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MEGF11 (multiple EGF-like-domains 11)

Identity

Alias_namesmultiple EGF-like-domains 11
Alias_symbol (synonym)KIAA1781
DKFZp434L121
Other alias-
HGNC (Hugo) MEGF11
LocusID (NCBI) 84465
Atlas_Id 68895
Location 15q22.31  [Link to chromosome band 15q22]
Location_base_pair Starts at 66187634 and ends at 66546075 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DPP8 (15q22.31) / MEGF11 (15q22.31)FKBP10 (17q21.2) / MEGF11 (15q22.31)MEGF11 (15q22.31) / FKBP10 (17q21.2)
MEGF11 (15q22.31) / MEGF11 (15q22.31)MEGF11 (15q22.31) / RPL30 (8q22.2)SIK2 (11q23.1) / MEGF11 (15q22.31)
TTTY14 (Yq11.222) / MEGF11 (15q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MEGF11   29635
Cards
Entrez_Gene (NCBI)MEGF11  84465  multiple EGF-like-domains 11
Aliases
GeneCards (Weizmann)MEGF11
Ensembl hg19 (Hinxton)ENSG00000157890 [Gene_View]  chr15:66187634-66546075 [Contig_View]  MEGF11 [Vega]
Ensembl hg38 (Hinxton)ENSG00000157890 [Gene_View]  chr15:66187634-66546075 [Contig_View]  MEGF11 [Vega]
ICGC DataPortalENSG00000157890
TCGA cBioPortalMEGF11
AceView (NCBI)MEGF11
Genatlas (Paris)MEGF11
WikiGenes84465
SOURCE (Princeton)MEGF11
Genetics Home Reference (NIH)MEGF11
Genomic and cartography
GoldenPath hg19 (UCSC)MEGF11  -     chr15:66187634-66546075 -  15q22.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MEGF11  -     15q22.31   [Description]    (hg38-Dec_2013)
EnsemblMEGF11 - 15q22.31 [CytoView hg19]  MEGF11 - 15q22.31 [CytoView hg38]
Mapping of homologs : NCBIMEGF11 [Mapview hg19]  MEGF11 [Mapview hg38]
OMIM612454   
Gene and transcription
Genbank (Entrez)AB058677 AB300051 AK090663 AL834326 AY358226
RefSeq transcript (Entrez)NM_032445
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_010194 NW_003315944 NW_004929398
Consensus coding sequences : CCDS (NCBI)MEGF11
Cluster EST : UnigeneHs.712886 [ NCBI ]
CGAP (NCI)Hs.712886
Alternative Splicing GalleryENSG00000157890
Gene ExpressionMEGF11 [ NCBI-GEO ]   MEGF11 [ EBI - ARRAY_EXPRESS ]   MEGF11 [ SEEK ]   MEGF11 [ MEM ]
Gene Expression Viewer (FireBrowse)MEGF11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84465
GTEX Portal (Tissue expression)MEGF11
Protein : pattern, domain, 3D structure
UniProt/SwissProtA6BM72   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA6BM72  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA6BM72
Splice isoforms : SwissVarA6BM72
PhosPhoSitePlusA6BM72
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EMI (PS51041)   
Domains : Interpro (EBI)EG-like_dom    EGF-like_CS    EGF_laminin    EMI_domain   
Domain families : Pfam (Sanger)hEGF (PF12661)    Laminin_EGF (PF00053)   
Domain families : Pfam (NCBI)pfam12661    pfam00053   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_Lam (SM00180)  
Conserved Domain (NCBI)MEGF11
DMDM Disease mutations84465
Blocks (Seattle)MEGF11
SuperfamilyA6BM72
Human Protein AtlasENSG00000157890
Peptide AtlasA6BM72
HPRD14385
IPIIPI00064606   IPI00796004   IPI00872029   IPI00432703   
Protein Interaction databases
DIP (DOE-UCLA)A6BM72
IntAct (EBI)A6BM72
FunCoupENSG00000157890
BioGRIDMEGF11
STRING (EMBL)MEGF11
ZODIACMEGF11
Ontologies - Pathways
QuickGOA6BM72
Ontology : AmiGOretina layer formation  integral component of membrane  basolateral plasma membrane  homotypic cell-cell adhesion  
Ontology : EGO-EBIretina layer formation  integral component of membrane  basolateral plasma membrane  homotypic cell-cell adhesion  
NDEx NetworkMEGF11
Atlas of Cancer Signalling NetworkMEGF11
Wikipedia pathwaysMEGF11
Orthology - Evolution
OrthoDB84465
GeneTree (enSembl)ENSG00000157890
Phylogenetic Trees/Animal Genes : TreeFamMEGF11
HOVERGENA6BM72
HOGENOMA6BM72
Homologs : HomoloGeneMEGF11
Homology/Alignments : Family Browser (UCSC)MEGF11
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMEGF11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MEGF11
dbVarMEGF11
ClinVarMEGF11
1000_GenomesMEGF11 
Exome Variant ServerMEGF11
ExAC (Exome Aggregation Consortium)MEGF11 (select the gene name)
Genetic variants : HAPMAP84465
Genomic Variants (DGV)MEGF11 [DGVbeta]
DECIPHER (Syndromes)15:66187634-66546075  ENSG00000157890
CONAN: Copy Number AnalysisMEGF11 
Mutations
ICGC Data PortalMEGF11 
TCGA Data PortalMEGF11 
Broad Tumor PortalMEGF11
OASIS PortalMEGF11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMEGF11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMEGF11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MEGF11
DgiDB (Drug Gene Interaction Database)MEGF11
DoCM (Curated mutations)MEGF11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MEGF11 (select a term)
intoGenMEGF11
Cancer3DMEGF11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612454   
Orphanet
MedgenMEGF11
Genetic Testing Registry MEGF11
NextProtA6BM72 [Medical]
TSGene84465
GENETestsMEGF11
Huge Navigator MEGF11 [HugePedia]
snp3D : Map Gene to Disease84465
BioCentury BCIQMEGF11
ClinGenMEGF11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84465
Chemical/Pharm GKB GenePA144596411
Clinical trialMEGF11
Miscellaneous
canSAR (ICR)MEGF11 (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMEGF11
EVEXMEGF11
GoPubMedMEGF11
iHOPMEGF11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:28:00 CET 2017

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