MFGE8 (milk fat globule EGF and factor V/VIII domain containing)

2003-12-01  

Identity

HGNC
LOCATION
15q26.1
LOCUSID
ALIAS
BA46,EDIL1,HMFG,HsT19888,MFG-E8,MFGM,OAcGD3S,SED1,SPAG10,hP47
FUSION GENES

Other Information

Locus ID:

NCBI: 4240
MIM: 602281
HGNC: 7036
Ensembl: ENSG00000140545

Variants:

dbSNP: 4240
ClinVar: 4240
TCGA: ENSG00000140545
COSMIC: MFGE8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140545ENST00000268150Q08431
ENSG00000140545ENST00000268151Q08431
ENSG00000140545ENST00000542878Q08431
ENSG00000140545ENST00000558018H0YKB5
ENSG00000140545ENST00000558029H0YKS8
ENSG00000140545ENST00000566497Q08431
ENSG00000140545ENST00000613965A0A087WUV5

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
174203512007Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice.77
194438422009Milk fat globule protein epidermal growth factor-8: a pivotal relay element within the angiotensin II and monocyte chemoattractant protein-1 signaling cascade mediating vascular smooth muscle cells invasion.35
181604062008Crystal structure of lactadherin C2 domain at 1.7A resolution with mutational and computational analyses of its membrane-binding motif.34
183031312008Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus.33
268193732016Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Coordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth Factor.33
189741332008Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment.31
198345352009Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.27
238321172013Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids.26
249589002014Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8.20
279562292017Milk Fat Globule-EGF Factor 8, Secreted by Mesenchymal Stem Cells, Protects Against Liver Fibrosis in Mice.20

Citation

Dessen P

MFGE8 (milk fat globule EGF and factor V/VIII domain containing)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41342/mfge8