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METTL21A (methyltransferase like 21A)

Identity

Alias_namesFAM119A
family with sequence similarity 119
Alias_symbol (synonym)LOC151194
HCA557b
HSPA-KMT
Other alias
HGNC (Hugo) METTL21A
LocusID (NCBI) 151194
Atlas_Id 41173
Location 2q33.3  [Link to chromosome band 2q33]
Location_base_pair Starts at 207612739 and ends at 207625378 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
METTL21A (2q33.3) / PLEKHM3 (2q33.3)TRIM16L (17p11.2) / METTL21A (2q33.3)METTL21A 2q33.3 / PLEKHM3 2q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)METTL21A   30476
Cards
Entrez_Gene (NCBI)METTL21A  151194  methyltransferase like 21A
AliasesFAM119A; HCA557b; HSPA-KMT
GeneCards (Weizmann)METTL21A
Ensembl hg19 (Hinxton)ENSG00000144401 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144401 [Gene_View]  chr2:207612739-207625378 [Contig_View]  METTL21A [Vega]
ICGC DataPortalENSG00000144401
TCGA cBioPortalMETTL21A
AceView (NCBI)METTL21A
Genatlas (Paris)METTL21A
WikiGenes151194
SOURCE (Princeton)METTL21A
Genetics Home Reference (NIH)METTL21A
Genomic and cartography
GoldenPath hg38 (UCSC)METTL21A  -     chr2:207612739-207625378 -  2q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)METTL21A  -     2q33.3   [Description]    (hg19-Feb_2009)
EnsemblMETTL21A - 2q33.3 [CytoView hg19]  METTL21A - 2q33.3 [CytoView hg38]
Mapping of homologs : NCBIMETTL21A [Mapview hg19]  METTL21A [Mapview hg38]
OMIM615257   
Gene and transcription
Genbank (Entrez)AF455817 AI332764 AI363134 AK093812 BC009462
RefSeq transcript (Entrez)NM_001127395 NM_001308021 NM_001330130 NM_001330131 NM_001330132 NM_001330133 NM_001330134 NM_001330135 NM_001330136 NM_001330137 NM_145280
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)METTL21A
Cluster EST : UnigeneHs.734938 [ NCBI ]
CGAP (NCI)Hs.734938
Alternative Splicing GalleryENSG00000144401
Gene ExpressionMETTL21A [ NCBI-GEO ]   METTL21A [ EBI - ARRAY_EXPRESS ]   METTL21A [ SEEK ]   METTL21A [ MEM ]
Gene Expression Viewer (FireBrowse)METTL21A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)151194
GTEX Portal (Tissue expression)METTL21A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WXB1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WXB1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WXB1
Splice isoforms : SwissVarQ8WXB1
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.-2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   
PhosPhoSitePlusQ8WXB1
Domains : Interpro (EBI)Methyltransf_16    SAM-dependent_MTases   
Domain families : Pfam (Sanger)Methyltransf_16 (PF10294)   
Domain families : Pfam (NCBI)pfam10294   
Conserved Domain (NCBI)METTL21A
DMDM Disease mutations151194
Blocks (Seattle)METTL21A
PDB (SRS)4LEC   
PDB (PDBSum)4LEC   
PDB (IMB)4LEC   
PDB (RSDB)4LEC   
Structural Biology KnowledgeBase4LEC   
SCOP (Structural Classification of Proteins)4LEC   
CATH (Classification of proteins structures)4LEC   
SuperfamilyQ8WXB1
Human Protein AtlasENSG00000144401
Peptide AtlasQ8WXB1
HPRD14090
IPIIPI00550300   IPI00848124   IPI00927931   IPI00927383   IPI00924755   IPI01013636   
Protein Interaction databases
DIP (DOE-UCLA)Q8WXB1
IntAct (EBI)Q8WXB1
FunCoupENSG00000144401
BioGRIDMETTL21A
STRING (EMBL)METTL21A
ZODIACMETTL21A
Ontologies - Pathways
QuickGOQ8WXB1
Ontology : AmiGOprotein binding  nucleoplasm  cytoplasm  protein methylation  protein methylation  protein-lysine N-methyltransferase activity  protein-lysine N-methyltransferase activity  peptidyl-lysine methylation  Hsp70 protein binding  regulation of ATPase activity  ATPase binding  
Ontology : EGO-EBIprotein binding  nucleoplasm  cytoplasm  protein methylation  protein methylation  protein-lysine N-methyltransferase activity  protein-lysine N-methyltransferase activity  peptidyl-lysine methylation  Hsp70 protein binding  regulation of ATPase activity  ATPase binding  
NDEx NetworkMETTL21A
Atlas of Cancer Signalling NetworkMETTL21A
Wikipedia pathwaysMETTL21A
Orthology - Evolution
OrthoDB151194
GeneTree (enSembl)ENSG00000144401
Phylogenetic Trees/Animal Genes : TreeFamMETTL21A
HOVERGENQ8WXB1
HOGENOMQ8WXB1
Homologs : HomoloGeneMETTL21A
Homology/Alignments : Family Browser (UCSC)METTL21A
Gene fusions - Rearrangements
Fusion : MitelmanMETTL21A/PLEKHM3 [2q33.3/2q33.3]  
Fusion: TCGAMETTL21A 2q33.3 PLEKHM3 2q33.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMETTL21A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)METTL21A
dbVarMETTL21A
ClinVarMETTL21A
1000_GenomesMETTL21A 
Exome Variant ServerMETTL21A
ExAC (Exome Aggregation Consortium)METTL21A (select the gene name)
Genetic variants : HAPMAP151194
Genomic Variants (DGV)METTL21A [DGVbeta]
DECIPHERMETTL21A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMETTL21A 
Mutations
ICGC Data PortalMETTL21A 
TCGA Data PortalMETTL21A 
Broad Tumor PortalMETTL21A
OASIS PortalMETTL21A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMETTL21A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMETTL21A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch METTL21A
DgiDB (Drug Gene Interaction Database)METTL21A
DoCM (Curated mutations)METTL21A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)METTL21A (select a term)
intoGenMETTL21A
Cancer3DMETTL21A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615257   
Orphanet
MedgenMETTL21A
Genetic Testing Registry METTL21A
NextProtQ8WXB1 [Medical]
TSGene151194
GENETestsMETTL21A
Huge Navigator METTL21A [HugePedia]
snp3D : Map Gene to Disease151194
BioCentury BCIQMETTL21A
ClinGenMETTL21A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD151194
Chemical/Pharm GKB GenePA145008433
Clinical trialMETTL21A
Miscellaneous
canSAR (ICR)METTL21A (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMETTL21A
EVEXMETTL21A
GoPubMedMETTL21A
iHOPMETTL21A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:24:44 CEST 2017

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