MED27 (mediator complex subunit 27)

2016-08-01  

Identity

HGNC
LOCATION
9q34.13
LOCUSID
ALIAS
CRAP34,CRSP34,CRSP8,MED3,NEDSCAC,TRAP37
FUSION GENES

Other Information

Locus ID:

NCBI: 9442
MIM: 605044
HGNC: 2377
Ensembl: ENSG00000160563

Variants:

dbSNP: 9442
ClinVar: 9442
TCGA: ENSG00000160563
COSMIC: MED27

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160563ENST00000292035Q6P2C8
ENSG00000160563ENST00000292035A0A024R8B7
ENSG00000160563ENST00000357028Q6P2C8
ENSG00000160563ENST00000474263Q6P2C8
ENSG00000160563ENST00000651555A0A494C0P0
ENSG00000160563ENST00000651950A0A494C0K7

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Thyroid hormone signaling pathwayKEGGhsa04919
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
267974212016MED27 promotes melanoma growth by targeting AKT/MAPK and NF-κB/iNOS signaling pathways.5
296931352018MicroRNA-18a inhibits cell growth and induces apoptosis in osteosarcoma by targeting MED27.3
297306472018Silencing of MED27 inhibits adrenal cortical carcinogenesis by targeting the Wnt/β-catenin signaling pathway and the epithelial-mesenchymal transition process.1

Citation

Dessen P

MED27 (mediator complex subunit 27)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55849/med27