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MEIS2 (Meis homeobox 2)

Identity

Other namesHsT18361
MRG1
HGNC (Hugo) MEIS2
LocusID (NCBI) 4212
Location 15q14
Location_base_pair Starts at 37183222 and ends at 37393500 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MEIS2   7001
Cards
Entrez_Gene (NCBI)MEIS2  4212  Meis homeobox 2
GeneCards (Weizmann)MEIS2
Ensembl hg19 (Hinxton)ENSG00000134138 [Gene_View]  chr15:37183222-37393500 [Contig_View]  MEIS2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000134138 [Gene_View]  chr15:37183222-37393500 [Contig_View]  MEIS2 [Vega]
ICGC DataPortalENSG00000134138
cBioPortalMEIS2
AceView (NCBI)MEIS2
Genatlas (Paris)MEIS2
WikiGenes4212
SOURCE (Princeton)MEIS2
Genomic and cartography
GoldenPath hg19 (UCSC)MEIS2  -     chr15:37183222-37393500 -  15q14   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MEIS2  -     15q14   [Description]    (hg38-Dec_2013)
EnsemblMEIS2 - 15q14 [CytoView hg19]  MEIS2 - 15q14 [CytoView hg38]
Mapping of homologs : NCBIMEIS2 [Mapview hg19]  MEIS2 [Mapview hg38]
OMIM601740   
Gene and transcription
Genbank (Entrez)AF017418 AF178948 AF179896 AF179897 AF179898
RefSeq transcript (Entrez)NM_001220482 NM_002399 NM_020149 NM_170674 NM_170675 NM_170676 NM_170677 NM_172315 NM_172316
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_029108 NT_010194 NW_001838214 NW_004929398
Consensus coding sequences : CCDS (NCBI)MEIS2
Cluster EST : UnigeneHs.510989 [ NCBI ]
CGAP (NCI)Hs.510989
Alternative Splicing : Fast-db (Paris)GSHG0010304
Alternative Splicing GalleryENSG00000134138
Gene ExpressionMEIS2 [ NCBI-GEO ]     MEIS2 [ SEEK ]   MEIS2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14770 (Uniprot)
NextProtO14770  [Medical]
With graphics : InterProO14770
Splice isoforms : SwissVarO14770 (Swissvar)
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox_dom    Homeobox_KN_domain    Homeodomain-like   
Related proteins : CluSTrO14770
Domain families : Pfam (Sanger)Homeobox_KN (PF05920)   
Domain families : Pfam (NCBI)pfam05920   
Domain families : Smart (EMBL)HOX (SM00389)  
DMDM Disease mutations4212
Blocks (Seattle)O14770
PDB (SRS)3K2A   
PDB (PDBSum)3K2A   
PDB (IMB)3K2A   
PDB (RSDB)3K2A   
Human Protein AtlasENSG00000134138
Peptide AtlasO14770
HPRD03443
IPIIPI00023696   IPI00746958   IPI00221237   IPI00221238   IPI01014798   IPI00432354   IPI00171219   IPI00373944   IPI00373945   
Protein Interaction databases
DIP (DOE-UCLA)O14770
IntAct (EBI)O14770
FunCoupENSG00000134138
BioGRIDMEIS2
IntegromeDBMEIS2
STRING (EMBL)MEIS2
Ontologies - Pathways
QuickGOO14770
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  eye development  sequence-specific DNA binding transcription factor activity  transcription cofactor activity  transcription corepressor activity  protein binding  nucleus  transcription from RNA polymerase II promoter  transcription factor binding  response to mechanical stimulus  pancreas development  sequence-specific DNA binding  negative regulation of myeloid cell differentiation  positive regulation of transcription from RNA polymerase II promoter  response to growth factor  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  eye development  sequence-specific DNA binding transcription factor activity  transcription cofactor activity  transcription corepressor activity  protein binding  nucleus  transcription from RNA polymerase II promoter  transcription factor binding  response to mechanical stimulus  pancreas development  sequence-specific DNA binding  negative regulation of myeloid cell differentiation  positive regulation of transcription from RNA polymerase II promoter  response to growth factor  
Protein Interaction DatabaseMEIS2
DoCM (Curated mutations)MEIS2
Wikipedia pathwaysMEIS2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerMEIS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MEIS2
dbVarMEIS2
ClinVarMEIS2
1000_GenomesMEIS2 
Exome Variant ServerMEIS2
SNP (GeneSNP Utah)MEIS2
SNP : HGBaseMEIS2
Genetic variants : HAPMAPMEIS2
Genomic VariantsMEIS2  MEIS2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000134138 
Somatic Mutations in Cancer : COSMICMEIS2 
CONAN: Copy Number AnalysisMEIS2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:37183222-37393500
Mutations and Diseases : HGMDMEIS2
OMIM601740   
MedgenMEIS2
NextProtO14770 [Medical]
GENETestsMEIS2
Disease Genetic AssociationMEIS2
Huge Navigator MEIS2 [HugePedia]  MEIS2 [HugeCancerGEM]
snp3D : Map Gene to Disease4212
DGIdb (Drug Gene Interaction db)MEIS2
General knowledge
Homologs : HomoloGeneMEIS2
Homology/Alignments : Family Browser (UCSC)MEIS2
Phylogenetic Trees/Animal Genes : TreeFamMEIS2
Chemical/Protein Interactions : CTD4212
Chemical/Pharm GKB GenePA30741
Clinical trialMEIS2
Cancer Resource (Charite)ENSG00000134138
Other databases
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
CoreMineMEIS2
GoPubMedMEIS2
iHOPMEIS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 23:38:11 CET 2014

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