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MED27 (mediator complex subunit 27)

Identity

Alias_namesCRSP8
cofactor required for Sp1 transcriptional activation
Alias_symbol (synonym)TRAP37
CRSP34
MED3
Other aliasCRAP34
HGNC (Hugo) MED27
LocusID (NCBI) 9442
Atlas_Id 55849
Location 9q34.13  [Link to chromosome band 9q34]
Location_base_pair Starts at 131860110 and ends at 132079887 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MED27 (9q34.13) / MED27 (9q34.13)MED27 (9q34.13) / SYT3 (19q13.33)MED27 (9q34.13) / UVRAG (11q13.5)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MED27   2377
Cards
Entrez_Gene (NCBI)MED27  9442  mediator complex subunit 27
AliasesCRAP34; CRSP34; CRSP8; MED3; 
TRAP37
GeneCards (Weizmann)MED27
Ensembl hg19 (Hinxton)ENSG00000160563 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160563 [Gene_View]  chr9:131860110-132079887 [Contig_View]  MED27 [Vega]
ICGC DataPortalENSG00000160563
TCGA cBioPortalMED27
AceView (NCBI)MED27
Genatlas (Paris)MED27
WikiGenes9442
SOURCE (Princeton)MED27
Genetics Home Reference (NIH)MED27
Genomic and cartography
GoldenPath hg38 (UCSC)MED27  -     chr9:131860110-132079887 -  9q34.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED27  -     9q34.13   [Description]    (hg19-Feb_2009)
EnsemblMED27 - 9q34.13 [CytoView hg19]  MED27 - 9q34.13 [CytoView hg38]
Mapping of homologs : NCBIMED27 [Mapview hg19]  MED27 [Mapview hg38]
OMIM605044   
Gene and transcription
Genbank (Entrez)AF104252 AF230382 AI033804 AK022289 AK124232
RefSeq transcript (Entrez)NM_001253881 NM_001253882 NM_004269
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED27
Cluster EST : UnigeneHs.374262 [ NCBI ]
CGAP (NCI)Hs.374262
Alternative Splicing GalleryENSG00000160563
Gene ExpressionMED27 [ NCBI-GEO ]   MED27 [ EBI - ARRAY_EXPRESS ]   MED27 [ SEEK ]   MED27 [ MEM ]
Gene Expression Viewer (FireBrowse)MED27 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9442
GTEX Portal (Tissue expression)MED27
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P2C8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P2C8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P2C8
Splice isoforms : SwissVarQ6P2C8
PhosPhoSitePlusQ6P2C8
Domains : Interpro (EBI)Mediator_Med27   
Domain families : Pfam (Sanger)Med27 (PF11571)   
Domain families : Pfam (NCBI)pfam11571   
Conserved Domain (NCBI)MED27
DMDM Disease mutations9442
Blocks (Seattle)MED27
SuperfamilyQ6P2C8
Human Protein AtlasENSG00000160563
Peptide AtlasQ6P2C8
HPRD05438
IPIIPI00302652   IPI00455649   
Protein Interaction databases
DIP (DOE-UCLA)Q6P2C8
IntAct (EBI)Q6P2C8
FunCoupENSG00000160563
BioGRIDMED27
STRING (EMBL)MED27
ZODIACMED27
Ontologies - Pathways
QuickGOQ6P2C8
Ontology : AmiGOubiquitin ligase complex  transcription coactivator activity  protein binding  nucleus  nucleoplasm  transcription factor complex  nucleolus  cytosol  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  protein ubiquitination  mediator complex  stem cell population maintenance  ubiquitin protein ligase activity  
Ontology : EGO-EBIubiquitin ligase complex  transcription coactivator activity  protein binding  nucleus  nucleoplasm  transcription factor complex  nucleolus  cytosol  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  protein ubiquitination  mediator complex  stem cell population maintenance  ubiquitin protein ligase activity  
Pathways : KEGGThyroid hormone signaling pathway   
NDEx NetworkMED27
Atlas of Cancer Signalling NetworkMED27
Wikipedia pathwaysMED27
Orthology - Evolution
OrthoDB9442
GeneTree (enSembl)ENSG00000160563
Phylogenetic Trees/Animal Genes : TreeFamMED27
HOVERGENQ6P2C8
HOGENOMQ6P2C8
Homologs : HomoloGeneMED27
Homology/Alignments : Family Browser (UCSC)MED27
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED27 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED27
dbVarMED27
ClinVarMED27
1000_GenomesMED27 
Exome Variant ServerMED27
ExAC (Exome Aggregation Consortium)MED27 (select the gene name)
Genetic variants : HAPMAP9442
Genomic Variants (DGV)MED27 [DGVbeta]
DECIPHERMED27 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED27 
Mutations
ICGC Data PortalMED27 
TCGA Data PortalMED27 
Broad Tumor PortalMED27
OASIS PortalMED27 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED27  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED27
BioMutasearch MED27
DgiDB (Drug Gene Interaction Database)MED27
DoCM (Curated mutations)MED27 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED27 (select a term)
intoGenMED27
Cancer3DMED27(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605044   
Orphanet
MedgenMED27
Genetic Testing Registry MED27
NextProtQ6P2C8 [Medical]
TSGene9442
GENETestsMED27
Huge Navigator MED27 [HugePedia]
snp3D : Map Gene to Disease9442
BioCentury BCIQMED27
ClinGenMED27
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9442
Chemical/Pharm GKB GenePA162395634
Clinical trialMED27
Miscellaneous
canSAR (ICR)MED27 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED27
EVEXMED27
GoPubMedMED27
iHOPMED27
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:24:36 CEST 2017

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