METAP1 (methionyl aminopeptidase 1)

2007-08-01  

Identity

HGNC
LOCATION
4q23
LOCUSID
ALIAS
MAP1A,MetAP1A
FUSION GENES

Other Information

Locus ID:

NCBI: 23173
MIM: 610151
HGNC: 15789
Ensembl: ENSG00000164024

Variants:

dbSNP: 23173
ClinVar: 23173
TCGA: ENSG00000164024
COSMIC: METAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164024ENST00000296411P53582
ENSG00000164024ENST00000503247H0Y9L0
ENSG00000164024ENST00000506238D6RF24
ENSG00000164024ENST00000507537D6RF24
ENSG00000164024ENST00000510107H0YAI3
ENSG00000164024ENST00000510133H0Y955
ENSG00000164024ENST00000514051H0Y903
ENSG00000164024ENST00000625963D6RF24

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
The phototransduction cascadeREACTOMER-HSA-2514856
Inactivation, recovery and regulation of the phototransduction cascadeREACTOMER-HSA-2514859

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
205217642010Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases.59
162742222005Structural basis for the functional differences between type I and type II human methionine aminopeptidases.27
171142912006Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.25
179298332007Kinetic and mutational studies of the number of interacting divalent cations required by bacterial and human methionine aminopeptidases.10
275422282016MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state.7
237676982013Identification, biochemical and structural evaluation of species-specific inhibitors against type I methionine aminopeptidases.5
121445062002Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae.2

Citation

Dessen P

METAP1 (methionyl aminopeptidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47706/metap1