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MEP1B (meprin A subunit beta)

Identity

Alias_namesmeprin A
Other alias-
HGNC (Hugo) MEP1B
LocusID (NCBI) 4225
Atlas_Id 41336
Location 18q12.1  [Link to chromosome band 18q12]
Location_base_pair Starts at 29769987 and ends at 29800366 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MEP1B   7020
Cards
Entrez_Gene (NCBI)MEP1B  4225  meprin A subunit beta
Aliases
GeneCards (Weizmann)MEP1B
Ensembl hg19 (Hinxton)ENSG00000141434 [Gene_View]  chr18:29769987-29800366 [Contig_View]  MEP1B [Vega]
Ensembl hg38 (Hinxton)ENSG00000141434 [Gene_View]  chr18:29769987-29800366 [Contig_View]  MEP1B [Vega]
ICGC DataPortalENSG00000141434
TCGA cBioPortalMEP1B
AceView (NCBI)MEP1B
Genatlas (Paris)MEP1B
WikiGenes4225
SOURCE (Princeton)MEP1B
Genetics Home Reference (NIH)MEP1B
Genomic and cartography
GoldenPath hg19 (UCSC)MEP1B  -     chr18:29769987-29800366 +  18q12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MEP1B  -     18q12.1   [Description]    (hg38-Dec_2013)
EnsemblMEP1B - 18q12.1 [CytoView hg19]  MEP1B - 18q12.1 [CytoView hg38]
Mapping of homologs : NCBIMEP1B [Mapview hg19]  MEP1B [Mapview hg38]
OMIM600389   
Gene and transcription
Genbank (Entrez)AY695931 BC136559 BC144244 X81333
RefSeq transcript (Entrez)NM_001308171 NM_005925
RefSeq genomic (Entrez)NC_000018 NC_018929 NT_010966 NW_004929410
Consensus coding sequences : CCDS (NCBI)MEP1B
Cluster EST : UnigeneHs.194777 [ NCBI ]
CGAP (NCI)Hs.194777
Alternative Splicing GalleryENSG00000141434
Gene ExpressionMEP1B [ NCBI-GEO ]   MEP1B [ EBI - ARRAY_EXPRESS ]   MEP1B [ SEEK ]   MEP1B [ MEM ]
Gene Expression Viewer (FireBrowse)MEP1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4225
GTEX Portal (Tissue expression)MEP1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16820   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16820  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16820
Splice isoforms : SwissVarQ16820
Catalytic activity : Enzyme3.4.24.63 [ Enzyme-Expasy ]   3.4.24.633.4.24.63 [ IntEnz-EBI ]   3.4.24.63 [ BRENDA ]   3.4.24.63 [ KEGG ]   
PhosPhoSitePlusQ16820
Domaine pattern : Prosite (Expaxy)EGF_3 (PS50026)    MAM_1 (PS00740)    MAM_2 (PS50060)    MATH (PS50144)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ConA-like_dom    EGF-like_dom    MAM_dom    MATH/TRAF_dom    Meprin    MetalloPept_cat_dom    Peptidase_M12A    Peptidase_Metallo    TRAF-like   
Domain families : Pfam (Sanger)Astacin (PF01400)    MAM (PF00629)   
Domain families : Pfam (NCBI)pfam01400    pfam00629   
Domain families : Smart (EMBL)EGF (SM00181)  MAM (SM00137)  MATH (SM00061)  ZnMc (SM00235)  
Conserved Domain (NCBI)MEP1B
DMDM Disease mutations4225
Blocks (Seattle)MEP1B
PDB (SRS)4GWM    4GWN   
PDB (PDBSum)4GWM    4GWN   
PDB (IMB)4GWM    4GWN   
PDB (RSDB)4GWM    4GWN   
Structural Biology KnowledgeBase4GWM    4GWN   
SCOP (Structural Classification of Proteins)4GWM    4GWN   
CATH (Classification of proteins structures)4GWM    4GWN   
SuperfamilyQ16820
Human Protein AtlasENSG00000141434
Peptide AtlasQ16820
HPRD02667
IPIIPI00178015   
Protein Interaction databases
DIP (DOE-UCLA)Q16820
IntAct (EBI)Q16820
FunCoupENSG00000141434
BioGRIDMEP1B
STRING (EMBL)MEP1B
ZODIACMEP1B
Ontologies - Pathways
QuickGOQ16820
Ontology : AmiGOmetalloendopeptidase activity  protein binding  extracellular space  plasma membrane  integral component of plasma membrane  proteolysis  inflammatory response  digestion  zinc ion binding  toxin transport  
Ontology : EGO-EBImetalloendopeptidase activity  protein binding  extracellular space  plasma membrane  integral component of plasma membrane  proteolysis  inflammatory response  digestion  zinc ion binding  toxin transport  
Pathways : KEGGProtein digestion and absorption   
NDEx NetworkMEP1B
Atlas of Cancer Signalling NetworkMEP1B
Wikipedia pathwaysMEP1B
Orthology - Evolution
OrthoDB4225
GeneTree (enSembl)ENSG00000141434
Phylogenetic Trees/Animal Genes : TreeFamMEP1B
HOVERGENQ16820
HOGENOMQ16820
Homologs : HomoloGeneMEP1B
Homology/Alignments : Family Browser (UCSC)MEP1B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMEP1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MEP1B
dbVarMEP1B
ClinVarMEP1B
1000_GenomesMEP1B 
Exome Variant ServerMEP1B
ExAC (Exome Aggregation Consortium)MEP1B (select the gene name)
Genetic variants : HAPMAP4225
Genomic Variants (DGV)MEP1B [DGVbeta]
DECIPHER (Syndromes)18:29769987-29800366  ENSG00000141434
CONAN: Copy Number AnalysisMEP1B 
Mutations
ICGC Data PortalMEP1B 
TCGA Data PortalMEP1B 
Broad Tumor PortalMEP1B
OASIS PortalMEP1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMEP1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMEP1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MEP1B
DgiDB (Drug Gene Interaction Database)MEP1B
DoCM (Curated mutations)MEP1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MEP1B (select a term)
intoGenMEP1B
Cancer3DMEP1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600389   
Orphanet
MedgenMEP1B
Genetic Testing Registry MEP1B
NextProtQ16820 [Medical]
TSGene4225
GENETestsMEP1B
Huge Navigator MEP1B [HugePedia]
snp3D : Map Gene to Disease4225
BioCentury BCIQMEP1B
ClinGenMEP1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4225
Chemical/Pharm GKB GenePA30754
Clinical trialMEP1B
Miscellaneous
canSAR (ICR)MEP1B (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMEP1B
EVEXMEP1B
GoPubMedMEP1B
iHOPMEP1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:08:58 CEST 2017

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