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METTL14 (methyltransferase 14, N6-adenosine-methyltransferase subunit)

Identity

Alias (NCBI)hMETTL14
HGNC (Hugo) METTL14
HGNC Alias symbKIAA1627
HGNC Previous namemethyltransferase like 14
LocusID (NCBI) 57721
Atlas_Id 58112
Location 4q26  [Link to chromosome band 4q26]
Location_base_pair Starts at 118685392 and ends at 118715430 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)METTL14   29330
Cards
Entrez_Gene (NCBI)METTL14    methyltransferase 14, N6-adenosine-methyltransferase subunit
AliaseshMETTL14
GeneCards (Weizmann)METTL14
Ensembl hg19 (Hinxton)ENSG00000145388 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145388 [Gene_View]  ENSG00000145388 [Sequence]  chr4:118685392-118715430 [Contig_View]  METTL14 [Vega]
ICGC DataPortalENSG00000145388
TCGA cBioPortalMETTL14
AceView (NCBI)METTL14
Genatlas (Paris)METTL14
SOURCE (Princeton)METTL14
Genetics Home Reference (NIH)METTL14
Genomic and cartography
GoldenPath hg38 (UCSC)METTL14  -     chr4:118685392-118715430 +  4q26   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)METTL14  -     4q26   [Description]    (hg19-Feb_2009)
GoldenPathMETTL14 - 4q26 [CytoView hg19]  METTL14 - 4q26 [CytoView hg38]
ImmunoBaseENSG00000145388
Genome Data Viewer NCBIMETTL14 [Mapview hg19]  
OMIM616504   
Gene and transcription
Genbank (Entrez)AB046847 AK055555 AK296056 AW206149 BC006565
RefSeq transcript (Entrez)NM_020961
Consensus coding sequences : CCDS (NCBI)METTL14
Gene ExpressionMETTL14 [ NCBI-GEO ]   METTL14 [ EBI - ARRAY_EXPRESS ]   METTL14 [ SEEK ]   METTL14 [ MEM ]
Gene Expression Viewer (FireBrowse)METTL14 [ Firebrowse - Broad ]
GenevisibleExpression of METTL14 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57721
GTEX Portal (Tissue expression)METTL14
Human Protein AtlasENSG00000145388-METTL14 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCE5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCE5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCE5
PhosPhoSitePlusQ9HCE5
Domaine pattern : Prosite (Expaxy)MT_A70 (PS51143)   
Domains : Interpro (EBI)MT-A70-like    SAM-dependent_MTases   
Domain families : Pfam (Sanger)MT-A70 (PF05063)   
Domain families : Pfam (NCBI)pfam05063   
Conserved Domain (NCBI)METTL14
PDB (RSDB)5IL0    5IL1    5IL2    5K7M    5K7U    5K7W    5L6D    5L6E    5TEY    6TTP    6TTT    6TTV    6TTW    6TTX    6TU1    6Y4G    7ACD   
PDB Europe5IL0    5IL1    5IL2    5K7M    5K7U    5K7W    5L6D    5L6E    5TEY    6TTP    6TTT    6TTV    6TTW    6TTX    6TU1    6Y4G    7ACD   
PDB (PDBSum)5IL0    5IL1    5IL2    5K7M    5K7U    5K7W    5L6D    5L6E    5TEY    6TTP    6TTT    6TTV    6TTW    6TTX    6TU1    6Y4G    7ACD   
PDB (IMB)5IL0    5IL1    5IL2    5K7M    5K7U    5K7W    5L6D    5L6E    5TEY    6TTP    6TTT    6TTV    6TTW    6TTX    6TU1    6Y4G    7ACD   
Structural Biology KnowledgeBase5IL0    5IL1    5IL2    5K7M    5K7U    5K7W    5L6D    5L6E    5TEY    6TTP    6TTT    6TTV    6TTW    6TTX    6TU1    6Y4G    7ACD   
SCOP (Structural Classification of Proteins)5IL0    5IL1    5IL2    5K7M    5K7U    5K7W    5L6D    5L6E    5TEY    6TTP    6TTT    6TTV    6TTW    6TTX    6TU1    6Y4G    7ACD   
CATH (Classification of proteins structures)5IL0    5IL1    5IL2    5K7M    5K7U    5K7W    5L6D    5L6E    5TEY    6TTP    6TTT    6TTV    6TTW    6TTX    6TU1    6Y4G    7ACD   
SuperfamilyQ9HCE5
AlphaFold pdb e-kbQ9HCE5   
Human Protein Atlas [tissue]ENSG00000145388-METTL14 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9HCE5
IntAct (EBI)Q9HCE5
BioGRIDMETTL14
STRING (EMBL)METTL14
ZODIACMETTL14
Ontologies - Pathways
QuickGOQ9HCE5
Ontology : AmiGOmRNA splicing, via spliceosome  mRNA binding  mRNA binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  mRNA catabolic process  spermatogenesis  RNA metabolic process  mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity  mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity  mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity  stem cell population maintenance  forebrain radial glial cell differentiation  RNA N6-methyladenosine methyltransferase complex  RNA N6-methyladenosine methyltransferase complex  gliogenesis  positive regulation of translation  mRNA destabilization  mRNA methylation  mRNA methylation  mRNA methylation  negative regulation of hematopoietic progenitor cell differentiation  S-adenosyl-L-methionine binding  
Ontology : EGO-EBImRNA splicing, via spliceosome  mRNA binding  mRNA binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  mRNA catabolic process  spermatogenesis  RNA metabolic process  mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity  mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity  mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity  stem cell population maintenance  forebrain radial glial cell differentiation  RNA N6-methyladenosine methyltransferase complex  RNA N6-methyladenosine methyltransferase complex  gliogenesis  positive regulation of translation  mRNA destabilization  mRNA methylation  mRNA methylation  mRNA methylation  negative regulation of hematopoietic progenitor cell differentiation  S-adenosyl-L-methionine binding  
NDEx NetworkMETTL14
Atlas of Cancer Signalling NetworkMETTL14
Wikipedia pathwaysMETTL14
Orthology - Evolution
OrthoDB57721
GeneTree (enSembl)ENSG00000145388
Phylogenetic Trees/Animal Genes : TreeFamMETTL14
Homologs : HomoloGeneMETTL14
Homology/Alignments : Family Browser (UCSC)METTL14
Gene fusions - Rearrangements
Fusion : QuiverMETTL14
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMETTL14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)METTL14
dbVarMETTL14
ClinVarMETTL14
MonarchMETTL14
1000_GenomesMETTL14 
Exome Variant ServerMETTL14
GNOMAD BrowserENSG00000145388
Varsome BrowserMETTL14
ACMGMETTL14 variants
VarityQ9HCE5
Genomic Variants (DGV)METTL14 [DGVbeta]
DECIPHERMETTL14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMETTL14 
Mutations
ICGC Data PortalMETTL14 
TCGA Data PortalMETTL14 
Broad Tumor PortalMETTL14
OASIS PortalMETTL14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMETTL14  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMETTL14
Mutations and Diseases : HGMDMETTL14
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMETTL14
DgiDB (Drug Gene Interaction Database)METTL14
DoCM (Curated mutations)METTL14
CIViC (Clinical Interpretations of Variants in Cancer)METTL14
Cancer3DMETTL14
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616504   
Orphanet
DisGeNETMETTL14
MedgenMETTL14
Genetic Testing Registry METTL14
NextProtQ9HCE5 [Medical]
GENETestsMETTL14
Target ValidationMETTL14
Huge Navigator METTL14 [HugePedia]
ClinGenMETTL14
Clinical trials, drugs, therapy
MyCancerGenomeMETTL14
Protein Interactions : CTDMETTL14
Pharm GKB GenePA164722277
PharosQ9HCE5
Clinical trialMETTL14
Miscellaneous
canSAR (ICR)METTL14
HarmonizomeMETTL14
DataMed IndexMETTL14
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMETTL14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:18:21 CEST 2021

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