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METTL1 (methyltransferase like 1)

Identity

Alias_namesC12orf1
methyltransferase-like 1
Alias_symbol (synonym)TRM8
TRMT8
Other aliasYDL201w
HGNC (Hugo) METTL1
LocusID (NCBI) 4234
Atlas_Id 54449
Location 12q14.1  [Link to chromosome band 12q14]
Location_base_pair Starts at 57768568 and ends at 57772131 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
METTL1 (12q14.1) / TGFBRAP1 (2q12.1)METTL21B (12q14.1) / METTL1 (12q14.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)METTL1   7030
Cards
Entrez_Gene (NCBI)METTL1  4234  methyltransferase like 1
AliasesC12orf1; TRM8; TRMT8; YDL201w
GeneCards (Weizmann)METTL1
Ensembl hg19 (Hinxton)ENSG00000037897 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000037897 [Gene_View]  chr12:57768568-57772131 [Contig_View]  METTL1 [Vega]
ICGC DataPortalENSG00000037897
TCGA cBioPortalMETTL1
AceView (NCBI)METTL1
Genatlas (Paris)METTL1
WikiGenes4234
SOURCE (Princeton)METTL1
Genetics Home Reference (NIH)METTL1
Genomic and cartography
GoldenPath hg38 (UCSC)METTL1  -     chr12:57768568-57772131 -  12q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)METTL1  -     12q14.1   [Description]    (hg19-Feb_2009)
EnsemblMETTL1 - 12q14.1 [CytoView hg19]  METTL1 - 12q14.1 [CytoView hg38]
Mapping of homologs : NCBIMETTL1 [Mapview hg19]  METTL1 [Mapview hg38]
OMIM604466   
Gene and transcription
Genbank (Entrez)AA317248 AI168455 AK223202 AK314851 BC000550
RefSeq transcript (Entrez)NM_005371 NM_023032 NM_023033
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)METTL1
Cluster EST : UnigeneHs.42957 [ NCBI ]
CGAP (NCI)Hs.42957
Alternative Splicing GalleryENSG00000037897
Gene ExpressionMETTL1 [ NCBI-GEO ]   METTL1 [ EBI - ARRAY_EXPRESS ]   METTL1 [ SEEK ]   METTL1 [ MEM ]
Gene Expression Viewer (FireBrowse)METTL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4234
GTEX Portal (Tissue expression)METTL1
Human Protein AtlasENSG00000037897-METTL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBP6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBP6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBP6
Splice isoforms : SwissVarQ9UBP6
PhosPhoSitePlusQ9UBP6
Domaine pattern : Prosite (Expaxy)SAM_MT_TRMB (PS51625)   
Domains : Interpro (EBI)SAM-dependent_MTases    Trm8_euk    tRNA_(Gua-N-7)_MeTrfase_Trmb   
Domain families : Pfam (Sanger)Methyltransf_4 (PF02390)   
Domain families : Pfam (NCBI)pfam02390   
Conserved Domain (NCBI)METTL1
DMDM Disease mutations4234
Blocks (Seattle)METTL1
PDB (SRS)3CKK   
PDB (PDBSum)3CKK   
PDB (IMB)3CKK   
PDB (RSDB)3CKK   
Structural Biology KnowledgeBase3CKK   
SCOP (Structural Classification of Proteins)3CKK   
CATH (Classification of proteins structures)3CKK   
SuperfamilyQ9UBP6
Human Protein Atlas [tissue]ENSG00000037897-METTL1 [tissue]
Peptide AtlasQ9UBP6
HPRD06834
IPIIPI00290184   IPI01021166   IPI01020763   IPI01021604   IPI01021739   IPI00853470   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBP6
IntAct (EBI)Q9UBP6
FunCoupENSG00000037897
BioGRIDMETTL1
STRING (EMBL)METTL1
ZODIACMETTL1
Ontologies - Pathways
QuickGOQ9UBP6
Ontology : AmiGOtRNA binding  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  tRNA modification  tRNA (guanine-N7-)-methyltransferase activity  tRNA (guanine-N7-)-methyltransferase activity  tRNA methyltransferase complex  tRNA (guanine-N7)-methylation  
Ontology : EGO-EBItRNA binding  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  tRNA modification  tRNA (guanine-N7-)-methyltransferase activity  tRNA (guanine-N7-)-methyltransferase activity  tRNA methyltransferase complex  tRNA (guanine-N7)-methylation  
NDEx NetworkMETTL1
Atlas of Cancer Signalling NetworkMETTL1
Wikipedia pathwaysMETTL1
Orthology - Evolution
OrthoDB4234
GeneTree (enSembl)ENSG00000037897
Phylogenetic Trees/Animal Genes : TreeFamMETTL1
HOVERGENQ9UBP6
HOGENOMQ9UBP6
Homologs : HomoloGeneMETTL1
Homology/Alignments : Family Browser (UCSC)METTL1
Gene fusions - Rearrangements
Fusion : MitelmanMETTL21B/METTL1 [12q14.1/12q14.1]  [t(12;12)(q14;q14)]  
Fusion : QuiverMETTL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMETTL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)METTL1
dbVarMETTL1
ClinVarMETTL1
1000_GenomesMETTL1 
Exome Variant ServerMETTL1
ExAC (Exome Aggregation Consortium)ENSG00000037897
GNOMAD BrowserENSG00000037897
Genetic variants : HAPMAP4234
Genomic Variants (DGV)METTL1 [DGVbeta]
DECIPHERMETTL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMETTL1 
Mutations
ICGC Data PortalMETTL1 
TCGA Data PortalMETTL1 
Broad Tumor PortalMETTL1
OASIS PortalMETTL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMETTL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMETTL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch METTL1
DgiDB (Drug Gene Interaction Database)METTL1
DoCM (Curated mutations)METTL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)METTL1 (select a term)
intoGenMETTL1
Cancer3DMETTL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604466   
Orphanet
DisGeNETMETTL1
MedgenMETTL1
Genetic Testing Registry METTL1
NextProtQ9UBP6 [Medical]
TSGene4234
GENETestsMETTL1
Target ValidationMETTL1
Huge Navigator METTL1 [HugePedia]
snp3D : Map Gene to Disease4234
BioCentury BCIQMETTL1
ClinGenMETTL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4234
Chemical/Pharm GKB GenePA30766
Clinical trialMETTL1
Miscellaneous
canSAR (ICR)METTL1 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMETTL1
EVEXMETTL1
GoPubMedMETTL1
iHOPMETTL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jun 18 19:30:37 CEST 2018

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