MEPE (matrix extracellular phosphoglycoprotein)

2003-02-01  

Identity

HGNC
LOCATION
4q22.1
LOCUSID
ALIAS
OF45

Other Information

Locus ID:

NCBI: 56955
MIM: 605912
HGNC: 13361
Ensembl: ENSG00000152595

Variants:

dbSNP: 56955
ClinVar: 56955
TCGA: ENSG00000152595
COSMIC: MEPE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152595ENST00000361056Q9NQ76
ENSG00000152595ENST00000361056A0A024RDD1
ENSG00000152595ENST00000395102Q9NQ76
ENSG00000152595ENST00000424957Q9NQ76
ENSG00000152595ENST00000424957A0A024RDD1
ENSG00000152595ENST00000497649D6RAC8
ENSG00000152595ENST00000511670D6RFW6
ENSG00000152595ENST00000540395Q9NQ76
ENSG00000152595ENST00000560249Q9NQ76

Expression (GTEx)

0
1
2
3
4
5

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124218222003Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass.86
196792052009Patterns of FGF-23, DMP1, and MEPE expression in patients with chronic kidney disease.83
127916012003FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization.74
153293692004Expression of SIBLINGs and their partner MMPs in salivary glands.70
213122672011Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism.66
159549042005Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs).59
151080582004Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone.30
199980302010MEPE's diverse effects on mineralization.22
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
152923642004Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density.18

Citation

Dessen P

MEPE (matrix extracellular phosphoglycoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41337/mepe