteins structures)2KY6    2L23    2L6U    2XNF   
SuperfamilyQ71SY5
Human Protein Atlas [tissue]ENSG00000104973-MED25 [tissue]
Peptide AtlasQ71SY5
HPRD14380
IPIIPI00479592   IPI00418271   IPI00867552   IPI00163419   IPI00867722   IPI00953122   IPI00923525   IPI00923536   IPI00923617   IPI00923603   IPI00923442   IPI00744110   IPI00873857   IPI00923562   IPI00434725   
Protein Interaction databases
DIP (DOE-UCLA)Q71SY5
IntAct (EBI)Q71SY5
FunCoupENSG00000104973
BioGRIDMED25
STRING (EMBL)MED25
ZODIACMED25
Ontologies - Pathways
QuickGOQ71SY5
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  transcription coactivator binding  protein binding  nucleoplasm  nucleoplasm  transcription factor complex  transcription initiation from RNA polymerase II promoter  transcription factor binding  mediator complex  positive regulation of chromatin binding  retinoic acid receptor binding  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  retinoid X receptor binding  negative regulation of fibroblast proliferation  positive regulation of cell cycle arrest  positive regulation of mediator complex assembly  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  transcription coactivator binding  protein binding  nucleoplasm  nucleoplasm  transcription factor complex  transcription initiation from RNA polymerase II promoter  transcription factor binding  mediator complex  positive regulation of chromatin binding  retinoic acid receptor binding  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  retinoid X receptor binding  negative regulation of fibroblast proliferation  positive regulation of cell cycle arrest  positive regulation of mediator complex assembly  
NDEx NetworkMED25
Atlas of Cancer Signalling NetworkMED25
Wikipedia pathwaysMED25
Orthology - Evolution
OrthoDB81857
GeneTree (enSembl)ENSG00000104973
Phylogenetic Trees/Animal Genes : TreeFamMED25
HOGENOMQ71SY5
Homologs : HomoloGeneMED25
Homology/Alignments : Family Browser (UCSC)MED25
Gene fusions - Rearrangements
Fusion : MitelmanMED25/AP2A1 [19q13.33/19q13.33]  
Fusion : MitelmanMED25/MAPK15 [19q13.33/8q24.3]  [t(8;19)(q24;q13)]  
Fusion : MitelmanMED25/SIGLEC12 [19q13.33/19q13.41]  [t(19;19)(q13;q13)]  
Fusion PortalMED25 19q13.33 AP2A1 19q13.33 BRCA
Fusion PortalMED25 19q13.33 MAPK15 8q24.3 BRCA
Fusion PortalMED25 19q13.33 SIGLEC12 19q13.41 LUAD
Fusion : QuiverMED25
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED25 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED25
dbVarMED25
ClinVarMED25
1000_GenomesMED25 
Exome Variant ServerMED25
ExAC (Exome Aggregation Consortium)ENSG00000104973
GNOMAD BrowserENSG00000104973
Varsome BrowserMED25
Genetic variants : HAPMAP81857
Genomic Variants (DGV)MED25 [DGVbeta]
DECIPHERMED25 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED25 
Mutations
ICGC Data PortalMED25 
TCGA Data PortalMED25 
Broad Tumor PortalMED25
OASIS PortalMED25 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED25  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMED25
Mutations and Diseases : HGMDMED25
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED25
DgiDB (Drug Gene Interaction Database)MED25
DoCM (Curated mutations)MED25 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED25 (select a term)
intoGenMED25
Cancer3DMED25(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605589    610197    616449   
Orphanet14812   
DisGeNETMED25
MedgenMED25
Genetic Testing Registry MED25
NextProtQ71SY5 [Medical]
TSGene81857
GENETestsMED25
Target ValidationMED25
Huge Navigator MED25 [HugePedia]
snp3D : Map Gene to Disease81857
BioCentury BCIQMED25
ClinGenMED25
Clinical trials, drugs, therapy
Protein Interactions : CTD81857
Pharm GKB GenePA134984839
Clinical trialMED25
Miscellaneous
canSAR (ICR)MED25 (select the gene name)
HarmonizomeMED25
DataMed IndexMED25
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED25
EVEXMED25
GoPubMedMED25
iHOPMED25
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Jun 30 20:22:03 CEST 2020
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