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MED4 (mediator complex subunit 4)

Identity

Alias_namesVDRIP
vitamin D receptor interacting protein
mediator of RNA polymerase II transcription, subunit 4 homolog (S. cerevisiae)
Alias_symbol (synonym)HSPC126
DRIP36
TRAP36
Other aliasARC36
HGNC (Hugo) MED4
LocusID (NCBI) 29079
Atlas_Id 68882
Location 13q14.2  [Link to chromosome band 13q14]
Location_base_pair Starts at 48075728 and ends at 48095141 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DLK1 (14q32.2) / MED4 (13q14.2)LMO7 (13q22.2) / MED4 (13q14.2)MED4 (13q14.2) / HTR2A (13q14.2)
MED4 (13q14.2) / STAT5A (17q21.2)RB1 (13q14.2) / MED4 (13q14.2)LMO7 MED4
RB1 MED4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MED4   17903
Cards
Entrez_Gene (NCBI)MED4  29079  mediator complex subunit 4
AliasesARC36; DRIP36; HSPC126; TRAP36; 
VDRIP
GeneCards (Weizmann)MED4
Ensembl hg19 (Hinxton)ENSG00000136146 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136146 [Gene_View]  chr13:48075728-48095141 [Contig_View]  MED4 [Vega]
ICGC DataPortalENSG00000136146
TCGA cBioPortalMED4
AceView (NCBI)MED4
Genatlas (Paris)MED4
WikiGenes29079
SOURCE (Princeton)MED4
Genetics Home Reference (NIH)MED4
Genomic and cartography
GoldenPath hg38 (UCSC)MED4  -     chr13:48075728-48095141 -  13q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED4  -     13q14.2   [Description]    (hg19-Feb_2009)
EnsemblMED4 - 13q14.2 [CytoView hg19]  MED4 - 13q14.2 [CytoView hg38]
Mapping of homologs : NCBIMED4 [Mapview hg19]  MED4 [Mapview hg38]
OMIM605718   
Gene and transcription
Genbank (Entrez)AF161475 AF230381 AF300618 AI613470 AK001934
RefSeq transcript (Entrez)NM_001270629 NM_014166
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED4
Cluster EST : UnigeneHs.741275 [ NCBI ]
CGAP (NCI)Hs.741275
Alternative Splicing GalleryENSG00000136146
Gene ExpressionMED4 [ NCBI-GEO ]   MED4 [ EBI - ARRAY_EXPRESS ]   MED4 [ SEEK ]   MED4 [ MEM ]
Gene Expression Viewer (FireBrowse)MED4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29079
GTEX Portal (Tissue expression)MED4
Human Protein AtlasENSG00000136146-MED4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPJ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPJ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPJ6
Splice isoforms : SwissVarQ9NPJ6
PhosPhoSitePlusQ9NPJ6
Domains : Interpro (EBI)Mediator_Med4   
Domain families : Pfam (Sanger)Med4 (PF10018)   
Domain families : Pfam (NCBI)pfam10018   
Conserved Domain (NCBI)MED4
DMDM Disease mutations29079
Blocks (Seattle)MED4
SuperfamilyQ9NPJ6
Human Protein Atlas [tissue]ENSG00000136146-MED4 [tissue]
Peptide AtlasQ9NPJ6
HPRD16145
IPIIPI00556494   IPI00033546   IPI00646646   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPJ6
IntAct (EBI)Q9NPJ6
FunCoupENSG00000136146
BioGRIDMED4
STRING (EMBL)MED4
ZODIACMED4
Ontologies - Pathways
QuickGOQ9NPJ6
Ontology : AmiGORNA polymerase II transcription cofactor activity  transcription cofactor activity  receptor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  membrane  mediator complex  ligand-dependent nuclear receptor transcription coactivator activity  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  vitamin D receptor binding  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  core mediator complex  
Ontology : EGO-EBIRNA polymerase II transcription cofactor activity  transcription cofactor activity  receptor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  membrane  mediator complex  ligand-dependent nuclear receptor transcription coactivator activity  intracellular steroid hormone receptor signaling pathway  androgen receptor signaling pathway  vitamin D receptor binding  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  core mediator complex  
Pathways : KEGGThyroid hormone signaling pathway   
NDEx NetworkMED4
Atlas of Cancer Signalling NetworkMED4
Wikipedia pathwaysMED4
Orthology - Evolution
OrthoDB29079
GeneTree (enSembl)ENSG00000136146
Phylogenetic Trees/Animal Genes : TreeFamMED4
HOVERGENQ9NPJ6
HOGENOMQ9NPJ6
Homologs : HomoloGeneMED4
Homology/Alignments : Family Browser (UCSC)MED4
Gene fusions - Rearrangements
Fusion: TCGA_MDACCLMO7 MED4
Fusion: TCGA_MDACCRB1 MED4
Tumor Fusion PortalMED4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED4
dbVarMED4
ClinVarMED4
1000_GenomesMED4 
Exome Variant ServerMED4
ExAC (Exome Aggregation Consortium)ENSG00000136146
GNOMAD BrowserENSG00000136146
Genetic variants : HAPMAP29079
Genomic Variants (DGV)MED4 [DGVbeta]
DECIPHERMED4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED4 
Mutations
ICGC Data PortalMED4 
TCGA Data PortalMED4 
Broad Tumor PortalMED4
OASIS PortalMED4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED4
DgiDB (Drug Gene Interaction Database)MED4
DoCM (Curated mutations)MED4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED4 (select a term)
intoGenMED4
Cancer3DMED4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605718   
Orphanet
DisGeNETMED4
MedgenMED4
Genetic Testing Registry MED4
NextProtQ9NPJ6 [Medical]
TSGene29079
GENETestsMED4
Target ValidationMED4
Huge Navigator MED4 [HugePedia]
snp3D : Map Gene to Disease29079
BioCentury BCIQMED4
ClinGenMED4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29079
Chemical/Pharm GKB GenePA134877001
Clinical trialMED4
Miscellaneous
canSAR (ICR)MED4 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED4
EVEXMED4
GoPubMedMED4
iHOPMED4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:28:34 CET 2017

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