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MED30 (mediator complex subunit 30)

Identity

Alias_namesTHRAP6
thyroid hormone receptor associated protein 6
Alias_symbol (synonym)TRAP25
Other aliasMED30S
HGNC (Hugo) MED30
LocusID (NCBI) 90390
Atlas_Id 68880
Location 8q24.11  [Link to chromosome band 8q24]
Location_base_pair Starts at 117520713 and ends at 117540262 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RPL23 (17q12) / MED30 (8q24.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MED30   23032
Cards
Entrez_Gene (NCBI)MED30  90390  mediator complex subunit 30
AliasesMED30S; THRAP6; TRAP25
GeneCards (Weizmann)MED30
Ensembl hg19 (Hinxton)ENSG00000164758 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164758 [Gene_View]  chr8:117520713-117540262 [Contig_View]  MED30 [Vega]
ICGC DataPortalENSG00000164758
TCGA cBioPortalMED30
AceView (NCBI)MED30
Genatlas (Paris)MED30
WikiGenes90390
SOURCE (Princeton)MED30
Genetics Home Reference (NIH)MED30
Genomic and cartography
GoldenPath hg38 (UCSC)MED30  -     chr8:117520713-117540262 +  8q24.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED30  -     8q24.11   [Description]    (hg19-Feb_2009)
EnsemblMED30 - 8q24.11 [CytoView hg19]  MED30 - 8q24.11 [CytoView hg38]
Mapping of homologs : NCBIMED30 [Mapview hg19]  MED30 [Mapview hg38]
OMIM610237   
Gene and transcription
Genbank (Entrez)AA812233 AW160991 AY083305 BC008226 DQ891518
RefSeq transcript (Entrez)NM_001282986 NM_080651
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED30
Cluster EST : UnigeneHs.492612 [ NCBI ]
CGAP (NCI)Hs.492612
Alternative Splicing GalleryENSG00000164758
Gene ExpressionMED30 [ NCBI-GEO ]   MED30 [ EBI - ARRAY_EXPRESS ]   MED30 [ SEEK ]   MED30 [ MEM ]
Gene Expression Viewer (FireBrowse)MED30 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)90390
GTEX Portal (Tissue expression)MED30
Human Protein AtlasENSG00000164758-MED30 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96HR3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96HR3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96HR3
Splice isoforms : SwissVarQ96HR3
PhosPhoSitePlusQ96HR3
Domains : Interpro (EBI)Mediator_Med30_met   
Domain families : Pfam (Sanger)Med30 (PF11315)   
Domain families : Pfam (NCBI)pfam11315   
Conserved Domain (NCBI)MED30
DMDM Disease mutations90390
Blocks (Seattle)MED30
SuperfamilyQ96HR3
Human Protein Atlas [tissue]ENSG00000164758-MED30 [tissue]
Peptide AtlasQ96HR3
HPRD11631
IPIIPI00063213   IPI00943893   
Protein Interaction databases
DIP (DOE-UCLA)Q96HR3
IntAct (EBI)Q96HR3
FunCoupENSG00000164758
BioGRIDMED30
STRING (EMBL)MED30
ZODIACMED30
Ontologies - Pathways
QuickGOQ96HR3
Ontology : AmiGOubiquitin ligase complex  RNA polymerase II transcription cofactor activity  transcription cofactor activity  receptor activity  protein binding  nucleus  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  protein ubiquitination  mediator complex  stem cell population maintenance  ligand-dependent nuclear receptor transcription coactivator activity  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  vitamin D receptor binding  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  ubiquitin protein ligase activity  
Ontology : EGO-EBIubiquitin ligase complex  RNA polymerase II transcription cofactor activity  transcription cofactor activity  receptor activity  protein binding  nucleus  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  protein ubiquitination  mediator complex  stem cell population maintenance  ligand-dependent nuclear receptor transcription coactivator activity  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  vitamin D receptor binding  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  ubiquitin protein ligase activity  
Pathways : KEGGThyroid hormone signaling pathway   
NDEx NetworkMED30
Atlas of Cancer Signalling NetworkMED30
Wikipedia pathwaysMED30
Orthology - Evolution
OrthoDB90390
GeneTree (enSembl)ENSG00000164758
Phylogenetic Trees/Animal Genes : TreeFamMED30
HOVERGENQ96HR3
HOGENOMQ96HR3
Homologs : HomoloGeneMED30
Homology/Alignments : Family Browser (UCSC)MED30
Gene fusions - Rearrangements
Tumor Fusion PortalMED30
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED30 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED30
dbVarMED30
ClinVarMED30
1000_GenomesMED30 
Exome Variant ServerMED30
ExAC (Exome Aggregation Consortium)ENSG00000164758
GNOMAD BrowserENSG00000164758
Genetic variants : HAPMAP90390
Genomic Variants (DGV)MED30 [DGVbeta]
DECIPHERMED30 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED30 
Mutations
ICGC Data PortalMED30 
TCGA Data PortalMED30 
Broad Tumor PortalMED30
OASIS PortalMED30 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED30  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED30
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED30
DgiDB (Drug Gene Interaction Database)MED30
DoCM (Curated mutations)MED30 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED30 (select a term)
intoGenMED30
Cancer3DMED30(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610237   
Orphanet
DisGeNETMED30
MedgenMED30
Genetic Testing Registry MED30
NextProtQ96HR3 [Medical]
TSGene90390
GENETestsMED30
Target ValidationMED30
Huge Navigator MED30 [HugePedia]
snp3D : Map Gene to Disease90390
BioCentury BCIQMED30
ClinGenMED30
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD90390
Chemical/Pharm GKB GenePA162395656
Clinical trialMED30
Miscellaneous
canSAR (ICR)MED30 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED30
EVEXMED30
GoPubMedMED30
iHOPMED30
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:18:29 CET 2017

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