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MESP1 (mesoderm posterior bHLH transcription factor 1)

Identity

Other aliasbHLHc5
HGNC (Hugo) MESP1
LocusID (NCBI) 55897
Atlas_Id 56735
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 89749867 and ends at 89751309 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BTBD1 (15q25.2) / MESP1 (15q26.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(15;15)(q25;q26) BTBD1/MESP1


External links

Nomenclature
HGNC (Hugo)MESP1   29658
Cards
Entrez_Gene (NCBI)MESP1  55897  mesoderm posterior bHLH transcription factor 1
AliasesbHLHc5
GeneCards (Weizmann)MESP1
Ensembl hg19 (Hinxton)ENSG00000166823 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166823 [Gene_View]  ENSG00000166823 [Sequence]  chr15:89749867-89751309 [Contig_View]  MESP1 [Vega]
ICGC DataPortalENSG00000166823
TCGA cBioPortalMESP1
AceView (NCBI)MESP1
Genatlas (Paris)MESP1
WikiGenes55897
SOURCE (Princeton)MESP1
Genetics Home Reference (NIH)MESP1
Genomic and cartography
GoldenPath hg38 (UCSC)MESP1  -     chr15:89749867-89751309 -  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MESP1  -     15q26.1   [Description]    (hg19-Feb_2009)
EnsemblMESP1 - 15q26.1 [CytoView hg19]  MESP1 - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBIMESP1 [Mapview hg19]  MESP1 [Mapview hg38]
OMIM608689   
Gene and transcription
Genbank (Entrez)AL357533 AL357534 AL357535 AL357570 AL357571
RefSeq transcript (Entrez)NM_018670
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MESP1
Cluster EST : UnigeneHs.447531 [ NCBI ]
CGAP (NCI)Hs.447531
Alternative Splicing GalleryENSG00000166823
Gene ExpressionMESP1 [ NCBI-GEO ]   MESP1 [ EBI - ARRAY_EXPRESS ]   MESP1 [ SEEK ]   MESP1 [ MEM ]
Gene Expression Viewer (FireBrowse)MESP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55897
GTEX Portal (Tissue expression)MESP1
Human Protein AtlasENSG00000166823-MESP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BRJ9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BRJ9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BRJ9
Splice isoforms : SwissVarQ9BRJ9
PhosPhoSitePlusQ9BRJ9
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom    HLH_DNA-bd_sf   
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
Conserved Domain (NCBI)MESP1
DMDM Disease mutations55897
Blocks (Seattle)MESP1
SuperfamilyQ9BRJ9
Human Protein Atlas [tissue]ENSG00000166823-MESP1 [tissue]
Peptide AtlasQ9BRJ9
IPIIPI00032924   
Protein Interaction databases
DIP (DOE-UCLA)Q9BRJ9
IntAct (EBI)Q9BRJ9
FunCoupENSG00000166823
BioGRIDMESP1
STRING (EMBL)MESP1
ZODIACMESP1
Ontologies - Pathways
QuickGOQ9BRJ9
Ontology : AmiGORNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific  somitogenesis  heart looping  heart morphogenesis  secondary heart field specification  embryonic heart tube morphogenesis  cardiac atrium formation  cardiac ventricle formation  sinus venosus morphogenesis  growth involved in heart morphogenesis  cardioblast anterior-lateral migration  DNA-binding transcription factor activity  nucleus  nucleus  Notch signaling pathway  gastrulation  mesodermal cell migration  neurogenesis  signal transduction involved in regulation of gene expression  enhancer binding  positive regulation of Notch signaling pathway involved in heart induction  negative regulation of mesodermal cell fate specification  negative regulation of endodermal cell fate specification  transcription regulatory region DNA binding  endothelial cell differentiation  positive regulation of Notch signaling pathway  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein dimerization activity  lateral mesoderm development  positive regulation of striated muscle cell differentiation  cardiac muscle cell differentiation  cardiac cell fate determination  sinoatrial node cell differentiation  cardiac vascular smooth muscle cell differentiation  cardioblast migration to the midline involved in heart field formation  positive regulation of hepatocyte differentiation  positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIRNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific  somitogenesis  heart looping  heart morphogenesis  secondary heart field specification  embryonic heart tube morphogenesis  cardiac atrium formation  cardiac ventricle formation  sinus venosus morphogenesis  growth involved in heart morphogenesis  cardioblast anterior-lateral migration  DNA-binding transcription factor activity  nucleus  nucleus  Notch signaling pathway  gastrulation  mesodermal cell migration  neurogenesis  signal transduction involved in regulation of gene expression  enhancer binding  positive regulation of Notch signaling pathway involved in heart induction  negative regulation of mesodermal cell fate specification  negative regulation of endodermal cell fate specification  transcription regulatory region DNA binding  endothelial cell differentiation  positive regulation of Notch signaling pathway  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein dimerization activity  lateral mesoderm development  positive regulation of striated muscle cell differentiation  cardiac muscle cell differentiation  cardiac cell fate determination  sinoatrial node cell differentiation  cardiac vascular smooth muscle cell differentiation  cardioblast migration to the midline involved in heart field formation  positive regulation of hepatocyte differentiation  positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway  
NDEx NetworkMESP1
Atlas of Cancer Signalling NetworkMESP1
Wikipedia pathwaysMESP1
Orthology - Evolution
OrthoDB55897
GeneTree (enSembl)ENSG00000166823
Phylogenetic Trees/Animal Genes : TreeFamMESP1
HOVERGENQ9BRJ9
HOGENOMQ9BRJ9
Homologs : HomoloGeneMESP1
Homology/Alignments : Family Browser (UCSC)MESP1
Gene fusions - Rearrangements
Fusion : QuiverMESP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMESP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MESP1
dbVarMESP1
ClinVarMESP1
1000_GenomesMESP1 
Exome Variant ServerMESP1
ExAC (Exome Aggregation Consortium)ENSG00000166823
GNOMAD BrowserENSG00000166823
Varsome BrowserMESP1
Genetic variants : HAPMAP55897
Genomic Variants (DGV)MESP1 [DGVbeta]
DECIPHERMESP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMESP1 
Mutations
ICGC Data PortalMESP1 
TCGA Data PortalMESP1 
Broad Tumor PortalMESP1
OASIS PortalMESP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMESP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMESP1
BioMutasearch MESP1
DgiDB (Drug Gene Interaction Database)MESP1
DoCM (Curated mutations)MESP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MESP1 (select a term)
intoGenMESP1
Cancer3DMESP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608689   
Orphanet
DisGeNETMESP1
MedgenMESP1
Genetic Testing Registry MESP1
NextProtQ9BRJ9 [Medical]
TSGene55897
GENETestsMESP1
Target ValidationMESP1
Huge Navigator MESP1 [HugePedia]
snp3D : Map Gene to Disease55897
BioCentury BCIQMESP1
ClinGenMESP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55897
Chemical/Pharm GKB GenePA142671468
Clinical trialMESP1
Miscellaneous
canSAR (ICR)MESP1 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMESP1
EVEXMESP1
GoPubMedMESP1
iHOPMESP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:19:40 CET 2018

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