METTL1 (methyltransferase 1, tRNA methylguanosine)

2014-08-01  

Identity

HGNC
METTL1
LOCATION
12q14.1
LOCUSID
4234
ALIAS
C12orf1,TRM8,TRMT8,YDL201w
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4234
MIM: 604466
HGNC: 7030
Ensembl: ENSG00000037897

Variants:

dbSNP: 4234
ClinVar: 4234
TCGA: ENSG00000037897
COSMIC: METTL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000037897ENST00000257848Q9UBP6
ENSG00000037897ENST00000324871Q9UBP6
ENSG00000037897ENST00000547653H0YHU4
ENSG00000037897ENST00000548504H0YIH0
ENSG00000037897ENST00000551117H0YHX0
ENSG00000037897ENST00000553125F8VSD9

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
310310842019Transcriptome-wide Mapping of Internal N<sup>7</sup>-Methylguanosine Methylome in Mammalian mRNA.21
252332132014tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells.20
310310832019METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation.16
203949452010Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
314637322019METTL1 overexpression is correlated with poor prognosis and promotes hepatocellular carcinoma via PTEN.3
321351852020Methyltransferase-like 1 (METTL1) served as a tumor suppressor in colon cancer by activating 7-methyguanosine (m7G) regulated let-7e miRNA/HMGA2 axis.0

Citation

Dessen P

METTL1 (methyltransferase 1, tRNA methylguanosine)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54449/mettl1