MED8 (mediator complex subunit 8)

2014-11-01  

Identity

HGNC
LOCATION
1p34.2
LOCUSID
ALIAS
ARC32
FUSION GENES

Other Information

Locus ID:

NCBI: 112950
MIM: 607956
HGNC: 19971
Ensembl: ENSG00000159479

Variants:

dbSNP: 112950
ClinVar: 112950
TCGA: ENSG00000159479
COSMIC: MED8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159479ENST00000290663Q96G25
ENSG00000159479ENST00000372455Q96G25
ENSG00000159479ENST00000372457Q96G25

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
169735712006Interaction of Bunyamwera Orthobunyavirus NSs protein with mediator protein MED8: a mechanism for inhibiting the interferon response.42
121494802002Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.32

Citation

Dessen P

MED8 (mediator complex subunit 8)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68886/med8