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MFF (mitochondrial fission factor)

Identity

Alias_namesC2orf33
chromosome 2 open reading frame 33
Alias_symbol (synonym)GL004
Other aliasEMPF2
HGNC (Hugo) MFF
LocusID (NCBI) 56947
Atlas_Id 52156
Location 2q36.3  [Link to chromosome band 2q36]
Location_base_pair Starts at 227325151 and ends at 227357836 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AGFG1 (2q36.3) / MFF (2q36.3)MFF (2q36.3) / COL4A3 (2q36.3)MFF (2q36.3) / MFF (2q36.3)
RAB1A (2p14) / MFF (2q36.3)SLC39A9 (14q24.1) / MFF (2q36.3)AGFG1 2q36.3 / MFF 2q36.3
MFF 2q36.3 / COL4A3 2q36.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MFF   24858
Cards
Entrez_Gene (NCBI)MFF  56947  mitochondrial fission factor
AliasesC2orf33; EMPF2; GL004
GeneCards (Weizmann)MFF
Ensembl hg19 (Hinxton)ENSG00000168958 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168958 [Gene_View]  chr2:227325151-227357836 [Contig_View]  MFF [Vega]
ICGC DataPortalENSG00000168958
TCGA cBioPortalMFF
AceView (NCBI)MFF
Genatlas (Paris)MFF
WikiGenes56947
SOURCE (Princeton)MFF
Genetics Home Reference (NIH)MFF
Genomic and cartography
GoldenPath hg38 (UCSC)MFF  -     chr2:227325151-227357836 +  2q36.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MFF  -     2q36.3   [Description]    (hg19-Feb_2009)
EnsemblMFF - 2q36.3 [CytoView hg19]  MFF - 2q36.3 [CytoView hg38]
Mapping of homologs : NCBIMFF [Mapview hg19]  MFF [Mapview hg38]
OMIM614785   617086   
Gene and transcription
Genbank (Entrez)AA629429 AF226049 AF246239 AF258660 AK026137
RefSeq transcript (Entrez)NM_001277061 NM_001277062 NM_001277063 NM_001277064 NM_001277065 NM_001277066 NM_001277067 NM_001277068 NM_020194
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MFF
Cluster EST : UnigeneHs.471528 [ NCBI ]
CGAP (NCI)Hs.471528
Alternative Splicing GalleryENSG00000168958
Gene ExpressionMFF [ NCBI-GEO ]   MFF [ EBI - ARRAY_EXPRESS ]   MFF [ SEEK ]   MFF [ MEM ]
Gene Expression Viewer (FireBrowse)MFF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56947
GTEX Portal (Tissue expression)MFF
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZY8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9GZY8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9GZY8
Splice isoforms : SwissVarQ9GZY8
PhosPhoSitePlusQ9GZY8
Domains : Interpro (EBI)FATE/Miff/Tango-11   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)MFF
DMDM Disease mutations56947
Blocks (Seattle)MFF
SuperfamilyQ9GZY8
Human Protein AtlasENSG00000168958
Peptide AtlasQ9GZY8
HPRD16653
IPIIPI00026448   IPI00024816   IPI00555826   IPI00024627   IPI00031927   IPI00917584   IPI00917708   IPI00917411   IPI00915899   IPI00917883   IPI00918012   IPI00975535   IPI01012545   IPI01012448   IPI00979120   IPI00978499   
Protein Interaction databases
DIP (DOE-UCLA)Q9GZY8
IntAct (EBI)Q9GZY8
FunCoupENSG00000168958
BioGRIDMFF
STRING (EMBL)MFF
ZODIACMFF
Ontologies - Pathways
QuickGOQ9GZY8
Ontology : AmiGOmitochondrial fission  release of cytochrome c from mitochondria  protein binding  mitochondrion  mitochondrial outer membrane  peroxisome  protein targeting to mitochondrion  synaptic vesicle  mitochondrial fusion  regulation of mitochondrion organization  peroxisome fission  cell junction  integral component of mitochondrial membrane  protein homodimerization activity  mitochondrial fragmentation involved in apoptotic process  protein homooligomerization  mitochondrion morphogenesis  positive regulation of mitochondrial fission  positive regulation of release of cytochrome c from mitochondria  positive regulation of protein targeting to membrane  regulation of peroxisome organization  
Ontology : EGO-EBImitochondrial fission  release of cytochrome c from mitochondria  protein binding  mitochondrion  mitochondrial outer membrane  peroxisome  protein targeting to mitochondrion  synaptic vesicle  mitochondrial fusion  regulation of mitochondrion organization  peroxisome fission  cell junction  integral component of mitochondrial membrane  protein homodimerization activity  mitochondrial fragmentation involved in apoptotic process  protein homooligomerization  mitochondrion morphogenesis  positive regulation of mitochondrial fission  positive regulation of release of cytochrome c from mitochondria  positive regulation of protein targeting to membrane  regulation of peroxisome organization  
NDEx NetworkMFF
Atlas of Cancer Signalling NetworkMFF
Wikipedia pathwaysMFF
Orthology - Evolution
OrthoDB56947
GeneTree (enSembl)ENSG00000168958
Phylogenetic Trees/Animal Genes : TreeFamMFF
HOVERGENQ9GZY8
HOGENOMQ9GZY8
Homologs : HomoloGeneMFF
Homology/Alignments : Family Browser (UCSC)MFF
Gene fusions - Rearrangements
Fusion : MitelmanAGFG1/MFF [2q36.3/2q36.3]  [t(2;2)(q36;q36)]  
Fusion : MitelmanMFF/COL4A3 [2q36.3/2q36.3]  [t(2;2)(q36;q36)]  
Fusion: TCGAAGFG1 2q36.3 MFF 2q36.3 LUAD
Fusion: TCGAMFF 2q36.3 COL4A3 2q36.3 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMFF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MFF
dbVarMFF
ClinVarMFF
1000_GenomesMFF 
Exome Variant ServerMFF
ExAC (Exome Aggregation Consortium)MFF (select the gene name)
Genetic variants : HAPMAP56947
Genomic Variants (DGV)MFF [DGVbeta]
DECIPHERMFF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMFF 
Mutations
ICGC Data PortalMFF 
TCGA Data PortalMFF 
Broad Tumor PortalMFF
OASIS PortalMFF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMFF  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMFF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MFF
DgiDB (Drug Gene Interaction Database)MFF
DoCM (Curated mutations)MFF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MFF (select a term)
intoGenMFF
Cancer3DMFF(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614785    617086   
Orphanet
MedgenMFF
Genetic Testing Registry MFF
NextProtQ9GZY8 [Medical]
TSGene56947
GENETestsMFF
Target ValidationMFF
Huge Navigator MFF [HugePedia]
snp3D : Map Gene to Disease56947
BioCentury BCIQMFF
ClinGenMFF
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56947
Chemical/Pharm GKB GenePA162395839
Clinical trialMFF
Miscellaneous
canSAR (ICR)MFF (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMFF
EVEXMFF
GoPubMedMFF
iHOPMFF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:59:06 CEST 2017

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