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MEIS2 (Meis homeobox 2)

Identity

Other namesHsT18361
MRG1
HGNC (Hugo) MEIS2
LocusID (NCBI) 4212
Atlas_Id 41332
Location 15q14
Location_base_pair Starts at 37183222 and ends at 37393500 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
C15orf41 15q14 / MEIS2 15q14MEIS2 15q14 / MYO5A 15q21.2MEIS2 15q14 / ZNF143 11p15.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MEIS2   7001
Cards
Entrez_Gene (NCBI)MEIS2  4212  Meis homeobox 2
GeneCards (Weizmann)MEIS2
Ensembl hg19 (Hinxton)ENSG00000134138 [Gene_View]  chr15:37183222-37393500 [Contig_View]  MEIS2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000134138 [Gene_View]  chr15:37183222-37393500 [Contig_View]  MEIS2 [Vega]
ICGC DataPortalENSG00000134138
TCGA cBioPortalMEIS2
AceView (NCBI)MEIS2
Genatlas (Paris)MEIS2
WikiGenes4212
SOURCE (Princeton)MEIS2
Genomic and cartography
GoldenPath hg19 (UCSC)MEIS2  -     chr15:37183222-37393500 -  15q14   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MEIS2  -     15q14   [Description]    (hg38-Dec_2013)
EnsemblMEIS2 - 15q14 [CytoView hg19]  MEIS2 - 15q14 [CytoView hg38]
Mapping of homologs : NCBIMEIS2 [Mapview hg19]  MEIS2 [Mapview hg38]
OMIM601740   
Gene and transcription
Genbank (Entrez)AF017418 AF178948 AF179896 AF179897 AF179898
RefSeq transcript (Entrez)NM_001220482 NM_002399 NM_020149 NM_170674 NM_170675 NM_170676 NM_170677 NM_172315 NM_172316
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_029108 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)MEIS2
Cluster EST : UnigeneHs.510989 [ NCBI ]
CGAP (NCI)Hs.510989
Alternative Splicing : Fast-db (Paris)GSHG0010304
Alternative Splicing GalleryENSG00000134138
Gene ExpressionMEIS2 [ NCBI-GEO ]     MEIS2 [ SEEK ]   MEIS2 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)4212
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14770 (Uniprot)
NextProtO14770  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14770
Splice isoforms : SwissVarO14770 (Swissvar)
PhosPhoSitePlusO14770
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox_dom    Homeobox_KN_domain    Homeodomain-like   
Domain families : Pfam (Sanger)Homeobox_KN (PF05920)   
Domain families : Pfam (NCBI)pfam05920   
Domain families : Smart (EMBL)HOX (SM00389)  
DMDM Disease mutations4212
Blocks (Seattle)MEIS2
PDB (SRS)3K2A   
PDB (PDBSum)3K2A   
PDB (IMB)3K2A   
PDB (RSDB)3K2A   
Structural Biology KnowledgeBase3K2A   
SCOP (Structural Classification of Proteins)3K2A   
CATH (Classification of proteins structures)3K2A   
Human Protein AtlasENSG00000134138
Peptide AtlasO14770
HPRD03443
IPIIPI00023696   IPI00746958   IPI00221237   IPI00221238   IPI01014798   IPI00432354   IPI00171219   IPI00373944   IPI00373945   
Protein Interaction databases
DIP (DOE-UCLA)O14770
IntAct (EBI)O14770
FunCoupENSG00000134138
BioGRIDMEIS2
IntegromeDBMEIS2
STRING (EMBL)MEIS2
ZODIACMEIS2
Ontologies - Pathways
QuickGOO14770
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  transcription cofactor activity  transcription corepressor activity  protein binding  nucleus  transcription from RNA polymerase II promoter  multicellular organismal development  transcription factor binding  sequence-specific DNA binding  negative regulation of myeloid cell differentiation  positive regulation of transcription from RNA polymerase II promoter  perinuclear region of cytoplasm  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  transcription factor activity, sequence-specific DNA binding  transcription cofactor activity  transcription corepressor activity  protein binding  nucleus  transcription from RNA polymerase II promoter  multicellular organismal development  transcription factor binding  sequence-specific DNA binding  negative regulation of myeloid cell differentiation  positive regulation of transcription from RNA polymerase II promoter  perinuclear region of cytoplasm  
Protein Interaction DatabaseMEIS2
Atlas of Cancer Signalling NetworkMEIS2
Wikipedia pathwaysMEIS2
Orthology - Evolution
OrthoDB4212
GeneTree (enSembl)ENSG00000134138
Phylogenetic Trees/Animal Genes : TreeFamMEIS2
Homologs : HomoloGeneMEIS2
Homology/Alignments : Family Browser (UCSC)MEIS2
Gene fusions - Rearrangements
Fusion: TCGAC15orf41 15q14 MEIS2 15q14 GBM
Fusion: TCGAMEIS2 15q14 MYO5A 15q21.2 BRCA
Fusion: TCGAMEIS2 15q14 ZNF143 11p15.4 GBM
Polymorphisms : SNP, variants
NCBI Variation ViewerMEIS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MEIS2
dbVarMEIS2
ClinVarMEIS2
1000_GenomesMEIS2 
Exome Variant ServerMEIS2
Exome Aggregation Consortium (ExAC)ENSG00000134138
SNP (GeneSNP Utah)MEIS2
SNP : HGBaseMEIS2
Genetic variants : HAPMAPMEIS2
Genomic Variants (DGV)MEIS2 [DGVbeta]
Mutations
ICGC Data PortalMEIS2 
TCGA Data PortalMEIS2 
Tumor PortalMEIS2
TCGA Copy Number PortalMEIS2
Somatic Mutations in Cancer : COSMICMEIS2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MEIS2
DgiDB (Drug Gene Interaction Database)MEIS2
DoCM (Curated mutations)MEIS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MEIS2 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:37183222-37393500
CONAN: Copy Number AnalysisMEIS2 
Mutations and Diseases : HGMDMEIS2
OMIM601740   
MedgenMEIS2
NextProtO14770 [Medical]
TSGene4212
GENETestsMEIS2
Huge Navigator MEIS2 [HugePedia]  MEIS2 [HugeCancerGEM]
snp3D : Map Gene to Disease4212
BioCentury BCIQMEIS2
General knowledge
Chemical/Protein Interactions : CTD4212
Chemical/Pharm GKB GenePA30741
Clinical trialMEIS2
Other databases
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMEIS2
GoPubMedMEIS2
iHOPMEIS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jan 16 19:00:00 CET 2016

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