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MEIS2 (Meis homeobox 2)

Identity

Alias_namesMeis (mouse) homolog 2
Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)
Alias_symbol (synonym)MRG1
HsT18361
HGNC (Hugo) MEIS2
LocusID (NCBI) 4212
Atlas_Id 41332
Location 15q14  [Link to chromosome band 15q14]
Location_base_pair Starts at 37183222 and ends at 37393500 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
C15orf41 (15q14) / MEIS2 (15q14)MEIS2 (15q14) / MEIS2 (15q14)MEIS2 (15q14) / MYO5A (15q21.2)
MEIS2 (15q14) / ZNF143 (11p15.4)PAPPA (9q33.1) / MEIS2 (15q14)C15orf41 15q14 / MEIS2 15q14
MEIS2 15q14 / MYO5A 15q21.2MEIS2 15q14 / ZNF143 11p15.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MEIS2   7001
Cards
Entrez_Gene (NCBI)MEIS2  4212  Meis homeobox 2
AliasesHsT18361; MRG1
GeneCards (Weizmann)MEIS2
Ensembl hg19 (Hinxton)ENSG00000134138 [Gene_View]  chr15:37183222-37393500 [Contig_View]  MEIS2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000134138 [Gene_View]  chr15:37183222-37393500 [Contig_View]  MEIS2 [Vega]
ICGC DataPortalENSG00000134138
TCGA cBioPortalMEIS2
AceView (NCBI)MEIS2
Genatlas (Paris)MEIS2
WikiGenes4212
SOURCE (Princeton)MEIS2
Genetics Home Reference (NIH)MEIS2
Genomic and cartography
GoldenPath hg19 (UCSC)MEIS2  -     chr15:37183222-37393500 -  15q14   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MEIS2  -     15q14   [Description]    (hg38-Dec_2013)
EnsemblMEIS2 - 15q14 [CytoView hg19]  MEIS2 - 15q14 [CytoView hg38]
Mapping of homologs : NCBIMEIS2 [Mapview hg19]  MEIS2 [Mapview hg38]
OMIM601740   
Gene and transcription
Genbank (Entrez)AF017418 AF178948 AF179896 AF179897 AF179898
RefSeq transcript (Entrez)NM_001220482 NM_002399 NM_020149 NM_170674 NM_170675 NM_170676 NM_170677 NM_172315 NM_172316
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_029108 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)MEIS2
Cluster EST : UnigeneHs.510989 [ NCBI ]
CGAP (NCI)Hs.510989
Alternative Splicing GalleryENSG00000134138
Gene ExpressionMEIS2 [ NCBI-GEO ]   MEIS2 [ EBI - ARRAY_EXPRESS ]   MEIS2 [ SEEK ]   MEIS2 [ MEM ]
Gene Expression Viewer (FireBrowse)MEIS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4212
GTEX Portal (Tissue expression)MEIS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14770   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14770  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14770
Splice isoforms : SwissVarO14770
PhosPhoSitePlusO14770
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox_dom    Homeobox_KN_domain    Homeodomain-like    PKNOX/Meis_N   
Domain families : Pfam (Sanger)Homeobox_KN (PF05920)    Meis_PKNOX_N (PF16493)   
Domain families : Pfam (NCBI)pfam05920    pfam16493   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)MEIS2
DMDM Disease mutations4212
Blocks (Seattle)MEIS2
PDB (SRS)3K2A    4XRM    5BNG   
PDB (PDBSum)3K2A    4XRM    5BNG   
PDB (IMB)3K2A    4XRM    5BNG   
PDB (RSDB)3K2A    4XRM    5BNG   
Structural Biology KnowledgeBase3K2A    4XRM    5BNG   
SCOP (Structural Classification of Proteins)3K2A    4XRM    5BNG   
CATH (Classification of proteins structures)3K2A    4XRM    5BNG   
SuperfamilyO14770
Human Protein AtlasENSG00000134138
Peptide AtlasO14770
HPRD03443
IPIIPI00023696   IPI00746958   IPI00221237   IPI00221238   IPI01014798   IPI00432354   IPI00171219   IPI00373944   IPI00373945   
Protein Interaction databases
DIP (DOE-UCLA)O14770
IntAct (EBI)O14770
FunCoupENSG00000134138
BioGRIDMEIS2
STRING (EMBL)MEIS2
ZODIACMEIS2
Ontologies - Pathways
QuickGOO14770
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  eye development  transcription factor activity, sequence-specific DNA binding  transcription cofactor activity  transcription corepressor activity  protein binding  nucleus  transcription from RNA polymerase II promoter  transcription factor binding  visual learning  response to mechanical stimulus  pancreas development  sequence-specific DNA binding  negative regulation of myeloid cell differentiation  positive regulation of transcription from RNA polymerase II promoter  perinuclear region of cytoplasm  response to growth factor  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  eye development  transcription factor activity, sequence-specific DNA binding  transcription cofactor activity  transcription corepressor activity  protein binding  nucleus  transcription from RNA polymerase II promoter  transcription factor binding  visual learning  response to mechanical stimulus  pancreas development  sequence-specific DNA binding  negative regulation of myeloid cell differentiation  positive regulation of transcription from RNA polymerase II promoter  perinuclear region of cytoplasm  response to growth factor  
NDEx NetworkMEIS2
Atlas of Cancer Signalling NetworkMEIS2
Wikipedia pathwaysMEIS2
Orthology - Evolution
OrthoDB4212
GeneTree (enSembl)ENSG00000134138
Phylogenetic Trees/Animal Genes : TreeFamMEIS2
HOVERGENO14770
HOGENOMO14770
Homologs : HomoloGeneMEIS2
Homology/Alignments : Family Browser (UCSC)MEIS2
Gene fusions - Rearrangements
Fusion : MitelmanMEIS2/MYO5A [15q14/15q21.2]  
Fusion : MitelmanMEIS2/ZNF143 [15q14/11p15.4]  [t(11;15)(p15;q14)]  
Fusion: TCGAC15orf41 15q14 MEIS2 15q14 GBM
Fusion: TCGAMEIS2 15q14 MYO5A 15q21.2 BRCA
Fusion: TCGAMEIS2 15q14 ZNF143 11p15.4 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMEIS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MEIS2
dbVarMEIS2
ClinVarMEIS2
1000_GenomesMEIS2 
Exome Variant ServerMEIS2
ExAC (Exome Aggregation Consortium)MEIS2 (select the gene name)
Genetic variants : HAPMAP4212
Genomic Variants (DGV)MEIS2 [DGVbeta]
DECIPHER (Syndromes)15:37183222-37393500  ENSG00000134138
CONAN: Copy Number AnalysisMEIS2 
Mutations
ICGC Data PortalMEIS2 
TCGA Data PortalMEIS2 
Broad Tumor PortalMEIS2
OASIS PortalMEIS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMEIS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMEIS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MEIS2
DgiDB (Drug Gene Interaction Database)MEIS2
DoCM (Curated mutations)MEIS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MEIS2 (select a term)
intoGenMEIS2
Cancer3DMEIS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601740   
Orphanet19856   
MedgenMEIS2
Genetic Testing Registry MEIS2
NextProtO14770 [Medical]
TSGene4212
GENETestsMEIS2
Huge Navigator MEIS2 [HugePedia]
snp3D : Map Gene to Disease4212
BioCentury BCIQMEIS2
ClinGenMEIS2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4212
Chemical/Pharm GKB GenePA30741
Clinical trialMEIS2
Miscellaneous
canSAR (ICR)MEIS2 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMEIS2
EVEXMEIS2
GoPubMedMEIS2
iHOPMEIS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:43:16 CET 2016

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