Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MEIS1 (Meis homeobox 1)

Identity

HGNC (Hugo) MEIS1
LocusID (NCBI) 4211
Location 2p14
Location_base_pair Starts at 66662532 and ends at 66799891 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Local_order MEIS1 is located between LINE1 retrotransposable element (LOC729348) and the uncharacterized sequence LOC100507073.
 
  MEIS1 locus is 2p14. The gene length is 137360 bp. In this region is located along with LOC729348, LOC100507073 and DNA methyltransferase 3A pseudogene 1 (DNMT3AP1).

DNA/RNA

Note MEIS1 (myeloid ecotropic viral insertion site 1) was identified in the mid-90's by Moskow and cols. (Moskow et al., 1995), as a viral integration site in murine myeloid leukemia cells. This gene encodes a transcription factor which belongs to the TALE-class (Three Amino-acid Loop Extension) of homeobox genes. TALE proteins are distinguished by the presence of three extra amino acids in the loop binding the first to the second alpha helix of the homeodomain (Holland et al., 2007). The MEIS1 gene has a length of 137360 base-pairs, and is constituted by 13 exons; there are four isoforms described to date that are produced by alternative splicing: the isoform Meis1a comprise all 13 exons and the Meis1b isoform lacks exon number 12 (Steelman et al., 1997; Sitwala et al., 2008). Meis1c lacks nucleotides encoding 49 amino acids (Val-162 to Gln-210), in murine embryos (Knoepfler et al., 1997). Furthermore, an isoform named Meis1d witch retains exon 12, but lacking exon number 8 has been described in murine colorectal cancer cells (Crist et al., 2011).
 
  Linear diagram of MEIS1 gene with their 13 exons (green boxes).
Description The MEIS1 gene has a length of 137360 base-pairs, encodes a homeodomain-containing protein. The gene is located on 2p14.
Transcription 13 exons; mRNA linear (NM_002398.2) with 3198 bp.
Pseudogene No pseudogenes have been identified.

Protein

Note The MEIS1 protein consists of 390 amino acids and has a molecular weight of 43016 Daltons. Its expression has been found in hematopoietic stem cells, in murine fetal liver and also in other embryonic and fetal tissues. During embryogenesis, MEIS1 is actively involved in vascular development and hematopoiesis and after birth, is present in the bone marrow (Hisa et al., 2004; Azcoitia et al., 2005). MEIS1 expression is a necessary requirement to maintain cells in an undifferentiated and proliferative stage (Calvo et al., 2001).
 
  Diagram of MEIS1 interactions with other proteins. MEIS1 can be regulated directly or indirectly by other transcription factors, like HOXA9, PREP1 or CREB1 (yellow colored). Factors suggested to be downstream of MEIS1 are mostly involved in proliferation and differentiation (light blue colored).
Description 390 amino acids. 43KDa. Presents homeodomain and MEIS1 recognizes the DNA binding sequence TGACAG (Shen et al., 1997).
Expression MEIS1 is expressed physiologically in different tissues like bone marrow, hematopoietic stem cells, hindbrain, cerebellum, liver, pancreas islets, colon, smooth muscle, small intestine, eye, salivary gland, adrenal gland, endometrium, uterus, ovary, fetal lung, trachea and appendix. Additionally, MEIS1 is present in numerous cancers such as melanoma (Svingen and Tonissen, 2003), neuroblastoma (Geerts et al., 2005), pancreatic cancer (Tomoeda et al., 2011), colorectal cancer (Crist et al., 2011), breast cancer (Svingen and Tonissen, 2003), ovarian cancer (Crijns et al., 2007; Kelly et al., 2011), myeloid leukemia and lymphoblastic leukemia (Owens and Hawley, 2002). Cell lines IMR32, Jurkat and K562, also expresses MEIS1 (Jones et al., 2000; Spieker et al., 2001; Rosales-Aviña et al., 2011).
Localisation Nuclear (Dintilhac et al., 2005; Royo et al., 2012). In some cancers may also be cytoplasmic (Crijns et al., 2007).
Function Hematopoiesis and hepatic development are blocked in knockout mice for MEIS1, causing the death of specimens due to bleeding and liver hypoplasia (Hisa et al., 2004; Azcoitia et al., 2005). MEIS1 is regulated by various transcription factors such as HOXA7, HOXA9, PREP1 and CREB1; the latter two are also regulated by HOXA9 (Afonja et al., 2000; Thorsteindottir et al., 2001; Morgado et al., 2007; Hu et al., 2009). CREB proteins promote DNA binding of MEIS1 complexes and this collaboration could be favored by GSK3 (glycogen synthase kinase 3) (Wang et al., 2010).
Heterodimers of MEIS1 and PBX proteins (PBX1B or PBX2) activate platelet factor type 4 gene (PF4), demonstrating the involvement of MEIS1 in megakaryopoiesis (Okada et al., 2003).
Pax6 protein form heterodimers with Meis1 or Meis2, influencing the development of ocular structures such as lens and retina in vertebrates (Zhang et al., 2002; Heine et al., 2008). In Danio rerio, Meis1 regulates eph and Smad1, participating in the polarity of the visual pathway (Erickson et al., 2010); moreover, Bessa and cols., demonstrated that Meis1 regulates cyclin D1 and c-myc, both required for cell cycle (Bessa et al., 2008). Additionally, it has been described as a positive regulator of c-myb, a transcription factor with repressor functions (Dassé et al., 2012). The growth pattern of the zebrafish hindbrain is mediated through Pbx4; when this protein is suppressed in embryos, Meis1 plays a "rescue" role continuing the cerebellum development (Waskiewicz et al., 2001).
Dimeric complexes among MEIS1 and PBX1 upregulates SOX3 by binding to promoter region; SOX3 is a transcription factor involved in the final stages of cell development in the cerebral cortex and pituitary gland (Mojsin and Stevanovic , 2009).
In the embryonic pancreas, Pdx1 downregulates Meis1a, this depletion reduces significantly Keratin-19 (Krt19) mRNA expression. Krt19 is expressed in pancreatic ductal cells (von Burstin et al., 2010).
At the reproductive level, MEIS1 contributes to the endometrium development during the proliferative phase of the menstrual cycle, in both mice and humans (Sarno et al., 2005; Xu et al., 2008); and is expressed in the nuclei of granulosa cells (Ota et al., 2008).
Homology Homologs of MEIS1 protein are highly conserved in different species.
Mus musculus: Meis1 (370 aminoacids)
Danio rerio: Meis1 (388aa)
Rattus norvegicus: Meis1 (390aa)
Gallus gallus: Meis1 (390aa)
Xenopus laevis: Meis1 (464aa)
Bos taurus: Meis1 (390aa)
Macaca mulatta: Meis1 (390aa)
Pan troglodytes: Meis homeobox 1 (390aa)
Drosophila melanogaster: homothorax isoform A (472aa), isoform B (471aa), isoform C (487aa), isoform d (457aa), isoform e (266aa), isoform f (266aa), isoform g (218aa), isoform h (458aa).

Implicated in

Entity Leukemia
Note High levels of MEIS1 in CD34+ hematopoietic cells are related with suppression of differentiation and promotion of proliferation (Abramovich et al., 2005). MEIS1 protein is overexpressed in bone marrow cells isolated from lymphoblastic and myeloid leukemia; this overexpression prevents the cell to respond to granulocyte-colony stimulating factor (G-CSF), an inducer of terminal differentiation (Calvo et al., 2001). Further, MEIS1 accelerates the leukemic process in cells expressing HOXA7, HOXA9 or HOXB3 (Thorsteindottir et al., 2001; Morgado et al., 2007; Wong et al., 2007). Additionally, MEIS1 unregulate FLT3 expression, promoting the formation of protein complexes with NUP98-HOXA10 and NUP98-HOXD13 and increasing the affinity of Homeobox proteins to bind DNA (Palmqvist et al., 2006). Interestingly, HOXA9 also upregulates FLT3 expression (Gwin et al., 2010). The co-expression of NUP98-HOXA9 complexes with Meis1 accelerates the transformation to acute myeloid leukemia (Kroon et al., 2001). HOXA9 and MEIS1 can repeal caspase-mediated apoptosis (Wermuth and Buchberg, 2005). MEIS1 overexpression is a poor prognosis marker in patients with leukemia (Diaz-Blanco et al., 2007). Down-modulation of MEIS1 by RNA interference produces a lower leukemic cell proliferation rate; this effect is more pronounced in K562 myeloid cell line than Jurkat lymphoblastic cell line. Interestingly, K562 expresses more MEIS1 than Jurkat, possibly because the cells have trisomy 2, and MEIS1 locus in 2p14. Silenced-MEIS1 Jurkat cells exhibit increased survival after exposure to etoposide (Rosales-Aviña et al., 2011).
 
MEIS1 is present from the earliest stages of hematopoiesis. HSCP: Hematopoietic Stem Cell Proliferative, HSC: Hematopoietic Stem Cell, LPC: Lymphoid Precursor Cell, MPC: Myeloid Precursor Cell (partial diagram).
  
Entity Prostate cancer
Note Prostate cancer is related to failure of androgen receptor pathway; however, MEIS1 deregulation is also implicated. Paradoxically unlike leukemias, in prostate cancer the opposite occurs, elevated levels of Meis1 are highly associated with improved survival. In fact expression of Meis1 is higher in prostatic normal tissue than in prostate cancer tissue; this decreased expression plays a role in tumor initiation and progression. Not only decreased Meis1 is related to poor prognosis, loss of other proteins TALE class (Meis2 and Pbx1) also impacts life span (Chen et al., 2012).
  
Entity Pancreas cancer
Note Meis1 regulated the expression of mitochondrial genes by binding to the H-strand mitochondrial promoter region. In knocked down pancreatic cancer cells, decreases mitochondrial gene expression such as MT-CO1, MT-CO2, MT-CO3 (mitochondrial-cytochrome c oxidase subunits 1, 2 and 3, respectively), ATP synthase 6, ATP synthase 8, and multiple NADH-ubiquinone oxidoreductase chains. These findings have not been observed with low levels of other proteins TALE-class like PBX1 or PBX2 (Tomoeda et al., 2011).
  
Entity Endometrial and ovarian cancer
Note MEIS1 is highly expressed in endometrial and ovarian carcinomas. It has been demonstrated that in the normal endometrium this protein is expressed in early proliferative glandular epithelium, and after exposure of the ovarian surface epithelium cell line MCV152 to follicle-stimulating hormone (FSH) MEIS1 expression is elevated; the overexpression increases cellular proliferation (Ji et al., 2004; Sarno et al., 2005). Apparently MEIS1 expression is associated with resistance to cisplatin, a first-line chemotherapeutic agent (Crijns et al., 2007).
  
Entity Restless legs syndrome
Note The presence of the rs2300478 polymorphism in MEIS1 has been associated with high susceptibility to Restless Legs Syndrome (RLS) (Winkelmann et al., 2007), an autosomal dominant disorder characterized by irresistible desire to move the legs, presence of paresthesias and dysesthesias, decreased iron content in the substantia nigra, and abnormal levels of ferritin and transferrin in cerebrospinal fluid. Samples of lymphoblastic cells and cerebral tissue of RLS patients reveals subexpression of MEIS1 (Xiong et al., 2009).
  

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

External links

Nomenclature
HGNC (Hugo)MEIS1   7000
Cards
AtlasMEIS1ID41331ch2p14
Entrez_Gene (NCBI)MEIS1  4211  Meis homeobox 1
GeneCards (Weizmann)MEIS1
Ensembl hg19 (Hinxton)ENSG00000143995 [Gene_View]  chr2:66662532-66799891 [Contig_View]  MEIS1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000143995 [Gene_View]  chr2:66662532-66799891 [Contig_View]  MEIS1 [Vega]
ICGC DataPortalENSG00000143995
cBioPortalMEIS1
AceView (NCBI)MEIS1
Genatlas (Paris)MEIS1
WikiGenes4211
SOURCE (Princeton)MEIS1
Genomic and cartography
GoldenPath hg19 (UCSC)MEIS1  -     chr2:66662532-66799891 +  2p14   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MEIS1  -     2p14   [Description]    (hg38-Dec_2013)
EnsemblMEIS1 - 2p14 [CytoView hg19]  MEIS1 - 2p14 [CytoView hg38]
Mapping of homologs : NCBIMEIS1 [Mapview hg19]  MEIS1 [Mapview hg38]
OMIM601739   
Gene and transcription
Genbank (Entrez)AI203963 AK098174 AK297109 AK297817 AK314949
RefSeq transcript (Entrez)NM_002398
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_011467 NT_022184 NW_001838769 NW_004929300
Consensus coding sequences : CCDS (NCBI)MEIS1
Cluster EST : UnigeneHs.603755 [ NCBI ]
CGAP (NCI)Hs.603755
Alternative Splicing : Fast-db (Paris)GSHG0016515
Alternative Splicing GalleryENSG00000143995
Gene ExpressionMEIS1 [ NCBI-GEO ]     MEIS1 [ SEEK ]   MEIS1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00470 (Uniprot)
NextProtO00470  [Medical]
With graphics : InterProO00470
Splice isoforms : SwissVarO00470 (Swissvar)
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox_dom    Homeobox_KN_domain    Homeodomain-like   
Related proteins : CluSTrO00470
Domain families : Pfam (Sanger)Homeobox_KN (PF05920)   
Domain families : Pfam (NCBI)pfam05920   
Domain families : Smart (EMBL)HOX (SM00389)  
DMDM Disease mutations4211
Blocks (Seattle)O00470
Human Protein AtlasENSG00000143995
Peptide AtlasO00470
HPRD03442
IPIIPI00011756   IPI00903304   IPI00877633   IPI00877788   IPI00917508   IPI00917897   
Protein Interaction databases
DIP (DOE-UCLA)O00470
IntAct (EBI)O00470
FunCoupENSG00000143995
BioGRIDMEIS1
IntegromeDBMEIS1
STRING (EMBL)MEIS1
Ontologies - Pathways
QuickGOO00470
Ontology : AmiGOsequence-specific DNA binding transcription factor activity  protein binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  multicellular organismal development  sequence-specific DNA binding  negative regulation of myeloid cell differentiation  
Ontology : EGO-EBIsequence-specific DNA binding transcription factor activity  protein binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  multicellular organismal development  sequence-specific DNA binding  negative regulation of myeloid cell differentiation  
Pathways : KEGGTranscriptional misregulation in cancer   
Protein Interaction DatabaseMEIS1
DoCM (Curated mutations)MEIS1
Wikipedia pathwaysMEIS1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerMEIS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MEIS1
dbVarMEIS1
ClinVarMEIS1
1000_GenomesMEIS1 
Exome Variant ServerMEIS1
SNP (GeneSNP Utah)MEIS1
SNP : HGBaseMEIS1
Genetic variants : HAPMAPMEIS1
Genomic VariantsMEIS1  MEIS1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000143995 
Somatic Mutations in Cancer : COSMICMEIS1 
CONAN: Copy Number AnalysisMEIS1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:66662532-66799891
Mutations and Diseases : HGMDMEIS1
OMIM601739   
MedgenMEIS1
NextProtO00470 [Medical]
GENETestsMEIS1
Disease Genetic AssociationMEIS1
Huge Navigator MEIS1 [HugePedia]  MEIS1 [HugeCancerGEM]
snp3D : Map Gene to Disease4211
DGIdb (Drug Gene Interaction db)MEIS1
General knowledge
Homologs : HomoloGeneMEIS1
Homology/Alignments : Family Browser (UCSC)MEIS1
Phylogenetic Trees/Animal Genes : TreeFamMEIS1
Chemical/Protein Interactions : CTD4211
Chemical/Pharm GKB GenePA30740
Clinical trialMEIS1
Cancer Resource (Charite)ENSG00000143995
Other databases
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
CoreMineMEIS1
GoPubMedMEIS1
iHOPMEIS1

Bibliography

Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice.
Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM.
Mol Cell Biol. 1995 Oct;15(10):5434-43.
PMID 7565694
 
Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1.
Knoepfler PS, Calvo KR, Chen H, Antonarakis SE, Kamps MP.
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14553-8.
PMID 9405651
 
AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins.
Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C.
Mol Cell Biol. 1997 Nov;17(11):6448-58.
PMID 9343407
 
Identification of a conserved family of Meis1-related homeobox genes.
Steelman S, Moskow JJ, Muzynski K, North C, Druck T, Montgomery JC, Huebner K, Daar IO, Buchberg AM.
Genome Res. 1997 Feb;7(2):142-56.
PMID 9049632
 
MEIS1 and HOXA7 genes in human acute myeloid leukemia.
Afonja O, Smith JE Jr, Cheng DM, Goldenberg AS, Amorosi E, Shimamoto T, Nakamura S, Ohyashiki K, Ohyashiki J, Toyama K, Takeshita K.
Leuk Res. 2000 Oct;24(10):849-55.
PMID 10996203
 
The homeobox gene MEIS1 is amplified in IMR-32 and highly expressed in other neuroblastoma cell lines.
Jones TA, Flomen RH, Senger G, Nizetic D, Sheer D.
Eur J Cancer. 2000 Dec;36(18):2368-74.
PMID 11094311
 
Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia.
Calvo KR, Knoepfler PS, Sykes DB, Pasillas MP, Kamps MP.
Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13120-5. Epub 2001 Oct 30.
PMID 11687616
 
NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice.
Kroon E, Thorsteinsdottir U, Mayotte N, Nakamura T, Sauvageau G.
EMBO J. 2001 Feb 1;20(3):350-61.
PMID 11157742
 
The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32.
Spieker N, van Sluis P, Beitsma M, Boon K, van Schaik BD, van Kampen AH, Caron H, Versteeg R.
Genomics. 2001 Jan 15;71(2):214-21.
PMID 11161815
 
Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia.
Thorsteinsdottir U, Kroon E, Jerome L, Blasi F, Sauvageau G.
Mol Cell Biol. 2001 Jan;21(1):224-34.
PMID 11113197
 
Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning.
Waskiewicz AJ, Rikhof HA, Hernandez RE, Moens CB.
Development. 2001 Nov;128(21):4139-51.
PMID 11684652
 
HOX and non-HOX homeobox genes in leukemic hematopoiesis.
Owens BM, Hawley RG.
Stem Cells. 2002;20(5):364-79. (REVIEW)
PMID 12351808
 
Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis.
Zhang X, Friedman A, Heaney S, Purcell P, Maas RL.
Genes Dev. 2002 Aug 15;16(16):2097-107.
PMID 12183364
 
Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene.
Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T.
Blood. 2003 Jun 15;101(12):4748-56. Epub 2003 Feb 27.
PMID 12609849
 
Altered HOX gene expression in human skin and breast cancer cells.
Svingen T, Tonissen KF.
Cancer Biol Ther. 2003 Sep-Oct;2(5):518-23.
PMID 14614318
 
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals.
Hisa T, Spence SE, Rachel RA, Fujita M, Nakamura T, Ward JM, Devor-Henneman DE, Saiki Y, Kutsuna H, Tessarollo L, Jenkins NA, Copeland NG.
EMBO J. 2004 Jan 28;23(2):450-9. Epub 2004 Jan 8.
PMID 14713950
 
Follicle stimulating hormone-induced growth promotion and gene expression profiles on ovarian surface epithelial cells.
Ji Q, Liu PI, Chen PK, Aoyama C.
Int J Cancer. 2004 Dec 10;112(5):803-14.
PMID 15386376
 
Hox genes: from leukemia to hematopoietic stem cell expansion.
Abramovich C, Pineault N, Ohta H, Humphries RK.
Ann N Y Acad Sci. 2005 Jun;1044:109-16. (REVIEW)
PMID 15958703
 
The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo.
Azcoitia V, Aracil M, Martinez-A C, Torres M.
Dev Biol. 2005 Apr 15;280(2):307-20.
PMID 15882575
 
PBX1 intracellular localization is independent of MEIS1 in epithelial cells of the developing female genital tract.
Dintilhac A, Bihan R, Guerrier D, Deschamps S, Bougerie H, Watrin T, Bonnec G, Pellerin I.
Int J Dev Biol. 2005;49(7):851-8.
PMID 16172981
 
MEIS homeobox genes in neuroblastoma.
Geerts D, Revet I, Jorritsma G, Schilderink N, Versteeg R.
Cancer Lett. 2005 Oct 18;228(1-2):43-50. (REVIEW)
PMID 15919149
 
HOXA10, Pbx2, and Meis1 protein expression in the human endometrium: formation of multimeric complexes on HOXA10 target genes.
Sarno JL, Kliman HJ, Taylor HS.
J Clin Endocrinol Metab. 2005 Jan;90(1):522-8. Epub 2004 Oct 19.
PMID 15494461
 
Meis1-mediated apoptosis is caspase dependent and can be suppressed by coexpression of HoxA9 in murine and human cell lines.
Wermuth PJ, Buchberg AM.
Blood. 2005 Feb 1;105(3):1222-30. Epub 2004 Oct 12.
PMID 15479723
 
The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia.
Palmqvist L, Argiropoulos B, Pineault N, Abramovich C, Sly LM, Krystal G, Wan A, Humphries RK.
Blood. 2006 Aug 1;108(3):1030-6.
PMID 16861351
 
MEIS and PBX homeobox proteins in ovarian cancer.
Crijns AP, de Graeff P, Geerts D, Ten Hoor KA, Hollema H, van der Sluis T, Hofstra RM, de Bock GH, de Jong S, van der Zee AG, de Vries EG.
Eur J Cancer. 2007 Nov;43(17):2495-505. Epub 2007 Oct 18.
PMID 17949970
 
Molecular signature of CD34(+) hematopoietic stem and progenitor cells of patients with CML in chronic phase.
Diaz-Blanco E, Bruns I, Neumann F, Fischer JC, Graef T, Rosskopf M, Brors B, Pechtel S, Bork S, Koch A, Baer A, Rohr UP, Kobbe G, Haeseler Av, Gattermann N, Haas R, Kronenwett R.
Leukemia. 2007 Mar;21(3):494-504. Epub 2007 Jan 25.
PMID 17252012
 
Classification and nomenclature of all human homeobox genes.
Holland PW, Booth HA, Bruford EA.
BMC Biol. 2007 Oct 26;5:47.
PMID 17963489
 
Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation.
Morgado E, Albouhair S, Lavau C.
Blood. 2007 May 1;109(9):4020-2. Epub 2007 Jan 3.
PMID 17202314
 
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
Winkelmann J, Schormair B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, Fulda S, Putz B, Eckstein G, Hauk S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Peglau I, Eisensehr I, Montplaisir J, Turecki G, Rouleau G, Gieger C, Illig T, Wichmann HE, Holsboer F, Muller-Myhsok B, Meitinger T.
Nat Genet. 2007 Aug;39(8):1000-6. Epub 2007 Jul 18.
PMID 17637780
 
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.
Wong P, Iwasaki M, Somervaille TC, So CW, Cleary ML.
Genes Dev. 2007 Nov 1;21(21):2762-74. Epub 2007 Oct 17.
PMID 17942707
 
meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye.
Bessa J, Tavares MJ, Santos J, Kikuta H, Laplante M, Becker TS, Gomez-Skarmeta JL, Casares F.
Development. 2008 Mar;135(5):799-803. doi: 10.1242/dev.011932. Epub 2008 Jan 23.
PMID 18216175
 
Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development.
Heine P, Dohle E, Bumsted-O'Brien K, Engelkamp D, Schulte D.
Development. 2008 Mar;135(5):805-11. doi: 10.1242/dev.012088. Epub 2008 Jan 23.
PMID 18216174
 
HOX cofactors expression and regulation in the human ovary.
Ota T, Asahina H, Park SH, Huang Q, Minegishi T, Auersperg N, Leung PC.
Reprod Biol Endocrinol. 2008 Oct 30;6:49. doi: 10.1186/1477-7827-6-49.
PMID 18973687
 
HOX proteins and leukemia.
Sitwala KV, Dandekar MN, Hess JL.
Int J Clin Exp Pathol. 2008 Mar 30;1(6):461-74.
PMID 18787682
 
Myeloid ecotropic viral integration site 1 (MEIS) 1 involvement in embryonic implantation.
Xu B, Geerts D, Qian K, Zhang H, Zhu G.
Hum Reprod. 2008 Jun;23(6):1394-406. doi: 10.1093/humrep/den082. Epub 2008 Apr 11.
PMID 18408019
 
HOXA9 modulates its oncogenic partner Meis1 to influence normal hematopoiesis.
Hu YL, Fong S, Ferrell C, Largman C, Shen WF.
Mol Cell Biol. 2009 Sep;29(18):5181-92. doi: 10.1128/MCB.00545-09. Epub 2009 Jul 20.
PMID 19620287
 
PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region.
Mojsin M, Stevanovic M.
Biochem J. 2009 Dec 14;425(1):107-16. doi: 10.1042/BJ20090694.
PMID 19799567
 
MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels.
Xiong L, Catoire H, Dion P, Gaspar C, Lafreniere RG, Girard SL, Levchenko A, Riviere JB, Fiori L, St-Onge J, Bachand I, Thibodeau P, Allen R, Earley C, Turecki G, Montplaisir J, Rouleau GA.
Hum Mol Genet. 2009 Mar 15;18(6):1065-74. doi: 10.1093/hmg/ddn443. Epub 2009 Jan 6.
PMID 19126776
 
Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system.
Erickson T, French CR, Waskiewicz AJ.
Neural Dev. 2010 Sep 1;5:22. doi: 10.1186/1749-8104-5-22.
PMID 20809932
 
Hoxa9 regulates Flt3 in lymphohematopoietic progenitors.
Gwin K, Frank E, Bossou A, Medina KL.
J Immunol. 2010 Dec 1;185(11):6572-83. doi: 10.4049/jimmunol.0904203. Epub 2010 Oct 22.
PMID 20971928
 
The pancreatic and duodenal homeobox protein PDX-1 regulates the ductal specific keratin 19 through the degradation of MEIS1 and DNA binding.
von Burstin J, Reichert M, Wescott MP, Rustgi AK.
PLoS One. 2010 Aug 19;5(8):e12311. doi: 10.1371/journal.pone.0012311.
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Contributor(s)

Written01-2013Jorge Torres-Flores, Luis Felipe Jave-Suárez
Doctorado de Genetica Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara. Division de Inmunologia, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico (JTF); Division de Inmunologia, Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico (LFJS)

Citation

This paper should be referenced as such :
Torres-Flores, J ; Jave-Suarez, LF
MEIS1 (Meis homeobox 1)
Atlas Genet Cytogenet Oncol Haematol. 2013;17(6):424-429.
Free online version   Free pdf version   [Bibliographic record ]
URL : http://AtlasGeneticsOncology.org/Genes/MEIS1ID41331ch2p14.html

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