MEP1A (meprin A subunit alpha)

2007-02-01  

Identity

HGNC
LOCATION
6p12.3
LOCUSID
ALIAS
PPHA
FUSION GENES

Other Information

Locus ID:

NCBI: 4224
MIM: 600388
HGNC: 7015
Ensembl: ENSG00000112818

Variants:

dbSNP: 4224
ClinVar: 4224
TCGA: ENSG00000112818
COSMIC: MEP1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112818ENST00000230588Q16819
ENSG00000112818ENST00000611727B7ZL91

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
171950122007The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation.42
192625052009MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease.29
192625052009MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease.29
206317302010Processing of procollagen III by meprins: new players in extracellular matrix assembly?28
208068992010Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases.17
121891452002Activation of human meprin-alpha in a cell culture model of colorectal cancer is triggered by the plasminogen-activating system.16
220964852011Enhanced activity of meprin-α, a pro-migratory and pro-angiogenic protease, in colorectal cancer.16
244746952014Meprin metalloproteases inactivate interleukin 6.15
223265572012TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis.14
229236092012Meprinα transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration.11

Citation

Dessen P

MEP1A (meprin A subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45861/mep1a