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METTL16 (methyltransferase like 16)

Identity

Alias (NCBI)METT10D
HGNC (Hugo) METTL16
HGNC Alias symbMGC3329
HGNC Alias nameU6 snRNA methyltransferase
HGNC Previous nameMETT10D
HGNC Previous namemethyltransferase 10 domain containing
LocusID (NCBI) 79066
Atlas_Id 47510
Location 17p13.3  [Link to chromosome band 17p13]
Location_base_pair Starts at 2416054 and ends at 2511888 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
H6PD (1p36.22) / METTL16 (17p13.3)METTL16 (17p13.3) / METTL16 (17p13.3)METTL16 (17p13.3) / TXNDC17 (17p13.1)
PTPRF (1p34.2) / METTL16 (17p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;17)(p34;p13) PTPRF/METTL16


External links

Nomenclature
HGNC (Hugo)METTL16   28484
Cards
Entrez_Gene (NCBI)METTL16  79066  methyltransferase like 16
AliasesMETT10D
GeneCards (Weizmann)METTL16
Ensembl hg19 (Hinxton)ENSG00000127804 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127804 [Gene_View]  ENSG00000127804 [Sequence]  chr17:2416054-2511888 [Contig_View]  METTL16 [Vega]
ICGC DataPortalENSG00000127804
TCGA cBioPortalMETTL16
AceView (NCBI)METTL16
Genatlas (Paris)METTL16
WikiGenes79066
SOURCE (Princeton)METTL16
Genetics Home Reference (NIH)METTL16
Genomic and cartography
GoldenPath hg38 (UCSC)METTL16  -     chr17:2416054-2511888 -  17p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)METTL16  -     17p13.3   [Description]    (hg19-Feb_2009)
GoldenPathMETTL16 - 17p13.3 [CytoView hg19]  METTL16 - 17p13.3 [CytoView hg38]
ImmunoBaseENSG00000127804
genome Data Viewer NCBIMETTL16 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK027410 AK098286 AK294547 AK296464 AL832612
RefSeq transcript (Entrez)NM_024086
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)METTL16
Alternative Splicing GalleryENSG00000127804
Gene ExpressionMETTL16 [ NCBI-GEO ]   METTL16 [ EBI - ARRAY_EXPRESS ]   METTL16 [ SEEK ]   METTL16 [ MEM ]
Gene Expression Viewer (FireBrowse)METTL16 [ Firebrowse - Broad ]
GenevisibleExpression of METTL16 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79066
GTEX Portal (Tissue expression)METTL16
Human Protein AtlasENSG00000127804-METTL16 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86W50   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86W50  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86W50
Splice isoforms : SwissVarQ86W50
PhosPhoSitePlusQ86W50
Domains : Interpro (EBI)METTL16/PsiM    METTL16/RlmF    SAM-dependent_MTases   
Domain families : Pfam (Sanger)Methyltransf_10 (PF05971)   
Domain families : Pfam (NCBI)pfam05971   
Conserved Domain (NCBI)METTL16
DMDM Disease mutations79066
Blocks (Seattle)METTL16
PDB (RSDB)2H00    6B91    6B92    6DU4    6DU5    6GFK    6GFN    6GT5   
PDB Europe2H00    6B91    6B92    6DU4    6DU5    6GFK    6GFN    6GT5   
PDB (PDBSum)2H00    6B91    6B92    6DU4    6DU5    6GFK    6GFN    6GT5   
PDB (IMB)2H00    6B91    6B92    6DU4    6DU5    6GFK    6GFN    6GT5   
Structural Biology KnowledgeBase2H00    6B91    6B92    6DU4    6DU5    6GFK    6GFN    6GT5   
SCOP (Structural Classification of Proteins)2H00    6B91    6B92    6DU4    6DU5    6GFK    6GFN    6GT5   
CATH (Classification of proteins structures)2H00    6B91    6B92    6DU4    6DU5    6GFK    6GFN    6GT5   
SuperfamilyQ86W50
Human Protein Atlas [tissue]ENSG00000127804-METTL16 [tissue]
Peptide AtlasQ86W50
HPRD14556
IPIIPI00163391   IPI00792378   IPI01009560   IPI01018183   IPI00921997   
Protein Interaction databases
DIP (DOE-UCLA)Q86W50
IntAct (EBI)Q86W50
FunCoupENSG00000127804
BioGRIDMETTL16
STRING (EMBL)METTL16
ZODIACMETTL16
Ontologies - Pathways
QuickGOQ86W50
Ontology : AmiGOmRNA (N6-adenosine)-methyltransferase activity  RNA binding  RNA binding  nucleus  nucleus  mRNA catabolic process  S-adenosylmethionine biosynthetic process  S-adenosylmethionine biosynthetic process  posttranscriptional regulation of gene expression  U6 snRNA 3'-end binding  RNA stem-loop binding  regulation of mRNA splicing, via spliceosome  23S rRNA (adenine(1618)-N(6))-methyltransferase activity  mRNA destabilization  rRNA base methylation  mRNA methylation  U6 snRNA (adenine-(43)-N(6))-methyltransferase activity  snRNA (adenine-N6)-methylation  negative regulation of 3'-UTR-mediated mRNA stabilization  
Ontology : EGO-EBImRNA (N6-adenosine)-methyltransferase activity  RNA binding  RNA binding  nucleus  nucleus  mRNA catabolic process  S-adenosylmethionine biosynthetic process  S-adenosylmethionine biosynthetic process  posttranscriptional regulation of gene expression  U6 snRNA 3'-end binding  RNA stem-loop binding  regulation of mRNA splicing, via spliceosome  23S rRNA (adenine(1618)-N(6))-methyltransferase activity  mRNA destabilization  rRNA base methylation  mRNA methylation  U6 snRNA (adenine-(43)-N(6))-methyltransferase activity  snRNA (adenine-N6)-methylation  negative regulation of 3'-UTR-mediated mRNA stabilization  
NDEx NetworkMETTL16
Atlas of Cancer Signalling NetworkMETTL16
Wikipedia pathwaysMETTL16
Orthology - Evolution
OrthoDB79066
GeneTree (enSembl)ENSG00000127804
Phylogenetic Trees/Animal Genes : TreeFamMETTL16
HOGENOMQ86W50
Homologs : HomoloGeneMETTL16
Homology/Alignments : Family Browser (UCSC)METTL16
Gene fusions - Rearrangements
Fusion : MitelmanPTPRF/METTL16 [1p34.2/17p13.3]  
Fusion : QuiverMETTL16
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMETTL16 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)METTL16
dbVarMETTL16
ClinVarMETTL16
MonarchMETTL16
1000_GenomesMETTL16 
Exome Variant ServerMETTL16
GNOMAD BrowserENSG00000127804
Varsome BrowserMETTL16
Genetic variants : HAPMAP79066
Genomic Variants (DGV)METTL16 [DGVbeta]
DECIPHERMETTL16 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMETTL16 
Mutations
ICGC Data PortalMETTL16 
TCGA Data PortalMETTL16 
Broad Tumor PortalMETTL16
OASIS PortalMETTL16 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMETTL16  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMETTL16
Mutations and Diseases : HGMDMETTL16
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch METTL16
DgiDB (Drug Gene Interaction Database)METTL16
DoCM (Curated mutations)METTL16 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)METTL16 (select a term)
intoGenMETTL16
Cancer3DMETTL16(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETMETTL16
MedgenMETTL16
Genetic Testing Registry METTL16
NextProtQ86W50 [Medical]
TSGene79066
GENETestsMETTL16
Target ValidationMETTL16
Huge Navigator METTL16 [HugePedia]
snp3D : Map Gene to Disease79066
BioCentury BCIQMETTL16
ClinGenMETTL16
Clinical trials, drugs, therapy
Protein Interactions : CTD79066
Pharm GKB GenePA142671460
Clinical trialMETTL16
Miscellaneous
canSAR (ICR)METTL16 (select the gene name)
HarmonizomeMETTL16
DataMed IndexMETTL16
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMETTL16
EVEXMETTL16
GoPubMedMETTL16
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:20:06 CEST 2020

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