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MED6 (mediator complex subunit 6)

Identity

Alias_namesmediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae)
Alias_symbol (synonym)NY-REN-28
Other aliasARC33
HGNC (Hugo) MED6
LocusID (NCBI) 10001
Atlas_Id 68884
Location 14q24.2  [Link to chromosome band 14q24]
Location_base_pair Starts at 71049938 and ends at 71067407 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MED6   19970
Cards
Entrez_Gene (NCBI)MED6  10001  mediator complex subunit 6
AliasesARC33; NY-REN-28
GeneCards (Weizmann)MED6
Ensembl hg19 (Hinxton)ENSG00000133997 [Gene_View]  chr14:71049938-71067407 [Contig_View]  MED6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000133997 [Gene_View]  chr14:71049938-71067407 [Contig_View]  MED6 [Vega]
ICGC DataPortalENSG00000133997
TCGA cBioPortalMED6
AceView (NCBI)MED6
Genatlas (Paris)MED6
WikiGenes10001
SOURCE (Princeton)MED6
Genetics Home Reference (NIH)MED6
Genomic and cartography
GoldenPath hg19 (UCSC)MED6  -     chr14:71049938-71067407 -  14q24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MED6  -     14q24.2   [Description]    (hg38-Dec_2013)
EnsemblMED6 - 14q24.2 [CytoView hg19]  MED6 - 14q24.2 [CytoView hg38]
Mapping of homologs : NCBIMED6 [Mapview hg19]  MED6 [Mapview hg38]
OMIM602984   
Gene and transcription
Genbank (Entrez)AF074723 AF155104 AK222587 AK223346 AK290647
RefSeq transcript (Entrez)NM_001284209 NM_001284210 NM_001284211 NM_005466
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)MED6
Cluster EST : UnigeneHs.497353 [ NCBI ]
CGAP (NCI)Hs.497353
Alternative Splicing GalleryENSG00000133997
Gene ExpressionMED6 [ NCBI-GEO ]   MED6 [ EBI - ARRAY_EXPRESS ]   MED6 [ SEEK ]   MED6 [ MEM ]
Gene Expression Viewer (FireBrowse)MED6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10001
GTEX Portal (Tissue expression)MED6
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75586   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75586  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75586
Splice isoforms : SwissVarO75586
PhosPhoSitePlusO75586
Domains : Interpro (EBI)Mediator_Med6    Mediator_Med6_met/pln   
Domain families : Pfam (Sanger)Med6 (PF04934)   
Domain families : Pfam (NCBI)pfam04934   
Conserved Domain (NCBI)MED6
DMDM Disease mutations10001
Blocks (Seattle)MED6
SuperfamilyO75586
Human Protein AtlasENSG00000133997
Peptide AtlasO75586
HPRD04284
IPIIPI00942495   IPI00908674   IPI00102495   IPI00909716   IPI01025302   
Protein Interaction databases
DIP (DOE-UCLA)O75586
IntAct (EBI)O75586
FunCoupENSG00000133997
BioGRIDMED6
STRING (EMBL)MED6
ZODIACMED6
Ontologies - Pathways
QuickGOO75586
Ontology : AmiGORNA polymerase II transcription cofactor activity  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription factor binding  gene expression  membrane  mediator complex  mediator complex  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBIRNA polymerase II transcription cofactor activity  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription factor binding  gene expression  membrane  mediator complex  mediator complex  positive regulation of transcription from RNA polymerase II promoter  
NDEx NetworkMED6
Atlas of Cancer Signalling NetworkMED6
Wikipedia pathwaysMED6
Orthology - Evolution
OrthoDB10001
GeneTree (enSembl)ENSG00000133997
Phylogenetic Trees/Animal Genes : TreeFamMED6
HOVERGENO75586
HOGENOMO75586
Homologs : HomoloGeneMED6
Homology/Alignments : Family Browser (UCSC)MED6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED6
dbVarMED6
ClinVarMED6
1000_GenomesMED6 
Exome Variant ServerMED6
ExAC (Exome Aggregation Consortium)MED6 (select the gene name)
Genetic variants : HAPMAP10001
Genomic Variants (DGV)MED6 [DGVbeta]
DECIPHER (Syndromes)14:71049938-71067407  ENSG00000133997
CONAN: Copy Number AnalysisMED6 
Mutations
ICGC Data PortalMED6 
TCGA Data PortalMED6 
Broad Tumor PortalMED6
OASIS PortalMED6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED6
DgiDB (Drug Gene Interaction Database)MED6
DoCM (Curated mutations)MED6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED6 (select a term)
intoGenMED6
Cancer3DMED6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602984   
Orphanet
MedgenMED6
Genetic Testing Registry MED6
NextProtO75586 [Medical]
TSGene10001
GENETestsMED6
Huge Navigator MED6 [HugePedia]
snp3D : Map Gene to Disease10001
BioCentury BCIQMED6
ClinGenMED6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10001
Chemical/Pharm GKB GenePA134868263
Clinical trialMED6
Miscellaneous
canSAR (ICR)MED6 (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED6
EVEXMED6
GoPubMedMED6
iHOPMED6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:27:58 CET 2017

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