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METTL3 (methyltransferase like 3)

Identity

Other aliasIME4
M6A
MT-A70
Spo8
hMETTL3
HGNC (Hugo) METTL3
LocusID (NCBI) 56339
Atlas_Id 57050
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 21498131 and ends at 21511375 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DHRS1 (14q12) / METTL3 (14q11.2)METTL3 (14q11.2) / SALL2 (14q11.2)STRN3 (14q12) / METTL3 (14q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)METTL3   17563
Cards
Entrez_Gene (NCBI)METTL3  56339  methyltransferase like 3
AliasesIME4; M6A; MT-A70; Spo8; 
hMETTL3
GeneCards (Weizmann)METTL3
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr14:21498131-21511375 [Contig_View]  METTL3 [Vega]
TCGA cBioPortalMETTL3
AceView (NCBI)METTL3
Genatlas (Paris)METTL3
WikiGenes56339
SOURCE (Princeton)METTL3
Genetics Home Reference (NIH)METTL3
Genomic and cartography
GoldenPath hg38 (UCSC)METTL3  -     chr14:21498131-21511375 -  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)METTL3  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblMETTL3 - 14q11.2 [CytoView hg19]  METTL3 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBIMETTL3 [Mapview hg19]  METTL3 [Mapview hg38]
OMIM612472   
Gene and transcription
Genbank (Entrez)AK000222 AK093509 AK097873 AK098655 AK300289
RefSeq transcript (Entrez)NM_019852
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)METTL3
Cluster EST : UnigeneHs.168799 [ NCBI ]
CGAP (NCI)Hs.168799
Gene ExpressionMETTL3 [ NCBI-GEO ]   METTL3 [ EBI - ARRAY_EXPRESS ]   METTL3 [ SEEK ]   METTL3 [ MEM ]
Gene Expression Viewer (FireBrowse)METTL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56339
GTEX Portal (Tissue expression)METTL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86U44   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86U44  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86U44
Splice isoforms : SwissVarQ86U44
PhosPhoSitePlusQ86U44
Domaine pattern : Prosite (Expaxy)MT_A70 (PS51143)   
Domains : Interpro (EBI)MT-A70    MT-A70-like    SAM-dependent_MTases   
Domain families : Pfam (Sanger)MT-A70 (PF05063)   
Domain families : Pfam (NCBI)pfam05063   
Conserved Domain (NCBI)METTL3
DMDM Disease mutations56339
Blocks (Seattle)METTL3
PDB (SRS)5IL0    5IL1    5IL2    5K7M    5K7U    5K7W    5L6D    5L6E    5TEY   
PDB (PDBSum)5IL0    5IL1    5IL2    5K7M    5K7U    5K7W    5L6D    5L6E    5TEY   
PDB (IMB)5IL0    5IL1    5IL2    5K7M    5K7U    5K7W    5L6D    5L6E    5TEY   
PDB (RSDB)5IL0    5IL1    5IL2    5K7M    5K7U    5K7W    5L6D    5L6E    5TEY   
Structural Biology KnowledgeBase5IL0    5IL1    5IL2    5K7M    5K7U    5K7W    5L6D    5L6E    5TEY   
SCOP (Structural Classification of Proteins)5IL0    5IL1    5IL2    5K7M    5K7U    5K7W    5L6D    5L6E    5TEY   
CATH (Classification of proteins structures)5IL0    5IL1    5IL2    5K7M    5K7U    5K7W    5L6D    5L6E    5TEY   
SuperfamilyQ86U44
Peptide AtlasQ86U44
IPIIPI00009755   IPI00328636   IPI01009990   IPI01009524   IPI00908862   IPI00909630   IPI01014647   IPI01013684   IPI01014941   
Protein Interaction databases
DIP (DOE-UCLA)Q86U44
IntAct (EBI)Q86U44
BioGRIDMETTL3
STRING (EMBL)METTL3
ZODIACMETTL3
Ontologies - Pathways
QuickGOQ86U44
Ontology : AmiGOmRNA splicing, via spliceosome  RNA methylation  mRNA binding  nucleus  nucleoplasm  adenosine to inosine editing  mRNA processing  circadian rhythm  RNA methyltransferase activity  RNA metabolic process  mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity  mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity  nuclear speck  stem cell population maintenance  primary miRNA processing  MIS complex  protein heterodimerization activity  protein heterodimerization activity  mRNA destabilization  mRNA methylation  mRNA methylation  positive regulation of cap-independent translational initiation  S-adenosyl-L-methionine binding  primary miRNA methylation  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA methylation  mRNA binding  nucleus  nucleoplasm  adenosine to inosine editing  mRNA processing  circadian rhythm  RNA methyltransferase activity  RNA metabolic process  mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity  mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity  nuclear speck  stem cell population maintenance  primary miRNA processing  MIS complex  protein heterodimerization activity  protein heterodimerization activity  mRNA destabilization  mRNA methylation  mRNA methylation  positive regulation of cap-independent translational initiation  S-adenosyl-L-methionine binding  primary miRNA methylation  
NDEx NetworkMETTL3
Atlas of Cancer Signalling NetworkMETTL3
Wikipedia pathwaysMETTL3
Orthology - Evolution
OrthoDB56339
Phylogenetic Trees/Animal Genes : TreeFamMETTL3
HOVERGENQ86U44
HOGENOMQ86U44
Homologs : HomoloGeneMETTL3
Homology/Alignments : Family Browser (UCSC)METTL3
Gene fusions - Rearrangements
Tumor Fusion PortalMETTL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMETTL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)METTL3
dbVarMETTL3
ClinVarMETTL3
1000_GenomesMETTL3 
Exome Variant ServerMETTL3
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP56339
Genomic Variants (DGV)METTL3 [DGVbeta]
DECIPHERMETTL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMETTL3 
Mutations
ICGC Data PortalMETTL3 
TCGA Data PortalMETTL3 
Broad Tumor PortalMETTL3
OASIS PortalMETTL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMETTL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMETTL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch METTL3
DgiDB (Drug Gene Interaction Database)METTL3
DoCM (Curated mutations)METTL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)METTL3 (select a term)
intoGenMETTL3
Cancer3DMETTL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612472   
Orphanet
DisGeNETMETTL3
MedgenMETTL3
Genetic Testing Registry METTL3
NextProtQ86U44 [Medical]
TSGene56339
GENETestsMETTL3
Target ValidationMETTL3
Huge Navigator METTL3 [HugePedia]
snp3D : Map Gene to Disease56339
BioCentury BCIQMETTL3
ClinGenMETTL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56339
Chemical/Pharm GKB GenePA134955499
Clinical trialMETTL3
Miscellaneous
canSAR (ICR)METTL3 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMETTL3
EVEXMETTL3
GoPubMedMETTL3
iHOPMETTL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:22:12 CET 2017

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