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MEGF6 (multiple EGF like domains 6)

Identity

Alias_namesEGFL3
EGF-like-domain, multiple 3
multiple EGF-like-domains 6
Other alias
HGNC (Hugo) MEGF6
LocusID (NCBI) 1953
Atlas_Id 68896
Location 1p36.32  [Link to chromosome band 1p36]
Location_base_pair Starts at 3487942 and ends at 3611495 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MEGF6 (1p36.32) / CASP4 (11q22.3)MEGF6 (1p36.32) / MUL1 (1p36.12)MEGF6 (1p36.32) / PLCH2 (1p36.32)
MEGF6 (1p36.32) / UBE2I (16p13.3)MEGF6 (1p36.32) / VAV2 (9q34.2)MEGF6 (1p36.32) / WRAP73 (1p36.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MEGF6   3232
Cards
Entrez_Gene (NCBI)MEGF6  1953  multiple EGF like domains 6
AliasesEGFL3
GeneCards (Weizmann)MEGF6
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr1:3487942-3611495 [Contig_View]  MEGF6 [Vega]
TCGA cBioPortalMEGF6
AceView (NCBI)MEGF6
Genatlas (Paris)MEGF6
WikiGenes1953
SOURCE (Princeton)MEGF6
Genetics Home Reference (NIH)MEGF6
Genomic and cartography
GoldenPath hg38 (UCSC)MEGF6  -     chr1:3487942-3611495 -  1p36.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MEGF6  -     1p36.32   [Description]    (hg19-Feb_2009)
EnsemblMEGF6 - 1p36.32 [CytoView hg19]  MEGF6 - 1p36.32 [CytoView hg38]
Mapping of homologs : NCBIMEGF6 [Mapview hg19]  MEGF6 [Mapview hg38]
OMIM604266   
Gene and transcription
Genbank (Entrez)AB011539 AB231860 AF086226 AF086414 BC146386
RefSeq transcript (Entrez)NM_001409
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MEGF6
Cluster EST : UnigeneHs.593645 [ NCBI ]
CGAP (NCI)Hs.593645
Gene ExpressionMEGF6 [ NCBI-GEO ]   MEGF6 [ EBI - ARRAY_EXPRESS ]   MEGF6 [ SEEK ]   MEGF6 [ MEM ]
Gene Expression Viewer (FireBrowse)MEGF6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1953
GTEX Portal (Tissue expression)MEGF6
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75095   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75095  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75095
Splice isoforms : SwissVarO75095
PhosPhoSitePlusO75095
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    EMI (PS51041)   
Domains : Interpro (EBI)EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    EMI_domain    Growth_fac_rcpt_    Laminin_EGF   
Domain families : Pfam (Sanger)EGF_CA (PF07645)    hEGF (PF12661)    Laminin_EGF (PF00053)   
Domain families : Pfam (NCBI)pfam07645    pfam12661    pfam00053   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  EGF_Lam (SM00180)  
Conserved Domain (NCBI)MEGF6
DMDM Disease mutations1953
Blocks (Seattle)MEGF6
SuperfamilyO75095
Peptide AtlasO75095
HPRD11973
IPIIPI00306850   IPI00788209   IPI00945258   IPI00947435   
Protein Interaction databases
DIP (DOE-UCLA)O75095
IntAct (EBI)O75095
BioGRIDMEGF6
STRING (EMBL)MEGF6
ZODIACMEGF6
Ontologies - Pathways
QuickGOO75095
Ontology : AmiGOcalcium ion binding  protein binding  cellular_component  extracellular region  biological_process  
Ontology : EGO-EBIcalcium ion binding  protein binding  cellular_component  extracellular region  biological_process  
NDEx NetworkMEGF6
Atlas of Cancer Signalling NetworkMEGF6
Wikipedia pathwaysMEGF6
Orthology - Evolution
OrthoDB1953
Phylogenetic Trees/Animal Genes : TreeFamMEGF6
HOVERGENO75095
HOGENOMO75095
Homologs : HomoloGeneMEGF6
Homology/Alignments : Family Browser (UCSC)MEGF6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMEGF6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MEGF6
dbVarMEGF6
ClinVarMEGF6
1000_GenomesMEGF6 
Exome Variant ServerMEGF6
ExAC (Exome Aggregation Consortium)MEGF6 (select the gene name)
Genetic variants : HAPMAP1953
Genomic Variants (DGV)MEGF6 [DGVbeta]
DECIPHERMEGF6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMEGF6 
Mutations
ICGC Data PortalMEGF6 
TCGA Data PortalMEGF6 
Broad Tumor PortalMEGF6
OASIS PortalMEGF6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMEGF6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMEGF6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MEGF6
DgiDB (Drug Gene Interaction Database)MEGF6
DoCM (Curated mutations)MEGF6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MEGF6 (select a term)
intoGenMEGF6
Cancer3DMEGF6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604266   
Orphanet
MedgenMEGF6
Genetic Testing Registry MEGF6
NextProtO75095 [Medical]
TSGene1953
GENETestsMEGF6
Target ValidationMEGF6
Huge Navigator MEGF6 [HugePedia]
snp3D : Map Gene to Disease1953
BioCentury BCIQMEGF6
ClinGenMEGF6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1953
Chemical/Pharm GKB GenePA27665
Clinical trialMEGF6
Miscellaneous
canSAR (ICR)MEGF6 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMEGF6
EVEXMEGF6
GoPubMedMEGF6
iHOPMEGF6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:29:28 CEST 2017

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