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METTL4 (methyltransferase like 4)

Identity

Alias (NCBI)HsT661
HGNC (Hugo) METTL4
HGNC Alias symbFLJ23017
HsT661
LocusID (NCBI) 64863
Atlas_Id 47028
Location 18p11.32  [Link to chromosome band 18p11]
Location_base_pair Starts at 2537530 and ends at 2571505 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
METTL4 (18p11.32) / RPS14 (5q33.1)TMX3 (18q22.1) / METTL4 (18p11.32)TMX3 18q22.1 / METTL4 18p11.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(18;18)(p11;q22) TMX3/METTL4


External links

Nomenclature
HGNC (Hugo)METTL4   24726
Cards
Entrez_Gene (NCBI)METTL4  64863  methyltransferase like 4
AliasesHsT661
GeneCards (Weizmann)METTL4
Ensembl hg19 (Hinxton)ENSG00000101574 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101574 [Gene_View]  ENSG00000101574 [Sequence]  chr18:2537530-2571505 [Contig_View]  METTL4 [Vega]
ICGC DataPortalENSG00000101574
TCGA cBioPortalMETTL4
AceView (NCBI)METTL4
Genatlas (Paris)METTL4
WikiGenes64863
SOURCE (Princeton)METTL4
Genetics Home Reference (NIH)METTL4
Genomic and cartography
GoldenPath hg38 (UCSC)METTL4  -     chr18:2537530-2571505 -  18p11.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)METTL4  -     18p11.32   [Description]    (hg19-Feb_2009)
GoldenPathMETTL4 - 18p11.32 [CytoView hg19]  METTL4 - 18p11.32 [CytoView hg38]
ImmunoBaseENSG00000101574
genome Data Viewer NCBIMETTL4 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK022584 AK026670 AK290001 AL834296 BC056270
RefSeq transcript (Entrez)NM_001308401 NM_022840
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)METTL4
Alternative Splicing GalleryENSG00000101574
Gene ExpressionMETTL4 [ NCBI-GEO ]   METTL4 [ EBI - ARRAY_EXPRESS ]   METTL4 [ SEEK ]   METTL4 [ MEM ]
Gene Expression Viewer (FireBrowse)METTL4 [ Firebrowse - Broad ]
GenevisibleExpression of METTL4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64863
GTEX Portal (Tissue expression)METTL4
Human Protein AtlasENSG00000101574-METTL4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N3J2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N3J2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N3J2
Splice isoforms : SwissVarQ8N3J2
PhosPhoSitePlusQ8N3J2
Domaine pattern : Prosite (Expaxy)MT_A70 (PS51143)    N6_MTASE (PS00092)   
Domains : Interpro (EBI)DNA_methylase_N6_adenine_CS    MT-A70-like    SAM-dependent_MTases   
Domain families : Pfam (Sanger)MT-A70 (PF05063)   
Domain families : Pfam (NCBI)pfam05063   
Conserved Domain (NCBI)METTL4
DMDM Disease mutations64863
Blocks (Seattle)METTL4
SuperfamilyQ8N3J2
Human Protein Atlas [tissue]ENSG00000101574-METTL4 [tissue]
Peptide AtlasQ8N3J2
HPRD14390
IPIIPI00394998   
Protein Interaction databases
DIP (DOE-UCLA)Q8N3J2
IntAct (EBI)Q8N3J2
FunCoupENSG00000101574
BioGRIDMETTL4
STRING (EMBL)METTL4
ZODIACMETTL4
Ontologies - Pathways
QuickGOQ8N3J2
Ontology : AmiGORNA methylation  nucleic acid binding  nucleus  nucleus  chromatin organization  methyltransferase activity  RNA methyltransferase activity  site-specific DNA-methyltransferase (adenine-specific) activity  site-specific DNA-methyltransferase (adenine-specific) activity  DNA methylation on adenine  regulation of RNA splicing  snRNA (adenine-N6)-methylation  regulation of chromatin organization  
Ontology : EGO-EBIRNA methylation  nucleic acid binding  nucleus  nucleus  chromatin organization  methyltransferase activity  RNA methyltransferase activity  site-specific DNA-methyltransferase (adenine-specific) activity  site-specific DNA-methyltransferase (adenine-specific) activity  DNA methylation on adenine  regulation of RNA splicing  snRNA (adenine-N6)-methylation  regulation of chromatin organization  
NDEx NetworkMETTL4
Atlas of Cancer Signalling NetworkMETTL4
Wikipedia pathwaysMETTL4
Orthology - Evolution
OrthoDB64863
GeneTree (enSembl)ENSG00000101574
Phylogenetic Trees/Animal Genes : TreeFamMETTL4
HOGENOMQ8N3J2
Homologs : HomoloGeneMETTL4
Homology/Alignments : Family Browser (UCSC)METTL4
Gene fusions - Rearrangements
Fusion : MitelmanTMX3/METTL4 [18q22.1/18p11.32]  
Fusion PortalTMX3 18q22.1 METTL4 18p11.32 LUSC
Fusion : QuiverMETTL4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMETTL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)METTL4
dbVarMETTL4
ClinVarMETTL4
1000_GenomesMETTL4 
Exome Variant ServerMETTL4
GNOMAD BrowserENSG00000101574
Varsome BrowserMETTL4
Genetic variants : HAPMAP64863
Genomic Variants (DGV)METTL4 [DGVbeta]
DECIPHERMETTL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMETTL4 
Mutations
ICGC Data PortalMETTL4 
TCGA Data PortalMETTL4 
Broad Tumor PortalMETTL4
OASIS PortalMETTL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMETTL4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMETTL4
Mutations and Diseases : HGMDMETTL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch METTL4
DgiDB (Drug Gene Interaction Database)METTL4
DoCM (Curated mutations)METTL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)METTL4 (select a term)
intoGenMETTL4
Cancer3DMETTL4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETMETTL4
MedgenMETTL4
Genetic Testing Registry METTL4
NextProtQ8N3J2 [Medical]
TSGene64863
GENETestsMETTL4
Target ValidationMETTL4
Huge Navigator METTL4 [HugePedia]
snp3D : Map Gene to Disease64863
BioCentury BCIQMETTL4
ClinGenMETTL4
Clinical trials, drugs, therapy
Protein Interactions : CTD64863
Pharm GKB GenePA134916468
Clinical trialMETTL4
Miscellaneous
canSAR (ICR)METTL4 (select the gene name)
HarmonizomeMETTL4
DataMed IndexMETTL4
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMETTL4
EVEXMETTL4
GoPubMedMETTL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:22:48 CEST 2020

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