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METAP1 (methionyl aminopeptidase 1)

Identity

Alias_symbol (synonym)KIAA0094
MetAP1A
MAP1A
Other alias
HGNC (Hugo) METAP1
LocusID (NCBI) 23173
Atlas_Id 47706
Location 4q23  [Link to chromosome band 4q23]
Location_base_pair Starts at 98995637 and ends at 99062809 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
METAP1 (4q23) / EIF4E (4q23)PERP (6q23.3) / METAP1 (4q23)TSPAN5 (4q23) / METAP1 (4q23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)METAP1   15789
Cards
Entrez_Gene (NCBI)METAP1  23173  methionyl aminopeptidase 1
AliasesMAP1A; MetAP1A
GeneCards (Weizmann)METAP1
Ensembl hg19 (Hinxton)ENSG00000164024 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164024 [Gene_View]  chr4:98995637-99062809 [Contig_View]  METAP1 [Vega]
ICGC DataPortalENSG00000164024
TCGA cBioPortalMETAP1
AceView (NCBI)METAP1
Genatlas (Paris)METAP1
WikiGenes23173
SOURCE (Princeton)METAP1
Genetics Home Reference (NIH)METAP1
Genomic and cartography
GoldenPath hg38 (UCSC)METAP1  -     chr4:98995637-99062809 +  4q23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)METAP1  -     4q23   [Description]    (hg19-Feb_2009)
EnsemblMETAP1 - 4q23 [CytoView hg19]  METAP1 - 4q23 [CytoView hg38]
Mapping of homologs : NCBIMETAP1 [Mapview hg19]  METAP1 [Mapview hg38]
OMIM610151   
Gene and transcription
Genbank (Entrez)AK304239 AK309465 BC030054 CR936632 D42084
RefSeq transcript (Entrez)NM_015143
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)METAP1
Cluster EST : UnigeneHs.480364 [ NCBI ]
CGAP (NCI)Hs.480364
Alternative Splicing GalleryENSG00000164024
Gene ExpressionMETAP1 [ NCBI-GEO ]   METAP1 [ EBI - ARRAY_EXPRESS ]   METAP1 [ SEEK ]   METAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)METAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23173
GTEX Portal (Tissue expression)METAP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53582   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53582  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53582
Splice isoforms : SwissVarP53582
PhosPhoSitePlusP53582
Domaine pattern : Prosite (Expaxy)MAP_1 (PS00680)   
Domains : Interpro (EBI)Pept_M24    Pept_M24_MAP    Pept_M24A_MAP1    Zfn-C6H2   
Domain families : Pfam (Sanger)Peptidase_M24 (PF00557)    zf-C6H2 (PF15801)   
Domain families : Pfam (NCBI)pfam00557    pfam15801   
Conserved Domain (NCBI)METAP1
DMDM Disease mutations23173
Blocks (Seattle)METAP1
PDB (SRS)2B3H    2B3K    2B3L    2G6P    2GZ5    2NQ6    2NQ7    4FLI    4FLJ    4FLK    4FLL    4HXX    4IKR    4IKS    4IKT    4IKU    4IU6    4U1B    4U69    4U6C    4U6E    4U6J    4U6W    4U6Z    4U70    4U71    4U73    4U75    4U76   
PDB (PDBSum)2B3H    2B3K    2B3L    2G6P    2GZ5    2NQ6    2NQ7    4FLI    4FLJ    4FLK    4FLL    4HXX    4IKR    4IKS    4IKT    4IKU    4IU6    4U1B    4U69    4U6C    4U6E    4U6J    4U6W    4U6Z    4U70    4U71    4U73    4U75    4U76   
PDB (IMB)2B3H    2B3K    2B3L    2G6P    2GZ5    2NQ6    2NQ7    4FLI    4FLJ    4FLK    4FLL    4HXX    4IKR    4IKS    4IKT    4IKU    4IU6    4U1B    4U69    4U6C    4U6E    4U6J    4U6W    4U6Z    4U70    4U71    4U73    4U75    4U76   
PDB (RSDB)2B3H    2B3K    2B3L    2G6P    2GZ5    2NQ6    2NQ7    4FLI    4FLJ    4FLK    4FLL    4HXX    4IKR    4IKS    4IKT    4IKU    4IU6    4U1B    4U69    4U6C    4U6E    4U6J    4U6W    4U6Z    4U70    4U71    4U73    4U75    4U76   
Structural Biology KnowledgeBase2B3H    2B3K    2B3L    2G6P    2GZ5    2NQ6    2NQ7    4FLI    4FLJ    4FLK    4FLL    4HXX    4IKR    4IKS    4IKT    4IKU    4IU6    4U1B    4U69    4U6C    4U6E    4U6J    4U6W    4U6Z    4U70    4U71    4U73    4U75    4U76   
SCOP (Structural Classification of Proteins)2B3H    2B3K    2B3L    2G6P    2GZ5    2NQ6    2NQ7    4FLI    4FLJ    4FLK    4FLL    4HXX    4IKR    4IKS    4IKT    4IKU    4IU6    4U1B    4U69    4U6C    4U6E    4U6J    4U6W    4U6Z    4U70    4U71    4U73    4U75    4U76   
CATH (Classification of proteins structures)2B3H    2B3K    2B3L    2G6P    2GZ5    2NQ6    2NQ7    4FLI    4FLJ    4FLK    4FLL    4HXX    4IKR    4IKS    4IKT    4IKU    4IU6    4U1B    4U69    4U6C    4U6E    4U6J    4U6W    4U6Z    4U70    4U71    4U73    4U75    4U76   
SuperfamilyP53582
Human Protein AtlasENSG00000164024
Peptide AtlasP53582
HPRD10071
IPIIPI00022239   IPI00965235   IPI01010848   IPI00966935   IPI00967863   IPI00967611   IPI00968209   IPI00967186   
Protein Interaction databases
DIP (DOE-UCLA)P53582
IntAct (EBI)P53582
FunCoupENSG00000164024
BioGRIDMETAP1
STRING (EMBL)METAP1
ZODIACMETAP1
Ontologies - Pathways
QuickGOP53582
Ontology : AmiGOaminopeptidase activity  cytoplasm  cytosol  regulation of translation  proteolysis  metalloexopeptidase activity  peptidyl-methionine modification  regulation of rhodopsin mediated signaling pathway  N-terminal protein amino acid modification  metal ion binding  platelet aggregation  
Ontology : EGO-EBIaminopeptidase activity  cytoplasm  cytosol  regulation of translation  proteolysis  metalloexopeptidase activity  peptidyl-methionine modification  regulation of rhodopsin mediated signaling pathway  N-terminal protein amino acid modification  metal ion binding  platelet aggregation  
NDEx NetworkMETAP1
Atlas of Cancer Signalling NetworkMETAP1
Wikipedia pathwaysMETAP1
Orthology - Evolution
OrthoDB23173
GeneTree (enSembl)ENSG00000164024
Phylogenetic Trees/Animal Genes : TreeFamMETAP1
HOVERGENP53582
HOGENOMP53582
Homologs : HomoloGeneMETAP1
Homology/Alignments : Family Browser (UCSC)METAP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMETAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)METAP1
dbVarMETAP1
ClinVarMETAP1
1000_GenomesMETAP1 
Exome Variant ServerMETAP1
ExAC (Exome Aggregation Consortium)METAP1 (select the gene name)
Genetic variants : HAPMAP23173
Genomic Variants (DGV)METAP1 [DGVbeta]
DECIPHERMETAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMETAP1 
Mutations
ICGC Data PortalMETAP1 
TCGA Data PortalMETAP1 
Broad Tumor PortalMETAP1
OASIS PortalMETAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMETAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMETAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch METAP1
DgiDB (Drug Gene Interaction Database)METAP1
DoCM (Curated mutations)METAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)METAP1 (select a term)
intoGenMETAP1
Cancer3DMETAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610151   
Orphanet
MedgenMETAP1
Genetic Testing Registry METAP1
NextProtP53582 [Medical]
TSGene23173
GENETestsMETAP1
Target ValidationMETAP1
Huge Navigator METAP1 [HugePedia]
snp3D : Map Gene to Disease23173
BioCentury BCIQMETAP1
ClinGenMETAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23173
Chemical/Pharm GKB GenePA30764
Clinical trialMETAP1
Miscellaneous
canSAR (ICR)METAP1 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMETAP1
EVEXMETAP1
GoPubMedMETAP1
iHOPMETAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:17:47 CEST 2017

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