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MEGF8 (multiple EGF like domains 8)

Identity

Other namesC19orf49
CRPT2
EGFL4
SBP1
HGNC (Hugo) MEGF8
LocusID (NCBI) 1954
Atlas_Id 51685
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 42829761 and ends at 42882921 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FKBP8 (19p13.11) / MEGF8 (19q13.2)MEGF8 (19q13.2) / MEGF8 (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MEGF8   3233
Cards
Entrez_Gene (NCBI)MEGF8  1954  multiple EGF like domains 8
AliasesC19orf49; CRPT2; EGFL4; SBP1
GeneCards (Weizmann)MEGF8
Ensembl hg19 (Hinxton)ENSG00000105429 [Gene_View]  chr19:42829761-42882921 [Contig_View]  MEGF8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000105429 [Gene_View]  chr19:42829761-42882921 [Contig_View]  MEGF8 [Vega]
ICGC DataPortalENSG00000105429
TCGA cBioPortalMEGF8
AceView (NCBI)MEGF8
Genatlas (Paris)MEGF8
WikiGenes1954
SOURCE (Princeton)MEGF8
Genomic and cartography
GoldenPath hg19 (UCSC)MEGF8  -     chr19:42829761-42882921 +  19q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MEGF8  -     19q13.2   [Description]    (hg38-Dec_2013)
EnsemblMEGF8 - 19q13.2 [CytoView hg19]  MEGF8 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIMEGF8 [Mapview hg19]  MEGF8 [Mapview hg38]
OMIM604267   614976   
Gene and transcription
Genbank (Entrez)AB011541 AF497566 AK026018 AY280362 BC033228
RefSeq transcript (Entrez)NM_001271938 NM_001410 NM_178121
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_033030 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)MEGF8
Cluster EST : UnigeneHs.132483 [ NCBI ]
CGAP (NCI)Hs.132483
Alternative Splicing GalleryENSG00000105429
Gene ExpressionMEGF8 [ NCBI-GEO ]   MEGF8 [ EBI - ARRAY_EXPRESS ]   MEGF8 [ SEEK ]   MEGF8 [ MEM ]
Gene Expression Viewer (FireBrowse)MEGF8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1954
GTEX Portal (Tissue expression)MEGF8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z7M0 (Uniprot)
NextProtQ7Z7M0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z7M0
Splice isoforms : SwissVarQ7Z7M0 (Swissvar)
PhosPhoSitePlusQ7Z7M0
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    CUB (PS01180)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)   
Domains : Interpro (EBI)CUB_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    EGF_dom    Kelch-typ_b-propeller    Laminin_EGF    Plexin-like_fold    Plexin_repeat   
Domain families : Pfam (Sanger)CUB (PF00431)    EGF_3 (PF12947)    EGF_CA (PF07645)    Laminin_EGF (PF00053)    PSI (PF01437)   
Domain families : Pfam (NCBI)pfam00431    pfam12947    pfam07645    pfam00053    pfam01437   
Domain families : Smart (EMBL)CUB (SM00042)  EGF (SM00181)  EGF_CA (SM00179)  EGF_Lam (SM00180)  PSI (SM00423)  
DMDM Disease mutations1954
Blocks (Seattle)MEGF8
SuperfamilyQ7Z7M0
Human Protein AtlasENSG00000105429
Peptide AtlasQ7Z7M0
HPRD10370
IPIIPI00027310   IPI00607580   IPI00791343   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z7M0
IntAct (EBI)Q7Z7M0
FunCoupENSG00000105429
BioGRIDMEGF8
STRING (EMBL)MEGF8
ZODIACMEGF8
Ontologies - Pathways
QuickGOQ7Z7M0
Ontology : AmiGOembryonic heart tube morphogenesis  calcium ion binding  protein binding  nucleus  regulation of gene expression  integral component of membrane  embryonic limb morphogenesis  BMP signaling pathway  limb morphogenesis  cell migration involved in gastrulation  embryonic skeletal system morphogenesis  positive regulation of axon extension involved in axon guidance  epiboly involved in gastrulation with mouth forming second  embryonic heart tube left/right pattern formation  left/right pattern formation  coronary vasculature development  determination of heart left/right asymmetry  extracellular exosome  determination of digestive tract left/right asymmetry  craniofacial suture morphogenesis  fasciculation of sensory neuron axon  
Ontology : EGO-EBIembryonic heart tube morphogenesis  calcium ion binding  protein binding  nucleus  regulation of gene expression  integral component of membrane  embryonic limb morphogenesis  BMP signaling pathway  limb morphogenesis  cell migration involved in gastrulation  embryonic skeletal system morphogenesis  positive regulation of axon extension involved in axon guidance  epiboly involved in gastrulation with mouth forming second  embryonic heart tube left/right pattern formation  left/right pattern formation  coronary vasculature development  determination of heart left/right asymmetry  extracellular exosome  determination of digestive tract left/right asymmetry  craniofacial suture morphogenesis  fasciculation of sensory neuron axon  
NDEx Network
Atlas of Cancer Signalling NetworkMEGF8
Wikipedia pathwaysMEGF8
Orthology - Evolution
OrthoDB1954
GeneTree (enSembl)ENSG00000105429
Phylogenetic Trees/Animal Genes : TreeFamMEGF8
Homologs : HomoloGeneMEGF8
Homology/Alignments : Family Browser (UCSC)MEGF8
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerMEGF8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MEGF8
dbVarMEGF8
ClinVarMEGF8
1000_GenomesMEGF8 
Exome Variant ServerMEGF8
ExAC (Exome Aggregation Consortium)MEGF8 (select the gene name)
Genetic variants : HAPMAP1954
Genomic Variants (DGV)MEGF8 [DGVbeta]
Mutations
ICGC Data PortalMEGF8 
TCGA Data PortalMEGF8 
Broad Tumor PortalMEGF8
OASIS PortalMEGF8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMEGF8 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MEGF8
DgiDB (Drug Gene Interaction Database)MEGF8
DoCM (Curated mutations)MEGF8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MEGF8 (select a term)
intoGenMEGF8
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:42829761-42882921  ENSG00000105429
CONAN: Copy Number AnalysisMEGF8 
Mutations and Diseases : HGMDMEGF8
OMIM604267    614976   
MedgenMEGF8
Genetic Testing Registry MEGF8
NextProtQ7Z7M0 [Medical]
TSGene1954
GENETestsMEGF8
Huge Navigator MEGF8 [HugePedia]
snp3D : Map Gene to Disease1954
BioCentury BCIQMEGF8
ClinGenMEGF8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1954
Chemical/Pharm GKB GenePA27666
Clinical trialMEGF8
Miscellaneous
canSAR (ICR)MEGF8 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMEGF8
EVEXMEGF8
GoPubMedMEGF8
iHOPMEGF8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Aug 9 19:02:06 CEST 2016

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