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METTL5 (methyltransferase 5, N6-adenosine)

Identity

Alias (NCBI)HSPC133
MRT72
HGNC (Hugo) METTL5
HGNC Alias symbHSPC133
LocusID (NCBI) 29081
Atlas_Id 68925
Location 2q31.1  [Link to chromosome band 2q31]
Location_base_pair Starts at 169811758 and ends at 169824905 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)METTL5   25006
Cards
Entrez_Gene (NCBI)METTL5    methyltransferase 5, N6-adenosine
AliasesHSPC133; MRT72
GeneCards (Weizmann)METTL5
Ensembl hg19 (Hinxton)ENSG00000138382 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138382 [Gene_View]  ENSG00000138382 [Sequence]  chr2:169811758-169824905 [Contig_View]  METTL5 [Vega]
ICGC DataPortalENSG00000138382
TCGA cBioPortalMETTL5
AceView (NCBI)METTL5
Genatlas (Paris)METTL5
SOURCE (Princeton)METTL5
Genetics Home Reference (NIH)METTL5
Genomic and cartography
GoldenPath hg38 (UCSC)METTL5  -     chr2:169811758-169824905 -  2q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)METTL5  -     2q31.1   [Description]    (hg19-Feb_2009)
GoldenPathMETTL5 - 2q31.1 [CytoView hg19]  METTL5 - 2q31.1 [CytoView hg38]
ImmunoBaseENSG00000138382
Genome Data Viewer NCBIMETTL5 [Mapview hg19]  
OMIM618628   618665   
Gene and transcription
Genbank (Entrez)AF161482 AF201938 AK001321 AL523293 BC000921
RefSeq transcript (Entrez)NM_001293186 NM_001293187 NM_014168
Consensus coding sequences : CCDS (NCBI)METTL5
Gene ExpressionMETTL5 [ NCBI-GEO ]   METTL5 [ EBI - ARRAY_EXPRESS ]   METTL5 [ SEEK ]   METTL5 [ MEM ]
Gene Expression Viewer (FireBrowse)METTL5 [ Firebrowse - Broad ]
GenevisibleExpression of METTL5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29081
GTEX Portal (Tissue expression)METTL5
Human Protein AtlasENSG00000138382-METTL5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRN9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRN9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRN9
PhosPhoSitePlusQ9NRN9
Domaine pattern : Prosite (Expaxy)N6_MTASE (PS00092)   
Domains : Interpro (EBI)DNA_methylase_N6_adenine_CS    SAM-dependent_MTases    Small_mtfrase_dom   
Domain families : Pfam (Sanger)MTS (PF05175)   
Domain families : Pfam (NCBI)pfam05175   
Conserved Domain (NCBI)METTL5
PDB (RSDB)6H2U    6H2V   
PDB Europe6H2U    6H2V   
PDB (PDBSum)6H2U    6H2V   
PDB (IMB)6H2U    6H2V   
Structural Biology KnowledgeBase6H2U    6H2V   
SCOP (Structural Classification of Proteins)6H2U    6H2V   
CATH (Classification of proteins structures)6H2U    6H2V   
SuperfamilyQ9NRN9
AlphaFold pdb e-kbQ9NRN9   
Human Protein Atlas [tissue]ENSG00000138382-METTL5 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9NRN9
IntAct (EBI)Q9NRN9
BioGRIDMETTL5
STRING (EMBL)METTL5
ZODIACMETTL5
Ontologies - Pathways
QuickGOQ9NRN9
Ontology : AmiGOnucleic acid binding  protein binding  nucleus  rRNA (adenine-N6-)-methyltransferase activity  rRNA methylation  cell projection  positive regulation of translation  stem cell differentiation  presynapse  postsynapse  S-adenosyl-L-methionine binding  
Ontology : EGO-EBInucleic acid binding  protein binding  nucleus  rRNA (adenine-N6-)-methyltransferase activity  rRNA methylation  cell projection  positive regulation of translation  stem cell differentiation  presynapse  postsynapse  S-adenosyl-L-methionine binding  
NDEx NetworkMETTL5
Atlas of Cancer Signalling NetworkMETTL5
Wikipedia pathwaysMETTL5
Orthology - Evolution
OrthoDB29081
GeneTree (enSembl)ENSG00000138382
Phylogenetic Trees/Animal Genes : TreeFamMETTL5
Homologs : HomoloGeneMETTL5
Homology/Alignments : Family Browser (UCSC)METTL5
Gene fusions - Rearrangements
Fusion : QuiverMETTL5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMETTL5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)METTL5
dbVarMETTL5
ClinVarMETTL5
MonarchMETTL5
1000_GenomesMETTL5 
Exome Variant ServerMETTL5
GNOMAD BrowserENSG00000138382
Varsome BrowserMETTL5
ACMGMETTL5 variants
VarityQ9NRN9
Genomic Variants (DGV)METTL5 [DGVbeta]
DECIPHERMETTL5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMETTL5 
Mutations
ICGC Data PortalMETTL5 
TCGA Data PortalMETTL5 
Broad Tumor PortalMETTL5
OASIS PortalMETTL5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMETTL5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMETTL5
Mutations and Diseases : HGMDMETTL5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMETTL5
DgiDB (Drug Gene Interaction Database)METTL5
DoCM (Curated mutations)METTL5
CIViC (Clinical Interpretations of Variants in Cancer)METTL5
Cancer3DMETTL5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618628    618665   
Orphanet
DisGeNETMETTL5
MedgenMETTL5
Genetic Testing Registry METTL5
NextProtQ9NRN9 [Medical]
GENETestsMETTL5
Target ValidationMETTL5
Huge Navigator METTL5 [HugePedia]
ClinGenMETTL5
Clinical trials, drugs, therapy
MyCancerGenomeMETTL5
Protein Interactions : CTDMETTL5
Pharm GKB GenePA142671461
PharosQ9NRN9
Clinical trialMETTL5
Miscellaneous
canSAR (ICR)METTL5
HarmonizomeMETTL5
DataMed IndexMETTL5
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMETTL5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 16:07:11 CEST 2021

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