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MFGE8 (milk fat globule-EGF factor 8 protein)

Identity

Alias_namesSPAG10
sperm associated antigen 10
Alias_symbol (synonym)SED1
EDIL1
BA46
OAcGD3S
HsT19888
MFG-E8
hP47
Other aliasHMFG
MFGM
HGNC (Hugo) MFGE8
LocusID (NCBI) 4240
Atlas_Id 41342
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 88898683 and ends at 88913469 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MFGE8 (15q26.1) / HAPLN3 (15q26.1)MFGE8 (15q26.1) / MFGE8 (15q26.1)MFGE8 (15q26.1) / PABPC1 (8q22.3)
MFGE8 (15q26.1) / UGP2 (2p15)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MFGE8   7036
Cards
Entrez_Gene (NCBI)MFGE8  4240  milk fat globule-EGF factor 8 protein
AliasesBA46; EDIL1; HMFG; HsT19888; 
MFG-E8; MFGM; OAcGD3S; SED1; SPAG10; hP47
GeneCards (Weizmann)MFGE8
Ensembl hg19 (Hinxton)ENSG00000140545 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140545 [Gene_View]  chr15:88898683-88913469 [Contig_View]  MFGE8 [Vega]
ICGC DataPortalENSG00000140545
TCGA cBioPortalMFGE8
AceView (NCBI)MFGE8
Genatlas (Paris)MFGE8
WikiGenes4240
SOURCE (Princeton)MFGE8
Genetics Home Reference (NIH)MFGE8
Genomic and cartography
GoldenPath hg38 (UCSC)MFGE8  -     chr15:88898683-88913469 -  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MFGE8  -     15q26.1   [Description]    (hg19-Feb_2009)
EnsemblMFGE8 - 15q26.1 [CytoView hg19]  MFGE8 - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBIMFGE8 [Mapview hg19]  MFGE8 [Mapview hg38]
OMIM602281   
Gene and transcription
Genbank (Entrez)AK092157 AK095908 AK222735 AK223182 AK304627
RefSeq transcript (Entrez)NM_001114614 NM_001310319 NM_001310320 NM_001310321 NM_005928
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MFGE8
Cluster EST : UnigeneHs.720851 [ NCBI ]
CGAP (NCI)Hs.720851
Alternative Splicing GalleryENSG00000140545
Gene ExpressionMFGE8 [ NCBI-GEO ]   MFGE8 [ EBI - ARRAY_EXPRESS ]   MFGE8 [ SEEK ]   MFGE8 [ MEM ]
Gene Expression Viewer (FireBrowse)MFGE8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4240
GTEX Portal (Tissue expression)MFGE8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08431   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08431  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08431
Splice isoforms : SwissVarQ08431
PhosPhoSitePlusQ08431
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    FA58C_1 (PS01285)    FA58C_2 (PS01286)    FA58C_3 (PS50022)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom    FA58C    Galactose-bd-like    Lactadherin   
Domain families : Pfam (Sanger)EGF (PF00008)    F5_F8_type_C (PF00754)   
Domain families : Pfam (NCBI)pfam00008    pfam00754   
Domain families : Smart (EMBL)EGF (SM00181)  FA58C (SM00231)  
Conserved Domain (NCBI)MFGE8
DMDM Disease mutations4240
Blocks (Seattle)MFGE8
SuperfamilyQ08431
Human Protein AtlasENSG00000140545
Peptide AtlasQ08431
HPRD03789
IPIIPI00966900   IPI00334005   IPI00002236   IPI01015593   IPI00879639   
Protein Interaction databases
DIP (DOE-UCLA)Q08431
IntAct (EBI)Q08431
FunCoupENSG00000140545
BioGRIDMFGE8
STRING (EMBL)MFGE8
ZODIACMFGE8
Ontologies - Pathways
QuickGOQ08431
Ontology : AmiGOangiogenesis  phosphatidylserine binding  integrin binding  extracellular region  extracellular space  phagocytosis, recognition  phagocytosis, engulfment  cell adhesion  single fertilization  phosphatidylethanolamine binding  external side of plasma membrane  membrane  viral process  extrinsic component of plasma membrane  extracellular matrix  cellular protein metabolic process  extracellular exosome  extracellular vesicle  positive regulation of apoptotic cell clearance  
Ontology : EGO-EBIangiogenesis  phosphatidylserine binding  integrin binding  extracellular region  extracellular space  phagocytosis, recognition  phagocytosis, engulfment  cell adhesion  single fertilization  phosphatidylethanolamine binding  external side of plasma membrane  membrane  viral process  extrinsic component of plasma membrane  extracellular matrix  cellular protein metabolic process  extracellular exosome  extracellular vesicle  positive regulation of apoptotic cell clearance  
NDEx NetworkMFGE8
Atlas of Cancer Signalling NetworkMFGE8
Wikipedia pathwaysMFGE8
Orthology - Evolution
OrthoDB4240
GeneTree (enSembl)ENSG00000140545
Phylogenetic Trees/Animal Genes : TreeFamMFGE8
HOVERGENQ08431
HOGENOMQ08431
Homologs : HomoloGeneMFGE8
Homology/Alignments : Family Browser (UCSC)MFGE8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMFGE8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MFGE8
dbVarMFGE8
ClinVarMFGE8
1000_GenomesMFGE8 
Exome Variant ServerMFGE8
ExAC (Exome Aggregation Consortium)MFGE8 (select the gene name)
Genetic variants : HAPMAP4240
Genomic Variants (DGV)MFGE8 [DGVbeta]
DECIPHERMFGE8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMFGE8 
Mutations
ICGC Data PortalMFGE8 
TCGA Data PortalMFGE8 
Broad Tumor PortalMFGE8
OASIS PortalMFGE8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMFGE8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMFGE8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MFGE8
DgiDB (Drug Gene Interaction Database)MFGE8
DoCM (Curated mutations)MFGE8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MFGE8 (select a term)
intoGenMFGE8
Cancer3DMFGE8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602281   
Orphanet
MedgenMFGE8
Genetic Testing Registry MFGE8
NextProtQ08431 [Medical]
TSGene4240
GENETestsMFGE8
Target ValidationMFGE8
Huge Navigator MFGE8 [HugePedia]
snp3D : Map Gene to Disease4240
BioCentury BCIQMFGE8
ClinGenMFGE8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4240
Chemical/Pharm GKB GenePA30772
Clinical trialMFGE8
Miscellaneous
canSAR (ICR)MFGE8 (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMFGE8
EVEXMFGE8
GoPubMedMFGE8
iHOPMFGE8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:17:52 CEST 2017

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