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MEGF8 (multiple EGF-like-domains 8)

Identity

Other namesC19orf49
CRPT2
EGFL4
SBP1
HGNC (Hugo) MEGF8
LocusID (NCBI) 1954
Location 19q13.2
Location_base_pair Starts at 42829761 and ends at 42882921 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)MEGF8   3233
Cards
Entrez_Gene (NCBI)MEGF8  1954  multiple EGF-like-domains 8
GeneCards (Weizmann)MEGF8
Ensembl (Hinxton)ENSG00000105429 [Gene_View]  chr19:42829761-42882921 [Contig_View]  MEGF8 [Vega]
ICGC DataPortalENSG00000105429
AceView (NCBI)MEGF8
Genatlas (Paris)MEGF8
WikiGenes1954
SOURCE (Princeton)NM_001271938 NM_001410 NM_178121
Genomic and cartography
GoldenPath (UCSC)MEGF8  -  19q13.2   chr19:42829761-42882921 +  19q13.2   [Description]    (hg19-Feb_2009)
EnsemblMEGF8 - 19q13.2 [CytoView]
Mapping of homologs : NCBIMEGF8 [Mapview]
OMIM604267   614976   
Gene and transcription
Genbank (Entrez)AB011541 AF497566 AK026018 AY280362 BC033228
RefSeq transcript (Entrez)NM_001271938 NM_001410 NM_178121
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_033030 NT_011109 NW_001838496 NW_004929415
Consensus coding sequences : CCDS (NCBI)MEGF8
Cluster EST : UnigeneHs.132483 [ NCBI ]
CGAP (NCI)Hs.132483
Alternative Splicing : Fast-db (Paris)GSHG0014965
Alternative Splicing GalleryENSG00000105429
Gene ExpressionMEGF8 [ NCBI-GEO ]     MEGF8 [ SEEK ]   MEGF8 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z7M0 (Uniprot)
NextProtQ7Z7M0  [Medical]
With graphics : InterProQ7Z7M0
Splice isoforms : SwissVarQ7Z7M0 (Swissvar)
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    CUB (PS01180)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)   
Domains : Interpro (EBI)CUB_dom    EG-like_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    EGF_laminin    Kelch-typ_b-propeller    Plexin-like_fold    Plexin_repeat   
Related proteins : CluSTrQ7Z7M0
Domain families : Pfam (Sanger)CUB (PF00431)    EGF_CA (PF07645)    Laminin_EGF (PF00053)    PSI (PF01437)   
Domain families : Pfam (NCBI)pfam00431    pfam07645    pfam00053    pfam01437   
Domain families : Smart (EMBL)CUB (SM00042)  EGF (SM00181)  EGF_CA (SM00179)  EGF_Lam (SM00180)  PSI (SM00423)  
DMDM Disease mutations1954
Blocks (Seattle)Q7Z7M0
Human Protein AtlasENSG00000105429
Peptide AtlasQ7Z7M0
HPRD10370
IPIIPI00027310   IPI00607580   IPI00791343   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z7M0
IntAct (EBI)Q7Z7M0
FunCoupENSG00000105429
BioGRIDMEGF8
IntegromeDBMEGF8
STRING (EMBL)MEGF8
Ontologies - Pathways
QuickGOQ7Z7M0
Ontology : AmiGOembryonic heart tube morphogenesis  receptor activity  calcium ion binding  protein binding  nucleus  regulation of gene expression  integral component of membrane  embryonic limb morphogenesis  BMP signaling pathway  limb morphogenesis  cell migration involved in gastrulation  embryonic skeletal system morphogenesis  positive regulation of axon extension involved in axon guidance  epiboly involved in gastrulation with mouth forming second  embryonic heart tube left/right pattern formation  left/right pattern formation  determination of heart left/right asymmetry  extracellular vesicular exosome  determination of digestive tract left/right asymmetry  craniofacial suture morphogenesis  fasciculation of sensory neuron axon  
Ontology : EGO-EBIembryonic heart tube morphogenesis  receptor activity  calcium ion binding  protein binding  nucleus  regulation of gene expression  integral component of membrane  embryonic limb morphogenesis  BMP signaling pathway  limb morphogenesis  cell migration involved in gastrulation  embryonic skeletal system morphogenesis  positive regulation of axon extension involved in axon guidance  epiboly involved in gastrulation with mouth forming second  embryonic heart tube left/right pattern formation  left/right pattern formation  determination of heart left/right asymmetry  extracellular vesicular exosome  determination of digestive tract left/right asymmetry  craniofacial suture morphogenesis  fasciculation of sensory neuron axon  
Protein Interaction DatabaseMEGF8
Wikipedia pathwaysMEGF8
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MEGF8
SNP (GeneSNP Utah)MEGF8
SNP : HGBaseMEGF8
Genetic variants : HAPMAPMEGF8
1000_GenomesMEGF8 
ICGC programENSG00000105429 
CONAN: Copy Number AnalysisMEGF8 
Somatic Mutations in Cancer : COSMICMEGF8 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DECIPHER (Syndromes)19:42829761-42882921
Mutations and Diseases : HGMDMEGF8
OMIM604267    614976   
MedgenMEGF8
GENETestsMEGF8
Disease Genetic AssociationMEGF8
Huge Navigator MEGF8 [HugePedia]  MEGF8 [HugeCancerGEM]
Genomic VariantsMEGF8  MEGF8 [DGVbeta]
Exome VariantMEGF8
dbVarMEGF8
ClinVarMEGF8
snp3D : Map Gene to Disease1954
General knowledge
Homologs : HomoloGeneMEGF8
Homology/Alignments : Family Browser (UCSC)MEGF8
Phylogenetic Trees/Animal Genes : TreeFamMEGF8
Chemical/Protein Interactions : CTD1954
Chemical/Pharm GKB GenePA27666
Clinical trialMEGF8
Cancer Resource (Charite)ENSG00000105429
Other databases
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
CoreMineMEGF8
GoPubMedMEGF8
iHOPMEGF8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 17:40:13 CET 2014

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