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MED8 (mediator complex subunit 8)

Identity

Alias_namesmediator of RNA polymerase II transcription, subunit 8 homolog (S. cerevisiae)
Alias_symbol (synonym)MGC17544
MGC19641
ARC32
Other alias
HGNC (Hugo) MED8
LocusID (NCBI) 112950
Atlas_Id 68886
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 43383908 and ends at 43389812 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MED8 (1p34.2) / ELOVL1 (1p34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MED8   19971
Cards
Entrez_Gene (NCBI)MED8  112950  mediator complex subunit 8
AliasesARC32
GeneCards (Weizmann)MED8
Ensembl hg19 (Hinxton)ENSG00000159479 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159479 [Gene_View]  chr1:43383908-43389812 [Contig_View]  MED8 [Vega]
ICGC DataPortalENSG00000159479
TCGA cBioPortalMED8
AceView (NCBI)MED8
Genatlas (Paris)MED8
WikiGenes112950
SOURCE (Princeton)MED8
Genetics Home Reference (NIH)MED8
Genomic and cartography
GoldenPath hg38 (UCSC)MED8  -     chr1:43383908-43389812 -  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MED8  -     1p34.2   [Description]    (hg19-Feb_2009)
EnsemblMED8 - 1p34.2 [CytoView hg19]  MED8 - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIMED8 [Mapview hg19]  MED8 [Mapview hg38]
OMIM607956   
Gene and transcription
Genbank (Entrez)AF521562 AV684532 BC010019 BC010543 BF196855
RefSeq transcript (Entrez)NM_001001653 NM_052877 NM_201542
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MED8
Cluster EST : UnigeneHs.301756 [ NCBI ]
CGAP (NCI)Hs.301756
Alternative Splicing GalleryENSG00000159479
Gene ExpressionMED8 [ NCBI-GEO ]   MED8 [ EBI - ARRAY_EXPRESS ]   MED8 [ SEEK ]   MED8 [ MEM ]
Gene Expression Viewer (FireBrowse)MED8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)112950
GTEX Portal (Tissue expression)MED8
Human Protein AtlasENSG00000159479-MED8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96G25   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96G25  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96G25
Splice isoforms : SwissVarQ96G25
PhosPhoSitePlusQ96G25
Domains : Interpro (EBI)Mediatior_Med8_fun/met   
Domain families : Pfam (Sanger)Med8 (PF10232)   
Domain families : Pfam (NCBI)pfam10232   
Conserved Domain (NCBI)MED8
DMDM Disease mutations112950
Blocks (Seattle)MED8
SuperfamilyQ96G25
Human Protein Atlas [tissue]ENSG00000159479-MED8 [tissue]
Peptide AtlasQ96G25
HPRD06991
IPIIPI00419516   IPI00300278   IPI00418130   
Protein Interaction databases
DIP (DOE-UCLA)Q96G25
IntAct (EBI)Q96G25
FunCoupENSG00000159479
BioGRIDMED8
STRING (EMBL)MED8
ZODIACMED8
Ontologies - Pathways
QuickGOQ96G25
Ontology : AmiGORNA polymerase II transcription cofactor activity  protein binding  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  protein ubiquitination  mediator complex  
Ontology : EGO-EBIRNA polymerase II transcription cofactor activity  protein binding  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  protein ubiquitination  mediator complex  
Pathways : KEGGHerpes simplex infection   
NDEx NetworkMED8
Atlas of Cancer Signalling NetworkMED8
Wikipedia pathwaysMED8
Orthology - Evolution
OrthoDB112950
GeneTree (enSembl)ENSG00000159479
Phylogenetic Trees/Animal Genes : TreeFamMED8
HOVERGENQ96G25
HOGENOMQ96G25
Homologs : HomoloGeneMED8
Homology/Alignments : Family Browser (UCSC)MED8
Gene fusions - Rearrangements
Tumor Fusion PortalMED8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMED8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MED8
dbVarMED8
ClinVarMED8
1000_GenomesMED8 
Exome Variant ServerMED8
ExAC (Exome Aggregation Consortium)ENSG00000159479
GNOMAD BrowserENSG00000159479
Genetic variants : HAPMAP112950
Genomic Variants (DGV)MED8 [DGVbeta]
DECIPHERMED8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMED8 
Mutations
ICGC Data PortalMED8 
TCGA Data PortalMED8 
Broad Tumor PortalMED8
OASIS PortalMED8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMED8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMED8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MED8
DgiDB (Drug Gene Interaction Database)MED8
DoCM (Curated mutations)MED8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MED8 (select a term)
intoGenMED8
Cancer3DMED8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607956   
Orphanet
DisGeNETMED8
MedgenMED8
Genetic Testing Registry MED8
NextProtQ96G25 [Medical]
TSGene112950
GENETestsMED8
Target ValidationMED8
Huge Navigator MED8 [HugePedia]
snp3D : Map Gene to Disease112950
BioCentury BCIQMED8
ClinGenMED8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD112950
Chemical/Pharm GKB GenePA134893073
Clinical trialMED8
Miscellaneous
canSAR (ICR)MED8 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMED8
EVEXMED8
GoPubMedMED8
iHOPMED8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:01:23 CET 2017

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