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MGA (MAX dimerization protein MGA)

Identity

Alias (NCBI)MAD5
MXD5
HGNC (Hugo) MGA
HGNC Alias symbKIAA0518
MAD5
MXD5
FLJ12634
HGNC Previous nameMAX gene associated
LocusID (NCBI) 23269
Atlas_Id 53659
Location 15q15.1  [Link to chromosome band 15q15]
Location_base_pair Starts at 41660412 and ends at 41769943 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDKN2A (9p21.3)::MGA (15q15.1)MGA (15q15.1)::ANKLE1 (19p13.11)MGA (15q15.1)::CDKN2A (9p21.3)
MGA (15q15.1)::MGA (15q15.1)MGA (15q15.1)::PBX4 (19p13.11)MGA (15q15.1)::SCD (10q24.31)
MGA (15q15.1)::TMED7-TICAM2 (5q22.3)CDKN2A 9p21.3::MGA 15q15.1MGA 15q15.1::ANKLE1 19p13.11
MGA 15q15.1::CDKN2A 9p21.3MGA 15q15.1::PBX4 19p13.11MGA 15q15.1::SCD 10q24.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MGA   14010
Cards
Entrez_Gene (NCBI)MGA    MAX dimerization protein MGA
AliasesMAD5; MXD5
GeneCards (Weizmann)MGA
Ensembl hg19 (Hinxton)ENSG00000174197 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174197 [Gene_View]  ENSG00000174197 [Sequence]  chr15:41660412-41769943 [Contig_View]  MGA [Vega]
ICGC DataPortalENSG00000174197
TCGA cBioPortalMGA
AceView (NCBI)MGA
Genatlas (Paris)MGA
SOURCE (Princeton)MGA
Genetics Home Reference (NIH)MGA
Genomic and cartography
GoldenPath hg38 (UCSC)MGA  -     chr15:41660412-41769943 +  15q15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MGA  -     15q15.1   [Description]    (hg19-Feb_2009)
GoldenPathMGA - 15q15.1 [CytoView hg19]  MGA - 15q15.1 [CytoView hg38]
ImmunoBaseENSG00000174197
Genome Data Viewer NCBIMGA [Mapview hg19]  
OMIM616061   
Gene and transcription
Genbank (Entrez)AA188751 AB011090 AI434570 AK022696 AK023360
RefSeq transcript (Entrez)NM_001080541 NM_001164273
Consensus coding sequences : CCDS (NCBI)MGA
Gene ExpressionMGA [ NCBI-GEO ]   MGA [ EBI - ARRAY_EXPRESS ]   MGA [ SEEK ]   MGA [ MEM ]
Gene Expression Viewer (FireBrowse)MGA [ Firebrowse - Broad ]
GenevisibleExpression of MGA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23269
GTEX Portal (Tissue expression)MGA
Human Protein AtlasENSG00000174197-MGA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWI9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWI9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWI9
PhosPhoSitePlusQ8IWI9
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)    TBOX_2 (PS01264)    TBOX_3 (PS50252)   
Domains : Interpro (EBI)bHLH_dom    DUF4801    HLH_DNA-bd_sf    MAX_gene-associated_protein    p53-like_TF_DNA-bd    T-box_sf    TF_T-box    TF_T-box_CS   
Domain families : Pfam (Sanger)DUF4801 (PF16059)    HLH (PF00010)    T-box (PF00907)   
Domain families : Pfam (NCBI)pfam16059    pfam00010    pfam00907   
Domain families : Smart (EMBL)HLH (SM00353)  TBOX (SM00425)  
Conserved Domain (NCBI)MGA
SuperfamilyQ8IWI9
AlphaFold pdb e-kbQ8IWI9   
Human Protein Atlas [tissue]ENSG00000174197-MGA [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q8IWI9
IntAct (EBI)Q8IWI9
BioGRIDMGA
STRING (EMBL)MGA
ZODIACMGA
Ontologies - Pathways
QuickGOQ8IWI9
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  cell fate specification  protein binding  nucleoplasm  regulation of transcription by RNA polymerase II  protein dimerization activity  negative regulation of G0 to G1 transition  MLL1 complex  MLL1 complex  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  cell fate specification  protein binding  nucleoplasm  regulation of transcription by RNA polymerase II  protein dimerization activity  negative regulation of G0 to G1 transition  MLL1 complex  MLL1 complex  
NDEx NetworkMGA
Atlas of Cancer Signalling NetworkMGA
Wikipedia pathwaysMGA
Orthology - Evolution
OrthoDB23269
GeneTree (enSembl)ENSG00000174197
Phylogenetic Trees/Animal Genes : TreeFamMGA
Homologs : HomoloGeneMGA
Homology/Alignments : Family Browser (UCSC)MGA
Gene fusions - Rearrangements
Fusion : MitelmanCDKN2A::MGA [9p21.3/15q15.1]  
Fusion : MitelmanMGA::ANKLE1 [15q15.1/19p13.11]  
Fusion : MitelmanMGA::CDKN2A [15q15.1/9p21.3]  
Fusion : MitelmanMGA::PBX4 [15q15.1/19p13.11]  
Fusion : MitelmanMGA::SCD [15q15.1/10q24.31]  
Fusion : QuiverMGA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMGA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MGA
dbVarMGA
ClinVarMGA
MonarchMGA
1000_GenomesMGA 
Exome Variant ServerMGA
GNOMAD BrowserENSG00000174197
Varsome BrowserMGA
ACMGMGA variants
VarityQ8IWI9
Genomic Variants (DGV)MGA [DGVbeta]
DECIPHERMGA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMGA 
Mutations
ICGC Data PortalMGA 
TCGA Data PortalMGA 
Broad Tumor PortalMGA
OASIS PortalMGA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMGA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMGA
Mutations and Diseases : HGMDMGA
intOGen PortalMGA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMGA
DgiDB (Drug Gene Interaction Database)MGA
DoCM (Curated mutations)MGA
CIViC (Clinical Interpretations of Variants in Cancer)MGA
Cancer3DMGA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616061   
Orphanet
DisGeNETMGA
MedgenMGA
Genetic Testing Registry MGA
NextProtQ8IWI9 [Medical]
GENETestsMGA
Target ValidationMGA
Huge Navigator MGA [HugePedia]
ClinGenMGA
Clinical trials, drugs, therapy
MyCancerGenomeMGA
Protein Interactions : CTDMGA
Pharm GKB GenePA134976336
PharosQ8IWI9
Clinical trialMGA
Miscellaneous
canSAR (ICR)MGA
HarmonizomeMGA
ARCHS4MGA
DataMed IndexMGA
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMGA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:20:19 CET 2022

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