METTL17 (methyltransferase like 17)

2016-12-01  

Identity

HGNC
METTL17
LOCATION
14q11.2
LOCUSID
64745
ALIAS
METT11D1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64745
MIM: 616091
HGNC: 19280
Ensembl: ENSG00000165792

Variants:

dbSNP: 64745
ClinVar: 64745
TCGA: ENSG00000165792
COSMIC: METTL17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165792ENST00000339374Q9H7H0
ENSG00000165792ENST00000339374A0A0S2Z5L8
ENSG00000165792ENST00000382985Q9H7H0
ENSG00000165792ENST00000553564G3V3X6
ENSG00000165792ENST00000554283G3V4H5
ENSG00000165792ENST00000554751G3V4P2
ENSG00000165792ENST00000555533B4E298
ENSG00000165792ENST00000555640B4E298
ENSG00000165792ENST00000555670G3V353
ENSG00000165792ENST00000556670Q9H7H0
ENSG00000165792ENST00000556670A0A0S2Z5V5
ENSG00000165792ENST00000556733H0YJW1
ENSG00000165792ENST00000557550B4E298

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
112787692001Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues.25
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
241377632010Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies.5
264887682015Methyltransferase-like 17 physically and functionally interacts with estrogen receptors.3
314871962019Mettl17, a regulator of mitochondrial ribosomal RNA modifications, is required for the translation of mitochondrial coding genes.2

Citation

Dessen P

METTL17 (methyltransferase like 17)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56641/mettl17