MEX3C (mex-3 RNA binding family member C)

2007-04-01  

Identity

HGNC
LOCATION
18q21.2
LOCUSID
ALIAS
BM-013,MEX-3C,RKHD2,RNF194

Other Information

Locus ID:

NCBI: 51320
MIM: 611005
HGNC: 28040
Ensembl: ENSG00000176624

Variants:

dbSNP: 51320
ClinVar: 51320
TCGA: ENSG00000176624
COSMIC: MEX3C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176624ENST00000406189Q5U5Q3
ENSG00000176624ENST00000592416K7ER23
ENSG00000176624ENST00000616921M9T4I7

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164712563BisphosphonatesChemicalClinicalAnnotationassociatedPD
PA445187OsteonecrosisDiseaseClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
228637742012The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation.23
170157682006Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene.11
264711222015A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.11
288080602017The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity.4

Citation

Dessen P

MEX3C (mex-3 RNA binding family member C)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47496/mex3c