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MFN1 (mitofusin 1)

Identity

Alias (NCBI)hfzo1
hfzo2
HGNC (Hugo) MFN1
HGNC Alias symbFLJ20693
LocusID (NCBI) 55669
Atlas_Id 52408
Location 3q26.33  [Link to chromosome band 3q26]
Location_base_pair Starts at 179347709 and ends at 179394936 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DUSP1 (5q35.1) / MFN1 (3q26.33)GPC1 (2q37.3) / MFN1 (3q26.33)PCBP2 (12q13.13) / MFN1 (3q26.33)
PREX1 (20q13.13) / MFN1 (3q26.33)DUSP1 5q35.1 / MFN1 3q26.33GPC1 2q37.3 / MFN1 3q26.33
PCBP2 12q13.13 / MFN1 3q26.33PREX1 20q13.13 / MFN1 3q26.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MFN1   18262
Cards
Entrez_Gene (NCBI)MFN1    mitofusin 1
Aliaseshfzo1; hfzo2
GeneCards (Weizmann)MFN1
Ensembl hg19 (Hinxton)ENSG00000171109 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171109 [Gene_View]  ENSG00000171109 [Sequence]  chr3:179347709-179394936 [Contig_View]  MFN1 [Vega]
ICGC DataPortalENSG00000171109
TCGA cBioPortalMFN1
AceView (NCBI)MFN1
Genatlas (Paris)MFN1
SOURCE (Princeton)MFN1
Genetics Home Reference (NIH)MFN1
Genomic and cartography
GoldenPath hg38 (UCSC)MFN1  -     chr3:179347709-179394936 +  3q26.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MFN1  -     3q26.33   [Description]    (hg19-Feb_2009)
GoldenPathMFN1 - 3q26.33 [CytoView hg19]  MFN1 - 3q26.33 [CytoView hg38]
ImmunoBaseENSG00000171109
Genome Data Viewer NCBIMFN1 [Mapview hg19]  
OMIM608506   
Gene and transcription
Genbank (Entrez)AB043588 AB043589 AF054986 AF329637 AI656503
RefSeq transcript (Entrez)NM_017927 NM_033540
Consensus coding sequences : CCDS (NCBI)MFN1
Gene ExpressionMFN1 [ NCBI-GEO ]   MFN1 [ EBI - ARRAY_EXPRESS ]   MFN1 [ SEEK ]   MFN1 [ MEM ]
Gene Expression Viewer (FireBrowse)MFN1 [ Firebrowse - Broad ]
GenevisibleExpression of MFN1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55669
GTEX Portal (Tissue expression)MFN1
Human Protein AtlasENSG00000171109-MFN1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWA4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWA4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWA4
PhosPhoSitePlusQ8IWA4
Domaine pattern : Prosite (Expaxy)G_DYNAMIN_2 (PS51718)   
Domains : Interpro (EBI)Dynamin_SF    Fzo/mitofusin_HR2    G_DYNAMIN_dom    Mitofusin-1    Mitofusin_fam    P-loop_NTPase   
Domain families : Pfam (Sanger)Dynamin_N (PF00350)    Fzo_mitofusin (PF04799)   
Domain families : Pfam (NCBI)pfam00350    pfam04799   
Conserved Domain (NCBI)MFN1
PDB (RSDB)5GNR    5GNS    5GNT    5GNU    5GO4    5GOE    5GOF    5GOM    5YEW   
PDB Europe5GNR    5GNS    5GNT    5GNU    5GO4    5GOE    5GOF    5GOM    5YEW   
PDB (PDBSum)5GNR    5GNS    5GNT    5GNU    5GO4    5GOE    5GOF    5GOM    5YEW   
PDB (IMB)5GNR    5GNS    5GNT    5GNU    5GO4    5GOE    5GOF    5GOM    5YEW   
Structural Biology KnowledgeBase5GNR    5GNS    5GNT    5GNU    5GO4    5GOE    5GOF    5GOM    5YEW   
SCOP (Structural Classification of Proteins)5GNR    5GNS    5GNT    5GNU    5GO4    5GOE    5GOF    5GOM    5YEW   
CATH (Classification of proteins structures)5GNR    5GNS    5GNT    5GNU    5GO4    5GOE    5GOF    5GOM    5YEW   
SuperfamilyQ8IWA4
AlphaFold pdb e-kbQ8IWA4   
Human Protein Atlas [tissue]ENSG00000171109-MFN1 [tissue]
HPRD16344
Protein Interaction databases
DIP (DOE-UCLA)Q8IWA4
IntAct (EBI)Q8IWA4
BioGRIDMFN1
STRING (EMBL)MFN1
ZODIACMFN1
Ontologies - Pathways
QuickGOQ8IWA4
Ontology : AmiGOGTPase activity  GTPase activity  GTPase activity  protein binding  GTP binding  mitochondrion  mitochondrial outer membrane  mitochondrial fusion  mitochondrial fusion  mitochondrial fusion  positive regulation of mitochondrial membrane potential  integral component of membrane  macroautophagy  intrinsic component of mitochondrial outer membrane  integral component of mitochondrial outer membrane  identical protein binding  GTP metabolic process  mitochondrion localization  mitochondrion localization  outer mitochondrial membrane protein complex  mitochondrial membrane fusion  
Ontology : EGO-EBIGTPase activity  GTPase activity  GTPase activity  protein binding  GTP binding  mitochondrion  mitochondrial outer membrane  mitochondrial fusion  mitochondrial fusion  mitochondrial fusion  positive regulation of mitochondrial membrane potential  integral component of membrane  macroautophagy  intrinsic component of mitochondrial outer membrane  integral component of mitochondrial outer membrane  identical protein binding  GTP metabolic process  mitochondrion localization  mitochondrion localization  outer mitochondrial membrane protein complex  mitochondrial membrane fusion  
NDEx NetworkMFN1
Atlas of Cancer Signalling NetworkMFN1
Wikipedia pathwaysMFN1
Orthology - Evolution
OrthoDB55669
GeneTree (enSembl)ENSG00000171109
Phylogenetic Trees/Animal Genes : TreeFamMFN1
Homologs : HomoloGeneMFN1
Homology/Alignments : Family Browser (UCSC)MFN1
Gene fusions - Rearrangements
Fusion : MitelmanDUSP1/MFN1 [5q35.1/3q26.33]  
Fusion : MitelmanGPC1/MFN1 [2q37.3/3q26.33]  
Fusion : MitelmanPCBP2/MFN1 [12q13.13/3q26.33]  
Fusion : MitelmanPREX1/MFN1 [20q13.13/3q26.33]  
Fusion : QuiverMFN1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMFN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MFN1
dbVarMFN1
ClinVarMFN1
MonarchMFN1
1000_GenomesMFN1 
Exome Variant ServerMFN1
GNOMAD BrowserENSG00000171109
Varsome BrowserMFN1
ACMGMFN1 variants
VarityQ8IWA4
Genomic Variants (DGV)MFN1 [DGVbeta]
DECIPHERMFN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMFN1 
Mutations
ICGC Data PortalMFN1 
TCGA Data PortalMFN1 
Broad Tumor PortalMFN1
OASIS PortalMFN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMFN1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMFN1
Mutations and Diseases : HGMDMFN1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMFN1
DgiDB (Drug Gene Interaction Database)MFN1
DoCM (Curated mutations)MFN1
CIViC (Clinical Interpretations of Variants in Cancer)MFN1
Cancer3DMFN1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608506   
Orphanet
DisGeNETMFN1
MedgenMFN1
Genetic Testing Registry MFN1
NextProtQ8IWA4 [Medical]
GENETestsMFN1
Target ValidationMFN1
Huge Navigator MFN1 [HugePedia]
ClinGenMFN1
Clinical trials, drugs, therapy
MyCancerGenomeMFN1
Protein Interactions : CTDMFN1
Pharm GKB GenePA134945973
PharosQ8IWA4
Clinical trialMFN1
Miscellaneous
canSAR (ICR)MFN1
HarmonizomeMFN1
DataMed IndexMFN1
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMFN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:18:25 CEST 2021

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