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METTL1 (methyltransferase 1, tRNA methylguanosine)

Identity

Alias (NCBI)C12orf1
TRM8
TRMT8
YDL201w
HGNC (Hugo) METTL1
HGNC Alias symbTRM8
TRMT8
HGNC Previous nameC12orf1
HGNC Previous namemethyltransferase like 1
LocusID (NCBI) 4234
Atlas_Id 54449
Location 12q14.1  [Link to chromosome band 12q14]
Location_base_pair Starts at 57768471 and ends at 57772105 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
METTL1 (12q14.1) / TGFBRAP1 (2q12.1)METTL21B (12q14.1) / METTL1 (12q14.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)METTL1   7030
Cards
Entrez_Gene (NCBI)METTL1    methyltransferase 1, tRNA methylguanosine
AliasesC12orf1; TRM8; TRMT8; YDL201w
GeneCards (Weizmann)METTL1
Ensembl hg19 (Hinxton)ENSG00000037897 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000037897 [Gene_View]  ENSG00000037897 [Sequence]  chr12:57768471-57772105 [Contig_View]  METTL1 [Vega]
ICGC DataPortalENSG00000037897
TCGA cBioPortalMETTL1
AceView (NCBI)METTL1
Genatlas (Paris)METTL1
SOURCE (Princeton)METTL1
Genetics Home Reference (NIH)METTL1
Genomic and cartography
GoldenPath hg38 (UCSC)METTL1  -     chr12:57768471-57772105 -  12q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)METTL1  -     12q14.1   [Description]    (hg19-Feb_2009)
GoldenPathMETTL1 - 12q14.1 [CytoView hg19]  METTL1 - 12q14.1 [CytoView hg38]
ImmunoBaseENSG00000037897
Genome Data Viewer NCBIMETTL1 [Mapview hg19]  
OMIM604466   
Gene and transcription
Genbank (Entrez)AA317248 AI168455 AK223202 AK314851 BC000550
RefSeq transcript (Entrez)NM_005371 NM_023032 NM_023033
Consensus coding sequences : CCDS (NCBI)METTL1
Gene ExpressionMETTL1 [ NCBI-GEO ]   METTL1 [ EBI - ARRAY_EXPRESS ]   METTL1 [ SEEK ]   METTL1 [ MEM ]
Gene Expression Viewer (FireBrowse)METTL1 [ Firebrowse - Broad ]
GenevisibleExpression of METTL1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4234
GTEX Portal (Tissue expression)METTL1
Human Protein AtlasENSG00000037897-METTL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBP6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBP6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBP6
PhosPhoSitePlusQ9UBP6
Domaine pattern : Prosite (Expaxy)SAM_MT_TRMB (PS51625)   
Domains : Interpro (EBI)SAM-dependent_MTases    Trm8_euk    tRNA_(Gua-N-7)_MeTrfase_Trmb   
Domain families : Pfam (Sanger)Methyltransf_4 (PF02390)   
Domain families : Pfam (NCBI)pfam02390   
Conserved Domain (NCBI)METTL1
PDB (RSDB)3CKK   
PDB Europe3CKK   
PDB (PDBSum)3CKK   
PDB (IMB)3CKK   
Structural Biology KnowledgeBase3CKK   
SCOP (Structural Classification of Proteins)3CKK   
CATH (Classification of proteins structures)3CKK   
SuperfamilyQ9UBP6
AlphaFold pdb e-kbQ9UBP6   
Human Protein Atlas [tissue]ENSG00000037897-METTL1 [tissue]
HPRD06834
Protein Interaction databases
DIP (DOE-UCLA)Q9UBP6
IntAct (EBI)Q9UBP6
BioGRIDMETTL1
STRING (EMBL)METTL1
ZODIACMETTL1
Ontologies - Pathways
QuickGOQ9UBP6
Ontology : AmiGOtRNA binding  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  tRNA modification  tRNA (guanine-N7-)-methyltransferase activity  tRNA (guanine-N7-)-methyltransferase activity  tRNA methylation  RNA (guanine-N7)-methylation  tRNA methyltransferase complex  tRNA (guanine-N7)-methylation  
Ontology : EGO-EBItRNA binding  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  tRNA modification  tRNA (guanine-N7-)-methyltransferase activity  tRNA (guanine-N7-)-methyltransferase activity  tRNA methylation  RNA (guanine-N7)-methylation  tRNA methyltransferase complex  tRNA (guanine-N7)-methylation  
NDEx NetworkMETTL1
Atlas of Cancer Signalling NetworkMETTL1
Wikipedia pathwaysMETTL1
Orthology - Evolution
OrthoDB4234
GeneTree (enSembl)ENSG00000037897
Phylogenetic Trees/Animal Genes : TreeFamMETTL1
Homologs : HomoloGeneMETTL1
Homology/Alignments : Family Browser (UCSC)METTL1
Gene fusions - Rearrangements
Fusion : MitelmanMETTL21B/METTL1 [12q14.1/12q14.1]  
Fusion : QuiverMETTL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMETTL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)METTL1
dbVarMETTL1
ClinVarMETTL1
MonarchMETTL1
1000_GenomesMETTL1 
Exome Variant ServerMETTL1
GNOMAD BrowserENSG00000037897
Varsome BrowserMETTL1
ACMGMETTL1 variants
VarityQ9UBP6
Genomic Variants (DGV)METTL1 [DGVbeta]
DECIPHERMETTL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMETTL1 
Mutations
ICGC Data PortalMETTL1 
TCGA Data PortalMETTL1 
Broad Tumor PortalMETTL1
OASIS PortalMETTL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMETTL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMETTL1
Mutations and Diseases : HGMDMETTL1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMETTL1
DgiDB (Drug Gene Interaction Database)METTL1
DoCM (Curated mutations)METTL1
CIViC (Clinical Interpretations of Variants in Cancer)METTL1
Cancer3DMETTL1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604466   
Orphanet
DisGeNETMETTL1
MedgenMETTL1
Genetic Testing Registry METTL1
NextProtQ9UBP6 [Medical]
GENETestsMETTL1
Target ValidationMETTL1
Huge Navigator METTL1 [HugePedia]
ClinGenMETTL1
Clinical trials, drugs, therapy
MyCancerGenomeMETTL1
Protein Interactions : CTDMETTL1
Pharm GKB GenePA30766
PharosQ9UBP6
Clinical trialMETTL1
Miscellaneous
canSAR (ICR)METTL1
HarmonizomeMETTL1
DataMed IndexMETTL1
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMETTL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:18:21 CEST 2021

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