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MED4 (mediator complex subunit 4)

Identity

Alias (NCBI)ARC36
DRIP36
HSPC126
TRAP36
VDRIP
HGNC (Hugo) MED4
HGNC Alias symbHSPC126
DRIP36
TRAP36
HGNC Previous nameVDRIP
HGNC Previous namevitamin D receptor interacting protein
 mediator of RNA polymerase II transcription, subunit 4 homolog (S. cerevisiae)
LocusID (NCBI) 29079
Atlas_Id 68882
Location 13q14.2  [Link to chromosome band 13q14]
Location_base_pair Starts at 48075726 and ends at 48095104 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DLK1 (14q32.2) / MED4 (13q14.2)LMO7 (13q22.2) / MED4 (13q14.2)MED4 (13q14.2) / HTR2A (13q14.2)
MED4 (13q14.2) / STAT5A (17q21.2)RB1 (13q14.2) / MED4 (13q14.2)LMO7 MED4
RB1 MED4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)MED4   17903
Cards
Entrez_Gene (NCBI)MED4    mediator complex subunit 4
AliasesARC36; DRIP36; HSPC126; TRAP36; 
VDRIP
GeneCards (Weizmann)MED4
Ensembl hg19 (Hinxton)ENSG00000136146 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136146 [Gene_View]  ENSG00000136146 [Sequence]  chr13:48075726-48095104 [Contig_View]  MED4 [Vega]
ICGC DataPortalENSG00000136146
TCGA cBioPortalMED4
AceView (NCBI)MED4
Genatlas (Paris)MED4
SOURCE (Princeton)MED4
Genetics Home Reference (NIH)MED4
Genomic and cartography
GoldenPath hg38 (UCSC)MED4  -     chr13:48075726-48095104 -  13q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED4  -     13q14.2   [Description]    (hg19-Feb_2009)
GoldenPathMED4 - 13q14.2 [CytoView hg19]  MED4 - 13q14.2 [CytoView hg38]
ImmunoBaseENSG00000136146
genome Data Viewer NCBIMED4 [Mapview hg19]  
OMIM605718   
Gene and transcription
Genbank (Entrez)AF161475 AF230381 AF300618 AI613470 AK001934
RefSeq transcript (Entrez)NM_001270629 NM_014166
Consensus coding sequences : CCDS (NCBI)MED4
Alternative Splicing GalleryENSG00000136146
Gene ExpressionMED4 [ NCBI-GEO ]   MED4 [ EBI - ARRAY_EXPRESS ]   MED4 [ SEEK ]   MED4 [ MEM ]
Gene Expression Viewer (FireBrowse)MED4 [ Firebrowse - Broad ]
GenevisibleExpression of MED4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29079
GTEX Portal (Tissue expression)MED4
Human Protein AtlasENSG00000136146-MED4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPJ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPJ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPJ6
PhosPhoSitePlusQ9NPJ6
Domains : Interpro (EBI)Mediator_Med4   
Domain families : Pfam (Sanger)Med4 (PF10018)   
Domain families : Pfam (NCBI)pfam10018   
Conserved Domain (NCBI)MED4
SuperfamilyQ9NPJ6
AlphaFold pdb e-kbQ9NPJ6   
Human Protein Atlas [tissue]ENSG00000136146-MED4 [tissue]
HPRD16145
Protein Interaction databases
DIP (DOE-UCLA)Q9NPJ6
IntAct (EBI)Q9NPJ6
BioGRIDMED4
STRING (EMBL)MED4
ZODIACMED4
Ontologies - Pathways
QuickGOQ9NPJ6
Ontology : AmiGOtranscription coregulator activity  transcription coregulator activity  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  membrane  mediator complex  nuclear receptor coactivator activity  vitamin D receptor binding  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  regulation of transcription initiation from RNA polymerase II promoter  positive regulation of transcription initiation from RNA polymerase II promoter  core mediator complex  
Ontology : EGO-EBItranscription coregulator activity  transcription coregulator activity  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  membrane  mediator complex  nuclear receptor coactivator activity  vitamin D receptor binding  positive regulation of transcription, DNA-templated  thyroid hormone receptor binding  regulation of transcription initiation from RNA polymerase II promoter  positive regulation of transcription initiation from RNA polymerase II promoter  core mediator complex  
NDEx NetworkMED4
Atlas of Cancer Signalling NetworkMED4
Wikipedia pathwaysMED4
Orthology - Evolution
OrthoDB29079
GeneTree (enSembl)ENSG00000136146
Phylogenetic Trees/Animal Genes : TreeFamMED4
Homologs : HomoloGeneMED4
Homology/Alignments : Family Browser (UCSC)MED4
Gene fusions - Rearrangements
Fusion PortalLMO7 MED4
Fusion PortalRB1 MED4
Fusion : QuiverMED4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED4
dbVarMED4
ClinVarMED4
MonarchMED4
1000_GenomesMED4 
Exome Variant ServerMED4
GNOMAD BrowserENSG00000136146
Varsome BrowserMED4
Genomic Variants (DGV)MED4 [DGVbeta]
DECIPHERMED4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED4 
Mutations
ICGC Data PortalMED4 
TCGA Data PortalMED4 
Broad Tumor PortalMED4
OASIS PortalMED4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMED4
Mutations and Diseases : HGMDMED4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch MED4
DgiDB (Drug Gene Interaction Database)MED4
DoCM (Curated mutations)MED4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED4 (select a term)
Cancer3DMED4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605718   
Orphanet
DisGeNETMED4
MedgenMED4
Genetic Testing Registry MED4
NextProtQ9NPJ6 [Medical]
GENETestsMED4
Target ValidationMED4
Huge Navigator MED4 [HugePedia]
ClinGenMED4
Clinical trials, drugs, therapy
MyCancerGenomeMED4
Protein Interactions : CTDMED4
Pharm GKB GenePA134877001
PharosQ9NPJ6
Clinical trialMED4
Miscellaneous
canSAR (ICR)MED4
HarmonizomeMED4
DataMed IndexMED4
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMED4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Sep 15 23:14:32 CEST 2021

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